Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7851 - 7900 OF 15394 RESULTS

February 1, 2012

Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Journal of Clinical Investigation, ISSN: 00219738 15588238

A. Phillip Owens III; Freda H. Passam; Silvio Antoniak; Stephanie M. Marshall; Allison L. McDaniel; Lawrence Rudel; Julie C. Williams; Brian K. Hubbard; Julie-Ann Dutton; Jian-Guo Wang; Peter S. Tobias; Linda K. Curtiss; Alan Daugherty; Daniel Kirchhofer; James P. Luyendyk; Patrick M. Moriarty; Shanmugam Nagarajan; Barbara C. Furie; Bruce Furie; Douglas G. Johns; Ryan E. Temel; Nigel Mackman

February 1, 2012

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation

Journal of Virology, ISSN: 0022538X 10985514

Sungyong Won; Celine Eidenschenk; Carrie N. Arnold; Owen M. Siggs; Lei Sun; Katharina Brandl; Tina-Marie Mullen; Glen R. Nemerow; Eva Marie Y. Moresco; Bruce Beutler

February 1, 2012

Cost-effectiveness of adding rituximab to fludarabine and cyclophosphamide for the treatment of previously untreated chronic lymphocytic leukemia

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Ashwini Shewade; Susan Lerner; Mark Friedmann; Leona Han; Hialy Gutierrez; Sacha Satram-Hoang; Michael J. Keating

February 1, 2012

Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

James L. Zazzali; Michael S. Broder; Eunice Chang; Melvin W. Chiu; Daniel J. Hogan

February 1, 2012

Pharmacokinetic effects of coadministration of lersivirine with raltegravir or maraviroc in healthy subjects

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Manoli Vourvahis; Grant Langdon; Robert R. LaBadie; Gary Layton; Marie-Noella Ndongo; Subhashis Banerjee; John Davis

February 1, 2012

Purification and characterization of novel sperm motility-related proteins

Protein Purification,

Gopal C. Majumder; Kaushik Das; Sudipta Saha; Debjani Nath; Arunima Maiti; Sujoy Das; Nabina Dey; Saswati Banerjee; Madhabi Barua; Mahitosh Mandal; Bijay S. Jaiswal; Rupamanjari Biswas; Arpita Bhoumik; Debarun Roy; Souvik Dey; Jharna Som; Debdas Bhattacharyya; Sandhya Rekha Dungdung

February 1, 2012

Targeting IAP proteins for therapeutic intervention in cancer

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Fulda; Domagoj Vucic

February 1, 2012

Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

William F. Rigby; Tony; Oelke; Bernard Combe; Laster; Von Muhlen; Fisheleva; Carmen Martin; Travers; Wolfgang Dummer

February 1, 2012

Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

Paul P. Tak; Philip J. Mease; Mark C. Genovese; Joel M. Kremer; Haraoui; Tanaka; Bingham; Ashrafzadeh; Travers; Safa-Leathers; Kumar; Wolfgang Dummer

February 1, 2012

Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: Pharmacogenetic implications

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Laetitia Dahan; Joseph Ciccolini; Alexandre Evrard; Litaty Mbatchi; Jay Tibbitts; Pauline Ries; Emmanuelle Norguet; Cedric Mercier; Athanassios Iliadis; L'Houcine Ouafik; Bruno Lacarelle; Jean-Francois Seitz

February 1, 2012

Monoclonal antibodies: What are the pharmacokinetic and pharmacodynamic considerations for drug development?

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607

Rong Deng; Feng Jin; Saileta Prabhu; Suhasini Iyer

February 1, 2012

Characterization of nonrapid virologic response patients infected with HCV genotype 1 who may relapse after standard therapy with peginterferon plus ribavirin

Journal of Viral Hepatitis, ISSN: 13520504 13652893

Reau; Hamzeh; Lentz; Zhou; Donald Jensen

February 1, 2012

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates

Journal of Biomolecular Screening, ISSN: 10870571 1552454X

Yichin Liu; Beresini; Adam R. Johnson; Robert Mintzer; Kinjalkumar Shah; Clark; Stephen Schmidt; Lewis; Marya Liimatta; Linda O. Elliott; Amy Gustafson; Christopher E. Heise

