Genentech: Publications

February 17, 2011

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells

Blood, ISSN: 15280020 00064971

David Favre; Cheryl A. Stoddart; Brinda Emu; Rebecca Hoh; Jeffrey N. Martin; Frederick M. Hecht; Steven G. Deeks; Joseph M. McCune

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February 17, 2011

NFKBIA deletion in glioblastomas

New England Journal of Medicine, ISSN: 15334406 00284793

Markus Bredel; Denise M. Scholtens; Ajay K. Yadav; Angel A. Alvarez; Jaclyn J. Renfrow; James P. Chandler; Irene L. Y. Yu; Maria S. Carro; Fangping Dai; Michael J. Tagge; Roberto Ferrarese; Claudia Bredel; Phillips; Paul J. Lukac; Pierre A. Robe; Astrid Weyerbrock; Hannes Vogel; Steven Dubner; Bret Mobley; Xiao-Lin He; Adrienne C. Scheck; Branimir I. Sikic; Kenneth D. Aldape; Arnab Chakravarti; Griffith R. Harsh IV

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February 15, 2011

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher J. Westlake; Lisa M. Baye; Maxence V. Nachury; Kevin J. Wright; Karen E. Ervin; Lilian Phu; Cecile Chalouni; John S. Beck; Donald S. Kirkpatrick; Diane C. Slusarski; Val C. Sheffield; Richard H. Scheller; Peter K Jackson

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February 15, 2011

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Alexandre J. Buckmelter; Li Ren; Ellen R. Laird; Bryson Rast; Greg Miknis; Steve Wenglowsky; Stephen Schlachter; Michael Welch; Eugene Tarlton; Jonas Grina; Joseph P. Lyssikatos; Barbara J. Brandhuber; Tony Morales; Nikole Randolph; Guy Vigers; Matthew Martinson; Michele Callejo

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February 15, 2011

Non-oxime inhibitors of B-RafV600E kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Li Ren; Steve Wenglowsky; Greg Miknis; Bryson Rast; Alexandre J. Buckmelter; Robert J. Ely; Stephen Schlachter; Ellen R. Laird; Nikole Randolph; Michele Callejo; Matthew Martinson; Sarah Galbraith; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Walter C. Voegtli; Joseph P. Lyssikatos

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February 15, 2011

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

Molecular Biology of the Cell, ISSN: 10591524 19394586

Chih-Wen Chu; Fajian Hou; Junmei Zhang; Lilian Phu; Alexander V. Loktev; Donald S. Kirkpatrick; Peter K Jackson; Yingming Zhao; Hui Zou

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February 14, 2011

Population pharmacokinetic evaluation with external validation and bayesian estimator of voriconazole in liver transplant recipients

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Kelong Han; Robert Bies; Heather Johnson; Blair Capitano; Raman Venkataramanan

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February 11, 2011

Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses

Molecular Vision, ISSN: 10900535

Kenneth W. Olsen; Vlad Bantseev; Vivan Choh

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February 10, 2011

Do we need to optimize plasma protein and tissue binding in drug discovery?

Current Topics in Medicinal Chemistry, ISSN: 15680266

Xingrong Liu; Cuiping Chen; Cornelis E. Hop

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February 10, 2011

A general asymmetric synthesis of phenylglycinols

Tetrahedron Asymmetry, ISSN: 09574166 1362511X

Xingang Pan; Liangbin Jia; Xuejian Liu; Haikuo Ma; Wenqian Yang; Jacob B. Schwarz

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February 9, 2011

Differences in reversion of resistance mutations to wild- type under structured treatment interruption and related increase in replication capacity

PLoS ONE, ISSN: 19326203

Agnes C. Paquet; John Baxter; Jodi Weidler; Yolanda S. Lie; Jody Lawrence; Rose Kim; Michael Bates; Eoin Coakley; Colombe Chappey

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February 9, 2011

Tree pruner: An efficient tool for selecting data from a biased genetic database

BMC Bioinformatics, ISSN: 14712105

Mohan Krishnamoorthy; Pragneshkumar Patel; Mira Dimitrijevic; Jonathan Dietrich; Margaret Green; Catherine Macken

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February 3, 2011

Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay

PLoS ONE, ISSN: 19326203

Rajiv Dua; Jianhuan Zhang; Gordon Parry; Elicia M. Penuel

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February 1, 2011

Extractables and leachables

BioProcess International, ISSN: 15426319

Mire-Sluis; Stacey Ma; Ingrid Markovic; Lorna McLeod

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February 1, 2011

The quality product steward model: The genentech approach

BioPharm International, ISSN: 1542166X

Zhengyu Dong; Sharon Ma; Feuerhelm

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February 1, 2011

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes

PLoS Genetics, ISSN: 15537390 15537404

Kimberly E. Taylor; Sharon A. Chung; Robert R. Graham; Ward Ortmann; Annette T. Lee; Carl D. Langefeld; Chaim O. Jacob; M. Ilyas Kamboh; Marta E. Alarcón-Riquelme; Betty P. Tsao; Kathy L. Moser; Patrick M. Gaffney; John B. Harley; Michelle Petri; Manzi; Peter K. Gregersen; Timothy W. Behrens; Lindsey A. Criswell

