Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8351 - 8400 OF 15394 RESULTS

April 1, 2011

AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme

Advances in Therapy, ISSN: 0741238X 18658652

Olivier L. Chinot; De La Motte Rouge; Moore; Zeaiter; Asha Das; Phillips; Zora Modrusan; Timothy Cloughesy

April 1, 2011

A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

British Journal of Pharmacology, ISSN: 00071188 14765381

Stefanich; Dimitry Danilenko; Hong Wang; Sharon O'Byrne; Erickson; Thomas R. Gelzleichter; Hajime Hiraragi; Chiu; Ivelja; Surinc Er Jeet; Gadkari; Hwang; Franklin Fuh; Looney; Howell; Albert; Mercedesz Balazs; Refino; Sherman Fong; Suhasini Iyer; Marna Williams

April 1, 2011

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Cell Death and Differentiation, ISSN: 13509047 14765403

Nele Vanlangenakker; Vanden Berghe; Bogaert; Bram Laukens; Zobel; Deshayes; Domagoj Vucic; Fulda; Vandenabeele; Mathieu J.M. Bertrand

April 1, 2011

Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3- fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl) -2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor

Xenobiotica, ISSN: 00498254 13665928

Bianca M. Liederer; Leonid M. Berezhkovskiy; Brian J. Dean; Victoria Dinkel; Jing Peng; Mark Merchant; Emile G. Plise; Harvey Wong; Xingrong Liu

April 1, 2011

Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial

Journal of Rheumatology, ISSN: 0315162X 14992752

Jin-Shei Lai; Jennifer L. Beaumont; Sarika Ogale; Paul Brunetta; Cella

April 1, 2011

A candidate gene study of the type i interferon pathway implicates IKBKE and IL8 as risk loci for SLE

European Journal of Human Genetics, ISSN: 10184813 14765438

Johanna K. Sandling; Sophie Garnier; Snaevar Sigurdsson; Chuan Wang; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Anders Mälarstig; Rona J. Strawbridge; Anders Hamsten; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Maija-Leena Eloranta; Gunnar Alm; Lars Rönnblom; Ann-Christine Syvänen

April 1, 2011

Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK Inhibitors in BRAF mutant cancers

Oncotarget, ISSN: 19492553

Ryan B. Corcoran; Jeffrey Settleman; Jeff A. Engelman

March 31, 2011

An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

Mark Danese; Robert I. Griffiths; Michelle Gleeson; Sacha Satram-Hoang; Kevin Knopf; Joseph Mikhael; Carolina Reyes

March 30, 2011

A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice

Science Translational Medicine, ISSN: 19466234 19466242

Natalya Lyubynska; Matthew F. Gorman; Jennifer O. Lauchle; Wan Xing Hong; Jon Akutagawa; Kevin Shannon; Benjamin S. Braun

March 25, 2011

Advancing translational research

Science, ISSN: 10959203 00368075

Brad Bolon; Bruce Altrock; Stephen W. Barthold; Nicole Baumgarth; David Besselsen; Gregory Boivin; Kelli L. Boyd; Cory Brayton; Robert D. Cardiff; Suzana Couto; Kathryn A. Eaton; Oded Foreman; Stephen M. Griffey; la Perle; Michael D. Lairmore; Chen Liu; David K. Meyerholz; Alexander Yu. Nikitin; Trenton R. Schoeb; Denise Schwahn; Rani Sellers; John P. Sundberg; Ravi Tolwani; Victor E. Valli; M. Christine Zink

March 24, 2011

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cell

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Stephanie M. Stanford; Divya Krishnamurthy; Matthew D. Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew A. Chan; Zhong-Yin Zhang; Amy M. Barrios; Virgil L. Woods Jr.; Nouri Neamati; Nunzio Bottini

March 24, 2011

FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

PLoS ONE, ISSN: 19326203

Ai-Luen Wu; Sally Coulter; Christopher Liddle; Anne Wong; Jeffrey Eastham-Anderson; French; Andrew S. Peterson; Junichiro Sonoda

