Genentech: Publications

February 1, 2012

Cost-effectiveness of adding rituximab to fludarabine and cyclophosphamide for the treatment of previously untreated chronic lymphocytic leukemia

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Ashwini Shewade; Susan Lerner; Mark Friedmann; Leona Han; Hialy Gutierrez; Sacha Satram-Hoang; Michael J. Keating

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February 1, 2012

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation

Journal of Virology, ISSN: 0022538X 10985514

Sungyong Won; Celine Eidenschenk; Carrie N. Arnold; Owen M. Siggs; Lei Sun; Katharina Brandl; Tina-Marie Mullen; Glen R. Nemerow; Eva Marie Y. Moresco; Bruce Beutler

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February 1, 2012

Monocyte tissue factor - Dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Journal of Clinical Investigation, ISSN: 00219738 15588238

A. Phillip Owens III; Freda H. Passam; Silvio Antoniak; Stephanie M. Marshall; Allison L. McDaniel; Lawrence Rudel; Julie C. Williams; Brian K. Hubbard; Julie-Ann Dutton; Jian-Guo Wang; Peter S. Tobias; Linda K. Curtiss; Alan Daugherty; Daniel Kirchhofer; James P. Luyendyk; Patrick M. Moriarty; Shanmugam Nagarajan; Barbara C. Furie; Bruce Furie; Douglas G. Johns; Ryan E. Temel; Nigel Mackman

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February 1, 2012

Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis

Current Opinion in Genetics and Development, ISSN: 0959437X 18790380

Robert Yauch; Jeffrey Settleman

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February 1, 2012

Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Yazici; Jeffrey R. Curtis; Ince; Baraf; Raymond L. Malamet; Lichen L. Teng; Arthur Kavanaugh

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February 1, 2012

A risk-based approach to transferring a mature biopharmaceutical process

BioPharm International, ISSN: 1542166X 19391862

Jean Harms; Purav Dave

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February 1, 2012

Phosphorylation-dependent activity of the deubiquitinase DUBA

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Oscar W Huang; Xiaolei Ma; Jianping Yin; Jeremy Flinders; Till Maurer; Nobuhiko Kayagaki; Qui Phung; Ivan Bosanac; David Arnott; Vishva M. Dixit; Sarah G. Hymowitz; Melissa A. Starovasnik; Andrea G Cochran

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January 31, 2012

Thermodynamics of coupled folding in the interaction of archaeal RNase P proteins RPP21 and RPP29

Biochemistry, ISSN: 00062960 15204995

Yiren Xu; Sri Vidya Oruganti; Venkat Gopalan; Mark P. Foster

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January 30, 2012

Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus

Brain Research, ISSN: 00068993 18726240

Joel C. Selcher; Weifeng Xu; Jesse E. Hanson; Robert C. Malenka; Daniel V. Madison

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January 24, 2012

Oncogene addiction

Current Biology, ISSN: 09609822

Jeffrey Settleman

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January 23, 2012

A guide to rational dosing of monoclonal antibodies

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Shuang Bai; Karin Jorga; Yan Xin; Denise Jin; Zheng; Lisa A. Damico; Manish Gupta; Meina Tao Tang; David E. Allison; Dan Lu; Yi Zhang; Amita Joshi; Mark J. Dresser

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January 22, 2012

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Nature Biotechnology, ISSN: 15461696 10870156

Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula

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January 22, 2012

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Nature Medicine, ISSN: 1546170X 10788956

Clara Montagut; Alba Dalmases; Beatriz Bellosillo; Marta Crespo; Silvia Pairet; Mar Iglesias; Marta Salido; Manuel Gallen; Scot A. Marsters; Siao Ping Tsai; André Minoche; Somasekar Seshagiri; Sergi Serrano; Heinz Himmelbauer; Joaquim Bellmunt; Ana Rovira; Jeffrey Settleman; Francesc Bosch; Joan Albanell

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January 19, 2012

Heteroarylation of azine N-oxides

Organic Letters, ISSN: 15237052 15237060

Francis Gosselin; Scott Savage; Nicole Blaquiere; Steven T. Staben

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January 17, 2012

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

Developmental Cell, ISSN: 15345807 18781551

Linda N. Geng; Zizhen Yao; Lauren Snider; Abraham P. Fong; Jennifer N. Cech; Janet M. Young; Silvere M. vanderMaarel; Walter L. Ruzzo; Robert Gentleman; Rabi Tawil; Stephen J. Tapscott

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January 16, 2012

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

NeuroImage, ISSN: 10538119 10959572

Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope; Taryar M. Zaw; Phillips; Shadi Lalezari; Phioanh L. Nghiemphu; Hassana Ibrahim; Kourosh M. Naeini; Robert J. Harris; Albert Lai

