Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7901 - 7950 OF 15795 RESULTS

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
Cell, ISSN: 10974172 00928674
Robert M. Samstein; Aaron Arvey; Steven Z. Josefowicz; Xiao Peng; Alex Reynolds; Richard Sandstrom; Shane Neph; Peter Sabo; Kim; Will Liao; Ming Li; Christina Leslie; John A. Stamatoyannopoulos; Alexander Y. Rudensky
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The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang
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Cross-neutralization of influenza A viruses mediated by a single antibody loop
Nature, ISSN: 00280836 14764687
Damian C. Ekiert; Arun K. Kashyap; John Steel; Adam Rubrum; Gira Bhabha; Reza Khayat; Jeong Hyun Lee; Michael Dillon; Ryann E. O'Neil; Aleksandr M. Faynboym; Michael Horowitz; Lawrence Horowitz; Andrew B. Ward; Peter Palese; Richard Webby; Richard A. Lerner; Ramesh R. Bhatt; Ian A. Wilson
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Blood, ISSN: 15280020 00064971
Raghuveer Singh Mali; Peilin Ma; Li-Fan Zeng; Holly Martin; Baskar Ramdas; Yantao He; Emily Sims; Sarah Nabinger; Joydeep Ghosh; Namit Sharma; Veerendra Munugalavadla; Anindya Chatterjee; Shuo Li; Sandusky; Andrew W. Craig; Kevin D. Bunting; Gen-Sheng Feng; Rebecca J. Chan; Zhong-Yin Zhang; Reuben Kapur
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Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James F. Blake; Rui Xu; Josef R. Bencsik; Dengming Xiao; Nicholas C. Kallan; Stephen Schlachter; Ian S. Mitchell; Keith L. Spencer; Anna L. Banka; Eli M. Wallace; Susan L. Gloor; Matthew Martinson; Richard D. Woessner; Guy Vigers; Barbara J. Brandhuber; Jun Liang; Brian S. Safina; Jun Li; Birong Zhang; Christine Chabot; Steven Do; Leslie Lee; Jason Oeh; Deepak Sampath; Brian B. Lee; Kui Lin; Bianca M. Liederer; Nicholas J. Skelton
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Spatially coordinated kinase signaling regulates local axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
Mark Chen; Janice Maloney; Dara Y. Kallop; Jasvinder K. Atwal; Stephen Tam; Kristin Baer; Holger Kissel; Joshua S. Kaminker; Joe Lewcock; Robby M. Weimer; Ryan J. Watts
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Loss of the tumor suppressor BAP1 causes myeloid transformation
Science, ISSN: 10959203 00368075
Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit
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Effectiveness of first-line management strategies for stage I follicular lymphoma: Analysis of the National Lymphocare Study
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jonathan W. Friedberg; Michelle Byrtek; Brian K. Link; Christopher R. Flowers; Taylor; John Hainsworth; James R. Cerhan; Zelenetz; Jamie Hirata; Thomas P. Miller
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Childhood disorders of the synapse: Challenges and opportunities
Science Translational Medicine, ISSN: 19466234 19466242
Virginia Hughes; Morgan Sheng; Huda Y. Zoghbi
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Impact of hemodialysis catheter dysfunction on dialysis and other medical services: An observational cohort study
International Journal of Nephrology, ISSN: 2090214X 20902158
Robert I. Griffiths; Britt B. Newsome; Grace Leung; Geoffrey A. Block; Robert J. Herbert; Mark Danese
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Validity of cost and utility results?
PharmacoEconomics, ISSN: 11707690 11792027
Alex Diamantopoulos; Laura Sawyer; Sarika Ogale; Fred Dejonckheere
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Pharmacokinetics and Biodistribution of a Human Monoclonal Antibody to Oxidized LDL in Cynomolgus Monkey Using PET Imaging
PLoS ONE, ISSN: 19326203
Amrita Kamath; Simon P. Williams; Sherron Bullens; Kyra J. Cowan; Yvonne Stenberg; Simon R. Cherry; Stephen Rendig; David L. Kukis; Chris Griesemer; Lisa A. Damico; Bunting
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Ras inhibition via direct Ras binding - Is there a path forward?
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Weiru Wang; Guowei Fang; Joachim Rudolph
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Potent and highly selective benzimidazole inhibitors of PI3-kinase delta
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Jeremy Murray; Zachary K. Sweeney; Bryan K. Chan; Mercedesz Balazs; Erin K. Bradley; Georgette M. Castanedo; Christine Chabot; David Chantry; Michael Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian S. Safina; Pascal P. A. Savy; Eileen Seward; Ultsch; Daniel P. Sutherlin
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RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Nature, ISSN: 00280836 14764687
David Vilchez; Ianessa Morantte; Zheng Liu; Peter M. Douglas; Carsten Merkwirth; Ana P. C. Rodrigues; Gerard Manning; Andrew Dillin
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A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Ian E. Krop; Patricia M. LoRusso; Kathy Miller; Shanu Modi; Denise A. Yardley; Gladys Rodriguez; Ellie Guardino; Michael W. Lu; Maoxia Zheng; Sandhya Girish; Lukas Amler; Eric P. Winer; Hope S. Rugo
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High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production
Blood, ISSN: 15280020 00064971
Jonathan N. Thon; Matthew T. Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E. Italiano Jr.
