Genentech: Publications

January 1, 2012

Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab

Annals of Oncology, ISSN: 15698041 09237534

Lenihan; Suter; Melissa Brammer; Neate; Graham Ross; Baselga

January 1, 2012

Influenza a virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells

PLoS Pathogens, ISSN: 15537374 15537366

Anna Smed-Sörensen; Cecile Chalouni; Bithi Chatterjee; Lillian Cohn; Peter Blattmann; Norihiro Nakamura; Lélia Delamarre; Ira Mellman

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January 1, 2012

Viscosity behavior of high-concentration protein mixtures

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

William J. Galush; Lan N. Le; Jamie M. R. Moore

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January 1, 2012

Transforming the untransformable: Application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis

mBio, ISSN: 21507511

Ian R. Monk; Ishita M. Shah; Min Xu; Man-Wah Tan; Timothy J. Foster

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January 1, 2012

Viscosity behavior of high-concentration monoclonal antibody solutions: Correlation with interaction parameter and electroviscous effects

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia

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January 1, 2012

DEGAS: Sharing and tracking target compound ideas with external collaborators

Journal of Chemical Information and Modeling, ISSN: 15205142 15499596

Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron

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January 1, 2012

Evaluation of the National Heart, Lung, and Blood Institute guidelines impairment domain for classifying asthma control and predicting asthma exacerbations

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Robert S. Zeiger; Ashley Yegin; F. Estelle R. Simons; Tmirah Haselkorn; Lawrence Rasouliyan; Stanley J. Szefler; Bradley E. Chipps

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January 1, 2012

Signaling: An oxysterol ligand for Smoothened

Nature Chemical Biology, ISSN: 15524469 15524450

Hayley J. Sharpe; Frederic J. De Sauvage

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January 1, 2012

The Yin and Yang of Immunomodulatory Biologics: Assessing the Delicate Balance between Benefit and Risk

Toxicologic Pathology, ISSN: 15331601 01926233

Dimitry Danilenko; Hong Wang

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January 1, 2012

Consistency of the novel equations for determination of hepatic clearance and drug time course in liver that account for the difference in drug ionization in extracellular and intracellular tissue water

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy; Ning Liu; Jason S Halladay

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January 1, 2012

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

Nature Chemical Biology, ISSN: 15524469 15524450

Karen Stanger; Micah Steffek; Lijuan Zhou; Christine D. Pozniak; Quan; Yvonne Franke; Jeffrey Tom; Christine Tam; J. Michael Elliott; Joe Lewcock; Yingnan Zhang; Jeremy Murray; Rami N. Hannoush

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January 1, 2012

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney

Toxicological Sciences, ISSN: 10960929 10966080

Dolores Diaz; Krishna P. Allamneni; Jacqueline M. Tarrant; Sock-Cheng Lewin-Koh; Rama Pai; Preeti Dhawan; Cain; Cleopatra Kozlowski; Hajime Hiraragi; Nghi La; Dylan P. Hartley; Xiao Ding; Brian J. Dean; Sheila Bheddah; Donna M. Dambach

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January 1, 2012

Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Sharlene R. Lim; Xiaoli Qin; Simone Susser; John B. Nicholas; Christian Lange; Eva Herrmann; Jin Hong; Ann Elizabeth Arfsten; Lisa Hooi; Williamson Bradford; Nájera; Patrick F. Smith; Stefan Zeuzem; Karl Kossen; Christophe Sarrazin; Scott D. Seiwert

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January 1, 2012

Stability of IgG1 monoclonal antibodies in intravenous infusion bags under clinical in-use conditions

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Alavattam Sreedhara; Zephania Kwong Glover; Nicole Piros; Nina Xiao; Ankit Patel; Bruce Kabakoff

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January 1, 2012

Culture temperature modulates aggregation of recombinant antibody in cho cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Natalia Gomez; Jayashree Subramanian; Jun Ouyang; Mary D. H. Nguyen; Matthew Hutchinson; Vikas Sharma; Andy Lin; Inn H. Yuk

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January 1, 2012

Interdependence of drug substance physical properties and corresponding quality control strategy

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Xiling Song; Mark E. Reynolds; King Chuang; Minli Xie

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January 1, 2012

The Role of Pharmaceutical Medical Information in Promotional Review: Three Benchmarking Surveys