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February 1, 2011

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

Journal of Immunology, ISSN: 00221767 15506606

David F. Choy; Barmak Modrek; Abbas Alexander; Sarah K. Kummerfeld; Hilary F. Clark; Lawren C. Wu; Grazyna Fedorowicz; Zora Modrusan; John V. Fahy; Prescott G. Woodruff; Joseph R. Arron

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February 1, 2011

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase i study

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Saloumeh Kadkhodayan Fischer; Cynthia Woods; Fielder; Stefanich

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February 1, 2011

Advances in the assessment and control of the effector functions of therapeutic antibodies

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Xu-Rong Jiang; An Song; Svetlana Bergelson; Thomas Arroll; Bhavin S. Parekh; Kimberly May; Shan Chung; Robert Strouse; Mire-Sluis; Mark Schenerman

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February 1, 2011

Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Robert A. Wood; Deepen Patel; Jin Zhu; Ashley Yegin; Gitika Dhillon; James E. Fish

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February 1, 2011

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Sunaga; David S. Shames; Girard; Michael Peyton; Larsen; Imai; Junichi Soh; Sato; Noriko Yanagitani; Kaira; Yang Xie; Adi Gazdar; Mori; Minna

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February 1, 2011

Effect of electrostatic spray on human pulmonary epithelial cells

Journal of Electrostatics, ISSN: 03043886

Michelle G. Zeles-Hahn; Yvonne Lentz; Thomas J. Anchordoquy; Corinne S. Lengsfeld

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February 1, 2011

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Protein Science, ISSN: 09618368 1469896X

Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. Villaseñor; J. Michael Bradshaw; David Shaw; Jim W. Barnett; Michelle F. Browner

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February 1, 2011

Harnessing dendritic cells for immunotherapy

Seminars in Immunology, ISSN: 10445323

Lélia Delamarre; Ira Mellman

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February 1, 2011

A method for removing the brain and spinal cord as one unit from adult mice and rats

Lab Animal, ISSN: 00937355 15484475

Heather S. Kennedy; Floresita Puth; Marjie Van Hoy; Claire E. Le Pichon

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February 1, 2011

Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody

Proteomics, ISSN: 16159853 16159861

Natalie E. Castellana; Krista McCutcheon; Victoria Pham; Kristin Harden; Allen Nguyen; Judy Young; Adams; Kurt A. Schroeder; David Arnott; Vineet Bafna; Jane L. Grogan; Jennie R. Lill

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February 1, 2011

The transcriptional diversity of 25 Drosophila cell lines

Genome Research, ISSN: 10889051 15495469

Lucy Cherbas; Aarron T. Willingham; Dayu Zhang; Li Yang; Yi Zou; Brian D. Eads; Joseph W. Carlson; Jane M. Landolin; Philipp Kapranov; Jacqueline Dumais; Anastasia Samsonova; Jeong-Hyeon Choi; Johnny Roberts; Carrie A. Davis; Haixu Tang; Marijke J. Van Baren; Srinka Ghosh; Alexander Dobin; Kim Bell; Wei Lin; Laura Langton; Michael O. Duff; Aaron E. Tenney; Chris Zaleski; Michael R. Brent; Roger A. Hoskins; Thomas C. Kaufman; Justen Andrews; Brenton R. Graveley; Norbert Perrimon; Susan E. Celniker; Thomas R. Gingeras; Peter Cherbas

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February 1, 2011

Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study

British Journal of Cancer, ISSN: 00070920 15321827

Natasha Leighl; Bennouna; Jing Yi; Moore; Julie Hambleton; Herbert Hurwitz

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February 1, 2011

Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer

Journal of Medical Economics, ISSN: 13696998

Josh J. Carlson; Wong; David L. Veenstra; Carolina Reyes

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February 1, 2011

Paper Covers Rock: In Search of the e-record Model

Law and Critique, ISSN: 09578536 15728617

Jacques Mourrain

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February 1, 2011

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Mark D. Eisner

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February 1, 2011

Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab

Neurology, ISSN: 00283878 1526632X

Whitney B. Pope; Qi Xia; Virginia Paton; Asha Das; Julie Hambleton; Kim; Huo; Brown; Goldin; Timothy Cloughesy

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February 1, 2011

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Craig J. Goergen; Junya Azuma; Kyla N. Barr; Lars Magdefessel; Dara Y. Kallop; Alvin Gogineni; Amarjeet Grewall; Robby M. Weimer; Andrew J. Connolly; Ronald L. Dalman; Charles A. Taylor; Philip S. Tsao; Joan M. Greve

