Genentech: Publications

October 1, 2011

Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X

Diya Ren; Jian Zhang; Ross Pritchett; Hongbin Liu; Jennifer Kyauk; Jun Luo; Ashraf Amanullah

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October 1, 2011

Regulation of interleukin-10 and interleukin-22 expression in T helper cells

Current Opinion in Immunology, ISSN: 09527915 18790372

Sascha Rutz; Wenjun Ouyang

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October 1, 2011

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus

PLoS Genetics, ISSN: 15537390 15537404

Deborah S. Cunninghame Graham; David L. Morris; Tushar Bhangale; Lindsey A. Criswell; Ann-Christine Syvänen; Lars Rönnblom; Timothy W. Behrens; Robert R. Graham; Timothy J. Vyse

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October 1, 2011

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model

American Journal of Pathology, ISSN: 00029440 15252191

Abbas Alexander; Janet Jackman; Sherron L. Bullens; Sarah M. Davis; David F. Choy; Grazyna Fedorowicz; Martha Tan; Bao-Tran Truong; Meng; Laurie Diehl; Lisa A. Miller; Edward S. Schelegle; Dallas M. Hyde; Hilary F. Clark; Zora Modrusan; Joseph R. Arron; Lawren C. Wu

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October 1, 2011

Overcoming challenges in WAVE bioreactors without feedback controls for pH and dissolved oxygen

Biotechnology Progress, ISSN: 87567938 15206033

Inn H. Yuk; Dinesh Baskar; Philip H. Duffy; Jenny Hsiung; Susan Leung; Andy Lin

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October 1, 2011

Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype

American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547

Subhash Kulkarni; Bende Zou; Jesse E. Hanson; Maria-Adelaide Micci; Gunjan Tiwari; Laren Becker; Martin Kaiser; Xinmin Xie; Pankaj Jay Pasricha

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October 1, 2011

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Lichuan Liu; Jason S Halladay; Young G. Shin; Susan C. Wong; Melis Coraggio; Hank La; Matthew Baumgardner; Hoa Le; Sashi Gopaul; Jason Boggs; Peter Kuebler; John C. Davis; X. Charlene Liao; Joseph W. Lubach; Alan Deese; C. Gregory Sowell; Kevin S. Currie; Wendy B. Young; S. Cyrus Khojasteh; Cornelis E. Hop; Harvey Wong

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October 1, 2011

Erratum: A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) (Annals of Biomedical Engineering (2005) 33:11 (1640-1652) DOI: 10.1007/s10439-005-7410-3)

Annals of Biomedical Engineering, ISSN: 00906964 15739686

Gregory Z. Ferl; Anna H. Wu; Joseph J. Distefano III

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October 1, 2011

Healthcare costs associated with bevacizumab and cetuximab in second-line treatment of metastatic colorectal cancer

Journal of Medical Economics, ISSN: 13696998 1941837X

Hongbo Yang; Andrew P. Yu; Eric Q. Wu; Yeun Mi Yim; Elaine B. Yu

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October 1, 2011

Sustained benefits from ranibizumab for macular edema following central retinal vein occlusion: Twelve-month outcomes of a phase III study

Ophthalmology, ISSN: 01616420 15494713

Peter A. Campochiaro; David M. Brown; Carl C. Awh; S. Young Lee; Sarah Gray; Namrata Saroj; Wendy Yee Murahashi; Roman G. Rubio

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October 1, 2011

Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: Data from 25 years of the genentech National Cooperative Growth Study

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X 21910251

Richard Noto; Thomas J. Maneatis; James W. Frane; Kimberly Alexander; Barbara M. Lippe; Daniel A. Davis

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October 1, 2011

Evaluation of dried blood spot sampling following cassette dosing in drug discovery

Bioanalysis, ISSN: 17576180 17576199

Xiaorong Liang; Lulu Yang; Leonid M. Berezhkovskiy; Bianca M. Liederer; Trung Nguyen; Wei Jia; Michelle G. Schweiger; Brian J. Dean; Yuzhong Deng

