Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8051 - 8100 OF 15487 RESULTS

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
Nature Cell Biology, ISSN: 14657392 14764679
Ben Chih; Peter S. Liu; Yvonne Chinn; Cecile Chalouni; László Kömüves; Hass; Wendy N. Sandoval; Andrew S. Peterson
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In vitro-in vivo extrapolation of clearance: Modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Jane R. Kenny; Cornelis E. Hop; Sami Haddad
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Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
David F. Choy; Daniel K. Hsu; Dhaya Seshasayee; Maxwell A. Fung; Zora Modrusan; Flavius Martin; Fu-Tong Liu; Joseph R. Arron
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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Science Translational Medicine, ISSN: 19466242
Zejuan Sheng; Shuo Zhang; Daisy J. Bustos; Tracy L. Kleinheinz; Claire E. Le Pichon; Sara L. Dominguez; Hilda Solanoy; Jason H. Drummond; Xiaolin Zhang; Xiao Ding; Fang Cai; Qinghua Song; Xianting Li; Zhenyu Yue; Marcel P Van Der Brug; Burdick; Janet Gunzner; Huifen Chen; Xingrong Liu; Anthony A. Estrada; Zachary K. Sweeney; Kimberly Scearce-Levie; John Moffat; Donald S. Kirkpatrick; Haitao Zhu
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Targeting a cystic fibrosis mutation opens door for personalized treatment.
Managed Care, ISSN: 10623388
Thomas Morrow
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Influence of the compound selection process on the performance of human clearance prediction methods
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Harvey Wong; Sock-Cheng Lewin-Koh; Frank-Peter Theil; Cornelis E. Hop
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A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 0920654X 15734951
Jeff Blaney
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Pioneers of oncology nursing.
ONS connect, ISSN: 19351623
Bertie Ford
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DEGAS: Sharing and tracking target compound ideas with external collaborators
Journal of Chemical Information and Modeling, ISSN: 1549960X 15499596
Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron
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Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach
Drug Metabolism Letters, ISSN: 18723128
Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny
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Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma
Investigational New Drugs, ISSN: 15730646 01676997
Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian
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Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Mayumi Bowen; Nick Armstrong; Maa
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Variable selection in multivariate modeling of drug product formula and manufacturing process
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie
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Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano
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Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler
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Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny
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Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin
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A phase i study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Sarah B. Goldberg; Jeffrey G. Supko; Joel W. Neal; Alona Muzikansky; Subba Digumarthy; Panos Fidias; Jennifer S. Temel; Rebecca S. Heist; Alice T. Shaw; Patricia O. McCarthy; Thomas J. Lynch; Sreenath Sharma; Jeffrey Settleman; Lecia V. Sequist
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Determination of hepatic clearance with the account of drug-protein binding kinetics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Effects of commercial air travel on patients with pulmonary hypertension
Chest, ISSN: 19313543 00123692
Nareg Roubinian; C. Gregory Elliott; Christopher F. Barnett; Paul D. Blanc; Joan Chen; Teresa De Marco; Hubert Chen
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Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.
PLoS ONE, ISSN: 19326203
French; Benjamin C. Lin; Manping Wang; Adams; Theresa Shek; Kathy Hötzel; Brad Bolon; Ron Ferrando; Craig Blackmore; Kurt A. Schroeder; Luis A Rodriguez; Maria Hristopoulos; Rayna Venook; Avi Ashkenazi; Luc Desnoyers
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Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Guiquan Jia; Erickson; David F. Choy; Mosesova; Lawren C. Wu; Owen D. Solberg; Aarti Shikotra; Richard Carter; Séverine Audusseau; Qutayba Hamid; Peter Bradding; John V. Fahy; Prescott G. Woodruff; Harris; Joseph R. Arron
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Rheumatoid arthritis and the incidence of influenza and influenza-related complications: A retrospective cohort study
BMC Musculoskeletal Disorders, ISSN: 14712474
William A. Blumentals; Anna Arreglado; Pavel Napalkov; Stephen Toovey
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An 'all-inclusive' 96-well cytochrome P450 induction method: Measuring enzyme: Activity, mrna levels, protein levels, and cytotoxicity from one well using: Cryopreserved human hepatocytes
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Jason S Halladay; Susan C. Wong; S. Cyrus Khojasteh; Susan Grepper
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The potential clinical relevance of visible particles in parenteral drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Lucette Doessegger; Hanns-Christian Mahler; Piotr Szczesny; Helmut Rockstroh; Georg Kallmeyer; Anja Langenkamp; Joerg Herrmann; Joseph Famulare
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Noninvasive optical sensor technology in shake flasks
BioProcess International, ISSN: 15426319
Wen-Lin Tsai; Jennifer Autsen; Julie Ma; Terry Hudson; Jun Luo
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Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
Mucosal Immunology, ISSN: 19330219 19353456
Jennifer Cox; Noelyn Kljavin; Naruhisa Ota; Leonard; Merone Roose-Girma; Laurie Diehl; Wenjun Ouyang; Nico Ghilardi
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A very short history of structure-based design: How did we get here and where do we need to go?