February 1, 2012

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

Nature Cell Biology, ISSN: 14657392 14764679

Nevena V. Dimova; Nathaniel A. Hathaway; Byung-Hoon Lee; Donald S. Kirkpatrick; Marie Lea Berkowitz; Steven P. Gygi; Daniel Finley; Randall W. King

February 1, 2012

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development (Cambridge), ISSN: 09501991 14779129

Kelli L. VanDussen; Alexis J. Carulli; Theresa M. Keeley; Sanjeevkumar R. Patel; Brent J. Puthoff; Scott T. Magness; Ivy T. Tran; Ivan Maillard; Christian W. Siebel; Åsa Kolterud; Ann S. Grosse; Deborah L. Gumucio; Stephen A. Ernst; Yu-Hwai Tsai; Peter J. Dempsey; Linda C. Samuelson

January 31, 2012

Thermodynamics of coupled folding in the interaction of archaeal RNase P proteins RPP21 and RPP29

Biochemistry, ISSN: 00062960 15204995

Yiren Xu; Sri Vidya Oruganti; Venkat Gopalan; Mark P. Foster

January 30, 2012

Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus

Brain Research, ISSN: 00068993 18726240

Joel C. Selcher; Weifeng Xu; Jesse E. Hanson; Robert C. Malenka; Daniel V. Madison

January 24, 2012

Oncogene addiction

Current Biology, ISSN: 09609822

Jeffrey Settleman

January 23, 2012

A guide to rational dosing of monoclonal antibodies

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Shuang Bai; Karin Jorga; Yan Xin; Denise Jin; Zheng; Lisa A. Damico; Manish Gupta; Meina Tao Tang; David E. Allison; Dan Lu; Yi Zhang; Amita Joshi; Mark J. Dresser

January 22, 2012

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Nature Medicine, ISSN: 1546170X 10788956

Clara Montagut; Alba Dalmases; Beatriz Bellosillo; Marta Crespo; Silvia Pairet; Mar Iglesias; Marta Salido; Manuel Gallen; Scot A. Marsters; Siao Ping Tsai; André Minoche; Somasekar Seshagiri; Sergi Serrano; Heinz Himmelbauer; Joaquim Bellmunt; Ana Rovira; Jeffrey Settleman; Francesc Bosch; Joan Albanell

January 22, 2012

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Nature Biotechnology, ISSN: 15461696 10870156

Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula

January 19, 2012

Heteroarylation of azine N-oxides

Organic Letters, ISSN: 15237052 15237060

Francis Gosselin; Scott Savage; Nicole Blaquiere; Steven T. Staben

January 17, 2012

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

Developmental Cell, ISSN: 15345807 18781551

Linda N. Geng; Zizhen Yao; Lauren Snider; Abraham P. Fong; Jennifer N. Cech; Janet M. Young; Silvere M. vanderMaarel; Walter L. Ruzzo; Robert Gentleman; Rabi Tawil; Stephen J. Tapscott

January 16, 2012

NMDA receptors and BAX are essential for Aβ impairment of LTP

Scientific Reports, ISSN: 20452322

Kimberly Moore Olsen; Morgan Sheng

January 16, 2012

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

NeuroImage, ISSN: 10538119 10959572

Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope; Taryar M. Zaw; Phillips; Shadi Lalezari; Phioanh L. Nghiemphu; Hassana Ibrahim; Kourosh M. Naeini; Robert J. Harris; Albert Lai

January 15, 2012

A secreted protein microarray platform for extracellular protein interaction discovery

Analytical Biochemistry, ISSN: 10960309 00032697

Sree R. Ramani; Irene Tom; Nicholas Lewin-Koh; Bernd Wranik; Laura DePalatis; Jianjun Zhang; Dan L. Eaton; Lino C. Gonzalez Jr.