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Structural transitions of transmembrane helix 6 in the formation of Metarhodopsin i
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Markus Eilers; Joseph A. Goncalves; Shivani Ahuja; Colleen Kirkup; Amiram Hirshfeld; Carlos Simmerling; Philip J. Reeves; Mordechai Sheves; Steven O. Smith
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Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
Blood, ISSN: 15280020 00064971
Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman
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Dr. Sekulic and colleagues reply
New England Journal of Medicine, ISSN: 15334406 00284793
Aleksandar Sekulic; Josina C. Reddy; Axel Hauschild
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Binding mechanism of metalṡNTP substrates and stringent-response alarmones to bacterial DnaG-type primases
Structure, ISSN: 18784186 09692126
Richard U. Rymer; Francisco A. Solorio; Ashley K. Tehranchi; Clement Chu; Jacob E. Corn; James L. Keck; Jue D. Wang; James M. Berger
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Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
Journal of Clinical Investigation, ISSN: 00219738 15588238
Yanqiu Liu; Agnes D. Berendsen; Shidong Jia; Sutada Lotinun; Roland Baron; Napoleone Ferrara; Bjorn R. Olsen
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Molecular basis for negative regulation of the glucagon receptor
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan
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FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Sunyoung Lee; Roland Meier; Saori Furuta; Marc E. Lenburg; Paraic A. Kenny; Ren Xu; Mina J. Bissell
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Anti-neuropilin-1 (MNRP1685A): Unexpected pharmacokinetic differences across species, from preclinical models to humans
Pharmaceutical Research, ISSN: 07248741 1573904X
Yan Xin; Shuang Bai; Lisa A. Damico; Denise Jin; Wei-Ching Liang; Yan Wu; Frank-Peter Theil; Amita Joshi; Yanmei Lu; John Lowe; Mauricio Maia; Rainer Brachmann; Hong Xiang
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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): An Emphasis on preclinical and clinical catabolism
Current Drug Metabolism, ISSN: 13892002 18755453
Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish
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Pharmacokinetic considerations for antibody drug conjugates
Pharmaceutical Research, ISSN: 07248741 1573904X
Kedan Lin; Jay Tibbitts
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Psychometric evaluation of the cystic fibrosis questionnaire-revised in a national sample
Quality of Life Research, ISSN: 09629343
Alexandra L. Quittner; Gregory S. Sawicki; Ann McMullen; Lawrence Rasouliyan; David J. Pasta; Ashley Yegin; Michael W. Konstan
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A role for Th17 cells in the regulation of tertiary lymphoid follicles
European Journal of Immunology, ISSN: 00142980 15214141
Jane L. Grogan; Wenjun Ouyang
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Tissue distribution studies of protein therapeutics using molecular probes: Molecular imaging
AAPS Journal, ISSN: 15507416
Simon P. Williams
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Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy
Arthritis Care and Research, ISSN: 2151464X 21514658
Jeffrey R. Curtis; Ani John; Onur Baser
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Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancer
Current Drug Metabolism, ISSN: 13892002 18755453
Dan Lu; Howard A. Burris; Wang; E. Claire Dees; Javier Cortés; Amita Joshi; Manish Gupta; Joo-Hee Yi; Yu-Waye Chu; Ted Shih; Liang Fang; Sandhya Girish
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Michael S. Schechter; Stephen Howard Sheldon; Karen Spruyt; Sally Davidson Ward; Christopher Lehmann; Richard N. Shiffman
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Diagnosis and management of childhood obstructive sleep apnea syndrome
Pediatrics, ISSN: 00314005 10984275
Carole L. Marcus; Lee Jay Brooks; Sally Davidson Ward; Kari A. Draper; David Gozal; Ann Carol Halbower; Jacqueline Jones; Christopher Lehmann; Michael S. Schechter; Stephen Howard Sheldon; Richard N. Shiffman; Karen Spruyt
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Compartmental tissue distribution of antibody therapeutics: Experimental approaches and interpretations
AAPS Journal, ISSN: 15507416
C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli
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Differential effects of predosing on tumor and tissue uptake of an 111in-labeled anti-TENB2 antibody-drug conjugate
