Genentech: Publications

February 1, 2013

Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas

PLoS Genetics, ISSN: 15537390 15537404

Teresa L. Mastracci; Keith R. Anderson; James B. Papizan; Lori Sussel

February 1, 2013

Hepatocyte Growth Factor, a Determinant of Airspace Homeostasis in the Murine Lung

PLoS Genetics, ISSN: 15537390 15537404

Carla Calvi; Megan Podowski; Armando Lopez-Mercado; Shana Metzger; Kaori Misono; Alla Malinina; Dustin Dikeman; Hataya Poonyagariyon; Leslie Ynalvez; Roshanak Derakhshandeh; Anne Le; Mark Merchant; Ralph H. Schwall; Enid R. Neptune

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January 31, 2013

Evaluation of semi-homogeneous assay formats for dual-specificity antibodies

Journal of Immunological Methods, ISSN: 00221759 18727905

Guoying Jiang; Chung W. Lee; Wong; Hélène Gazzano-Santoro

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January 31, 2013

Lgr5-Expressing Cells Are Sufficient And Necessary for Postnatal Mammary Gland Organogenesis

Cell Reports, ISSN: 22111247

Vicki Plaks; Audrey Brenot; Devon A. Lawson; Jelena R. Linnemann; Eline C. Van Kappel; Karren C. Wong; Frederic J. De Sauvage; Ophir D. Klein; Zena Werb

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January 30, 2013

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach

PLoS ONE, ISSN: 19326203

Ka Young Chung; Peter W. Day; Gisselle Vélez-Ruiz; Roger K. Sunahara; Brian K. Kobilka

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January 29, 2013

An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Stefan L. Oliver; Jennifer J. Brady; Marvin H. Sommer; Mike Reichelt; Phillip Sung; Helen M. Blau; Ann M. Arvin

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January 25, 2013

Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Steffan Vartanian; Carolyn Bentley; Matthew J. Brauer; Li Li; Senji Shirasawa; Takehiko Sasazuki; Jung-Sik Kim; Matthias Peter; Eric Stawiski; Zora Modrusan; Todd Waldman; David Stokoe

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January 24, 2013

Neuroscience: Strength in numbers

Nature, ISSN: 00280836 14764687

Morgan Sheng; Roberto Malinow; Richard Huganir

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January 18, 2013

Development of a scalable strategy for the synthesis of PI3Kδ inhibitors: Selective and efficient functionalization of purine derivatives

Organic Process Research and Development, ISSN: 10836160 1520586X

Diane Carrera; Peijue Sheng; Brian S. Safina; Jun Li; Remy Angelaud

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January 18, 2013

Cyanide anion as a leaving group in nucleophilic aromatic substitution: Synthesis of quaternary centers at azine heterocycles

Journal of Organic Chemistry, ISSN: 00223263 15206904

Alexander D. Thompson; Malcolm P. Huestis

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January 18, 2013

A practical synthesis of a PI3K inhibitor under noncryogenic conditions via functionalization of a lithium triarylmagnesiate intermediate

Organic Process Research and Development, ISSN: 10836160 1520586X

Qingping Tian; Zhigang Cheng; Herbert M. Yajima; Scott Savage; Keena L. Green; Theresa Humphries; Mark E. Reynolds; Srinivasan Babu; Francis Gosselin; David Askin; Isao Kurimoto; Norihiko Hirata; Mitsuhiro Iwasaki; Yasuharu Shimasaki; Takashi Miki

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January 17, 2013

Screening Reactive Metabolites: Role of Liquid Chromatography-High-Resolution Mass Spectrometry in Combination with "Intelligent" Data Mining Tools

Mass Spectrometry for Drug Discovery and Drug Development,

Shuguang Ma; Swapan K. Chowdhury

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January 17, 2013

Mass Spectrometry of siRNA

Mass Spectrometry for Drug Discovery and Drug Development,

Mark T. Cancilla; W. Michael Flanagan

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January 17, 2013

Conditional activation of Pik3ca H1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

Oncogene, ISSN: 09509232 14765594

Yuan; Eric Stawiski; Vasantharajan Janakiraman; Emily Chan; Durinck; Kyle A. Edgar; Noelyn Kljavin; Rivers; Florian Gnad; Merone Roose-Girma; Matthias Peter; Grazyna Fedorowicz; Sherry Heldens; Robert Soriano; Zemin Zhang; Jeffery J. Wallin; Johnson; Mark Merchant; Zora Modrusan; Howard M. Stern; Somasekar Seshagiri

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January 17, 2013

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the sonic hedgehog pathway via cAMP signaling

Cell, ISSN: 10974172 00928674

Saikat Mukhopadhyay; Xiaohui Wen; Navneet Ratti; Alexander V. Loktev; Linda Rangell; Suzie J. Scales; Peter K Jackson

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January 16, 2013

Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles

Tetrahedron Letters, ISSN: 00404039 18733581

Olivier René; Alexandra Souverneva; Steven Magnuson; Benjamin P. Fauber

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January 15, 2013

Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma

Cancer, ISSN: 10970142 0008543X

Han Chong Toh; Pei-Jer Chen; Brian I. Carr; Jennifer J. Knox; Sharlene Gill; Peter Ansell; Evelyn M. McKeegan; Barry Dowell; Michelle Pedersen; Qin Qin; Jiang Qian; Frank A. Scappaticci; Justin L. Ricker; Dawn M. Carlson; Wei Peng Yong

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January 15, 2013

Recommendations for including multiple symptoms as endpoints in cancer clinical trials: A report from the ASCPRO (Assessing the Symptoms of Cancer Using Patient-Reported Outcomes) Multisymptom Task Force

Cancer, ISSN: 0008543X 10970142

Charles S. Cleeland; Jeff A. Sloan; Cella; Connie Chen; Amylou Dueck; Nora A. Janjan; Astra M. Liepa; Rajiv Mallick; Ann O'Mara; Jay D. Pearson; Yasuhiro Torigoe; Xin Shelley Wang; Loretta A. Williams; Jeanie F. Woodruff

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January 15, 2013

Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma

Cancer, ISSN: 0008543X 10970142

Darrell White; Adetola Kassim; Birbal Bhaskar; Jing Yi; Karen Wamstad; Virginia Paton

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January 15, 2013

So, what's it really like to work in biotech?

Molecular Biology of the Cell, ISSN: 10591524 19394586

Lisa D. Belmont

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January 15, 2013

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer

Cancer Research, ISSN: 00085472 15387445

Kyle David Proffitt; Babita Madan; Zhiyuan Ke; Vishal Pendharkar; Lijun Ding; May Ann Lee; Rami N. Hannoush; David M. Virshup

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January 14, 2013

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: Insights from coarse-grained modeling

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Anuj Chaudhri; Isidro E. Zarraga; Sandeep Yadav; Thomas W. Patapoff; Steven J. Shire; Gregory A. Voth

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January 11, 2013

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

Journal of Chromatography A, ISSN: 00219673 18733778

Liangyi Zhang; Thomas W. Patapoff; Dell Farnan; Boyan Zhang

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January 10, 2013

Discovery and biological profiling of potent and selective mTOR inhibitor GDC-0349

ACS Medicinal Chemistry Letters, ISSN: 19485875

Zhonghua Pei; Elizabeth M. Blackwood; Lichuan Liu; Shiva Malek; Marcia Belvin; Michael F. T. Koehler; Daniel F. Ortwine; Huifen Chen; Frederick Cohen; Jane R. Kenny; Philippe Bergeron; Kevin Lau; Cuong Q. Ly; Xianrui Zhao; Anthony A. Estrada; Tom Truong; Jennifer A. Epler; Jim Nonomiya; Lan Trinh; Steve Sideris; John Lesnick; Linda Bao; Ulka Vijapurkar; Sophie Mukadam; Suzanne Tay; Gauri Deshmukh; Yunghsiang Chen; Xiao Ding; Lori S. Friedman; Joseph P. Lyssikatos

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January 10, 2013

Discovery of a highly selective, brain-penetrant aminopyrazole LRRK2 inhibitor

ACS Medicinal Chemistry Letters, ISSN: 19485875

Bryan K. Chan; Anthony A. Estrada; Huifen Chen; John Atherall; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Sara L. Dominguez; Jason H. Drummond; Andrew Gill; Tracy L. Kleinheinz; Claire E. Le Pichon; Andrew D. Medhurst; Xingrong Liu; John Moffat; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Hervé Van De Poël; Shuo Zhang; Haitao Zhu; Zachary K. Sweeney

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January 8, 2013

The Akt DUBbed inAktive

Science Signaling, ISSN: 19450877 19379145

Kui Lin

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January 7, 2013

Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway

Molecular Pharmaceutics, ISSN: 15438384 15438392

Alavattam Sreedhara; Kimberly Lau; Charlene Li; Brian Hosken; Frank D. Macchi; Dejin Zhan; Amy Shen; Daniel Steinmann; Christian Schöneich; Yvonne Lentz

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January 5, 2013

Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

Virology, ISSN: 00426822 10960341

Michael B.A. Oldstone; John R. Teijaro; Kevin B. Walsh; Hugh Rosen

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January 4, 2013

Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates

Analytical Chemistry, ISSN: 15206882 00032700

Jia Chen; Sheng Yin; Yongjian Wu; Jun Ouyang

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January 4, 2013

The chromosome-centric human proteome project: A call to action

Journal of Proteome Research, ISSN: 15353893 15353907

Andreas F. R. Hühmer; Aran Paulus; Leroy B. Martin; Kevin Millis; Tasha Agreste; Julian Saba; Jennie R. Lill; Steven M. Fischer; William Dracup; Paddy Laver

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January 1, 2013

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

EMBO Reports, ISSN: 14693178 1469221X

Dong Yun Lee; David Arnott; Eric J. Brown

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January 1, 2013

Use of Animal Models of Human Disease for Nonclinical Safety Assessment of Novel Pharmaceuticals

Toxicologic Pathology, ISSN: 15331601 01926233

Sherry J. Morgan; Chandikumar S. Elangbam; Shawn Berens; Evan B. Janovitz; Allison Vitsky; Tanja S. Zabka; Laura Conour

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January 1, 2013

Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: Formulation and biocompatibility considerations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Tim J. Kamerzell; Amanda L. Pace; Megan Li; Dimitry Danilenko; Michelle Mcdowell; Yatin Gokarn; Y. John Wang

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January 1, 2013

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial

The Lancet, ISSN: 1474547X 01406736

Cem Gabay; Paul Emery; Ronald Van Vollenhoven; Ara Dikranian; Rieke Alten; Karel Pavelka; Micki Klearman; David Musselman; Sunil Agarwal; Jennifer Green; Arthur Kavanaugh

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January 1, 2013

Redefining approaches to asthma: Developing targeted biologic therapies

Advances in Pharmacology, ISSN: 15578925 10543589

Joseph R. Arron; Heleen Scheerens; Matthews

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January 1, 2013

Response

Chest, ISSN: 19313543 00123692

Nareg Roubinian; Paul D. Blanc; Hubert Chen

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January 1, 2013

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)

Alzheimer's and Dementia, ISSN: 15525279 15525260

Adam L. Boxer; Michael Gold; Edward Huey; William T. Hu; Howard J. Rosen; Joel H. Kramer; Fen-Biao Gao; Edward A. Burton; Tiffany Chow; Aimee Kao; Blair R. Leavitt; Bruce Lamb; Megan Grether; David Knopman; Nigel J. Cairns; Ian R. Mackenzie; Laura Mitic; Erik D. Roberson; Daniel Van Kammen; Marc Cantillon; Kathleen Zahs; George Jackson; Stephen Salloway; John C. Morris; Gary Tong; Howard Feldman; Howard Fillit; Susan Dickinson; Zaven S. Khachaturian; Margaret Sutherland; Susan Abushakra; Joe Lewcock; Robert Farese; Robert O. Kenet; Frank Laferla; Steve Perrin; Steve Whitaker; Lawrence S. Honig; Marsel M. Mesulam; Brad Boeve; Murray Grossman; Bruce L. Miller; Jeffrey L. Cummings

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January 1, 2013

Avoiding pitfalls during technology transfer of cell culture manufacturing processes in the pharmaceutical industry - Mitigating risk and optimizing performance

Pharmaceutical Outsourcing, ISSN: 19453337

Michael Pohlscheidt; Mahalia Corrales; Salim Charanyia; Eric Fallon; Manfred Bruch; Marco Jenzsch; Christian Sieblist

