Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8601 - 8650 OF 15394 RESULTS

November 16, 2010

Reply to Talloen et al.: Independent filtering is a generic approach that needs domain specif c adaptation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Richard Bourgon; Robert Gentleman; Wolfgang Huber

November 16, 2010

Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Feng Su; Kathy R. Kozak; Satoshi Imaizumi; Feng Gao; Malaika W. Amneus; Victor Grijalva; Carey Ng; Alan Wagner; Greg Hough; Gina Farias-Eisner; Anantharamaiah; Brian J. Van Lenten; Mohamad Navab; Alan M. Fogelman; Srinivasa T. Reddy; Robin Farias-Eisner

November 15, 2010

Metabolism and toxicity of menthofuran in rat liver slices and in rats

Chemical Research in Toxicology, ISSN: 0893228X 15205010

S. Cyrus Khojasteh; Shimako Oishi; Sidney D. Nelson

November 15, 2010

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Georgette M. Castanedo; Shumei Wang; Kirk D. Robarge; Elizabeth M. Blackwood; Burdick; Christine Chang; Gerrit J. P. Dijkgraaf; Stephen Gould; Janet Gunzner; Oivin Guichert; Jason S Halladay; S. Cyrus Khojasteh; Leslie Lee; James C. Marsters Jr.; Lesley J. Murray; David Peterson; Emile G. Plise; Laurent Salphati; Frederic J. De Sauvage; Susan C. Wong; Daniel P. Sutherlin

November 15, 2010

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

Development (Cambridge), ISSN: 09501991 14779129

Kerstin Seidel; Christina Ahn; David Lyons; Alexander Nee; Kevin Ting; Isaac Brownell; Tim C. Cao; Richard A. D. Carano; Tom Curran; Markus Schober; Elaine Fuchs; Alexandra Joyner; Gail R. Martin; Frederic J. De Sauvage; Ophir D. Klein

November 11, 2010

Identification and functional analysis of endothelial tip cell-enriched genes

Blood, ISSN: 15280020 00064971

Raquel del Toro; Claudia Prahst; Thomas Mathivet; Geraldine Siegfried; Joshua S. Kaminker; Bruno Larrivee; Christiane Bréant; Antonio Duarte; Nobuyuki Takakura; Akiyoshi Fukamizu; Josef Penninger; Anne Eichmann

November 10, 2010

Dendritic sodium channels regulate network integration in globus pallidus neurons: A modeling study

Journal of Neuroscience, ISSN: 02706474 15292401

Jeremy R. Edgerton; Jesse E. Hanson; Cengiz Günay; Dieter Jaeger

November 9, 2010

Mild and general one-pot reduction and cyclization of aromatic and heteroaromatic 2-nitroamines to bicyclic 2 H -imidazoles

Synlett, ISSN: 09365214 14372096

Emily J. Hanan; Bryan K. Chan; Anthony A. Estrada; Daniel G. Shore; Joseph P. Lyssikatos

November 3, 2010

MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function

Journal of Neuroscience, ISSN: 02706474 15292401

Natasha K. Hussain; Honor Hsin; Richard Huganir; Morgan Sheng

November 1, 2010

Foreword

Separation Science and Technology, ISSN: 01496395 15205754

James M. Van Alstine; Philip M. Lester

November 1, 2010

New bone kit uses platelet growth factor

Managed Care, ISSN: 10623388

Thomas Morrow

November 1, 2010

Mechanism of antibody reduction in cell culture production processes

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Kao; Daniel Hewitt; Melody Trexler-Schmidt; Mike Laird

November 1, 2010

MR angiogenesis imaging with Robo4- vs. αVβ 3-targeted nanoparticles in a B16/F10 mouse melanoma model

FASEB Journal, ISSN: 08926638 15306860

Kent S. Boles; Anne H. Schmieder; Alexander W. Koch; Richard A. D. Carano; Yan Wu; Shelton D. Caruthers; Raymond K. Tong; Scott Stawicki; Grace Hu; Michael J. Scott; Huiying Zhang; Benton A. Reynolds; Samuel A. Wickline; Gregory M. Lanza

November 1, 2010

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

mAbs, ISSN: 19420862

Leslie A. Khawli; Sirj Goswami; Ryan Hutchinson; Zephania Kwong Glover; Yang; Xiangdan Wang; Zhenling Yao; Alavattam Sreedhara; Tony Cano; Devin B. Tesar; Ihsan Nijem; David E. Allison; Wong; Kao; Quan; Amita Joshi; Reed J. Harris; Paul Motchnik

November 1, 2010

Care of asthma patients in relation to guidelines

Allergy and Asthma Proceedings, ISSN: 10885412 15396304

Michael S. Broder; Eunice Chang; Sandhya Sapra

November 1, 2010

Crystallization of trehalose in frozen solutions and its phase behavior during drying

