Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8151 - 8200 OF 15394 RESULTS

Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors
Clinical Cancer Research, ISSN: 10780432 15573265
Patricia M. LoRusso; Antonio Jimeno; Grace Dy; Alex Adjei; Jordan Berlin; Lawrence Leichman; Low; Dawn Colburn; Ilsung Chang; Sravanthi Cheeti; Jin Y. Jin; Richard A. Graham
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Use of confocal scanning laser microscopy to study virus retention during virus filtration
Journal of Membrane Science, ISSN: 03767388 18733123
Meisam Bakhshayeshi; Nigel B. Jackson; Ralf Kuriyel; Amit Mehta; Robert Van Reis; Andrew Zydney
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Uniting small molecule and biologic drug perspectives: Analytical characterization and regulatory considerations for antibody-drug conjugates
BioProcess International, ISSN: 15426319
Jon Harris; Fred Jacobson; Claudia Jochheim; Godfrey Amphlett; Kathleen Francissen; Lorna McLeod
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Decision Making for a Companion Diagnostic in an Oncology Clinical Development Program
Drug Information Journal, ISSN: 00928615
Lee D. Kaiser; Claus Becker; Sharad Kukreti; Bernard M. Fine
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An Audit Strategy for Progression-Free Survival
Biometrics, ISSN: 15410420 0006341X
Lori E. Dodd; Edward L. Korn; Boris Freidlin; Robert Gray; Suman Bhattacharya
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Integrated safety in tocilizumab clinical trials
Arthritis Research and Therapy, ISSN: 14786354 14786362
Michael H. Schiff; Joel M. Kremer; Angelika Jahreis; Emma Vernon; John D. Isaacs; Ronald Van Vollenhoven
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Proteolytic activation of pro-macrophage-stimulating protein by hepsin
Molecular Cancer Research, ISSN: 15417786 15573125
Rajkumar Ganesan; Ganesh Kolumam; S. Jack Lin; Xie; Santell; Thomas D Wu; Lazarus; Amitabha Chaudhuri; Daniel Kirchhofer
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A note on importance resampling for multi-dimensional statistics
Communications in Statistics: Simulation and Computation, ISSN: 03610918 15324141
Zheng Su
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Evaluation of homogenization techniques for the preparation of mouse tissue samples to support drug discovery
Bioanalysis, ISSN: 17576180 17576199
Xiaorong Liang; Savita Ubhayakar; Bianca M. Liederer; Brian J. Dean; Ann R. Qin; Sheerin Shahidi-Latham; Yuzhong Deng
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Magnetic resonance imaging in rheumatoid arthritis clinical trials: Emerging patterns based on recent experience
Journal of Rheumatology, ISSN: 0315162X 14992752
Charles G. Peterfy; Peter Countryman; Annarita Gabriele; Tim Shaw; Andrew Anisfeld; Wayne Tsuji; Ewa Olech; Norman B. Gaylis; Philip G. Conaghan; Vibeke Strand; Julie DiCarlo
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Cross talk between ubiquitination and demethylation
Molecular and Cellular Biology, ISSN: 02707306 10985549
Xiaodong Huang; Vishva M. Dixit
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Dextran sieving test for characterization of virus filtration membranes
Journal of Membrane Science, ISSN: 03767388 18733123
Meisam Bakhshayeshi; Dharmesh M. Kanani; Amit Mehta; Robert Van Reis; Ralf Kuriyel; Nigel B. Jackson; Andrew Zydney
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Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Michael A. Matthay; Roy G. Brower; Shannon Carson; Ivor S. Douglas; Mark D. Eisner; Duncan Hite; Steven Holets; Richard H. Kallet; Kathleen D. Liu; Neil MacIntyre; Marc Moss; David Schoenfeld; Jay S. Steingrub; B. Taylor Thompson
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A hybrid approach to predicting events in clinical trials with time-to-event outcomes
Contemporary Clinical Trials, ISSN: 15517144 15592030
Liang Fang; Zheng Su
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The science of project management: Project controls systems integration
Pharmaceutical Engineering, ISSN: 02738139
Frederick Cramer; Susanne Keller; Christopher Law; Thomas Shih; Britton L. Wolf
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PPM1H Is a p27 phosphatase implicated in trastuzumab resistance
Cancer Discovery, ISSN: 21598274 21598290
Si Tuen Lee-Hoeflich; Thinh Q. Pham; Dowbenko; Xander Munroe; James Lee; Li Li; Wei Zhou; Matthias Peter; Kanan Pujara; Stinson; Sara M. Chan; Jeffrey Eastham-Anderson; Ajay Pandita; Somasekar Seshagiri; Klaus P. Hoeflich; Gulisa Turashvili; Karen A. Gelmon; Samuel A. Aparicio; David P. Davis; Mark X. Sliwkowski; Howard M. Stern
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2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections
Bioanalysis, ISSN: 17576180 17576199
Fabio Garofolo; Mario Rocci; Isabelle Dumont; Suzanne Martinez; Steve Lowes; Eric Woolf; Peter Van Amsterdam; Surendra Bansal; Ariadna Cristina Gomes Barra; Ronald Bauer; Brian Booth; Montserrat Carrasco-Triguero; Binodh DeSilva; John Dunn; Keith Gallicano; Dominique Gouty; Stacy Ho; Richard Hucker; Mohammed Jemal; Noriko Katori; Olivier Le Blaye; Jean W. Lee; Wenkui Li; Steve Michael; Corey Nehls; Robert Nicholson; Eric Ormsby; Daniel Tang; Viswanathan; Russell Weiner; Graeme Young