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January 16, 2012

NMDA receptors and BAX are essential for Aβ impairment of LTP

Scientific Reports, ISSN: 20452322

Kimberly Moore Olsen; Morgan Sheng

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January 15, 2012

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen- deprivation therapy

Cancer Research, ISSN: 00085472 15387445

Yuting Sun; Bu-Er Wang; Kevin G. Leong; Peng Yue; Li Li; Suchit Jhunjhunwala; Darrell Chen; Kyounghee Seo; Zora Modrusan; Gao; Jeffrey Settleman; Leisa Johnson

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January 15, 2012

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Li Ren; Ellen R. Laird; Alexandre J. Buckmelter; Victoria Dinkel; Susan L. Gloor; Jonas Grina; Bradley J. Newhouse; Kevin Rasor; Gregg Hastings; Stefan Gradl; Joachim Rudolph

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January 15, 2012

Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; David Moreno; Joachim Rudolph; Yingqing Ran; Kateri Ahrendt; Alisha Arrigo; Ben Colson; Susan L. Gloor; Gregg Hastings

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January 15, 2012

Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Baselga; Javier Cortés; Sung-Bae Kim; Seock-Ah Im; Roberto Hegg; Im; Laslo Roman; José Luiz Pedrini; Tadeusz Pienkowski; Adam Knott; Emma Clark; Benyunes; Graham Ross; Sandra M. Swain

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January 15, 2012

A secreted protein microarray platform for extracellular protein interaction discovery

Analytical Biochemistry, ISSN: 10960309 00032697

Sree R. Ramani; Irene Tom; Nicholas Lewin-Koh; Bernd Wranik; Laura DePalatis; Jianjun Zhang; Dan L. Eaton; Lino C. Gonzalez Jr.

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January 14, 2012

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

BMC Cancer, ISSN: 14712407

Carolyn D. Britten; Antoinette S. Gomes; Zev A. Wainberg; David Elashoff; Rafael Amado; Yan Xin; Ronald W. Busuttil; Dennis J. Slamon; Richard S. Finn

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January 13, 2012

Separation-Based Analytical Methods for Measuring Protein Aggregation

Analysis of Aggregates and Particles in Protein Pharmaceuticals,

Jun Liu; Barthélemy Demeule; Steven J. Shire

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January 12, 2012

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

PLoS ONE, ISSN: 19326203

Robert Mintzer; Sreemathy Ramaswamy; Kinjalkumar Shah; Rami N. Hannoush; Christine D. Pozniak; Frederick Cohen; Xianrui Zhao; Emile G. Plise; Joe Lewcock; Christopher E. Heise

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January 11, 2012

Genetic analysis of DSCAM'S role as a netrin-1 receptor in vertebrates

Journal of Neuroscience, ISSN: 02706474 15292401

Elena Palmesino; Patrick C. G. Haddick; Marc Tessier-Lavigne; Artur Kania

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January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

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January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Alan R. Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

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January 8, 2012

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: Results of a phase I randomized, placebo-controlled trial

Arthritis Research and Therapy, ISSN: 14786354 14786362

Brinda Emu; Diana Luca; Carolyn Offutt; Jane L. Grogan; Bernadette Rojkovich; Marna Williams; Meina Tao Tang; Jim J. Xiao; June H. Lee; John C. Davis

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January 6, 2012

Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis

Science, ISSN: 10959203 00368075

Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin

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January 6, 2012

Capillary size exclusion chromatography with picogram sensitivity for analysis of monoclonal antibodies purified from harvested cell culture fluid

Journal of Chromatography A, ISSN: 18733778 00219673

Jennifer C. Rea; G. Tony Moreno; Lisa Vampola; Yun Lou; Bjorn Van Haan; Guillaume Tremintin; Laura C. Simmons; Adrian Nava; Yajun Jennifer Wang; Dell Farnan

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January 6, 2012

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold

Journal of Molecular Biology, ISSN: 10898638 00222836

Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel

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January 5, 2012

Regulation of mitosis and taxane response by Daxx and Rassf1

Oncogene, ISSN: 09509232 14765594

Giovinazzi; Lindsay; Morozov; Escobar-Cabrera; Matthew K. Summers; Han; McIntosh; Ishov

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January 1, 2012

Key findings and clinical implications from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Bradley E. Chipps; Robert S. Zeiger; Larry Borish; Sally E. Wenzel; Ashley Yegin; Mary Lou Hayden; Dave P. Miller; Eugene R. Bleecker; F. Estelle R. Simons; Stanley J. Szefler; Weiss; Tmirah Haselkorn