March 24, 2011

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Brad E Sleebs; Czabotar; Wayne J. Fairbrother; Fairlie; Flygare; David C.S. Huang; Wilhelmus J A Kersten; Michael F. T. Koehler; Guillaume Lessene; Kym N Lowes; John P Parisot; Brian J. Smith; Morey L. Smith; Andrew J. Souers; Ian P Street; Hong Yang; Jonathan B Baell

March 23, 2011

Matrix metalloproteinase-9 predicts pulmonary status declines in α1-antitrypsin deficiency

Respiratory Research, ISSN: 1465993X 14659921

Theodore A. Omachi; Mark D. Eisner; Alexis Rames; Lada Markovtsova; Paul D. Blanc

March 21, 2011

Effects of anti-VEGF on predicted antibody biodistribution: Roles of vascular volume, interstitial volume, and blood flow

PLoS ONE, ISSN: 19326203

C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Daniela Bumbaca; Michelle G. Schweiger; Frank-Peter Theil; Fielder; Leslie A. Khawli

March 21, 2011

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes

PLoS ONE, ISSN: 19326203

Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B. van Ommen; Cornelis J. M. Melief; Sjoerd H. van der Burg; Judith M. Boer

March 16, 2011

CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma

Science Translational Medicine, ISSN: 19466234 19466242

Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana H. Advani; Jeffrey Lau; Jenille Tan; Susanna Y. Stinson; Stinson; Thomas Januario; Sven De Vos; Stephen Ansell; Andres Forero; Grazyna Fedorowicz; Teddy T. C. Yang; Kristi Elkins; Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Koeppen; French; Andrew G. Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan

March 15, 2011

Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells

Cancer Research, ISSN: 00085472 15387445

Yong-Yu Liu; Gauri A. Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S. Michal Jazwinski

March 15, 2011

Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region

American Journal of Cardiology, ISSN: 00029149

Jim Gilbert; Julie Lekstrom-Himes; Debra Donaldson; Yih Lee; Mingxiu Hu; Jing Xu; Tim Wyant; Michael Davidson

March 15, 2011

Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein

Analytical Biochemistry, ISSN: 10960309 00032697

Jennifer Zhang; Holly Yip; Viswanatham Katta

March 15, 2011

Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models

Clinical Cancer Research, ISSN: 10780432 15573265

Nguyen Tan; Mehnaz Malek; Jiping Zha; Peng Yue; Robert Kassees; Berry; Wayne J. Fairbrother; Deepak Sampath; Lisa D. Belmont

March 15, 2011

Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns

Chemical Communications, ISSN: 1364548X 13597345

James J. Crawford; Ben J. Fleming; Kennedy; Charles T. O’Hara; Samantha A. Orr

March 15, 2011

Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns

Chemical Communications, ISSN: 1364548X 13597345

James J. Crawford; Ben J. Fleming; Alan R. Kennedy; Charles T. O’Hara; Samantha A. Orr

March 14, 2011

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

Journal of Experimental Medicine, ISSN: 00221007 15409538

Naik; Vishva M. Dixit

March 10, 2011

Impact of β2 integrin deficiency on mouse natural killer cell development and function

Blood, ISSN: 15280020 00064971

Karine Crozat; Celine Eidenschenk; Baptiste N. Jaeger; Philippe Krebs; Sophie Guia; Bruce Beutler; Eric Vivier; Sophie Ugolini

March 7, 2011

Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies

Journal of Immunological Methods, ISSN: 00221759

Diya Ren; Maria R. Darlucio; Judy H. Chou

March 3, 2011

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Nature, ISSN: 00280836 14764687

Ingrid E. Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy N. Sandoval; Daniel J Anderson; Elizabeth Helgason; James A. Ernst; Mike Eby; Jinfeng Liu; Lisa D. Belmont; Joshua S. Kaminker; Karen M. O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R. Johnson; Mark L. Chiu; Jennie R. Lill; Peter K Jackson; Wayne J. Fairbrother; Somasekar Seshagiri; Mary J. C. Ludlam; Kevin G. Leong; Erin C. Dueber; Heather Maecker; David C.S. Huang; Vishva M. Dixit