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Bounds for an estimate of the optimal backward error for linear least squares problems
International Journal of Computer Mathematics, ISSN: 00207160 10290265
Zheng Su
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Conference report: The AAPS national biotechnology conference
Therapeutic Delivery, ISSN: 20415990 20416008
Margaret Kenrick
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The interleukin-17 cytokine family: Critical players in host defence and inflammatory diseases
Immunology, ISSN: 00192805 13652567
Rajita Pappu; Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam
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Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b
Journal of Experimental Medicine, ISSN: 00221007 15409538
Niko Föger; André Jenckel; Zane Orinska; Kyeong-Hee Lee; Andrew A. Chan; Silvia Bulfone-Paus
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Switchable Proteins and Channels
Molecular Switches, Second Edition,
Matthew Volgraf; Matthew Banghart; Dirk Trauner
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CCBE1 Is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-c in vivo
Circulation Research, ISSN: 00097330 15244571
Frank L. Bos; Maresa Caunt; Josi Peterson-Maduro; Lara Planas-Paz; Joe Kowalski; Terhi Karpanen; Andreas Van Impel; Raymond K. Tong; James A. Ernst; Jeroen Korving; Johan H. Van Es; Eckhard Lammert; Henricus J. Duckers; Stefan Schulte-Merker
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The notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development
Blood, ISSN: 15280020 00064971
Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Ganesh Kolumam; Christian W. Siebel; Minhong Yan
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Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex
EMBO Journal, ISSN: 02614189 14602075
Matthew L Bentley; Jacob E. Corn; Ken Dong; Qui Phung; Tommy K. Cheung; Andrea G Cochran
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miR-221/222 targeting of trichorh inophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer
Science Signaling, ISSN: 19450877 19379145
Susanna Y. Stinson; Lackner; Alex T. Adai; Nancy Yu; Hyo-Jin Kim; Carol O'Brien; Jill M. Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Thomas Januario; Robert J. Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard M. Stern; Søren Warming; Frederic J. De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan
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Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C
Journal of Infectious Diseases, ISSN: 00221899
Nicole Forestier; Dominique Larrey; Marcellin; Dominique Guyader; Alain Patat; Régine Rouzier; Patrick F. Smith; Xiaoli Qin; Sharlene R. Lim; Williamson Bradford; Steven Porter; Scott D. Seiwert; Stefan Zeuzem
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Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala
Journal of Comparative Neurology, ISSN: 00219967 10969861
Bei Wang; Thomas Lufkin; John L. R. Rubenstein
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Preparation of distinct ubiquitin chain reagents of high purity and yield
Structure, ISSN: 09692126 18784186
Ken Dong; Elizabeth Helgason; Christine Yu; Lilian Phu; David Arnott; Ivan Bosanac; Deanne M. Compaan; Oscar W Huang; Anna V. Fedorova; Donald S. Kirkpatrick; Sarah G. Hymowitz; Erin C. Dueber
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Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics
PLoS ONE, ISSN: 19326203
Daniel J Anderson; Jenni K. Durieux; Kyung Song; Ryan Alvarado; Peter K Jackson; Georgia Hatzivassiliou; Mary J. C. Ludlam
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Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
Journal of Chromatography A, ISSN: 00219673 18733778
Taylor Zhang; Justin Bourret; Tony Cano
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Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes
FEBS Letters, ISSN: 00145793 18733468
Xinxin Gao; Natalia Arenas-Ramirez; Suzie J. Scales; Rami N. Hannoush
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Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: Results of a phase 3b study
Molecular Genetics and Metabolism, ISSN: 10967192 10967206
Barbara K. Burton; Maria Nowacka; Julia B. Hennermann; Mark Lipson; Dorothy K. Grange; Anupam Chakrapani; Friedrich Trefz; Alejandro Dorenbaum; Michael Imperiale; Sun Sook Kim; Paul M. Fernhoff
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Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis
Analytical Chemistry, ISSN: 00032700
X. Christopher Yu; Koman Joe; Yu Zhang; Andrea Adriano; Yaning Wang; Hélène Gazzano-Santoro; Rodney Keck; Galahad Deperalta; Victor Ling
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Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus
Arthritis and Rheumatism, ISSN: 00043591 15290131
Alyssa M. Morimoto; Donna Thibault Flesher; Yang; Kristen Wolslegel; Xiangdan Wang; Ann Brady; Abbas Alexander; Quarmby; Eric Wakshull; Bruce C. Richardson; Michael J. Townsend; Timothy W. Behrens