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January 1, 2013

Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: A meta-analysis

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

John D. Isaacs; Stanley B. Cohen; Paul Emery; Paul P. Tak; Jianmei Wang; Guiyuan Lei; Sarah Williams; Preeti Lal; Simon J. Read

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January 1, 2013

Compatibility and stability of pertuzumab and trastuzumab admixtures in i.v. infusion bags for coadministration

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Zephania Kwong Glover; Lynn Gennaro; Sandeep Yadav; Barthélemy Demeule; Wong; Alavattam Sreedhara

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January 1, 2013

CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States

American Journal of Ophthalmology, ISSN: 18791891 00029394

Louis R. Pasquale; Stephanie J. Loomis; Jae H. Kang; Brian L. Yaspan; Wael Abdrabou; Donald L. Budenz; Teresa C. Chen; Elizabeth Delbono; Friedman; Douglas Gaasterland; Terry Gaasterland; Cynthia L. Grosskreutz; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Olson; Tony Realini; Douglas J. Rhee; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; R. Rand Allingham; Brian W. Kunkle; Robert N. Weinreb; Kang Zhang; Michael A. Hauser; Julia E. Richards; Jonathan L. Haines; Janey L. Wiggs

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January 1, 2013

An alternative approach for quantitative bioanalysis using diluted blood to profile oral exposure of small molecule anticancer drugs in mice

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Bianca M. Liederer; Leonid M. Berezhkovskiy; Savita Ubhayakar; Yuzhong Deng

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January 1, 2013

Prediction of drug terminal half-life and terminal volume of distribution after intravenous dosing based on drug clearance, steady-state volume of distribution, and physiological parameters of the body

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2013

Examination of the follicular lymphoma international prognostic index (FLIPI) in the national lymphocare study (NLCS): A prospective US patient cohort treated predominantly in community practices

Annals of Oncology, ISSN: 15698041 09237534

Nooka; Chadi Nabhan; Zhou; Taylor; Michelle Byrtek; Thomas P. Miller; Jonathan W. Friedberg; Zelenetz; Brian K. Link; James R. Cerhan; Dillon; Sinha; Shenoy; Levy; Keith Dawson; Jamie Hirata; Christopher R. Flowers

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January 1, 2013

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma

Blood, ISSN: 15280020 00064971

James L. Rubenstein; Jing Li; Lingjing Chen; Ranjana H. Advani; Jan Drappatz; Elizabeth Gerstner; Tracy Batchelor; Hendrikus Krouwer; James Hwang; Glenna Auerback; Cigall Kadoch; Clifford Lowell; Pamela N. Münster; Soonmee Cha; Shuman; Lloyd E. Damon

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January 1, 2013

Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Paolo Polucci; Paola Magnaghi; Mauro Angiolini; Daniela Asa; Nilla Avanzi; Alessandra Badari; Jay Bertrand; Elena Casale; Silvia Cauteruccio; Alessandra Cirla; Liviana Cozzi; Arturo Galvani; Peter K Jackson; Yichin Liu; Steven Magnuson; Beatrice Malgesini; Stefano Nuvoloni; Christian Orrenius; Federico Riccardi Sirtori; Laura Riceputi; Simona Rizzi; Beatrice Trucchi; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio

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January 1, 2013

Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation

Cancer Research, ISSN: 15387445 00085472

Shyhmin Huang; Chunrong Li; Eric A. Armstrong; Chimera R. Peet; Jarob Saker; Lukas Amler; Mark X. Sliwkowski; Paul M. Harari

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January 1, 2013

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

Cancer Cell, ISSN: 18783686 15356108

Ryan B. Corcoran; Katherine A. Cheng; Aaron N. Hata; Anthony C. Faber; Hiromichi Ebi; Erin M. Coffee; Patricia Greninger; Ronald D. Brown; Jason T. Godfrey; Travis J. Cohoon; Youngchul Song; Eugene Lifshits; Kenneth E. Hung; Toshi Shioda; Dora Dias-Santagata; Anurag Singh; Jeffrey Settleman; Cyril H. Benes; Mari Mino-Kenudson; Kwok-Kin Wong; Jeff A. Engelman

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January 1, 2013

Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?

Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041

Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ellen M. Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons

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January 1, 2013

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

Journal of Clinical Investigation, ISSN: 15588238 00219738

Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott C. Kogan; Benjamin S. Braun; Kevin Shannon

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