March 1, 2011

Ultra-High-Pressure LC (UHPLC) for therapeutic protein characterization

American Pharmaceutical Review, ISSN: 10998012

Justin Jeong; Taylor Zhang; Jennifer Zhang; Kao

March 1, 2011

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Yuan Chen; Liling Liu; Khanh Nguyen; Adrian J. Fretland

March 1, 2011

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production

PLoS Genetics, ISSN: 15537390 15537404

Sharon A. Chung; Kimberly E. Taylor; Robert R. Graham; Joanne Nititham; Annette T. Lee; Ward Ortmann; Chaim O. Jacob; Marta E. Alarcón-Riquelme; Betty P. Tsao; John B. Harley; Patrick M. Gaffney; Kathy L. Moser; Michelle Petri; F. Yesim Demirci; M. Ilyas Kamboh; Manzi; Peter K. Gregersen; Carl D. Langefeld; Timothy W. Behrens; Criswell

March 1, 2011

Dense mapping of IL18 shows no association in SLE

Human Molecular Genetics, ISSN: 09646906 14602083

Sandra G. Guerra; David L. Morris; Vesela Gateva; Robert R. Graham; Timothy J. Vyse; Deborah S. Cunninghame Graham

March 1, 2011

Engaging neuroscience to advance translational research in brain barrier biology

Nature Reviews Neuroscience, ISSN: 1471003X 14710048

Edward A. Neuwelt; Björn Bauer; Christoph Fahlke; Gert Fricker; Constantino Iadecola; Damir Janigro; Luc Leybaert; Zoltán Molnár; Martha E. O'Donnell; John T. Povlishock; Norman R. Saunders; Frank Sharp; Danica Stanimirovic; Ryan J. Watts; Lester R. Drewes

March 1, 2011

Treatment of growth hormone-deficient infants with recombinant human growth hormone to near-adult height: Patterns of growth

Hormone Research in Paediatrics, ISSN: 16632818 16632826

Allen W. Root; Ken Dana; Barbara M. Lippe

March 1, 2011

Can modeling of health outcomes facilitate regulatory decision making? The benefit-risk tradeoff for rosiglitazone in 1999 vs. 2007

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Cross; David L. Veenstra; Gardner; Louis P. Garrison Jr.

March 1, 2011

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: A re-evaluation of P450 isoform selectivity

European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 03787966 21070180

S. Cyrus Khojasteh; Saileta Prabhu; Jane R. Kenny; Jason S Halladay; Anthony Y. H. Lu

March 1, 2011

Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions

Protein Science, ISSN: 09618368 1469896X

Yatin Gokarn; R. Matthew Fesinmeyer; Atul Saluja; Vladimir Razinkov; Susan F. Chase; Thomas M. Laue; David N. Brems

March 1, 2011

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Aimee Shen; Patrick J. Lupardus; Malte M. Gersch; Aaron W. Puri; Victoria E. Albrow; Garcia; Matthew Bogyo

March 1, 2011

Single-use technology roundtable

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen; Jonathan Royce; Maik W. Jornitz; Michael LaBreck; Juliette Schick; Rick Stock; Nick Warne; Helene Pora; Peter Lambert

March 1, 2011

Bioanalytical approaches to quantify "total" and "free" therapeutic antibodies and their targets: Technical challenges and PK/PD applications over the course of drug development

AAPS Journal, ISSN: 15507416

Jean W. Lee; Marian Kelley; Lindsay King; Yang; Hossein Salimi-Moosavi; Meina Tao Tang; Jian-Feng Lu; John Kamerud; Ago Ahene; Heather Myler; Cindy Rogers

March 1, 2011

Prioritizing "psychological" consequences for disaster preparedness and response: A framework for addressing the emotional, behavioral, and cognitive effects of patient surge in large-scale disasters

Disaster Medicine and Public Health Preparedness, ISSN: 19357893 1938744X

Lisa S. Meredith; David P. Eisenman; Terri Tanielian; Stephanie L. Taylor; Ricardo Basurto-Davila; James L. Zazzali; Dickson Diamond; Barbara Cienfuegos; Sandra Shields