Pharmaceutical Research, ISSN: 07248741 1573904X

Prakash Sundaramurthi; Thomas W. Patapoff; Raj Suryanarayanan

November 1, 2010

Practical approaches to dose selection for first-in-human clinical trials with novel biopharmaceuticals

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Jay Tibbitts; Joy A. Cavagnaro; Christine A. Haller; Marafino Jr.; Paul A. Andrews; John T. Sullivan

November 1, 2010

Assessing the success probability of a Phase III clinical trial based on Phase II data

Contemporary Clinical Trials, ISSN: 15517144

Zheng Su

November 1, 2010

A model for harmonizing flow cytometry in clinical trials

Nature Immunology, ISSN: 15292908 15292916

Holden T. Maecker; J Philip McCoy; Michael Amos; John Elliott; Adolfas Gaigalas; Lili Wang; Richard Aranda; Jacques Banchereau; Chris Boshoff; Jonathan Braun; Yael Korin; Elaine Reed; Judy H. Cho; David A. Hafler; Mark M. Davis; C Garrison Fathman; William Robinson; Thomas Denny; Kent Weinhold; Bela Desai; Betty Diamond; Peter K. Gregersen; Paola Dimeglio; Frank Nestle; Mark Peakman; Federica Villnova; John Ferbas; Elizabeth Field; Aaron Kantor; Thomas Kawabata; Wendy Komocsar; Michael Lotze; Gerald Nepom; Hans D. Ochs; Raegan O'Lone; Deborah J. Phippard; Scott E. Plevy; Stephen S. Rich; Mario Roederer; Dan Rotrosen; Jung-Hua Yeh

November 1, 2010

High-throughput multi-product liquid chromatography for the characterization of monoclonal antibodies

BioPharm International, ISSN: 1542166X

Jennifer C. Rea; G. Tony Moreno; Yun Lou; Rahul Parikh; Dell Farnan

November 1, 2010

Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans

Experimental and Toxicologic Pathology, ISSN: 09402993

Mark Fielden; Mary Hassani; Hirdesh Uppal; Patricia Day-Lollini; Donald Button; Renee S. Martin; Rosario Garrido; Xingrong Liu; Kolaja

November 1, 2010

Unleashing cell death: The Fas-FADD complex

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Sarah G. Hymowitz; Vishva M. Dixit

November 1, 2010

Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies

PLoS ONE, ISSN: 19326203

Yan Gong; Eric Bourhis; Cecilia Chiu; Scott Stawicki; Venita I. DeAlmeida; Bob Y. Liu; Khanhky Phamluong; Tim C. Cao; Richard A. D. Carano; James A. Ernst; Mark J. Solloway; Bonnee Rubinfeld; Rami N. Hannoush; Yan Wu; Paul G. Polakis; Michael Costa

November 1, 2010

Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor

Xenobiotica, ISSN: 00498254 13665928

Edna F. Choo; Marcia Belvin; Jocelyn Chan; Klaus P. Hoeflich; Christine Orr; Kirk D. Robarge; Xiaoye Yang; Mark Zak; Jason Boggs

November 1, 2010

Leachables from saline-containing IV bags can alter therapeutic protein properties

Pharmaceutical Research, ISSN: 07248741 1573904X

Judy H. Chang; Nina Xiao; Min Zhu; Jennifer Zhang; Ed Hoff; Russell; Viswanatham Katta; Steven J. Shire

November 1, 2010

Systematic approaches to develop chemically defined cell culture feed media

BioPharm International, ISSN: 1542166X

Efren Pacis; Natarajan Vijayasankaran; Jincai Li; Martin Gawlitzek; Ashraf Amanullah; Feng Li

October 31, 2010

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum

Journal of Immunological Methods, ISSN: 00221759

Zhihua Julia Qiu; Yong Ying; Michael Fox; Kun Peng; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Jeremy Good; John Lowe; Amena Rahman; Yang; Jenny Jiang; Quarmby; An Song

October 31, 2010

Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF

Journal of Immunological Methods, ISSN: 00221759

Laura DeForge; Kelly M. Loyet; Donnie Delarosa; Jason Chinn; Fojan Zamanian; Anan Chuntharapai; James Lee; Hass; Nathan Wei; Michael J. Townsend; Jianyong Wang; Wai Lee T. Wong

October 29, 2010

Designing vaccines based on biology of human dendritic cell subsets

Immunity, ISSN: 10747613

A. Karolina Palucka; Jacques Banchereau; Ira Mellman

October 20, 2010

Diffusion and sedimentation interaction parameters for measuring the second virial coefficient and their utility as predictors of protein aggregation