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Jeff Blaney
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Anti-angiogenesis therapy in melanoma
Targeted Therapeutics in Melanoma,
Daniel S. Chen
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Randomized and balancing allocation schemes for clinical trials: Computational perspectives on design and deployment
Designs for Clinical Trials: Perspectives on Current Issues,
Vincent J. Carey; Robert Gentleman
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ggbio: an R package for extending the grammar of graphics for genomic data
Genome Biology, ISSN: 14656914
Tengfei Yin; Dianne Cook; Michael Lawrence
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SpeCond: A method to detect condition-specific gene expression
Genome Biology, ISSN: 14747596 1474760X
Florence M.G. Cavalli; Richard Bourgon; Juan M. Vaquerizas; Nicholas M. Luscombe
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The A-MYSM Power of Deubiquitinases
Immunity, ISSN: 10747613 10974180
Ignacio A. Demarco; Harinder Singh
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Cancer immunotherapy comes of age
Nature, ISSN: 14764687 00280836
Ira Mellman; George Coukos; Glenn Dranoff
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The authors reply
New England Journal of Medicine, ISSN: 00284793 15334406
Joseph R. Arron; Jonathan Corren; Matthews
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Identification of surprisingly diverse type IV Pili, across a broad range of gram-positive bacteria
PLoS ONE, ISSN: 19326203
Saheed Imam; Zhongqiang Chen; David S. Roos; Mechthild Pohlschröder
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Workshop summary: Novel aspects of the functions of the TRAFs and cIAPs
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
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TRAF2 and cellular IAPs: A critical link in TNFR family signaling
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Science Translational Medicine, ISSN: 19466242
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Feng; Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David A. West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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Influence of 17β-estradiol on gene expression of paracoccidioides during mycelia-to-yeast transition
PLoS ONE, ISSN: 19326203
Jata Shankar; Thomas D Wu; Karl V. Clemons; Jomar P. Monteiro; Laurence F. Mirels; David A. Stevens
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Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
Science Translational Medicine, ISSN: 19466242 19466234
Ai-Luen Wu; Ganesh Kolumam; Scott Stawicki; Yongmei Chen; Jun Li; Jose Zavala-Solorio; Khanhky Phamluong; Bo Feng; Li Li; Scot A. Marsters; Lance Kates; Nicholas Van Bruggen; Maya Leabman; Anne Wong; David West; Howard M. Stern; Luis; Hok Seon Kim; Yansura; Andrew S. Peterson; Ellen H. Filvaroff; Yan Wu; Junichiro Sonoda
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The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly
Cell, ISSN: 10974172 00928674
Jorge Z. Torres; Matthew K. Summers; David Peterson; Matthew J. Brauer; James Lee; Silvia Senese; Ankur A. Gholkar; Yu-Chen Lo; Xingye Lei; Kenneth Jung; David C. Anderson; David P. Davis; Lisa D. Belmont; Peter K Jackson
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Process validation challenges for technology transfer
Pharmaceutical Outsourcing, ISSN: 19453337
Judy H. Chang
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Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
British Journal of Cancer, ISSN: 00070920 15321827
Pan; Xu; Peach; Huang; Branstetter; Novotny; Herbst; Gail Eckhardt; Holland
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Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yifan Mao; Yonglei Shang; Victoria Pham; James A. Ernst; Jennie R. Lill; Suzie J. Scales; Jiping Zha
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Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome
Dermatology Reports, ISSN: 20367392 20367406
Glen J. Weiss; Raoul Tibes; Lisa Blaydorn; Gayle Jameson; Molly Downhour; Erica White; Ivor Caro; Daniel D. Von Hoff
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Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure
European Journal of Cancer, ISSN: 09598049 18790852
Nizar M. Tannir; Yu-Ning Wong; Christian K. Kollmannsberger; Marc S. Ernstoff; David J. Perry; Leonard J. Appleman; Edwin M. Posadas; Daniel Cho; Toni K. Choueiri; Andrew Coates; Neeraj Gupta; Rajendra Pradhan; Jiang Qian; Jihong Chen; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Dror Michaelson
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Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration
Ophthalmology, ISSN: 01616420 15494713
Emmett T. Cunningham Jr.; Leonard Feiner; Carol Chung; Lisa Tuomi; Jason S. Ehrlich
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The Bcl-2/Bcl-X L/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Jun Chen; Sha Jin; Vivek Abraham; Xiaoli Huang; Bernard Liu; Michael J. Mitten; Paul M. Nimmer; Xiaoyu Lin; Morey L. Smith; Yu Shen; Alexander R. Shoemaker; Stephen K. Tahir; Haichao Zhang; Scott L. Ackler; Saul H. Rosenberg; Heather Maecker; Deepak Sampath; Joel D. Leverson; Chris Tse; Steven W. Elmore
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