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January 1, 2012

Mechanisms of acquired resistance to targeted cancer therapies

Future Oncology, ISSN: 17448301 14796694

Lackner; Wilson; Jeffrey Settleman

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January 1, 2012

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

Journal of Pathology, ISSN: 10969896 00223417

Mallika Singh; Suzana Couto; William F. Forrest; Anthony Lima; Jason H. Cheng; Rafael Molina; Jason E. Long; Patricia Hamilton; Angela McNutt; Ian Kasman; Michelle Nannini; Hani Bou-Reslan; Tim C. Cao; Calvin Ho; Kai H. Barck; Richard A. D. Carano; Oded Foreman; Jeffrey Eastham-Anderson; Adrian M. Jubb; Napoleone Ferrara; Leisa Johnson

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January 1, 2012

The power of FDG PET to detect treatment effects is increased by glucose correction using a Michaelis constant

EJNMMI Research, ISSN: 2191219X

Simon P. Williams; Judith E. Flores; Andreas R. Baudy; Ruediger E. Port; Thomas Bengtsson

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January 1, 2012

Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport

EJNMMI Research, ISSN: 2191219X

Simon P. Williams; Judith E. Flores; Ruediger E. Port; Thomas Bengtsson

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January 1, 2012

FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

EJNMMI Research, ISSN: 2191219X

Andreas R. Baudy; Taner Dogan; Judith E. Flores; Klaus P. Hoeflich; Fei Su; Nicholas Van Bruggen; Simon P. Williams

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January 1, 2012

Symptom burden & quality of life among patients receiving second-line treatment of metastatic colorectal cancer

BMC Research Notes, ISSN: 17560500

Mark S. Walker; Elaine B. Yu; Jiandong Kerr; Yeun Mi Yim; Edward J. Stepanski; Lee S. Schwartzberg

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January 1, 2012

On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenate

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2012

Phase II study of eribulin mesylate (E7389) in patients with metastatic castration-resistant prostate cancer stratified by prior taxane therapy

Annals of Oncology, ISSN: 15698041 09237534

De Bono; Molife; Guru Sonpavde; Pablo Maroto; Calvo; Cartwright; Loesch; Feit; Asha Das; Zang; Wanders; Agoulnik; Petrylak

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January 1, 2012

Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis

mBio, ISSN: 21507511

Tien-Huei Hsu; Irene W. Althaus; Oded Foreman; Katherine R. Spindlera

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January 1, 2012

Applying Nonexperimental Study Approach to Analyze Historical Batch Data

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Xiling Song; King Chuang; Minli Xie

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January 1, 2012

Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain

Current Molecular Medicine, ISSN: 18755666 15665240

Shelby K. Wyatt; H. Charles Manning; Mingfeng Bai; Moneeb Ehtesham; Khubaib Y. Mapara; Reid C. Thompson; Darryl J. Bornhop

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January 1, 2012

Synapses and Alzheimer's disease

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Morgan Sheng; Bernardo L Sabatini; Thomas C. Südhof

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January 1, 2012

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma

Thorax, ISSN: 14683296 00406376

Claire A. Butler; Stephen McQuaid; Cliff C. Taggart; Sinead Weldon; Richard Carter; Grzegorz Skibinski; Timothy J. Warke; David F. Choy; Lorcan P. McGarvey; Peter Bradding; Joseph R. Arron; Liam G. Heaney

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January 1, 2012

Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Paroma Chakravarty; Raj Suryanarayanan; Ramprakash Govindarajan

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January 1, 2012

Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C

Gastroenterology, ISSN: 15280012 00165085

Tom W. Chu; Rohit Kulkarni; Edward J. Gane; Stuart K. Roberts; Catherine Stedman; Peter Angus; Brett Ritchie; Xiao-Yu Lu; David Ipe; Uri Lopatin; Søren Germer; Victor A. Iglesias; Robert Elston; Patrick F. Smith; Nancy Shulman

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January 1, 2012

Escherichia coli Serotype O55:H7 Diversity Supports Parallel Acquisition of Bacteriophage at Shiga Toxin Phage Insertion Sites during evolution of the O157:H7 lineage

Journal of Bacteriology, ISSN: 10985530 00219193

Jennifer L. Kyle; Craig A. Cummings; Craig T. Parker; Beatriz Quiñones; Paolo Vatta; Elizabeth Newton; Steven Huynh; Michelle Swimley; Lovorka Degoricija; Melissa Barker; Samar Fontanoz; Kimberly Nguyen; Ronak Patel; Rixun Fang; Robert Tebbs; Olga Petrauskene; Manohar Furtado; Robert E. Mandrell

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