Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7751 - 7800 OF 15487 RESULTS

Efficacy and safety of vismodegib in advanced basal-cell carcinoma
New England Journal of Medicine, ISSN: 15334406 00284793
Aleksandar Sekulic; Michael R. Migden; Anthony E. Oro; Luc Dirix; Karl Lewis; John Hainsworth; James A. Solomon; Simon Yoo; Sarah T. Arron; Philip A. Friedlander; Ellen Marmur; Charles M. Rudin; Anne Lynn S. Chang; Low; Howard M. Mackey; Robert Yauch; Richard A. Graham; Josina C. Reddy; Axel Hauschild
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Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
New England Journal of Medicine, ISSN: 15334406 00284793
Jean Y. Tang; Julian M. Mackay-Wiggan; Michelle Aszterbaum; Robert Yauch; Joselyn Lindgren; Kris Chang; Carol Coppola; Anita M. Chanana; Jackleen Marji; David R. Bickers; Ervin H. Epstein Jr.
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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
Nature, ISSN: 00280836 14764687
Jian Payandeh; Tamer M. Gamal El-Din; Todd Scheuer; Ning Zheng; William A. Catterall
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Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer
Blood, ISSN: 15280020 00064971
Jian-Guo Wang; Julia E. Geddings; Maria M. Aleman; Jessica C. Cardenas; Pichika Chantrathammachart; Julie C. Williams; Daniel Kirchhofer; Vladimir Y. Bogdanov; Ronald R. Bach; Janusz Rak; Frank C. Church; Alisa S. Wolberg; Rafal Pawlinski; Nigel S. Key; Jen Jen Yeh; Nigel Mackman
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Structural and functional analysis of HtrA1 and its subdomains
Structure, ISSN: 09692126 18784186
Eigenbrot; Ultsch; Michael T. Lipari; Paul Moran; S. Jack Lin; Rajkumar Ganesan; Quan; Jeffrey Tom; Wendy N. Sandoval; Menno Van Lookeren Campagne; Daniel Kirchhofer
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MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jessica K. Ma; Mia Y. Platt; Jeffrey Eastham-Anderson; Jeoung-Sook Shin; Ira Mellman
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Impact of low-dose ritonavir on danoprevir pharmacokinetics: Results of computer-based simulations and a clinical drug-drug interaction study
Clinical Pharmacokinetics, ISSN: 03125963 11791926
Micaela B. Reddy; Yuan Chen; Joshua Haznedar; Jennifer Fretland; Steven Blotner; Patrick F. Smith; Jonathan Q. Tran
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In vivo human apolipoprotein E isoform fractional turnover rates in the CNS
PLoS ONE, ISSN: 19326203
Kristin R. Wildsmith; Jacob M. Basak; Bruce W. Patterson; Yuriy Pyatkivskyy; Jungsu Kim; Kevin E. Yarasheski; Jennifer X. Wang; Kwasi G. Mawuenyega; Hong Jiang; Maia Parsadanian; Hyejin Yoon; Tom Kasten; Wendy C. Sigurdson; Chengjie Xiong; Alison M. Goate; David M. Holtzman; Randall J. Bateman
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Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Eric Van Cutsem; Sanne De Haas; Yoon-Koo Kang; Atsushi Ohtsu; Niall C. Tebbutt; Jian M. Xu; Wei Peng Yong; Bernd Langer; Paul Delmar; Stefan J. Scherer; Manish A. Shah
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Synaptic structure and function
Current Opinion in Neurobiology, ISSN: 09594388 18736882
Antoine Triller; Morgan Sheng
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Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
John I. Trujillo; James R. Kiefer; Wei Huang; Jacqueline E. Day; Joseph Moon; Gina M. Jerome; Christine P. Bono; Christine M. Kornmeier; Melanie L. Williams; Cyrille Kuhn; Glen R. Rennie; Thomas A. Wynn; Christopher P. Carron; Atli Thorarensen
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Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery
Pharmaceutical Research, ISSN: 07248741 1573904X
Elaine E. Peters; Mahmoud Ameri; Xiaomei Wang; Maa; Peter E. Daddona
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HORIZON: An open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Michael Singer; Carl C. Awh; Srinivas Sadda; William R. Freeman; Andrew N. Antoszyk; Pamela Wong; Lisa Tuomi
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Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
Genes and Development, ISSN: 08909369 15495477
Karen Yap; Zhao Qin Lim; Piyush Khandelia; Brad A. Friedman; Eugene V. Makeyev
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Developmental genetics of secretory vesicle acidification during caenorhabditis Elegans spermatogenesis
Genetics, ISSN: 00166731 19432631
Elizabeth J. Gleason; Paul D. Hartley; Melissa Henderson; Katherine L. Hill-Harfe; Paul W. Price; Robby M. Weimer; Tim L. Kroft; Guang-dan Zhu; Suzanne Cordovado; Steven W. L'Hernault
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Genetically engineered mouse models: Closing the gap between preclinical data and trial outcomes
Cancer Research, ISSN: 00085472 15387445
Mallika Singh; Christopher L. Murriel; Leisa Johnson
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Issues and challenges of subvisible and submicron particulate analysis in protein solutions
AAPS Journal, ISSN: 15507416