Journal of Nuclear Medicine, ISSN: 01615505
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Shannon Stainton; Shang-Fan Yu; Jennifer A. Lacap; Mao; Katherine R. Kozak; Aimee Fourie-O'Donohue; Paul G. Polakis; Leslie A. Khawli; Kedan Lin
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The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy
Experimental Oncology, ISSN: 18129269
Maria Cristina De Almagro; Domagoj Vucic
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Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
Nature Protocols, ISSN: 17542189 17502799
Gerard M. J. Beaudoin III; Seung-Hye Lee; Dipika Singh; Yang Yuan; Yu-Gie Ng; Louis F. Reichardt; Jyothi Arikkath
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Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
Journal of Cystic Fibrosis, ISSN: 15691993 18735010
Michael W. Konstan; Wagener; Donald R. VanDevanter; David J. Pasta; Ashley Yegin; Lawrence Rasouliyan; Morgan
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Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Laurent Salphati; Jodie Pang; Emile G. Plise; Leslie Lee; Alan G. Olivero; Wei Wei Prior; Deepak Sampath; Susan C. Wong; Xiaolin Zhang
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Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Kelly M. Loyet; Laura DeForge; Kenneth J. Katschke Jr.; Laurie Diehl; Robert R. Graham; Lily Pao; Lizette Sturgeon; Sock-Cheng Lewin-Koh; Joe G. Hollyfield; Menno Van Lookeren Campagne
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Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes
Ophthalmology, ISSN: 01616420 15494713
Lucia Sobrin; Stephan Ripke; Yi Yu; Jesen Fagerness; Tushar Bhangale; Perciliz L. Tan; Eric H. Souied; Gabriëlle H.S. Buitendijk; Joanna E. Merriam; Andrea J. Richardson; Soumya Raychaudhuri; Robyn Reynolds; Kimberly A. Chin; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Ruth E. Hogg; Usha Chakravarthy; Timothy W. Behrens; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Milam A. Brantley Jr.; Paul N. Baird; Caroline C.W. Klaver; Rando Allikmets; Nicholas Katsanis; Robert R. Graham; John P.A. Ioannidis; Mark J. Daly; Johanna M. Seddon
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Neuropilin-2 expression in cancer
Histopathology, ISSN: 03090167 13652559
Adrian M. Jubb; Susan Sa; Navneet Ratti; Laura A. Strickland; Maike Schmidt; Christopher Callahan; Koeppen
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Long-term effects of ranibizumab on diabetic retinopathy severity and progression
Archives of Ophthalmology, ISSN: 00039950 15383601
Michael S. Ip; Amitha Domalpally; J. Jill Hopkins; Pamela Wong; Jason S. Ehrlich
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Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
AAPS Journal, ISSN: 15507416
Daniela Bumbaca; C. Andrew Boswell; Fielder; Leslie A. Khawli
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The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies
mAbs, ISSN: 19420862 19420870
Saloumeh Kadkhodayan Fischer; Yang; Banmeet S. Anand; Kyra J. Cowan; Robert Hendricks; Jing Li; Nakamura; An Song
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2012 White paper on recent issues in bioanalysis and alignment of multiple guidelines
Bioanalysis, ISSN: 17576180 17576199
Binodh DeSilva; Fabio Garofolo; Mario Rocci; Suzanne Martinez; Isabelle Dumont; France Landry; Catherine Dicaire; Gabriella Szekely-Klepser; Russell Weiner; Mark Arnold; Surendra Bansal; Kevin Bateman; Ronald Bauer; Brian Booth; Scott Davis; Sherri Dudal; Dominique Gouty; John Grundy; Sam Haidar; Roger Hayes; Mohammed Jemal; Surinder Kaur; Marian Kelley; Magnus Knutsson; Olivier Le Blaye; Jean W. Lee; Steve Lowes; Mark Ma; Toshinari Mitsuoka; João Tavares Neto; Robert Nicholson; Eric Ormsby; Jeff M. Sailstad; Lauren Stevenson; Daniel Tang; Jan Welink; Viswanathan; Laixin Wang; Eric Woolf; Eric Yang
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Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Jun Luo; Jian Zhang; Diya Ren; Wen-Lin Tsai; Feng Li; Ashraf Amanullah; Terry Hudson
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Safety and biodistribution of an equine infectious anemia virus-based gene therapy, retinostat®, for age-related macular degeneration
Human Gene Therapy, ISSN: 10430342 15577422
Katie Binley; Peter S. Widdowson; Michelle Kelleher; Jackie De Belin; Julie Loader; Georgina Ferrige; Marie Carlucci; Margaret Esapa; Daniel Chipchase; Diana Angell-Manning; Scott Ellis; Kyriacos Mitrophanous; James Miskin; Vlad Bantseev; Michael Nork; Paul Miller; Stuart Naylor
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