Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7901 - 7950 OF 15976 RESULTS

Biophysical analysis in support of development of protein pharmaceuticals
Biophysics for Therapeutic Protein Development,
Alavattam Sreedhara; Barthélemy Demeule; Jun Liu; Sandeep Yadav; Cromwell; Steven J. Shire
View on Scopus
Clinical pharmacology strategies in the development of antibody-drug conjugates
Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications,
Sandhya Girish; Manish Gupta
View on Scopus
Assay methodologies and challenges
Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications,
Katherine R. Kozak; Helga Raab
View on Scopus
Case study: An antibody-drug conjugate targeting MUC16 for ovarian cancer
Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications,
Douglas Leipold; William Mallet
View on Scopus
Antibody-drug conjugates and immunotoxins: From pre-clinical development to therapeutic applications
Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications,
Gail L. Phillips
View on Scopus
Hormone replacement therapy and women’s health
Estrogen Action, Selective Estrogen Receptor Modulators, and Women's Health: Progress and Promise,
Jennifer Eng-Wong; Ifeyinwa Obiorah; V. Craig Jordan
View on Scopus
Biopharmaceuticals
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3,
Wendy Halpern; David Hutto
View on Scopus
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-6181
Neoplasia (United States), ISSN: 14765586 15228002
Yang Xiao; Kristi Elkins; Jenni K. Durieux; Leslie Lee; Jason Oeh; Lulu Yang; Xiaorong Liang; Christopher J. Del Nagro; Jarrod Tremayne; Mandy Kwong; Bianca M. Liederer; Peter K Jackson; Lisa D. Belmont; Deepak Sampath; Thomas O'Brien
View on Scopus
The ASXL-BAP1 axis: New factors in myelopoiesis, cancer and epigenetics
Leukemia, ISSN: 08876924 14765551
Omar Abdel-Wahab; Anwesha Dey
View on Scopus
Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction
Biomedical chromatography : BMC, ISSN: 02693879 10990801
Young G. Shin; Steve A. Jones; Stanley Murakami; Nageshwar Budha; Joseph A. Ware; Harvey Wong; Michael H. Buonarati; Brian J. Dean; Cornelis E. Hop
View on Scopus
Software for Computing and Annotating Genomic Ranges
PLoS Computational Biology, ISSN: 15537358 1553734X
Michael Lawrence; Wolfgang Huber; Hervé Pagès; Patrick Aboyoun; Marc Carlson; Robert Gentleman; Martin Morgan; Vincent J. Carey
View on Scopus
SH3 interactome conserves general function over specific form
Molecular Systems Biology, ISSN: 17444292
Xiaofeng Xin; David Gfeller; Jackie Cheng; Raffi Tonikian; Lin Sun; Ailan Guo; Lianet Lopez; Alevtina Pavlenco; Adenrele Akintobi; Yingnan Zhang; Jean-François Rual; Bridget Currell; Somasekar Seshagiri; Tong Hao; Xinping Yang; Yun A. Shen; Kourosh Salehi-Ashtiani; Jingjing Li; Aaron T. Cheng; Dryden Bouamalay; Adrien Lugari; David E. Hill; Mark L. Grimes; Drubin; Barth D. Grant; Marc Vidal; Charles Boone; Sachdev S. Sidhu; Gary D. Bader
View on Scopus
Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?
Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041
Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons
View on Scopus
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice
Journal of Clinical Investigation, ISSN: 15588238 00219738
Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott Kogan; Benjamin S. Braun; Kevin Shannon
View on Scopus
UHPLC for Characterization of Protein Therapeutics
Ultra High Performance Liquid Chromatography and Its Applications,
Jennifer C. Rea; Yajun Jennifer Wang; Taylor Zhang
View on Scopus
Regarding confirmatory immunogenicity assays
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Daniel A. Coleman; Robert Hendricks; Reginald Delarosa; Eric Wakshull
View on Scopus
Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-Bevacizumab or FOLFIRI-bevacizumab: Results from ARIES, a bevacizumab observational cohort study
Oncologist, ISSN: 10837159 1549490X
Bendell; Bekaii-Saab; Cohn; Herbert Hurwitz; Kozloff; Haluk Tezcan; Roach; Yong Mun; Susan Fish; E. Dawn Flick; Darshan Dalal; Grothey
View on Scopus
Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator
Journal of Biotechnology, ISSN: 18734863 01681656
Huong Le; Santosh Kabbur; Luciano Pollastrini; Ziran Sun; Mills; Kevin Johnson; George Karypis; Hu
View on Scopus
MTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations
Cancer Letters, ISSN: 03043835 18727980
Ulka Vijapurkar; Liliane Robillard; Siqun Zhou; Michael Degtyarev; Kui Lin; Tom Truong; Jarrod Tremayne; Berry; Zhonghua Pei; Lori S. Friedman; Elizabeth M. Blackwood; Marcia Belvin
View on Scopus
TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
Molecular Cell, ISSN: 10972765 10974164
François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi
View on Scopus
Development of capillary size exclusion chromatography for the analysis of monoclonal antibody fragments extracted from human vitreous humor
Journal of Chromatography A, ISSN: 00219673 18733778
Jennifer C. Rea; Yun Lou; Joel Cuzzi; Yuhua Hu; Isabella de Jong; Yajun Jennifer Wang; Dell Farnan
View on Scopus
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Michael F. T. Koehler; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Yunghsiang Chen; Gauri Deshmukh; Xiao Ding; Jennifer A. Epler; Kevin Lau; Leslie Lee; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Jason Oeh; Daniel F. Ortwine; Deepak Sampath; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Zhonghua Pei; Joseph P. Lyssikatos
View on Scopus
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Michael T. Lipari; Wei Li; Paul Moran; Monica Kong-Beltran; Tao Sai; Joyce Lai; S. Jack Lin; Ganesh Kolumam; Jose Zavala-Solorio; Anita Izrael-Tomasevic; David Arnott; Jianyong Wang; Andrew S. Peterson; Daniel Kirchhofer
View on Scopus
The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily
Biochemistry, ISSN: 15204995 00062960
Goetz Parsiegla; Christophe Noguere; Santell; Lazarus; Yves Bourne
View on Scopus
LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Bernd Wranik; Erin Christensen; Gabriele Schaefer; Janet Jackman; Andrew C. Vendel; Dan L. Eaton
View on Scopus
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators
PLoS ONE, ISSN: 19326203
Justin M. Scheer; Wendy N. Sandoval; J. Michael Elliott; Lily Shao; Luis; Sock-Cheng Lewin-Koh; Gabriele Schaefer; Richard L. Vandlen
View on Scopus
Dynamic randomization and a randomization model for clinical trials data
Statistics in Medicine, ISSN: 02776715 10970258
Lee D. Kaiser
View on Scopus
A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Finbarr O'Sullivan; Ian Kasman; Greg D. Plowman
View on Scopus
Multiple secretoglobin 1A1 genes are differentially expressed in horses
BMC Genomics, ISSN: 14712164
Olivier Côté; Brandon N. Lillie; Michael Anthony Hayes; Mary Ellen Clark; Laura van den Bosch; Paula Katavolos; Laurent Viel; Dorothee Bienzle
View on Scopus
Studying dissolution with a model integrating solid-liquid interface kinetics and diffusion kinetics
Analytical Chemistry, ISSN: 00032700 15206882
Jeff Y. Gao
View on Scopus
Mutation Scanning Using MUT-MAP, a High-Throughput, Microfluidic Chip-Based, Multi-Analyte Panel
PLoS ONE, ISSN: 19326203
Rajesh Patel; Alison Tsan; Rachel Tam; Rupal Desai; Nancy Schoenbrunner; Thomas W. Myers; Keith Bauer; Edward Smith; Rajiv Raja
View on Scopus
Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
Clinical Cancer Research, ISSN: 10780432 15573265
Daniel S. Chen; Bryan Irving; F. Stephen Hodi
View on Scopus
The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma
International Journal of Cancer, ISSN: 00207136 10970215
Momen Elshazley; Sato; Tetsunari Hase; Ryo Yamashita; Kenya Yoshida; Shinya Toyokuni; Futoshi Ishiguro; Hirotaka Osada; Yoshitaka Sekido; Kohei Yokoi; Noriyasu Usami; David S. Shames; Masashi Kondo; Adi Gazdar; Minna; Yoshinori Hasegawa
View on Scopus
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Jill M. Spoerke; Carol O'Brien; Huw; Koeppen; Jane Fridlyand; Rainer Brachmann; Matthias Peter; Ajay Pandita; Sankar Mohan; Deepak Sampath; Lori S. Friedman; Berry; Garret M. Hampton; Lukas Amler; David S. Shames; Lackner
View on Scopus
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Sharada Labadie; Peter Dragovich; Kathy Barrett; Wade S. Blair; Philippe Bergeron; Christine Chang; Gauri Deshmukh; Eigenbrot; Nico Ghilardi; Paul Gibbons; Christopher A. Hurley; Adam R. Johnson; Jane R. Kenny; Pawan Bir Kohli; Janusz J. Kulagowski; Marya Liimatta; Patrick J. Lupardus; Rohan Mendonca; Jeremy Murray; Rebecca Pulk; Steven Shia; Micah Steffek; Savita Ubhayakar; Ultsch; Anne Van Abbema; Stuart I. Ward; Mark Zak
View on Scopus
miR-451 regulates dendritic cell cytokine responses to influenza infection
Journal of Immunology, ISSN: 00221767 15506606
Carrie M. Rosenberger; Rebecca L. Podyminogin; Garnet Navarro; Guo-Wei Zhao; Peter S. Askovich; Mitchell J. Weiss; Alan Aderem
View on Scopus
Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
Immunity, ISSN: 10747613 10974180
Rajatava Basu; Darrell B. O'Quinn; Daniel J. Silberger; Trenton R. Schoeb; Lynette Fouser; Wenjun Ouyang; Robin D. Hatton; Casey T. Weaver
View on Scopus
A caspase cascade regulating developmental axon degeneration
Journal of Neuroscience, ISSN: 02706474 15292401
David J. Simon; Robby M. Weimer; Todd McLaughlin; Dara Y. Kallop; Karen Stanger; Jing Yang; Dennis D.M. O'Leary; Rami N. Hannoush; Marc Tessier-Lavigne
View on Scopus
Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
PLoS ONE, ISSN: 19326203
Christopher E. Heise; Jeremy Murray; Katherine E. Augustyn; Brandon Bravo; Preeti Chugha; Frederick Cohen; Anthony M. Giannetti; Paul Gibbons; Rami N. Hannoush; Brian R. Hearn; Priyadarshini Jaishankar; Cuong Q. Ly; Kinjalkumar Shah; Karen Stanger; Micah Steffek; Yinyan Tang; Xianrui Zhao; Joe Lewcock; Adam R. Renslo; Flygare; Michelle R. Arkin
View on Scopus
Author response: Validation of the national eye institute visual function questionnaire-25 (NEIVFQ-25) in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
View on Scopus
Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Daisy J. Bustos; Corey Bakalarski; Yanling Yang; Junmin Peng; Donald S. Kirkpatrick
View on Scopus
Microwave-assisted protein staining, destaining, and in-gel/in-solution digestion of proteins
Methods in Molecular Biology, ISSN: 10643745
Jennie R. Lill; Victor J. Nesatyy
View on Scopus
Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
Journal of Cell Biology, ISSN: 00219525 15408140
Bryan Lo; Geraldine Strasser; Meredith Sagolla; Cary D. Austin; Melissa Junttila; Ira Mellman
View on Scopus
Phosphoproteome of Pristionchus pacificus provides insights into architecture of signaling networks in nematode models
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Nadine Borchert; Karsten Krug; Florian Gnad; Amit Sinha; Ralf J. Sommer; Boris Macek
View on Scopus
A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
Clinical Cancer Research, ISSN: 10780432 15573265
Stanley B. Kaye; Louis Fehrenbacher; Robert Holloway; Amnon Amit; Beth Karlan; Brian Slomovitz; Paul Sabbatini; Ling Fu; Robert Yauch; Ilsung Chang; Josina C. Reddy
View on Scopus
GWASTools: An R/Bioconductor package for quality control and analysis of genome-wide association studies
Bioinformatics, ISSN: 13674803 14602059
Stephanie M. Gogarten; Tushar Bhangale; Matthew P. Conomos; Cecelia A. Laurie; Caitlin P. McHugh; Ian Painter; Xiuwen Zheng; David R. Crosslin; David Levine; Thomas Lumley; Sarah C. Nelson; Kenneth Rice; Jess Shen; Rohit Swarnkar; Bruce S. Weir; Cathy C. Laurie
View on Scopus
Fixed monthly versus less frequent ranibizumab dosing and predictors of visual response in exudative age-related macular degeneration
Journal of Ophthalmology, ISSN: 2090004X 20900058
Seenu M. Hariprasad; Lawrence S. Morse; Howard Shapiro; Pamela Wong; Lisa Tuomi
View on Scopus
Pooled analysis of individual patient data from capecitabine monotherapy clinical trials in locally advanced or metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Blum; Carlos H. Barrios; Nancy Feldman; Sunil Verma; Edward McKenna; Lee; Nana Scotto; Julie Gralow
View on Scopus
A case of semantic variant primary progressive aphasia with severe insular atrophy
Neurocase, ISSN: 13554794 14653656
Tiffany Chow; Links; Masterman; Mendez; Harry V. Vinters
View on Scopus
Project execution risk management in the biopharmaceutical industry - A life cycle approach
AACE International Transactions, ISSN: 15287106
Britton L. Wolf
View on Scopus
© 2025 Genentech, Inc. All rights reserved. This site is intended for US residents only.