Drug Information Journal, ISSN: 00928615

Lisa Bonk; Madhuri Kothari; Alyson Sous Andrikanich; Ellen Yang

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January 1, 2012

Intermittent administration of MEK inhibitor GDC-0973 plus pi3k inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition

Cancer Research, ISSN: 00085472 15387445

Klaus P. Hoeflich; Mark Merchant; Christine Orr; Jocelyn Chan; Doug Den Otter; Berry; Ian Kasman; Koeppen; Ken Rice; Nai-Ying Yang; Stefan Engst; Stuart H. Johnston; Lori S. Friedman; Marcia Belvin

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January 1, 2012

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Aarti Shikotra; David F. Choy; Chandra M. Ohri; Emma Doran; Claire A. Butler; Beverley Hargadon; Maria Shelley; Abbas Alexander; Cary D. Austin; Janet Jackman; Lawren C. Wu; Liam G. Heaney; Joseph R. Arron; Peter Bradding

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January 1, 2012

Impact of baseline virologic, immunologic, and demographic characteristics on virologic responses in the Gemini study

HIV Clinical Trials, ISSN: 15284336 19455771

Anchalee Avihingsanon; Kiat Ruxrungtham; Harold Katner; Carol Jean Guittari; Sharon Walmsley

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January 1, 2012

Severity of asthma score predicts clinical outcomes in patients with moderate to severe persistent asthma

Chest, ISSN: 19313543 00123692

Mark D. Eisner; Ashley Yegin; Benjamin L. Trzaskoma

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January 1, 2012

Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays

Methods in Molecular Biology, ISSN: 10643745

Gabriela Lavezzari; Lackner

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January 1, 2012

The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether

Protein Science, ISSN: 09618368 1469896X

Ping Liu; Samuel Bouyain; Eigenbrot; Daniel J. Leahy

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January 1, 2012

Profiling cellular myristoylation and palmitoylation using ω-alkynyl fatty acids

Methods in Molecular Biology, ISSN: 10643745

Rami N. Hannoush

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January 1, 2012

Costs and clinical outcomes among patients with second-line non-small cell lung cancer in the outpatient community setting

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Eric Nadler; Michael Forsyth; Sacha Satram-Hoang; Carolina Reyes

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January 1, 2012

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Jun Luo; Natarajan Vijayasankaran; Jennifer Autsen; Rodell Santuray; Terry Hudson; Ashraf Amanullah; Feng Li

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January 1, 2012

The authors' reply

American Journal of Clinical Pathology, ISSN: 00029173 19437722

Mark H. Stoler; Teresa L. Wright

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January 1, 2012

Internet and print resources to facilitate pathology analysis when phenotyping genetically engineered rodents

Veterinary Pathology, ISSN: 03009858 15442217

Brad Bolon; Suzana Couto; Laurence Fiette; la Perle

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January 1, 2012

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

Nucleic Acids Research, ISSN: 03051048 13624962

Emily C. Knouf; Kavita Garg; Jason D. Arroyo; Yesenia Correa; Deepayan Sarkar; Rachael K. Parkin; Kaitlyn Wurz; Kathy C. O'Briant; Andrew K. Godwin; Nicole D. Urban; Walter L. Ruzzo; Robert Gentleman; Charles W. Drescher; Elizabeth M. Swisher; Muneesh Tewari

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January 1, 2012

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency

PLoS Genetics, ISSN: 15537390 15537404

Ricardo C. Ferreira; Qiang Pan-Hammarström; Robert R. Graham; Gumersindo Fontán; Annette T. Lee; Ward Ortmann; Ning Wang; Elena Urcelay; Miguel Fernández-Arquero; Concepción Núñez; Gudmundur Jorgensen; Björn R. Ludviksson; Sinikka Koskinen; Katri Haimila; Leonid Padyukov; Peter K. Gregersen; Lennart Hammarström; Timothy W. Behrens

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January 1, 2012

Neuropilin-1 expression in cancer and development

Journal of Pathology, ISSN: 00223417 10969896

Adrian M. Jubb; Laura A. Strickland; Scot D. Liu; Judy Mak; Maike Schmidt; Koeppen

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January 1, 2012

Differentiation programs in development and cancer

Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing,

Hosein Kouros-Mehr

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January 1, 2012

Tenecteplase for the improvement of blood flow rate in dysfunctional hemodialysis catheters

