Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8001 - 8050 OF 15394 RESULTS

The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
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Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
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Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
British Journal of Cancer, ISSN: 00070920 15321827
Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland
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Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha
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On-line characterization of monoclonal antibody variants by liquid chromatography-mass spectrometry operating in a two-dimensional format
Analytical Biochemistry, ISSN: 10960309 00032697
Melissa Alvarez; Guillaume Tremintin; Jennifer Wang; Eng; Kao; Justin Jeong; Victor Ling; Oleg V. Borisov
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Role of MetMAb (OA-5D5) in c-MET active lung malignancies
Expert Opinion on Biological Therapy, ISSN: 14712598
Mosmi Surati; Premal Patel; Amy Peterson; Ravi Salgia
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The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
Genes and Immunity, ISSN: 14664879 14765470
Paola G. Bronson; Goldstein; Ramsay; Beckman; Janelle A. Noble; Lane; Michael F. Seldin; Jennifer A. Kelly; John B. Harley; Kathy L. Moser; Patrick M. Gaffney; Timothy W. Behrens; Lindsey A. Criswell; Lisa F. Barcellos
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IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
Nature Immunology, ISSN: 15292908 15292916
Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam; Luis; Zhongua Lin; Surinc Er Jeet; Justin Lesch; Jason A. Hackney; Janice Kim; Meijuan Zhou; Joyce Lai; Zora Modrusan; Tao Sai; Wyne P. Lee; Min Xu; Patrick Caplazi; Laurie Diehl; Jason De Voss; Mercedesz Balazs; Lino C. Gonzalez Jr.; Harinder Singh; Wenjun Ouyang; Rajita Pappu
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Proposal for a new protein therapeutic immunogenicity titer assay cutpoint
Bioanalysis, ISSN: 17576180 17576199
Eric Wakshull; Robert Hendricks; Caroline Amaya; Daniel A. Coleman
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Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T H17 cells
Nature Immunology, ISSN: 15292908 15292916
Sascha Rutz; Rajkumar Noubade; Celine Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason A. Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
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It takes two to tango: A new couple in the family of ubiquitin-editing complexes
Nature Immunology, ISSN: 15292908 15292916
Ingrid E. Wertz
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A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
PLoS Genetics, ISSN: 15537390 15537404
Paula S. Ramos; Lindsey A. Criswell; Kathy L. Moser; Mary E. Comeau; Adrienne H. Williams; Nicholas M. Pajewski; Sharon A. Chung; Robert R. Graham; Raphael Zidovetzki; Jennifer A. Kelly; Kenneth M. Kaufman; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; Robert P. Kimberly; Patrick M. Gaffney; Marta E. Alarcón-Riquelme; John B. Harley; Carl D. Langefeld
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The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors
Endocrinology, ISSN: 00137227 19457170
Erik R. Nelson; Carolyn D. DuSell; Xiaojuan Wang; Matthew K. Howe; Glenda Evans; Ryan D. Michalek; Michihisa Umetani; Jeffrey C. Rathmell; Sundeep Khosla; Diane Gesty-Palmer; Donald P. McDonnell
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Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects
AAPS Journal, ISSN: 15507416
Nageshwar Budha; Andreas Kovar; Bernd Meibohm
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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Albert Lai; Samir Kharbanda; Whitney B. Pope; Anh Tran; Orestes E. Solis; Franklin V. Peale Jr.; William F. Forrest; Kanan Pujara; Jose A. Carrillo; Ajay Pandita; Benjamin M. Ellingson; Chauncey W. Bowers; Robert Soriano; Nils-Ole Schmidt; Sankar Mohan; William H. Yong; Somasekar Seshagiri; Zora Modrusan; Zhaoshi Jiang; Kenneth D. Aldape; Paul S. Mischel; Linda M. Liau; Cameron J. Escovedo; Weidong Chen; Phioanh L. Nghiemphu; C. David James; Michael D. Prados; Manfred Westphal; Katrin Lamszus; Timothy Cloughesy; Phillips