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October 1, 2011

Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Efren Pacis; Marcella Yu; Jennifer Autsen; Robert Bayer; Feng Li

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October 1, 2011

Site-specific tryptophan oxidation induced by autocatalytic reaction of polysorbate 20 in protein formulation

Pharmaceutical Research, ISSN: 07248741 1573904X

Lam; William G. Lai; Edwin K. Chan; Victor Ling; Chung C. Hsu

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October 1, 2011

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components

Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744

Wolfgang F. Richter; Hans Peter Grimm; Frank-Peter Theil

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October 1, 2011

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Nature Immunology, ISSN: 15292908 15292916

Naruhisa Ota; Kit Wong; Patricia A. Valdez; Yan Zheng; Natasha K Crellin; Laurie Diehl; Wenjun Ouyang

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October 1, 2011

The two-component sensor kinase KdpD is required for Salmonella typhimurium colonization of Caenorhabditis elegans and survival in macrophages

Cellular Microbiology, ISSN: 14625814 14625822

Rosanna A. Alegado; Chui-Yoke Chin; Denise M. Monack; Man-Wah Tan

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October 1, 2011

High-pressure refolding of human vascular endothelial growth factor (VEGF) recombinantly expressed in bacterial inclusion bodies: Refolding optimization, and feasibility assessment

Biotechnology Progress, ISSN: 87567938 15206033

Amber Cothran; Rick St. John; Charles H. Schmelzer; Shelly A. Pizarro

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October 1, 2011

Mutator suppression and escape from replication error-induced extinction in yeast

PLoS Genetics, ISSN: 15537390 15537404

Alan J. Herr; Masanori Ogawa; Nicole A. Lawrence; Lindsey N. Williams; Julie M. Eggington; Mallika Singh; Robert A. Smith; Bradley D. Preston

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October 1, 2011

The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and Migration

Genes and Cancer, ISSN: 19476019 19476027

Danielle R. Cook; Patricia A. Solski; Scott J. Bultman; Gunther Kauselmann; Michael Schoor; Ralf Kuehn; Lori S. Friedman; Dale O. Cowley; Terry van Dyke; Jen Jen Yeh; Leisa Johnson; Channing J. Der

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October 1, 2011

An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire

Current Medical Research and Opinion, ISSN: 03007995 14734877

Rubin; Peyrot; Catherine P. Metzinger; Yaping Xu; Barbara M. Lippe; Leah McCormack; Daniel Aaron Davis

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October 1, 2011

Inferring disease and gene set associations with rank coherence in networks

Bioinformatics, ISSN: 13674803 14602059

Tae Hyun Hwang; Wei Zhang; Maoqiang Xie; Jinfeng Liu; Rui Kuang

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October 1, 2011

Peptoids: Synthesis, characterization, and nanostructures

Comprehensive Biomaterials,

Seo; Lee; Zuckermann

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October 1, 2011

An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire

Current Medical Research and Opinion, ISSN: 03007995 14734877

Richard R. Rubin; Peyrot; Catherine P. Metzinger; Yaping Xu; Barbara M. Lippe; Leah McCormack; Daniel Aaron Davis

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September 30, 2011

Regioselective synthesis of β-iodo-enamides and β-yn-enamides

Tetrahedron, ISSN: 00404020 14645416

Adele E. Pasqua; Lynne H. Thomas; James J. Crawford; Rodolfo Marquez

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September 28, 2011

Exploration of overloaded cation exchange chromatography for monoclonal antibody purification

Journal of Chromatography A, ISSN: 00219673 18733778

Hui F. Liu; Beth McCooey; Tiago Duarte; Deanna E. Myers; Terry Hudson; Ashraf Amanullah; Robert Van Reis; Kelley