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A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Richard A. Graham; Bert L. Lum; Morrison; Ilsung Chang; Karin Jorga; Brian J. Dean; Young G. Shin; Qin Yue; Teresa Mulder; Vikram Malhi; Minli Xie; Low; Cornelis E. Hop
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Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: Results of a phase 3b study
Molecular Genetics and Metabolism, ISSN: 10967192 10967206
Barbara K. Burton; Maria Nowacka; Julia B. Hennermann; Mark Lipson; Dorothy K. Grange; Anupam Chakrapani; Friedrich Trefz; Alex Dorenbaum; Michael Imperiale; Sun Sook Kim; Paul M. Fernhoff
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Hedgehog fights back: Mechanisms of acquired resistance against smoothened antagonists
Cancer Research, ISSN: 00085472 15387445
Ciara Metcalfe; Frederic J. De Sauvage
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Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis
Hepatology, ISSN: 02709139 15273350
Henriette E. Meyer Zu Schwabedissen; Joseph A. Ware; David Finkelstein; Amarjit S. Chaudhry; Sara Mansell; Matilde Leon-Ponte; Stephen C. Strom; Hani Zaher; Ute I. Schwarz; David J. Freeman; Erin G. Schuetz; Rommel G. Tirona; Richard B. Kim
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Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells
Cancer Science, ISSN: 13479032 13497006
Tetsunari Hase; Sato; Kenya Yoshida; Girard; Yoshihiro Takeyama; Mihoko Horio; Momen Elshazley; Tomoyo Oguri; Yoshitaka Sekido; David S. Shames; Adi Gazdar; Minna; Masashi Kondo; Yoshinori Hasegawa
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Viscosity analysis of high concentration bovine serum albumin aqueous solutions
Pharmaceutical Research, ISSN: 07248741 1573904X
Sandeep Yadav; Steven J. Shire; Devendra S. Kalonia
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A phase III, open-label, single-arm study of tenecteplase for restoration of function in dysfunctional central venous catheters
Journal of Vascular and Interventional Radiology, ISSN: 10510443 15357732
Cameron Tebbi; John Costanzi; Robert Shulman; Luke Dreisbach; Brian R. Jacobs; Martha Blaney; Ashby; Barbara S. Gillespie; Susan M. Begelman
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Pervasive sharing of genetic effects in autoimmune disease
PLoS Genetics, ISSN: 15537390 15537404
Chris Cotsapas; Benjamin F. Voight; Elizabeth Rossin; Kasper Lage; Neale; Chris Wallace; Gonçalo R. AbecasisGonç; Jeffrey C. Barrett; Timothy W. Behrens; Judy H. Cho; Philip L. De Jager; James T. Elder; Robert R. Graham; Peter K. Gregersen; Lars Klareskog; Katherine A. Siminovitch; David A. van Heel; Cisca Wijmenga; Jane Worthington; John A. Todd; David A. Hafler; Stephen S. Rich; Mark J. Daly
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Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease
American Journal of Cardiology, ISSN: 00029149 18791913
Lin T. Guey; Clive R. Pullinger; Ishida; Patricia M. O'Connor; Christian Zellner; Omar L. Francone; Jason M. Laramie; Naya-Vigne; Ketevan A. Siradze; Prakash Deedwania; Redberg; Philip H. Frost; Albert B. Seymour; Kane; Malloy
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Molecular subclassification of diffuse gliomas: Seeing order in the chaos
GLIA, ISSN: 08941491 10981136
Jason T. Huse; Phillips; Cameron W. Brennan
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ErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer
Genes and Cancer, ISSN: 19476019 19476027
Christopher Mill; Michael D. Zordan; S. Michael Rothenberg; Jeffrey E. Settleman; James F. Leary; David J. Riese II
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Blinded independent central review of progression in cancer clinical trials: Results from a meta-analysis
European Journal of Cancer, ISSN: 09598049 18790852
Amit; Mannino; Stone; Bushnell; Denne; Jeffrey D. Helterbrand; Hans Ulrich Burger
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Research outcomes and recommendations for the assessment of progression in cancer clinical trials from a PhRMA working group
European Journal of Cancer, ISSN: 09598049 18790852
Stone; Bushnell; Denne; Daniel J. Sargent; Amit; Chen; Bailey-Iacona; Jeffrey D. Helterbrand; Williams
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Notch3 signalling promotes tumour growth in colorectal cancer
Journal of Pathology, ISSN: 00223417 10969896
Valentina Serafin; Luca Persano; Lidia Moserle; Giovanni Esposito; Margherita Ghisi; Matteo Curtarello; Laura Bonanno; Massimo Masiero; Domenico Ribatti; Michael Stürzl; Elisabeth Naschberger; Roland S Croner; Adrian M. Jubb; Adrian L. Harris; Koeppen; Alberto Amadori; Stefano Indraccolo
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Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study
Ophthalmology, ISSN: 01616420 15494713
David M. Brown; Peter A. Campochiaro; Robert B. Bhisitkul; Allen C. Ho; Sarah Gray; Namrata Saroj; Anthony P. Adamis; Roman G. Rubio; Wendy Yee Murahashi
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