Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8251 - 8300 OF 15394 RESULTS

Rituximab's new therapeutic target: The podocyte actin cytoskeleton
Science Translational Medicine, ISSN: 19466234 19466242
Andrew A. Chan
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Free versus total ligand-binding assays: Points to consider in biotherapeutic drug development
Bioanalysis, ISSN: 17576180 17576199
Yang; Quarmby
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Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex
Journal of Neuroscience Research, ISSN: 03604012 10974547
Guoxin Wu; Sethu Sankaranarayanan; Sidney H.-K. Hsieh; Adam J. Simon; Mary J. Savage
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Absorption, distribution, metabolism, and excretion of [ 14C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: A unique metabolic pathway via pyridine ring opening
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Qin Yue; Yunghsiang Chen; Teresa Mulder; Alan Deese; Ryan Takahashi; Patrick J. Rudewicz; Mark E. Reynolds; Eric G. Solon; Cornelis E. Hop; Harvey Wong; S. Cyrus Khojasteh
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Randomized phase II study of bevacizumab in combination with chemotherapy in previously untreated extensive-stage small-cell lung cancer: Results from the SALUTE trial
Journal of Clinical Oncology, ISSN: 0732183X 15277755
David Spigel; Peter Townley; David M. Waterhouse; Liang Fang; Ibrahim Adiguzel; Jane E. Huang; David A. Karlin; Leonardo Faoro; Frank A. Scappaticci; Mark A. Socinski
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Antibody delivery of drugs and radionuclides: Factors influencing clinical pharmacology
Therapeutic Delivery, ISSN: 20415990 20416008
Saileta Prabhu; C. Andrew Boswell; Douglas Leipold; Leslie A. Khawli; Dongwei Li; Dan Lu; Frank-Peter Theil; Amita Joshi; Bert L. Lum
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Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in patients with advanced Non-small Cell Lung Cancer (NSCLC)
Investigational New Drugs, ISSN: 01676997
Hai T. Tran; Ralph G. Zinner; George R. Blumenschein; Yun W. Oh; Vassiliki A. Papadimitrakopoulou; Edward S. Kim; Charles Lu; Mubashira Malik; Bert L. Lum; Roy S. Herbst
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Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
Journal of Immunology, ISSN: 00221767 15506606
Yan Qu; Shahram Misaghi; Kim Newton; Laurie L. Gilmour; Salina Louie; James Cupp; George R. Dubyak; David Hackos; Vishva M. Dixit
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Intercompany study to evaluate the robustness of capillary isoelectric focusing technology for the analysis of monoclonal antibodies
Chromatographia, ISSN: 00095893 16121112
Oscar Salas-Solano; Kunnel Babu; Park; Xinfeng Zhang; Li Zhang; Zoran Sosic; Boris Boumajny; Ming Zeng; Cheng; Angelia Reed-Bogan; Stacey Cummins-Bitz; David A. Michels; Monica Parker; Pauline Bonasia; Mingfang Hong; Steven Cook; Margaret Ruesch; David Lamb; Dora Bolyan; Steffen Kiessig; Darren Allender; Brian Nunnally
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Glycosylation of therapeutic proteins: Current understanding of structure-function relationships
BioProcess International, ISSN: 15426319
Joseph Siemiatkoski; Stacey Ma; Jun Park; Kurt Brorson; Patrick Swann; Lorna McLeod
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Regulation of hemocytes in Drosophila requires dappled cytochrome b5
Biochemical Genetics, ISSN: 00062928 15734927
Kurt Kleinhesselink; Corinna Conway; David Sholer; Irvin Huang; Deborah A. Kimbrell
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Non-oxime pyrazole based inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Bradley J. Newhouse; Joshua D. Hansen; Jonas Grina; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Matthew Martinson; Sarah Galbraith; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero
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Clinical use of dornase alfa is associated with a slower rate of FEV 1 decline in cystic fibrosis
Pediatric Pulmonology, ISSN: 87556863 10990496
Michael W. Konstan; Wagener; David J. Pasta; Stefanie J. Millar; Joan R. Jacobs; Ashley Yegin; Morgan
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The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians
Clinical Endocrinology, ISSN: 03000664 13652265
Anand Vaidya; Bei Sun; Forman; Paul N. Hopkins; Nancy J. Brown; Nikheel S. Kolatkar; Gordon H. Williams; Jonathan S. Williams
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B cell immunotherapy in autoimmunity - 2010 update
Molecular Immunology, ISSN: 01615890 18729142
Andrew A. Chan
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Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab
Neuro-Oncology, ISSN: 15228517 15235866
Jeffrey S. Wefel; Timothy Cloughesy; James L. Zazzali; Maoxia Zheng; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S. Friedman
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Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)
Lupus, ISSN: 09612033 14770962
Merrill; Jill P. Buyon; Richard A. Furie; Latinis; Gordon; Hsin-Ju Hsieh; Paul Brunetta
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Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411
Daugherty; Linda Rangell; Eckert; Jose Zavala-Solorio; Franklin V. Peale Jr.; Mrsny
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Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: Non-hispanic white population in the United States with age-related macular degeneration
Archives of Ophthalmology, ISSN: 00039950 15383601
Neil M. Bressler; Quan V. Doan; Rohit Varma; Paul P. Lee; Ivan J. Suñer; Chantal M. Dolan; Mark Danese; Elaine B. Yu; Irwin Tran; Shoshana Colman
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Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study
Journal of Hepatology, ISSN: 01688278 01688278
Nicole Forestier; Dominique Larrey; Dominique Guyader; Marcellin; Régine Rouzier; Alain Patat; Patrick F. Smith; Williamson Bradford; Steven Porter; Lawrence Blatt; Scott D. Seiwert; Stefan Zeuzem
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Streamlining downstream process development
BioProcess International, ISSN: 15426319
Brian Kluck; Binh Thai; Jim Furey; Dennis Annarelli
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Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: Anticipated thyroid effects and unique pituitary gland findings
Toxicologic Pathology, ISSN: 01926233 15331601
Tanja S. Zabka; Mark Fielden; Rosario Garrido; Jianhua Tao; Adrian J. Fretland; Jennifer Fretland; Mudher Albassam; Thomas Singer; Kolaja
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Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33
Biochemical Journal, ISSN: 02646021 14708728
Mislav Oreb; Anja Höfle; Patrick Koenig; Maik S. Sommer; Irmgard Sinning; Fei Wang; Ivo Tews; Danny J. Schnell; Enrico Schleiff
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Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Domagoj Vucic; Vishva M. Dixit; Ingrid E. Wertz
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Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
Journal of Cell Biology, ISSN: 00219525 00219525
Deanna G. Wilson; Khanhky Phamluong; Li Li; Mei Sun; Tim C. Cao; Peter S. Liu; Zora Modrusan; Wendy N. Sandoval; Linda Rangell; Richard A. D. Carano; Andrew S. Peterson; Mark J. Solloway
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Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas
Immunity, ISSN: 10747613 10974180
Jackson G. Egen; Antonio Gigliotti Rothfuchs; Carl G. Feng; Marcus A. Horwitz; Alan Sher; Ronald N. Germain
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Murine Insulin Growth Factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Adrian A. Lobito; Sree R. Ramani; Irene Tom; J.Fernando Bazan; Luis; Wayne J. Fairbrother; Wenjun Ouyang; Lino C. Gonzalez Jr.
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Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
Blood, ISSN: 15280020 00064971
David Yao; Yuanshuai Huang; Xiaoran Huang; Weihuan Wang; Quanjian Yan; Lebing L. Wei; Wei Xin; Stanton Gerson; Pamela Stanley; John Lowe; Lan Zhou
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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
Science Translational Medicine, ISSN: 19466234 19466242
Jasvinder K. Atwal; Yongmei Chen; Cecilia Chiu; Deborah L. Mortensen; William J. Meilandt; Yichin Liu; Christopher E. Heise; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kun Peng; Ping Wu; Lionel Rouge; Yingnan Zhang; Lazarus; Kimberly Scearce-Levie; Weiru Wang; Yan Wu; Marc Tessier-Lavigne; Ryan J. Watts
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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Science Translational Medicine, ISSN: 19466234 19466242
Y. Joy Yu; Yin Zhang; Margaret Kenrick; Kwame Hoyte; Wilman Luk; Yanmei Lu; Jasvinder K. Atwal; J. Michael Elliott; Saileta Prabhu; Ryan J. Watts; Dennis
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Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry
Molecular Cell, ISSN: 10972765 10974164
Xiaodong Huang; Matthew K. Summers; Victoria Pham; Jennie R. Lill; Jinfeng Liu; Gwanghee Lee; Donald S. Kirkpatrick; Peter K Jackson; Guowei Fang; Vishva M. Dixit
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Crystal structures of two aminoglycoside kinases bound with a Eukaryotic protein kinase inhibitor
PLoS ONE, ISSN: 19326203
Desiree H. Fong; Bing Xiong; Jiyoung Hwang; Albert M. Berghuis
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Toward understanding molecular heterogeneity of polysorbates by application of liquid chromatography-mass spectrometry with computer-aided data analysis
Analytical Chemistry, ISSN: 00032700
Oleg V. Borisov; Junyan A. Ji; Y. John Wang; Felix Vega; Victor Ling
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Targeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothened
Clinical Cancer Research, ISSN: 10780432 15573265
Tracy Tzu-Ling Tang; Jean Y. Tang; Dongwei Li; Mike Reich; Christopher Callahan; Ling Fu; Robert Yauch; Frank Wang; Karen Kotkow; Kris Chang; Elana Shpall; Angela Wu; Lee L. Rubin; James C. Marsters Jr.; Ervin H. Epstein Jr.; Ivor Caro; Frederic J. De Sauvage
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Changes in18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib
Clinical Cancer Research, ISSN: 10780432 15573265
Linda Mileshkin; Rodney Hicks; Brett Hughes; Paul Mitchell; Veena Charu; Barbara Gitlitz; David Macfarlane; Benjamin Solomon; Lukas Amler; Wei Yu; Andrea Pirzkall; Bernard M. Fine
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AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β(GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Li Zhang; Francois Jouret; Jesse Rinehart; Jeff Sfakianos; Ira Mellman; Richard P. Lifton; Lawrence H. Young; Michael J. Caplan
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Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
Cell, ISSN: 00928674
Liyun Sang; Julie J. Miller; Kevin C. Corbit; Rachel H. Giles; Matthew J. Brauer; Edgar A. Otto; Lisa M. Baye; Xiaohui Wen; Suzie J. Scales; Mandy Kwong; Erik G. Huntzicker; Mindan K. Sfakianos; Wendy N. Sandoval; J.Fernando Bazan; Priya Kulkarni; Francesc R. Garcia-Gonzalo; Allen D. Seol; John F. O'Toole; Susanne Held; Heiko M. Reutter; William Lane; Muhammad Arshad Rafiq; Abdul Noor; Muhammad Ansar; Akella Radha Rama Devi; Val C. Sheffield; Diane C. Slusarski; John B. Vincent; Daniel A. Doherty; Friedhelm Hildebrandt; Jeremy Reiter; Peter K Jackson
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Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
Science, ISSN: 00368075 10959203
Sarel J. Fleishman; Timothy A. Whitehead; Damian C. Ekiert; Cyrille Dreyfus; Jacob E. Corn; Eva-Maria Strauch; Ian A. Wilson; David Baker
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Pyrazolopyridine inhibitors of B-RafV600E. Part 1: The development of selective, orally bioavailable, and efficacious inhibitors
ACS Medicinal Chemistry Letters, ISSN: 19485875
Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy B. Young; Jonas Grina
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Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Frederick Cohen; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Huifen Chen; Antonio G. DiPasquale; Jennifer A. Epler; Michael F. T. Koehler; Kevin Lau; Lewis; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Daniel F. Ortwine; Zhonghua Pei; Kirk D. Robarge; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Xianrui Zhao; Joseph P. Lyssikatos
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TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
PLoS ONE, ISSN: 19326203
Kui Lin; James R. Taylor Jr.; Thomas D Wu; Johnny Gutierrez; J. Michael Elliott; Jean-Michel Vernes; Koeppen; Phillips; Frederic J. De Sauvage; Meng
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Facile synthesis of spiro oxindoles, azaoxindoles, and dihydroisoquinolone
Synthetic Communications, ISSN: 00397911 15322432
Sharada Labadie; Christa Parmer
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Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Pranav Parikh; Yuhan Hao; Mohsen Hosseinkhani; Shekhar B. Patil; George W. Huntley; Marc Tessier-Lavigne; Hongyan Zou
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Modulation of K11-linkage formation by variable loop residues within UbcH5A
Journal of Molecular Biology, ISSN: 00222836
Ivan Bosanac; Lilian Phu; Borlan Pan; Inna Zilberleyb; Brigitte Maurer; Vishva M. Dixit; Sarah G. Hymowitz; Donald S. Kirkpatrick
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Bevacizumab treatment to progression after chemotherapy: Outcomes from a U.S. community practice network
Oncologist, ISSN: 10837159 1549490X
Eric Nadler; Elaine B. Yu; Arliene Ravelo; Amy Sing; Michael Forsyth; Stephen Gruschkus
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Comparing protein VEGF inhibitors: In vitro biological studies
Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104
Lanlan Yu; Xiao Huan Liang; Napoleone Ferrara
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High affinity antigen recognition of the dual specific variants of Herceptin is entropy-driven in spite of structural plasticity
PLoS ONE, ISSN: 19326203
Jenny Bostrom; Lauric Haber; Patrick Koenig; Robert F. Kelley; Fuh
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Gelatin Capsule Shell Cross-Linking: Tier II Dissolution Method Development in the Presence of Sodium Lauryl Sulfate
Pharmaceutical Technology, ISSN: 15432521 21507376
Xiling Song; Yong Cui; Minli Xie
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Is this the end of painful injections?
Managed Care, ISSN: 10623388
Thomas Morrow
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Journey Forward: The new face of cancer survivorship care
Journal of Oncology Practice, ISSN: 15547477 1935469X
Jennifer Hausman; Patricia A. Ganz; Thomas P. Sellers; Joel Rosenquist
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