Thomas M. Scherer; Stephenie Leung; Laura Owyang; Steven J. Shire
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Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone
Haematologica, ISSN: 03906078 15928721
Daniel O. Persky; David Dornan; Bryan H. Goldman; Rita M. Braziel; Richard I. Fisher; Michael LeBlanc; David G. Maloney; Oliver W. Press; Thomas P. Miller; Lisa M. Rimsza
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Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery
AAPS PharmSciTech, ISSN: 15309932
Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Amy Sambrone; Connie Chan; Ryan Hart
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Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD
Primary Care Respiratory Journal, ISSN: 14714418 14751534
Moshe Zutler; Jonathan P. Singera; Theodore A. Omachia; Mark D. Eisner; Carlos Iribarren; Patricia Katz; Paul D. Blanc
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Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: Key role of Stat3 signaling
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Xueping Qu; Guanglei Zhuang; Lanlan Yu; Meng; Napoleone Ferrara
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Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: An analysis of GDC-0973, a MEK inhibitor
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Laurent Vernillet; Amy Peterson; Joseph A. Ware; Lillian Lee; Jean-Francois Martini; Peiwen Yu; Congfen Li; Geoffrey Del Rosario; Edna F. Choo; Klaus P. Hoeflich; Yongchang Shi; Blake T. Aftab; Ron Aoyama; Sanh Tan Lam; Marcia Belvin; John Prescott
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The cost-effectiveness of primary stroke centers for acute stroke care
Stroke, ISSN: 00392499 15244628
Gregory F. Guzauskas; Denise M. Boudreau; Kathleen F. Villa; Steven R. Levine; David L. Veenstra
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Capillary electrophoresis-mass spectrometry methods for tryptic peptide mapping of therapeutic antibodies
Electrophoresis, ISSN: 01730835 15222683
Colin D. Whitmore; Lynn Gennaro
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Economic evaluation of tocilizumab combination in the treatment of moderate-to-severe rheumatoid arthritis in Italy
Journal of Medical Economics, ISSN: 13696998 1941837X
Alex Diamantopoulos; Maurizio Benucci; Stefano Capri; Wolfgang Berger; Neil Wintfeld; Giovanni Giuliani; Walter Ricciardi
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FOXO3a and β-catenin co-localization: Double trouble in colon cancer?
Nature Medicine, ISSN: 10788956 1546170X
Yibing Yan; Lackner
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Differential gene expression in glioblastoma defined by ADC histogram analysis: Relationship to extracellular matrix molecules and survival
American Journal of Neuroradiology, ISSN: 01956108 1936959X
Whitney B. Pope; Mirsadraei; Albert Lai; Ascia Eskin; Qiao; Kim; Benjamin M. Ellingson; Phioanh L. Nghiemphu; Samir Kharbanda; Robert Soriano; Nelson; William H. Yong; Phillips; Timothy Cloughesy
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Protease activity of MALT1: A mystery unravelled
Biochemical Journal, ISSN: 02646021 14708728
Daniel Kirchhofer; Domagoj Vucic
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Ligand binding assays in the 21st century laboratory: Recommendations for characterization and supply of critical reagents
AAPS Journal, ISSN: 15507416
Denise M. O'Hara; Valerie Theobald; Adrienne Clements Egan; Joel Usansky; Murli Krishna; Julie TerWee; Mauricio Maia; Frank P. Spriggs; John Kenney; Afshin Safavi; Jeannine Keefe
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A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies
Blood, ISSN: 15280020 00064971
Laurie H. Sehn; Sarit E. Assouline; Douglas A. Stewart; Joy Mangel; Randy D. Gascoyne; Gregg D. Fine; Susan Frances-Lasserre; David J. Carlile; Michael Crump
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Synthesis of cyanoacetyl oxazolidinones
Synthesis (Germany), ISSN: 00397881 1437210X
Kaitlyn M. Weeber; Jacob B. Schwarz
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Mapping N-Glycosylation Sites across Seven Evolutionarily Distant Species Reveals a Divergent Substrate Proteome Despite a Common Core Machinery
Molecular Cell, ISSN: 10972765 10974164
Dorota F. Zielińska; Florian Gnad; Katharina Schropp; Jacek R. Wiśniewski; Matthias Mann
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Building a three-dimensional model of CYP2C9 inhibition using the autocorrelator: An autonomous model generator
Journal of Chemical Information and Modeling, ISSN: 15499596 15205142
Matthew A. Lardy; Laurie Lebrun; Drew Bullard; Charles Kissinger; Alberto Gobbi
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Building a three-dimensional model of CYP2C9 inhibition using the autocorrelator: An autonomous model generator
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Matthew A. Lardy; Laurie Lebrun; Drew Bullard; Charles Kissinger; Alberto Gobbi