March 1, 2011

Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion

Archives of Ophthalmology, ISSN: 00039950 15383601

Winifred Werther; Laura Chu; Nancy Holekamp; Diana V. Do; Roman G. Rubio

March 1, 2011

An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma

Clinical Cancer Research, ISSN: 10780432 15573265

Jyoti Asundi; Chae Reed; Jennifer Arca; Krista McCutcheon; Ron Ferrando; Suzanna Clark; Luis; Janet Y. Tien; Ron Firestein; Paul G. Polakis

March 1, 2011

Characteristics of patients losing vision after 2 years of monthly dosing in the phase III ranibizumab clinical trials

Ophthalmology, ISSN: 01616420

Philip J. Rosenfeld; Howard Shapiro; Lisa Tuomi; Mary Webster; Julee Elledge; Barbara A. Blodi

March 1, 2011

American college of rheumatology/European league against rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials

Arthritis and Rheumatism, ISSN: 00043591 15290131

David T. Felson; Josef S. Smolen; George Wells; Bin Zhang; Lilian H.D. Van Tuyl; Julia Funovits; Daniel Aletaha; Allaart; Joan Bathon; Stefano Bombardieri; Peter Brooks; Andrew Brown; Marco Matucci-Cerinic; Hyon Choi; Bernard Combe; Maarten De Wit; Maxime Dougados; Paul Emery; Daniel E. Furst; Juan Gomez-Reino; Gillian Hawker; Edward Keystone; Dinesh Khanna; John Kirwan; Tore K. Kvien; Robert Landewé; Joachim Listing; Kaleb Michaud; Emilio Martin-Mola; Pamela Montie; Theodore Pincus; Pamela Richards; Jeffrey N. Siegel; Lee S. Simon; Tuulikki Sokka; Vibeke Strand; Peter Tugwell; Alan Tyndall; Desirée Van Der Heijde; Suzan Verstappen; Barbara White; Frederick Wolfe; Angela Zink; Maarten Boers

March 1, 2011

Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates

Bioanalysis, ISSN: 17576180 17576199

Jean-Philippe Stephan; Katherine R. Kozak; Wai Lee T. Wong

March 1, 2011

The minimum L2 distance estimator for Poisson mixture models

Journal of Statistical Planning and Inference, ISSN: 03783758

Ian R. Harris; Shuyi Shen

March 1, 2011

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression

Neuro-Oncology, ISSN: 15228517 15235866

Shichun Zheng; E. Andres Houseman; Zachary Morrison; Margaret R. Wrensch; Joseph S. Patoka; Christian Ramos; Daphne A. Haas-Kogan; Sean McBride; Carmen J. Marsit; Brock C. Christensen; Heather H. Nelson; David Stokoe; Joseph L. Wiemels; Susan Chang; Michael D. Prados; Tarik Tihan; Scott R. VandenBerg; Karl T. Kelsey; Mitchel S. Berger; John K. Wiencke

February 28, 2011

Identification of IgG1 variants with increased affinity to FcΓRIIIa and unaltered affinity to FcΓRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Journal of Immunological Methods, ISSN: 00221759

Yanmei Lu; Jean-Michel Vernes; Nancy Y. Chiang; Qinglin Ou; Jiabing Ding; Adams; Kyu Hong; Bao-Tran Truong; Domingos Ng; Amy Shen; Nakamura; Qian Gong; Presta; Beresini; Bob Kelley; Henry B. Lowman; Wai Lee T. Wong; Meng

February 20, 2011

Clinical immunogenicity specificity assessments: A platform evaluation

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kun Peng; Ketevan A. Siradze; Quarmby; Saloumeh Kadkhodayan Fischer

February 18, 2011

Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines

Journal of Organic Chemistry, ISSN: 00223263 15206904

Georgette M. Castanedo; Pamela S. Seng; Nicole Blaquiere; Sean Trapp; Steven T. Staben

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