Biophysical Journal, ISSN: 15420086 00063495

Atul Saluja; R. Matthew Fesinmeyer; Sabine Hogan; David N. Brems; Yatin Gokarn

October 19, 2010

Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes

Developmental Cell, ISSN: 15345807

Diego Correa; Eric Hesse; Dutmanee Seriwatanachai; Riku Kiviranta; Hiroaki Saito; Kei Yamana; Lynn Neff; Azeddine Atfi; Lucie Coillard; Despina Sitara; Yukiko Maeda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; William C. Horne; Beate Lanske; Roland Baron

October 18, 2010

Genome-wide inference of regulatory networks in Streptomyces coelicolor

BMC Genomics, ISSN: 14712164

Marlene Castro-Melchor; Salim Charaniya; George Karypis; Eriko Takano; Hu

October 15, 2010

Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models

Statistics in Medicine, ISSN: 02776715 10970258

Kingshuk Roy Choudhury; Ian Kasman; Greg D. Plowman

October 15, 2010

Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations

PLoS ONE, ISSN: 19326203

Nathanael Mccurley; Ira Mellman

October 14, 2010

Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering

Journal of Physical Chemistry B, ISSN: 15205207 15206106

Thomas M. Scherer; Jun Liu; Steven J. Shire; Allen P. Minton

October 12, 2010

Incidence of progressive multifocal leukoencephalopathy in patients without HIV

Neurology, ISSN: 1526632X 00283878

Amend; Turnbull; Foskett; Pavel Napalkov; Kurth; Seeger

October 7, 2010

Chromatography-Advances and Applications in Pharmaceutical Analysis in the Corporate Sector

Chromatography: A Science of Discovery,

Pat Noland; Terry N. Hopper; Michael W. Dong; Yong Guo; Todd D. Maloney; Raymond N. Xu

October 7, 2010

ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells

Oncogene, ISSN: 09509232 14765594

Sheryl R. Krig; Miller; Frietze; Beckett; Richard M. Neve; Farnham; Paul Yaswen; Colleen A. Sweeney

October 6, 2010

Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon

Journal of Neuroscience, ISSN: 02706474 15292401

Abraham J. Langseth; Roeben N. Munji; Youngshik Choe; Trung Huynh; Christine D. Pozniak; Samuel J. Pleasure

October 4, 2010

Development and evaluation of a novel method for preclinical measurement of tissue vascular volume

Molecular Pharmaceutics, ISSN: 15438384 15438392

C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Michelle G. Schweiger; Jan Marik; Mike Reich; Frank-Peter Theil; Fielder; Leslie A. Khawli

October 1, 2010

Histologic Outcomes in Hepatitis C–Infected Patients with Varying Degrees of Virologic Response to Interferon-Based Treatments

Hepatology, ISSN: 02709139

Pockros; Hamzeh; Martin; Lentz; Zhou; Sugantha Govindarajan; Anna S. Lok

October 1, 2010

Peginterferon α-2a plus ribavirin in latino and non-latino whites with HCV genotype 1: Histologic outcomes and tolerability from the LATINO study

American Journal of Gastroenterology, ISSN: 00029270 15720241

Luis Balart; Mauricio Lisker-Melman; Hamzeh; Ambrose Kwok; Lentz; Maribel Rodriguez-Torres

October 1, 2010

Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing

Molecular BioSystems, ISSN: 1742206X 17422051

Andreas Ernst; David Gfeller; Zhengyan Kan; Somasekar Seshagiri; Philip M. Kim; Gary D. Bader; Sachdev S. Sidhu

October 1, 2010

Antibody purification: Drivers of change

Pharmaceutical Formulation and Quality, ISSN: 15312135 19363435

Narahari Pujar; Duncan Low; O'Leary

October 1, 2010

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages

European Journal of Immunology, ISSN: 00142980 15214141

Andrea J. McCoy; Yukiko Koizumi; Claudia Toma; Naomi Higa; Vishva M. Dixit; Shun'ichiro Taniguchi; Jurg Tschopp; Toshihiko Suzuki

October 1, 2010

Bioavailability and population pharmacokinetics of voriconazole in lung transplant recipients

Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596

Kelong Han; Blair Capitano; Robert Bies; Potoski; Husain; Gilbert; Paterson; McCurry; Raman Venkataramanan

October 1, 2010

Bioequivalence studies for three formulations of a recombinant human growth hormone: Challenges and lessons learned

Growth Hormone and IGF Research, ISSN: 10966374 15322238

Dao; Joan R. Jacobs; Peter Kuebler; Bert Bakker; Barbara M. Lippe

October 1, 2010

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Steven T. Staben; Timothy P. Heffron; Daniel P. Sutherlin; Seema R. Bhat; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Emile G. Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu

October 1, 2010

Pediatric multiple sclerosis

CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371

Ellen M. Mowry; Waubant

October 1, 2010

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

Trends in Biotechnology, ISSN: 01677799

Wendy Putnam; Saileta Prabhu; Zheng; