Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 751 - 800 OF 15487 RESULTS

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
Journal of Medicinal Chemistry, ISSN: 00222623
Alexander M. Taylor; Bret R. Williams; Fabrizio Giordanetto; Elizabeth H. Kelley; André Lescarbeau; Kelley Shortsleeves; Yong Tang; W. Patrick Walters; Alfonso Arrazate; Christine M. Bowman; Erin Brophy; Emily Chan; Gauri Deshmukh; Jack B. Greisman; Thomas Hunsaker; D. Randal Kipp; Pablo Saenz Lopez-Larrocha; Danilo Maddalo; Iain Martin; Paul Maragakis; Mark Merchant; Mark Murcko; Hunter Nisonoff; Vi Nguyen; Vy Nguyen; Olivia Orozco; Christopher Owen; Levi Pierce; Molly Schmidt; David Shaw; Sherri Smith; Eric Therrien; John C. Tran; James Watters; Nigel J. Waters; Jeremy Wilbur; Lindsay Willmore
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Nickel-Catalyzed Synthesis of Benzylamines from (Hetero)aryl Halides and Glycine-Derived N -Hydroxyphthalimide Esters
Synlett, ISSN: 09365214
Eun Seo Choi; Sophie A. L. Rousseaux; Malcolm P. Huestis
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N-tert-Butoxycarbonyl-N-(2-(tritylthio)ethoxy)glycine as a Building Block for Peptide Ubiquitination
Bioconjugate Chemistry, ISSN: 10431802
Lingling Peng; Elizabeth Helgason; Rafael Miranda; Jeffrey Tom; Jennifer Zhang; Erin C. Dueber; Aimin Song
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Scalable genetic screening for regulatory circuits using compressed Perturb-seq
Nature Biotechnology, ISSN: 10870156
Douglas Yao; Loic Binan; Jon Bezney; Brooke Simonton; Jahanara Freedman; Chris J. Frangieh; Kushal K. Dey; Kathryn R. Geiger-Schuller; Basak Eraslan; Alexander Gusev; Aviv Regev; Brian Cleary
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Optimized Nonviral Gene Disruption in Primary Murine and Human Myeloid Cells
Methods in Molecular Biology, ISSN: 19406029 10643745
Emily C. Freund; Simone M. Haag; Benjamin Haley; Aditya Murthy
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SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab
Frontiers in Neurology, ISSN: 16642295
Jeffrey L Bennett; Kazuo Fujihara; Ho Jin Kim; Romain Marignier; Kevin C. O'Connor; Robert C. Sergott; Traboulsee; Heinz Wiendl; Jens Wuerfel; Scott S. Zamvil; Veronica G. Anania; Regine Buffels; Thomas Künzel; Annemarie N. Lekkerkerker; Siân Lennon-Chrimes; Sean J. Pittock
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A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration
Cell Genomics,
Luz D. Orozco; Leah Owen; Jeffrey Hofmann; Amy Stockwell; Jianhua Tao; Susan Haller; Vineeth T. Mukundan; Christine Clarke; Jessica Lund; Akshayalakshmi Sridhar; Oleg Mayba; Julie L. Barr; Rylee A. Zavala; Elijah C. Graves; Charles Zhang; Nadine Husami; Robert Finley; Elizabeth Au; John H. Lillvis; Michael H. Farkas; Akbar Shakoor; Richard Sherva; Ivana K. Kim; Joshua S. Kaminker; Michael J. Townsend; Lindsay A. Farrer; Brian L. Yaspan; Hsu-Hsin Chen; Margaret M. DeAngelis
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Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR-SB
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Samira Jamalian; Michael J. Dolton; Pascal Chanu; Vidya Ramakrishnan; Yesenia Franco; Kristin R. Wildsmith; Paul T. Manser; Edmond Teng; Jin Y. Jin; Angelica Quartino; Joy C. Hsu
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The Use of Episodic Memory Tests for Screening in Clinical Trials for Early Alzheimer’s Disease: A Comparison of the Free and Cued Selective Reminding Test (FCSRT) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
Journal of Prevention of Alzheimer's Disease, ISSN: 24260266 22745807
Edmond Teng; Paul T. Manser; Shah; Karen Pickthorn; Nan Hu; Djakovic; Swendsen; Mira Blendstrup; Faccin; Ostrowitzki; Kaycee M. Sink
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Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Vidya Ramakrishnan; Christina M. Friedrich; Colleen Witt; Robert Sheehan; Meghan Pryor; Jasvinder K. Atwal; Kristin R. Wildsmith; Katherine Kudrycki; Seung-Hye Lee; Norman Mazer; Carsten Hofmann; Reina N. Fuji; Jin Y. Jin; Ramanujan; Michael J. Dolton; Angelica Quartino
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Mechanical ventilation for COVID-19: Outcomes following discharge from inpatient treatment
PLoS ONE, ISSN: 19326203
Mark J. Butler; Jennie Best; Shalini V. Mohan; Jennifer A. Jonas; Lindsay Arader; Jackson Yeh
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Targeted degradation via direct 26S proteasome recruitment
Nature Chemical Biology, ISSN: 15524469 15524450
Charlene Bashore; Sumit Prakash; Matthew C. Johnson; Ryan J. Conrad; Ivy Kekessie; Suzie J. Scales; Noriko Ishisoko; Tracy L. Kleinheinz; Peter S. Liu; Nataliya Popovych; Aaron T. Wecksler; Lijuan Zhou; Christine Tam; Inna Zilberleyb; Rajini Srinivasan; Robert A. Blake; Aimin Song; Steven T. Staben; Yingnan Zhang; David Arnott; Wayne J. Fairbrother; Scott A. Foster; Ingrid E. Wertz; Claudio Ciferri; Erin C. Dueber
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Systems-based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL
Clinical and Translational Science, ISSN: 17528062 17528054
Monica Susilo; Chi-Chung Li; Kapil Gadkar; Genevive Hernandez; Huw; Jin Y. Jin; Shen Yin; Michael C. Wei; Ramanujan; Iraj Hosseini
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Guided optimization of a crystallization-induced diastereomer transformation to access a key navoximod intermediate
Reaction Chemistry and Engineering, ISSN: 20589883
Andrew J. Kukor; Frederic St-Jean; Andreas Stumpf; Thomas C. Malig; Katarzyna A. Piechowicz; Kenji Kurita; Jason E. Hein
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Baseline Diabetic Retinopathy Severity and Time to Diabetic Macular Edema Resolution with Ranibizumab Treatment: A Meta-Analysis
Ophthalmology Retina, ISSN: 24686530
Katherine E. Talcott; Carolina C.S. Valentim; Lauren Hill; Ivaylo Stoilov; Rishi Singh
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Using SILAC to Develop Quantitative Data-Independent Acquisition (DIA) Proteomic Methods
Methods in Molecular Biology, ISSN: 19406029 10643745
Ellen Casavant; Jason Liang; Sumedh Sankhe; W Rodney Mathews; Veronica G. Anania
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Correction to: Preclinical development of ZED8, an 89Zr immuno‑PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy (European Journal of Nuclear Medicine and Molecular Imaging, (2023), 50, 2, (287-301), 10.1007/s00259-022-05968-6)
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070
Annie Ogasawara; James R. Kiefer; Herman S. Gill; Eugene Chiang; Shravan Sriraman; Gregory Z. Ferl; James Ziai; Sandra Sanabria Bohorquez; Sebastián Guelman; Xiangdan Wang; Jihong Yang; Minh Michael Phan; Van Nguyen; Shan Chung; Christine Yu; Jeff N. Tinianow; Stijn Jan Hein Waaijer; De Crespigny; Jan Marik; C. Andrew Boswell; Tanja S. Zabka; Karin Staflin; Simon‑Peter Williams
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International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs
Clinical and Translational Science, ISSN: 17528062 17528054
Ingrid M. Pruimboom-Brees; Swati Gupta; Nagendra V. Chemuturi; Helen Booler; Erik Nimz; Meg Ferrell Ramos; Antonello Caruso; Katie F. Maass; Vlad Bantseev; Qihong Huang; Mary P. Choules; Jesse C. Nussbaum; Jitendra Kanodia; Christopher Thompson; Chandrasekar Durairaj
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High concentration formulation developability approaches and considerations
mAbs, ISSN: 19420862
Jonathan Zarzar; Tarik A. Khan; Maniraj Bhagawati; Benjamin Weiche; Jasmin Sydow-Andersen; Sreedhara Alavattam
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Intraocular delivery considerations of ocular biologic products and key preclinical determinations
Expert Opinion on Drug Delivery, ISSN: 17447593 17425247
Patrick Hughes; Hongwen Rivers; Vlad Bantseev; Chun-Wan Yen; Hanns-Christian Mahler; Swati Gupta
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Glycochenodeoxycholate and glycodeoxycholate 3-O-glucuronides, but not hexadecanedioate and tetradecanedioate, detected weak inhibition of OATP1B caused by GDC-0810 in humans
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Yoshida; Allan Jaochico; Jialin Mao; Dewakar Sangaraju
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Archway Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration 2-Year Results
Ophthalmology, ISSN: 15494713 01616420
Carl D. Regillo; Brian Berger; Logan Brooks; W. Lloyd Clark; Robert Mittra; Charles C. Wykoff; Natalia F. Callaway; Stephanie DeGraaf; Han Ting Ding; Anne E. Fung; Shamika Gune; Sophie Le Pogam; Robert Smith; Jeffrey R. Willis; Giulio Barteselli
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Physiologically-based pharmacokinetic/pharmacodynamic modeling to predict tumor growth inhibition and the efficacious dose of selective estrogen receptor degraders in humans
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Anjani Ganti; Sijia Yu; Danielle Sharpnack; Ellen Ingalla; Tom De Bruyn
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The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 15737217 01676806
Aditya Bardia; Ingrid A. Mayer; Eric P. Winer; Hannah M. Linden; Cynthia X. Ma; Barbara A. Parker; Meritxell Bellet; Carlos L. Arteaga; Sravanthi Cheeti; Mary Gates; Ching-Wei Chang; Jill Fredrickson; Jill M. Spoerke; Heather M. Moore; Jennifer M. Giltnane; Lori S. Friedman; Edna Chow-Maneval; Iris Chan; Komal Jhaveri
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Prevalence of Macular Atrophy in the MARINA Study of Ranibizumab versus Sham for Neovascular Age-Related Macular Degeneration
Ophthalmology Retina, ISSN: 24686530
Barbara A. Blodi; Amitha Domalpally; Ellie Corkery; Aaron Osborne; Steven Blotner; Susanna M. Grzeschik; Shamika Gune
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TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics
Nature Biotechnology, ISSN: 15461696 10870156
Mages; Noa Moriel; Inbal Avraham-Davidi; Evan Murray; Jan Watter; Fei Chen; Orit Rozenblatt-Rosen; Johanna Klughammer; Aviv Regev; Mor Nitzan
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Phase 1b study of cobimetinib plus atezolizumab in patients with advanced BRAFV600 wild-type melanoma progressing on prior anti–programmed death-1 therapy
European Journal of Cancer, ISSN: 18790852 09598049
Shahneen Sandhu; Victoria Atkinson; Maria González Cao; Theresa Medina; Ainara Soria Rivas; Alexander M. Menzies; Ivor Caro; Louise Roberts; Yuyao Song; Yibing Yan; Yu Guo; Cloris Xue; Georgina V. Long
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Learning from data with structured missingness
Nature Machine Intelligence, ISSN: 25225839
Robin Mitra; Sarah F. McGough; Tapabrata Chakraborti; Chris Holmes; Ryan Copping; Niels Hagenbuch; Stefanie Biedermann; Jack Noonan; Brieuc Lehmann; Aditi Shenvi; Xuan Vinh Doan; David Leslie; Ginestra Bianconi; Ruben Sanchez-Garcia; Alisha Davies; Maxine Mackintosh; Eleni-Rosalina Andrinopoulou; Anahid Basiri; Chris Harbron; Ben D. MacArthur
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Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19
Clinical and Translational Science, ISSN: 17528062 17528054
Rebecca N. Bauer; Anastasia Teterina; Haridha Shivram; Jacqueline McBride; Carrie M. Rosenberger; Fang Cai; Min Bao; Larry Tsai; Oliver Gordon; Ivan T. Lee; Jeffrey J. Wallin; Danielle Porter; Kavita Juneja; Gregory Camus; Ivan O. Rosas; Steffen Wildum
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Astegolimab or Efmarodocokin Alfa in Patients with Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial∗
Critical Care Medicine, ISSN: 15300293 00903493
Michael Waters; James A. McKinnell; Andre C. Kalil; Greg S. Martin; Timothy G. Buchman; Wiebke Theess; Xiaoying Yang; Annemarie N. Lekkerkerker; Tracy Staton; Carrie M. Rosenberger; Rajita Pappu; Yehong Wang; Wenhui Zhang; Logan Brooks; Dorothy Cheung; Joshua Galanter; Hubert Chen; Divya Mohan; Melicent Peck
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Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial (Nature Medicine, (2019), 25, 11, (1706-1714), 10.1038/s41591-019-0628-7)
Nature Medicine, ISSN: 1546170X 10788956
Thomas Powles; Mark Kockx; Alejo Rodriguez-Vida; Ignacio Durán; Simon J. Crabb; Michiel S Van Der Heijden; Bernadett Szabados; Albert Font Pous; Gwenaëlle Gravis; Urbano Anido Herranz; Andrew Protheroe; Alain Ravaud; Denis Maillet; Maria Jose Mendez; Cristina Suarez; Mark Linch; Aaron Prendergast; Pieter-Jan van Dam; Diana Stanoeva; Sofie Daelemans; Sanjeev Mariathasan; Joy S. Tea; Kelly Mousa; Romain Banchereau; Daniel Castellano
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Exploring the Use of a Kinetic pH Calculation to Correct the ACAT Model with a Single Stomach Compartment Setting: Impact of Stomach Setting on Food Effect Prediction for Basic Compounds
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Michael J. Dolton; Karthik Nagapudi; Jia Liu
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Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control
mAbs, ISSN: 19420870 19420862
Feng Yang; Jennifer Zhang; Alexander Buettner; Eva Vosika; Monica Sadek; Zhiqi Hao; Dietmar Reusch; Maximiliane Koenig; Wayman Chan; Anja Bathke; Hilary Pallat; Victor Lundin; Kepert; Patrick Bulau; Galahad Deperalta; Christopher Yu; Richard L Beardsley; Tura Camilli; Reed J. Harris; Stults
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Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth
Biotechnology Progress, ISSN: 15206033 87567938
Cynthia Lam; Joe Carver; Domingos Ng; Dejin Zhan; Danming Tang; Thara Kandamkalam; Snedecor; Gavin Barnard; Amy Shen; Shahram Misaghi
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Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Jialin Mao; Fang Ma; Jesse Yu; Tom De Bruyn; Miaoran Ning; Christine M. Bowman; Yuan Chen
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Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study
The Lancet Oncology, ISSN: 14745488 14702045
Paolo A. Ascierto; Daniil Stroyakovskiy; Helen Gogas; Caroline Robert; Karl Lewis; Svetlana Protsenko; Rodrigo P Pereira; Thomas Eigentler; Piotr Rutkowski; Lev Demidov; Natalia Zhukova; Jacob Schachter; Yibing Yan; Ivor Caro; Christian Hertig; Cloris Xue; Lieke Kusters; Grant A McArthur; Ralf Gutzmer
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Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
Gut, ISSN: 14683288 00175749
Frank Wagner; John C. Mansfield; Annemarie N. Lekkerkerker; Yehong Wang; Mary E. Keir; Ajit Dash; Brandon Butcher; Brandon Harder; Luz D. Orozco; Jordan S. Mar; Hao Chen; Michael E. Rothenberg
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From Logic-Respecting Efficacy Estimands to Logic-Ensuring Analysis Principle for Time-to-Event Endpoint in Randomized Clinical Trials with Subgroups
Statistics in Biopharmaceutical Research, ISSN: 19466315
Yi Liu; Miao Yang; Siyoen Kil; Jiang Li; Shoubhik Mondal; Yue Shentu; Hong Tian; Liwei Wang; Godwin Yung
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ER+, HER2− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes
Molecular Oncology, ISSN: 18780261 15747891
Jessica W. Chen; William Jacot; Javier Cortés; Ian E. Krop; Susan Dent; Nadia Harbeck; De Laurentiis; Diéras; Young-Hyuck Im; Thomas J. Stout; Frauke Schimmoller; Heidi Savage; Katherine E. Hutchinson; Wilson
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Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling
Biotechnology Progress, ISSN: 87567938
Brian M. Castellano; Danming Tang; Scot A. Marsters; Cynthia Lam; Peter S. Liu; Christopher M. Rose; Wendy N. Sandoval; Avi Ashkenazi; Snedecor; Shahram Misaghi