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September 23, 2011

Immunoglobulin E receptor signaling and asthma

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Lawren C. Wu

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September 22, 2011

Lebrikizumab treatment in adults with asthma

New England Journal of Medicine, ISSN: 15334406 00284793

Jonathan Corren; Robert F. Lemanske Jr.; Nicola A. Hanania; Phillip Korenblat; Merdad V. Parsey; Joseph R. Arron; Harris; Heleen Scheerens; Lawren C. Wu; Zheng Su; Mosesova; Mark D. Eisner; Sean P. Bohen; Matthews

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September 21, 2011

Patterns of biologic agent utilization among patients with rheumatoid arthritis: A retrospective cohort study

BMC Musculoskeletal Disorders, ISSN: 14712474

Sarika Ogale; Hitraya; Henry J. Henk

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September 21, 2011

A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis

Science Translational Medicine, ISSN: 19466234 19466242

Kasia Owczarczyk; Preeti Lal; Abbas Alexander; Kristen Wolslegel; Cécile T.J. Holweg; Wolfgang Dummer; Ariella Kelman; Paul Brunetta; Nicholas Lewin-Koh; Marco Sorani; Diane Leong; Fielder; David E. Yocum; Carole Ho; Ward Ortmann; Michael J. Townsend; Timothy W. Behrens

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September 19, 2011

High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique and streamlined data analysis

Drug Metabolism Letters, ISSN: 18723128

Jason S Halladay; Erlie Marie Delarosa; Daniel Tran; Leslie Wang; Susan C. Wong; S. Cyrus Khojasteh

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September 16, 2011

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

Cell, ISSN: 10974172 00928674

Samuel A. Williams; Heather Maecker; French; Jinfeng Liu; Andrew Gregg; Leah B. Silverstein; Tim C. Cao; Richard A. D. Carano; Vishva M. Dixit

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September 16, 2011

Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Amitabha Chaudhuri; Xie; Becky Yang; Kaushiki Mahapatra; Jinfeng Liu; Scot A. Marsters; Sweta Bodepudi; Avi Ashkenazi

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September 15, 2011

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

Human Molecular Genetics, ISSN: 14602083 09646906

Yi Yu; Tushar Bhangale; Jesen Fagerness; Stephan Ripke; Gudmar Thorleifsson; Perciliz L. Tan; Eric H. Souied; Andrea J. Richardson; Joanna E. Merriam; Gabriëlle H.S. Buitendijk; Robyn Reynolds; Soumya Raychaudhuri; Kimberly A. Chin; Lucia Sobrin; Evangelos Evangelou; Phil H Lee; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Betsy Campochiaro; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Robyn H. Guymer; Ruth E. Hogg; Usha Chakravarthy; Luba D. Robman; Omar Gustafsson; Haraldur Sigurdsson; Ward Ortmann; Timothy W. Behrens; Kari Stefansson; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Caroline C.W. Klaver; Rando Allikmets; Milam A. Brantley Jr.; Paul N. Baird; Nicholas Katsanis; Unnur Thorsteinsdottir; John P.A. Ioannidis; Mark J. Daly; Robert R. Graham; Johanna M. Seddon

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September 15, 2011

The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1

Cell Cycle, ISSN: 15514005 15384101

Elizabeth Fidalgo Da Silva; Shora B. Ansari; Jiamila Maimaiti; Elizabeth A. Barnes; Monica Kong-Beltran; Daniel J. Donoghue; Lisa A. Porter

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September 15, 2011

A simple assay for 3-deoxy-D-manno-octulosonate cytidylyltransferase and its use as a pathway screen

Analytical Biochemistry, ISSN: 10960309 00032697

Li Yi; Melvin S. Velasquez; Tod P. Holler; Ronald W. Woodard

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September 15, 2011

Pyrazolopyridine inhibitors of B-Raf V600E. Part 2: Structure-activity relationships

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; Kateri Ahrendt; Alexandre J. Buckmelter; Bainian Feng; Susan L. Gloor; Stefan Gradl; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; Simon Mathieu; David Moreno; Bradley J. Newhouse; Li Ren; Tyler Risom; Joachim Rudolph; Jeongbeob Seo; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen

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September 12, 2011

Access to saturated fused pyrimidine derivatives via a flexible N -vinyl tertiary enamide synthesis

Synlett, ISSN: 09365214 14372096

Anthony A. Estrada; Joseph P. Lyssikatos; Frederic St-Jean; Philippe Bergeron

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September 9, 2011

Process Validation

Comprehensive Biotechnology, Second Edition,

David H. Reifsnyder; Nathan McKnight; Kelley

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September 9, 2011

Disposable Bioreactors

Comprehensive Biotechnology, Second Edition,

Oosterhuis; Terry Hudson; D'Avino; Zijlstra; Ashraf Amanullah

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September 9, 2011

Purification Process Design and the Influence of Product and Technology Platforms

Comprehensive Biotechnology, Second Edition,

Chris Dowd; Kelley

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September 9, 2011

Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1))

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Harinath Bahudhanapati; Yingnan Zhang; Sachdev S. Sidhu; Keith Brew

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September 5, 2011

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

Journal of Cell Biology, ISSN: 00219525 15408140

Arundhati Sengupta Ghosh; Bei Wang; Christine D. Pozniak; Mark Chen; Ryan J. Watts; Joe Lewcock

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September 1, 2011

AAPS workshop report: Strategies to address therapeutic protein-drug interactions during clinical development

AAPS Journal, ISSN: 15507416

Sandhya Girish; Steven W Martin; Mark C Peterson; Zhang; Hong Zhao; Joseph P. Balthasar; Raymond Evers; Honghui Zhou; Min Zhu; Lewis Klunk; Chao Han; Eva Gil Berglund; Huang; Amita Joshi

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September 1, 2011

Asthma in the elderly: Current understanding and future research needs - A report of a National Institute on Aging (NIA) workshop

Journal of Allergy and Clinical Immunology, ISSN: 00916749 10976825

Nicola A. Hanania; Monroe J. King; Sidney S. Braman; Carol Saltoun; Robert A. Wise; Paul Enright; Ann R. Falsey; Sameer K. Mathur; Joe W. Ramsdell; Linda Rogers; David A. Stempel; John Lima; James E. Fish; Sandra R. Wilson; Cynthia Boyd; Kushang V. Patel; Charles G. Irvin; Barbara P. Yawn; Ethan A. Halm; Stephen I. Wasserman; Mark F. Sands; William B. Ershler; Dennis Ledford

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September 1, 2011

Lyp breakdown and autoimmunity

Nature Genetics, ISSN: 10614036 15461718

Timothy W. Behrens

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September 1, 2011

Efficient production of antibodies against a mammalian integral membrane protein by phage display

Protein Engineering, Design and Selection, ISSN: 17410126 17410134

Isidro Hötzel; Vicki Chiang; Jingyu Diao; Homer Pantua; Henry R. Maun; Sharookh B. Kapadia

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September 1, 2011

AAPS workshop report: Strategies to address therapeutic protein-drug interactions during clinical development

AAPS Journal, ISSN: 15507416

Sandhya Girish; Steven W Martin; Mark C Peterson; Lei K. Zhang; Hong Zhao; Joseph P. Balthasar; Raymond Evers; Honghui Zhou; Min Zhu; Lewis Klunk; Chao Han; Eva Gil Berglund; Huang; Amita Joshi

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September 1, 2011

A20 edits ubiquitin and autoimmune paradigms

Nature Genetics, ISSN: 10614036 15461718

Flavius Martin; Vishva M. Dixit

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September 1, 2011

Stems to gems: Impact of stem cell technology on engineered animal models

Veterinary Pathology, ISSN: 03009858 15442217

Wendy Halpern; Mark McArthur; Elizabeth Galbreath; Elizabeth Uhl; Wayne Buck; Elizabeth Whitley

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