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Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans
Psychopharmacology, ISSN: 00333158 14322072
William Cho; Paul Maruff; John Connell; Cindy Gargano; Nicole Calder; Scott Doran; Sabrina Fox-Bosetti; Aizza Hassan; John Renger; Gary Herman; Christopher Lines; Ajay Verma
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Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human
Xenobiotica, ISSN: 00498254 13665928
Laurent Salphati; Jodie Pang; Emile G. Plise; Bilin Chou; Jason S Halladay; Alan G. Olivero; Patrick J. Rudewicz; Qingping Tian; Susan C. Wong; Xiaolin Zhang
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Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Rajesh Krishna; Daria Stypinski; Melissa Ali; Amit Garg; Isaias Noel Gendrano III; Andrea Maes; Bruce Degroot; Yang Liu; Susie Li; Sandra M. Connolly; John A. Wagner; S. Aubrey Stoch
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Identification of aberrant pathway and network activity from high-throughput data-workshop introduction
Pacific Symposium on Biocomputing 2011, PSB 2011,
Ochs; Karchin; Ressom; Robert Gentleman
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Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3- dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery
Nanoscale Research Letters, ISSN: 19317573 1556276X
Po-Chang Chiang; Yingqing Ran; Kang-Jye Chou; Yong Cui; Harvey Wong
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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jeffery J. Wallin; Kyle A. Edgar; Zhengyu Guan; Megan Berry; Wei Wei Prior; Leslie Lee; John Lesnick; Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan G. Olivero; Daniel P. Sutherlin; Carol O'Brien; Jill M. Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Berry; Lackner; Deepak Sampath; Marcia Belvin; Lori S. Friedman
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Concomitant asthma medication use by patients receiving omalizumab 20032008
Journal of Asthma, ISSN: 02770903 15324303
Michael S. Broder; James L. Zazzali; Eunice Chang; Ashley Yegin
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Kilogram-scale asymmetric ruthenium-catalyzed hydrogenation of a tetrasubstituted fluoroenamide
Advanced Synthesis and Catalysis, ISSN: 16154150 16154169
Andreas Stumpf; Mark E. Reynolds; Daniel P. Sutherlin; Srinivasan Babu; Erhard Bappert; Felix Spindler; Michael Welch; John J. Gaudino
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An introduction to wnt signaling
Targeting the Wnt Pathway in Cancer,
Paul G. Polakis
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Single-versus dual-infusion of B-cell-depleting antibody ocrelizumab in rheumatoid arthritis: Results from the phase III FEATURE trial
International Journal of Clinical Rheumatology, ISSN: 17584272 17584280
Joseph E. Huffstutter; James Taylor; Joy Schechtman; Piotr Leszczynski; Marek Brzosko; Farhad Sedarati; Dalia Moawad; Amy V. Kapp; Rebecca Sudlow; Wolfgang Dummer
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Dissecting cancer heterogeneity
Nature Biotechnology, ISSN: 10870156 15461696
David Dornan; Jeffrey Settleman
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Towards BioDBcore: A community-defined information specification for biological databases
Database, ISSN: 17580463
Pascale Gaudet; Amos Bairoch; Dawn Field; Susanna-Assunta Sansone; Chris Taylor; Teresa K. Attwood; Alex Bateman; Judith A. Blake; Carol J. Bult; J. Michael Cherry; Rex L. Chisholm; Guy Cochrane; Charles E. Cook; Janan T. Eppig; Michael Y. Galperin; Robert Gentleman; Carole A. Goble; Takashi Gojobori; John M. Hancock; Douglas G. Howe; Tadashi Imanishi; Janet Kelso; David Landsman; Suzanna E. Lewis; Ilene Karsch-Mizrachi; Sandra Orchard; B.F. Francis Ouellette; Shoba Ranganathan; Lorna Richardson; Philippe Rocca-Serra; Paul N. Schofield; Damian Smedley; Christopher Southan; Tin W. Tan; Tatiana Tatusova; Patricia L. Whetzel; Owen White; Chisato Yamasaki
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Phase I study evaluating the safety and pharmacokinetics of MDX-1303, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers
Clinical and Vaccine Immunology, ISSN: 15566811 1556679X
Valerie Riddle; Phillip Leese; Diann Blanset; Melany Adamcio; Matthew Meldorf; Israel Lowy
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Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment
Arthritis and Rheumatism, ISSN: 00043591 15290131
Preeti Lal; Zheng Su; Cécile T.J. Holweg; Gregg J. Silverman; Sergio Schwartzman; Ariella Kelman; Simon J. Read; Spaniolo; John G. Monroe; Timothy W. Behrens; Michael J. Townsend
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Durable complete response of metastatic gastric cancer with anti-met therapy followed by resistance at recurrence
Cancer Discovery, ISSN: 21598274 21598290
Daniel V.T. Catenacci; Les Henderson; Shu-Yuan Xiao; Premal Patel; Robert Yauch; Priti Hegde; Jiping Zha; Ajay Pandita; Amy Peterson; Ravi Salgia
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Therapeutic promise and challenges of targeting DLL4/NOTCH1
Vascular Cell, ISSN: 2045824X
Minhong Yan
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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
Biochimica et Biophysica Acta - Proteins and Proteomics, ISSN: 15709639 18781454
David Meininger; Leeanne Zalameda; Yichin Liu; Lara P. Stepan; Luis Borges; John D. McCarter; Claire L. Sutherland
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Preclinical assessment of novel BRAF inhibitors: Integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Bruno Alicke; Jason Boggs; Victoria Dinkel; Stephen Gould; Jonas Grina; Kristina West; Kapil Menghrajani; Yingqing Ran; Joachim Rudolph; Steve Wenglowsky
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The Bcl-2/Bcl-X L/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jun Chen; Sha Jin; Vivek Abraham; Xiaoli Huang; Bernard Liu; Michael J. Mitten; Paul M. Nimmer; Xiaoyu Lin; Morey L. Smith; Yu Shen; Alexander R. Shoemaker; Stephen K. Tahir; Haichao Zhang; Scott L. Ackler; Saul H. Rosenberg; Heather Maecker; Deepak Sampath; Joel D. Leverson; Chris Tse; Steven W. Elmore
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Chung; Lisa Tuomi; Jason S. Ehrlich
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Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure
European Journal of Cancer, ISSN: 09598049 18790852
Nizar M. Tannir; Yu-Ning Wong; Christian K. Kollmannsberger; Marc S. Ernstoff; David J. Perry; Leonard J. Appleman; Edwin M. Posadas; Daniel Cho; Toni K. Choueiri; Andrew Coates; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Jihong Chen; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Dror Michaelson
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Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome
Dermatology Reports, ISSN: 20367392 20367406
Glen J. Weiss; Raoul Tibes; Lisa Blaydorn; Gayle Jameson; Molly Downhour; Erica White; Ivor Caro; Daniel D. Von Hoff
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Y. Chung; Lisa Tuomi; Jason S. Ehrlich
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Vanadium bromoperoxidase from Delisea pulchra: Enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing
Chemical Communications, ISSN: 1364548X 13597345
Moriah Sandy; Jayme N. Carter-Franklin; Jessica D. Martin; Alison Butler
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Different mechanisms for resistance to trastuzumab versus lapatinib in HER2- positive breast cancers -- role of estrogen receptor and HER2 reactivation
Breast Cancer Research, ISSN: 14655411 1465542X
Yen-Chao Wang; Gladys Morrison; Ryan Gillihan; Jun Guo; Robin M. Ward; Xiaoyong Fu; Maria F. Botero; Nuala A. Healy; Susan G. Hilsenbeck; Gail L. Phillips; Gary C. Chamness; Mothaffar F. Rimawi; C.Kent Osborne; Rachel Schiff
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Community-wide assessment of protein-interface modeling suggests improvements to design methodology
Journal of Molecular Biology, ISSN: 10898638 00222836
Sarel J. Fleishman; Timothy A. Whitehead; Eva-Maria Strauch; Jacob E. Corn; Sanbo Qin; Huan-Xiang Zhou; Julie C. Mitchell; Omar N.A. Demerdash; Mayuko Takeda-Shitaka; Genki Terashi; Iain H. Moal; Xiaofan Li; Paul A. Bates; Martin Zacharias; Hahnbeom Park; Jun-Su Ko; Hasup Lee; Chaok Seok; Thomas Bourquard; Julie Bernauer; Anne Poupon; Jérôme Azé; Seren Soner; Şefik Kerem Ovali; Pemra Ozbek; Nir Ben Tal; Türkan Haliloglu; Howook Hwang; Thom Vreven; Brian G. Pierce; Zhi-Ping Weng; Laura Pérez-Cano; Carles Pons; Juan Fernández-Recio; Fan Jiang; Feng Yang; Xinqi Gong; Libin Cao; Xianjin Xu; Bin Liu; Panwen Wang; Chunhua Li; Cunxin Wang; Charles H. Robert; Mainak Guharoy; Shiyong Liu; Yangyu Huang; Lin Li; Dachuan Guo; Ying Chen; Yi Xiao; Nir London; Zohar Itzhaki; Ora Schueler-Furman; Yuval Inbar; Vladimir Potapov; Mati Cohen; Gideon Schreiber; Yuko Tsuchiya; Eiji Kanamori; Daron M. Standley; Haruki Nakamura; Kengo Kinoshita; Camden M. Driggers; Robert G. Hall; Jessica L. Morgan; Victor L. Hsu; Jian Zhan; Yuedong Yang; Yaoqi Zhou; Panagiotis L. Kastritis; Alexandre M.J.J. Bonvin; Weiyi Zhang; Carlos J. Camacho; Krishna P. Kilambi; Aroop Sircar; Jeffrey J. Gray; Masahito Ohue; Nobuyuki Uchikoga; Yuri Matsuzaki; Takashi Ishida; Yutaka Akiyama; Raed Khashan; Stephen Bush; Denis Fouches; Alexander Tropsha; Juan Esquivel-Rodríguez; Daisuke Kihara; P. Benjamin Stranges; Ron Jacak; Brian Kuhlman; Sheng-You Huang; Xiaoqin Zou; Shoshana J. Wodak; Joel Janin; David Baker
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Rational design of phosphoinositide 3-kinase inhibitors that exhibit selectivity over the phosphoinositide 3-kinase isoform
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Binqing Wei; Alan G. Olivero; Steven T. Staben; Vickie Tsui; Steven Do; Jennafer Dotson; Adrian J. Folkes; Paul Goldsmith; Richard Goldsmith; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Daniel P. Sutherlin; Nan Chi Wan; Shumei Wang; Wiesmann; Bing-Yan Zhu
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Lymphangiogenesis is required for pancreatic islet inflammation and diabetes
PLoS ONE, ISSN: 19326203
Na Yin; Nan Zhang; Girdhari Lal; Jiangnan Xu; Minhong Yan; Yaozhong Ding; Jonathan S. Bromberg
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Randomized phase II study of dulanermin in combination with paclitaxel, carboplatin, and bevacizumab in advanced non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jean-Charles Soria; Zsuzsanna Márk; Petr Zatloukal; Barna Szima; István Albert; Erzsébet Juhász; Jean-Louis Pujol; Jerzy Kozielski; Nigel Baker; Dominic Smethurst; Yong-Jiang Hei; Avi Ashkenazi; Howard M. Stern; Lukas Amler; Pan; Fiona Blackhall
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An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
Genes and Development, ISSN: 08909369 15495477
Kevin J. Wright; Lisa M. Baye; Anique Olivier-Mason; Saikat Mukhopadhyay; Liyun Sang; Mandy Kwong; Weiru Wang; Pamela R. Pretorius; Val C. Sheffield; Piali Sengupta; Diane C. Slusarski; Peter K Jackson
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The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P 3
Biochemistry, ISSN: 00062960 15204995
Carissa Pilling; Kyle E. Landgraf; Joseph J. Falke
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Hotspot-centric de novo design of protein binders
Journal of Molecular Biology, ISSN: 10898638 00222836
Sarel J. Fleishman; Jacob E. Corn; Eva-Maria Strauch; Timothy A. Whitehead; John Karanicolas; David Baker
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RIBBON-2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Adam Brufsky; Sara A. Hurvitz; Edith A. Perez; Raji Swamy; Vicente Valero; Vincent O'Neill; Hope S. Rugo
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Discovery of a potent, selective, and orally available class i phosphatidylinositol 3-kinase (PI3K)/Mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Linda Bao; Megan Berry; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian Folks; Lori S. Friedman; Richard Goldsmith; Janet Gunzner; Timothy P. Heffron; John Lesnick; Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Wiesmann; Ping Wu; Bing-Yan Zhu; Alan G. Olivero
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Non-canonical inflammasome activation targets caspase-11
Nature, ISSN: 00280836 14764687
Nobuhiko Kayagaki; Søren Warming; Lamkanfi; Lieselotte Vande Walle; Salina Louie; Jennifer Dong; Kim Newton; Yan Qu; Jinfeng Liu; Sherry Heldens; Juan Zhang; Wyne P. Lee; Merone Roose-Girma; Vishva M. Dixit
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