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marian C. Bryan; Charlotte Dalton; Alba Díaz-Rodríguez; Jaika Doerfler; Oliver D. Engl; Alejandro Gimenez Molina; Vanessa Harawa; Christopher B. Kelly; Wei Li; Rachel Munday; Jan Pawlas; Paul Richardson; William J. Smith; Alan Steven; Balaram S. Takale; Jack A. Terrett; Daniel S. Treitler; Mingshuo Zeng
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
Nature, ISSN: 00280836
Luis A. Rojas; Zachary Sethna; Kevin C. Soares; Cristina Olcese; Nan Pang; Erin Patterson; Jayon Lihm; Nicholas Ceglia; Pablo Guasp; Alexander Chu; Rebecca Yu; Adrienne Kaya Chandra; Theresa Waters; Jennifer Ruan; Masataka Amisaki; Abderezak Zebboudj; Zagaa Odgerel; George Payne; Evelyna Derhovanessian; Felicitas Müller; Ina Rhee; Mahesh Yadav; Anton Dobrin; Michel Sadelain; Marta Łuksza; Noah Cohen; Laura Tang; Olca Basturk; Mithat Gonen; Seth S. Katz; Richard Kinh Do; Andrew S. Epstein; Parisa Momtaz; Wungki Park; Ryan Sugarman; Anna M. Varghese; Elizabeth Won; Avni Desai; Alice C. Wei; Michael I. D’Angelica; T. Peter Kingham; Ira Mellman; Taha Merghoub; Jedd D Wolchok; Ugur Sahin; Özlem Türeci; Benjamin D. Greenbaum; William R. Jarnagin; Jeffrey Drebin; O'Reilly; Vinod P. Balachandran
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Tetramer-aided sorting and single-cell RNA sequencing facilitate transcriptional profiling of antigen-specific CD8+ T cells
Translational Oncology, ISSN: 19365233
Kamalakannan Rajasekaran; Xiangnan Guan; Alireza Tafazzol; Habib Hamidi; Martine Darwish; Mahesh Yadav
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Integrated summary of immunogenicity of polatuzumab vedotin in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma
Frontiers in Immunology, ISSN: 16643224
Randall Dere; Richard L. Beardsley; Dan Lu; Tong Lu; Grace Ku; Gabriel Man; Van Nguyen; Surinder Kaur
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Advanced Technologies and Automation in mES Cell Workflow
Methods in Molecular Biology, ISSN: 19406029 10643745
Charles Yu; Roger Caothien; Marques Jackson; Brian Nakao; Anna Pham; Lucinda Tam; Merone Roose-Girma
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Safety of adjuvant atezolizumab after pneumonectomy/bilobectomy in stage II-IIIA non–small cell lung cancer in the randomized phase III IMpower010 trial
Journal of Thoracic and Cardiovascular Surgery, ISSN: 1097685X 00225223
Jay M. Lee; Eric Vallières; Beiying Ding; Ann Johnson; Jan Bhagwakar; Sanam Rashidi; Qian (Cindy) Zhu; Barbara Gitlitz; Benny Weksler; Kimberly Costas; Nasser Altorki
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Toward Quantitative Models in Safety Assessment: A Case Study to Show Impact of Dose–Response Inference on hERG Inhibition Models
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Fjodor Melnikov; Lennart T. Anger; Catrin Hasselgren
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Fostering a High-Functioning Team in Cancer Care Using the 4R Oncology Model: Assessment in a Large Health System and a Blueprint for Other Institutions
JCO Oncology Practice, ISSN: 26881535 26881527
Raymond Liu; Christine B. Weldon; Elizabeth Linehan; Nancy Gordon; Thea Abbe; Marti Hennings; Henie James; Jed Katzel; Chun Ng; Megumi Tomita; Jeffrey B. Velotta; Stephanie Ossowski; Lori C. Sakoda; Sharon Likely Sprague; Anna Dowling; Kimberly Beringer; Arliene Ravelo; Elaine Yu; Julia R. Trosman
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Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling
Clinical and Translational Science, ISSN: 17528062 17528054
Stephanie N. Liu; Priya Agarwal; Katja Heinig; Asim Datye; Carolina Sturm-Pellanda; Andrea Crugnola; Marc Arca; Dale Miles
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ASIS-Seq: Transgene Insertion Site Mapping by Nanopore Adaptive Sampling
Methods in Molecular Biology, ISSN: 19406029 10643745
Charles Yu; Roger Caothien; Anna Pham; Lucinda Tam; Tuija M. Alcantar; Natasha Bacarro; Juan Reyes; Marques Jackson; Brian Nakao; Merone Roose-Girma
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