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Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Robert Heald; Philip Jackson; Pascal P. A. Savy; Mark Jones; Emanuela Gancia; Brenda Burton; Richard Newman; Jason Boggs; Emily Chan; Jocelyn Chan; Edna F. Choo; Mark Merchant; Patrick J. Rudewicz; Ultsch; Wiesmann; Qin Yue; Marcia Belvin; Steve Price
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BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor
PLoS ONE, ISSN: 19326203
Kateryna Kyrylkova; Sergiy Kyryachenko; Brian Biehs; Ophir D. Klein; Chrissa Kioussi; Mark Leid
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Origin of immunoglobulin isotype switching
Current Biology, ISSN: 09609822
Catherine Zhu; Victor Lee; Alyssa Finn; Kate Senger; Ali A. Zarrin; Louis Du Pasquier; Ellen Hsu
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Effect of central nervous system metastases on treatment discontinuation and survival in older women receiving trastuzumab for metastatic breast cancer
Journal of Cancer Epidemiology, ISSN: 16878558 16878566
Mark Danese; Karla Lindquist; Justin Doan; Deepa Lalla; Melissa Brammer; Robert I. Griffiths
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Cluster analysis of host cytokine responses to biodefense pathogens in a whole blood ex vivo exposure model (WEEM)
BMC Microbiology, ISSN: 14712180
Brett A Chromy; Imola K. Fodor; Nancy K Montgomery; Paul A Luciw; Sandra L McCutchen-Maloney
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Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy
Journal of Immunology, ISSN: 00221767 15506606
Maureen A. Su; Dan Davini; Philip Cheng; Karen Giang; Una Fan; Jason Devoss; Kellsey P. A. Johannes; Lorelei Taylor; Anthony K. Shum; Mariella Valenzise; Antonella Meloni; Helene Bour-Jordan; Mark S. Anderson
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Caspases in synaptic plasticity
Molecular Brain, ISSN: 17566606
Zheng Li; Morgan Sheng
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Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module
Developmental Cell, ISSN: 15345807 18781551
Matthew Koss; Alexandre Bolze; Andrea Brendolan; Matilde Saggese; Terence D. Capellini; Ekaterina Bojilova; Bertrand Boisson; Owen W.J. Prall; David A. Elliott; Mark J. Solloway; Elisa Lenti; Chisa Hidaka; Ching-Pin Chang; Nizar Mahlaoui; Richard P. Harvey; Jean-Laurent Casanova; Licia Selleri
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The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf V600E kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Li Ren; Kateri Ahrendt; Jonas Grina; Ellen R. Laird; Alexandre J. Buckmelter; Joshua D. Hansen; Bradley J. Newhouse; David Moreno; Steve Wenglowsky; Victoria Dinkel; Susan L. Gloor; Gregg Hastings; Sumeet Rana; Kevin Rasor; Tyler Risom; Hillary L. Sturgis; Walter C. Voegtli; Simon Mathieu
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Current Technology and Limitation of LC-MS
ADME-Enabling Technologies in Drug Design and Development,
Cornelis E. Hop
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Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology
BMC Bioinformatics, ISSN: 14712105
Steven M. Hill; Richard M. Neve; Nora Bayani; Wen-Lin Kuo; Safiyyah Ziyad; Paul T. Spellman; Joe W. Gray; Sach Mukherjee
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Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Flygare; Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Frederick Cohen; Deshayes; Karl Doerner; Gail Eckhardt; Linda O. Elliott; Bainian Feng; Matthew C Franklin; Stacy Frankovitz Reisner; Lewis Gazzard; Jason S Halladay; Sarah G. Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley J. Murray; Emile G. Plise; Quan; Jean-Philippe Stephan; Young G. Shin; Jeffrey Tom; Vickie Tsui; Joanne Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi J. A. Wallweber; Lan Wang; Joseph A. Ware; Zhaoyang Wen; Harvey Wong; Jonathan M. Wong; Melisa Wong; Susan C. Wong; Ron Yu; Zobel; Wayne J. Fairbrother
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Challenges and opportunities in the use of CTCs for companion diagnostic development
Recent Results in Cancer Research, ISSN: 00800015
Elizabeth A. Punnoose; Lackner
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An ATP-site on-off switch that restricts phosphatase accessibility of Akt
Science Signaling, ISSN: 19450877 19379145
Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber
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An ATP-site on-off switch that restricts phosphatase accessibility of Akt
Science Signaling, ISSN: 19450877 19379145
Kui Lin; Jie Lin; Wen-I. Wu; Joshua Ballard; Brian B. Lee; Susan L. Gloor; Guy Vigers; Tony Morales; Lori S. Friedman; Nicholas J. Skelton; Barbara J. Brandhuber
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Complementary proteomic tools for the dissection of apoptotic proteolysis events
Journal of Proteome Research, ISSN: 15353893 15353907
Victoria Pham; Pitti; Veronica G. Anania; Corey Bakalarski; Daisy J. Bustos; Suchit Jhunjhunwala; Qui Phung; Kebing Yu; William F. Forrest; Donald S. Kirkpatrick; Avi Ashkenazi; Jennie R. Lill
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