Clinical Nephrology, ISSN: 03010430

Jesse Goldman; Steven Fishbane; Matthew J. Oliver; Martha Blaney; Joan R. Jacobs; Susan M. Begelman

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January 1, 2012

Erratum: Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres (Bioorganic and Medicinal Chemistry Letters (2010) 20 (2229-2233))

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

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January 1, 2012

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

Pancreatology, ISSN: 14243911 14243903

Rebecca J. Brais; Susan E. Davies; Maria O'Donovan; Ben W. Simpson; Natalie Cook; Darbonne; Sian Chilcott; Martijn P. Lolkema; Albrecht Neesse; Michelle Lockley; Pippa G. Corrie; Duncan I. Jodrell; Raaj K. Praseedom; Emmanuel L. Huguet; Asif Jah; Neville V. Jamieson; Frederic J. De Sauvage; David Tuveson; Nicholas R. Carroll

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January 1, 2012

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against aspergillus fumigatus

Infection and Immunity, ISSN: 00199567 10985522

Melissa A. Gessner; Jessica L. Werner; Lauren M. Lilly; Michael P. Nelson; Allison E. Metz; Chad W. Dunaway; Yvonne R. Chan; Wenjun Ouyang; Gordon D. Brown; Casey T. Weaver; Chad Steele

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January 1, 2012

Evaluating the minimally important difference of the urticaria activity score and other measures of disease activity in patients with chronic idiopathic urticaria

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

Susan D. Mathias; Ross D. Crosby; James L. Zazzali; Marcus Maurer; Sarbjit S. Saini

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January 1, 2012

Treatment of HER2-positive breast cancer: Current status and future perspectives

Nature Reviews Clinical Oncology, ISSN: 17594774 17594782

Carlos L. Arteaga; Mark X. Sliwkowski; C.Kent Osborne; Edith A. Perez; Fabio Puglisi; Luca Gianni

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January 1, 2012

Assessing and improving asymmetric flow field-flow fractionation of therapeutic proteins

Field-Flow Fractionation in Biopolymer Analysis,

Jun Liu; Qing Zhu; Steven J. Shire; Barthélemy Demeule

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January 1, 2012

Editorial

Contemporary Clinical Trials, ISSN: 15517144 15592030

Zheng Su

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January 1, 2012

Hybridization of conditional and predictive power for futility assessment in sequential clinical trials with time-to-event outcomes: A resampling approach

Contemporary Clinical Trials, ISSN: 15517144 15592030

Jing Yi; Liang Fang; Zheng Su

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January 1, 2012

BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Kevin B. Kim; Jeffrey A. Sosman; John P. Fruehauf; Gerald Linette; Svetomir N. Markovic; David McDermott; Jeffrey S. Weber; Hoa Nguyen; Peter Cheverton; Daniel S. Chen; Amy Peterson; William E. Carson III; Steven J. O'Day

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January 1, 2012

Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture

Journal of Biotechnology, ISSN: 01681656 18734863

Kristen L. Koterba; Trissa Borgschulte; Mike Laird

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January 1, 2012

3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Dange V. Kumar; Roopa Rai; Ken A. Brameld; Jennifer Riggs; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Huiyong Hu; Isabelle Lehoux; Joseph D. Ho; Wendy B. Young; Barry Hart; Michael J. Green

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January 1, 2012

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Suman A. Luthra; Marcel Utz; Eric M. Gorman; Michael J. Pikal; Eric Munson; Joseph W. Lubach

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January 1, 2012

Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Alavattam Sreedhara; Cordoba; Qing Zhu; Jeanne Kwong; Jun Liu

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January 1, 2012

Effect of sulfobutyl ether beta-cyclodextrin modifier on selectivity of reversed phase hplc separations

Journal of Liquid Chromatography and Related Technologies, ISSN: 10826076 1520572X

Kenley K. Ngim; Qiqing Zhong; Kavita Mistry; Nik P. Chetwyn

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January 1, 2012

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

mAbs, ISSN: 19420862 19420870

Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu

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January 1, 2012

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

mAbs, ISSN: 19420870 19420862

Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter

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January 1, 2012

Transferrin antibodies into the brain

Neuropsychopharmacology, ISSN: 0893133X 1740634X

Dennis; Ryan J. Watts

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