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February 1, 2011

A new regulatory switch in a JAK protein kinase

Proteins: Structure, Function and Bioinformatics, ISSN: 08873585 10970134

Vickie Tsui; Paul Gibbons; Ultsch; Kyle Mortara; Christine Chang; Wade S. Blair; Rebecca Pulk; Mark S. Stanley; Melissa A. Starovasnik; David Williams; Maria Lamers; Phillip Leonard; Steven Magnuson; Jun Liang; Eigenbrot

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February 1, 2011

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

Developmental Dynamics, ISSN: 10588388 10970177

Sangho Yu; Dianna Crawford; Takatoshi Tsuchihashi; Timothy W. Behrens; Deepak Srivastava

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February 1, 2011

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells

Prostate, ISSN: 02704137 10970045

Manisha Tripathi; Alka A. Potdar; Hironobu Yamashita; Brandy Weidow; Peter T. Cummings; Daniel Kirchhofer; Vito Quaranta

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February 1, 2011

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro

PLoS ONE, ISSN: 19326203

Christina Menke; Tatiana Goncharov; Lubna Qamar; Christopher Korch; Heide L. Ford; Kian Behbakht; Andrew Thorburn

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February 1, 2011

TRAPing a new gene for autoimmunity

Nature Genetics, ISSN: 10614036 15461718

Timothy W. Behrens; Robert R. Graham

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January 30, 2011

Well differentiated follicular thyroid neoplasia: Impact of molecular and technological advances on detection, monitoring and treatment

Molecular and Cellular Endocrinology, ISSN: 03037207

Andrew G. Gianoukakis; Silvana M. Giannelli; Wael A. Salameh; Laron W. McPhaul

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January 27, 2011

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

Oncogene, ISSN: 09509232 14765594

Bender; Opel; Naumann; Kappler; Lori S. Friedman; Von Schweinitz; Debatin; Fulda

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January 26, 2011

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

BMC Medical Genomics, ISSN: 17558794

Serban Nacu; Yuan; Zhengyan Kan; Deepali Bhatt; Rivers; Stinson; Brock A. Peters; Zora Modrusan; Kenneth Jung; Somasekar Seshagiri; Thomas D Wu

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January 25, 2011

Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Zhenglei Pei; Bei Wang; Gang Chen; Motoshi Nagao; Masato Nakafuku; Kenneth Campbell

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January 25, 2011

Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Deborah Finco-Kent; Daniel Baltrukonis; Adrienne Clements-Egan; Kathy Delaria; George R. Gunn; John Lowe; Mauricio Maia; Teresa Wong

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January 25, 2011

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Jennifer C. Rea; G. Tony Moreno; Yun Lou; Dell Farnan

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January 21, 2011

Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium

Organic Process Research and Development, ISSN: 10836160 1520586X

Guy R. Humphrey; Philip J. Pye; Yong-Li Zhong; Remy Angelaud; David Askin; Kevin M. Belyk; Peter E. Maligres; Danny E. Mancheno; Ross A. Miller; Robert A. Reamer; Steven A. Weissman

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January 19, 2011

ACS chemical neuroscience spotlight on CEP-1347

ACS Chemical Neuroscience, ISSN: 19487193

Zachary K. Sweeney; Joe Lewcock

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January 18, 2011

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells

Cancer Cell, ISSN: 18783686 15356108

Nicholas S. Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A. Marsters; David Lawrence; Yun Li; Pitti; Klara Totpal; Sharon Fong Yee; Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G. Hymowitz; Dylan Daniel; Meng; Avi Ashkenazi

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January 18, 2011

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

Developmental Cell, ISSN: 15345807 18781551

Alexander W. Koch; Thomas Mathivet; Bruno Larrivee; Raymond K. Tong; Joe Kowalski; Laurence Pibouin-Fragner; Karine Bouvrée; Scott Stawicki; Nicholes; Nisha Rathore; Suzie J. Scales; Luis; Raquel del Toro; Catarina Freitas; Christiane Bréant; Annie Michaud; Pierre Corvol; Jean-Léon Thomas; Yan Wu; Franklin V. Peale Jr.; Ryan J. Watts; Marc Tessier-Lavigne; Anil Bagri; Anne Eichmann

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January 17, 2011

IL-27 promotes T cell-dependent colitis through multiple mechanisms

Journal of Experimental Medicine, ISSN: 00221007 15409538

Jennifer Cox; Noelyn Kljavin; Nandhini Ramamoorthi; Laurie Diehl; Marcel Batten; Nico Ghilardi

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January 15, 2011

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human

Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333

Patrick Poulin; Sean Ekins; Frank-Peter Theil

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