January 15, 2012

Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Baselga; Javier Cortés; Sung-Bae Kim; Seock-Ah Im; Roberto Hegg; Im; Laslo Roman; José Luiz Pedrini; Tadeusz Pienkowski; Adam Knott; Emma Clark; Benyunes; Graham Ross; Sandra M. Swain

January 15, 2012

Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; David Moreno; Joachim Rudolph; Yingqing Ran; Kateri Ahrendt; Alisha Arrigo; Ben Colson; Susan L. Gloor; Gregg Hastings

January 15, 2012

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Li Ren; Ellen R. Laird; Alexandre J. Buckmelter; Victoria Dinkel; Susan L. Gloor; Jonas Grina; Bradley J. Newhouse; Kevin Rasor; Gregg Hastings; Stefan Gradl; Joachim Rudolph

January 15, 2012

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen- deprivation therapy

Cancer Research, ISSN: 00085472 15387445

Yuting Sun; Bu-Er Wang; Kevin G. Leong; Peng Yue; Li Li; Suchit Jhunjhunwala; Darrell Chen; Kyounghee Seo; Zora Modrusan; Gao; Jeffrey Settleman; Leisa Johnson

January 14, 2012

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

BMC Cancer, ISSN: 14712407

Carolyn D. Britten; Antoinette S. Gomes; Zev A. Wainberg; David Elashoff; Rafael Amado; Yan Xin; Ronald W. Busuttil; Dennis J. Slamon; Richard S. Finn

January 13, 2012

Separation-Based Analytical Methods for Measuring Protein Aggregation

Analysis of Aggregates and Particles in Protein Pharmaceuticals,

Jun Liu; Barthélemy Demeule; Steven J. Shire

January 12, 2012

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

PLoS ONE, ISSN: 19326203

Robert Mintzer; Sreemathy Ramaswamy; Kinjalkumar Shah; Rami N. Hannoush; Christine D. Pozniak; Frederick Cohen; Xianrui Zhao; Emile G. Plise; Joe Lewcock; Christopher E. Heise

January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

January 11, 2012

Genetic analysis of DSCAM'S role as a netrin-1 receptor in vertebrates

Journal of Neuroscience, ISSN: 02706474 15292401

Elena Palmesino; Patrick C. G. Haddick; Marc Tessier-Lavigne; Artur Kania

January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Alan R. Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

January 8, 2012

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: Results of a phase I randomized, placebo-controlled trial

Arthritis Research and Therapy, ISSN: 14786354 14786362

Brinda Emu; Diana Luca; Carolyn Offutt; Jane L. Grogan; Bernadette Rojkovich; Marna Williams; Meina Tao Tang; Jim J. Xiao; June H. Lee; John C. Davis

January 6, 2012

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold

Journal of Molecular Biology, ISSN: 10898638 00222836

Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel

January 6, 2012

Capillary size exclusion chromatography with picogram sensitivity for analysis of monoclonal antibodies purified from harvested cell culture fluid

Journal of Chromatography A, ISSN: 18733778 00219673

Jennifer C. Rea; G. Tony Moreno; Lisa Vampola; Yun Lou; Bjorn Van Haan; Guillaume Tremintin; Laura C. Simmons; Adrian Nava; Yajun Jennifer Wang; Dell Farnan

January 6, 2012

Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis

Science, ISSN: 10959203 00368075

Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin

January 5, 2012

Regulation of mitosis and taxane response by Daxx and Rassf1

Oncogene, ISSN: 09509232 14765594

Giovinazzi; Lindsay; Morozov; Escobar-Cabrera; Matthew K. Summers; Han; McIntosh; Ishov

January 1, 2012

DEGAS: Sharing and tracking target compound ideas with external collaborators

Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596

Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron

January 1, 2012

ggbio: an R package for extending the grammar of graphics for genomic data

Genome Biology, ISSN: 14656914

Tengfei Yin; Dianne Cook; Michael Lawrence

January 1, 2012

Randomized and balancing allocation schemes for clinical trials: Computational perspectives on design and deployment

Designs for Clinical Trials: Perspectives on Current Issues,

Vincent J. Carey; Robert Gentleman

January 1, 2012

Anti-angiogenesis therapy in melanoma

Targeted Therapeutics in Melanoma,

Daniel S. Chen

January 1, 2012

Pioneers of oncology nursing.

ONS connect, ISSN: 19351623

Bertie Ford

January 1, 2012

A very short history of structure-based design: How did we get here and where do we need to go?

Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951

Jeff Blaney

January 1, 2012

Influence of the compound selection process on the performance of human clearance prediction methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop

January 1, 2012

Targeting a cystic fibrosis mutation opens door for personalized treatment.

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2012

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Science Translational Medicine, ISSN: 19466242

Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu

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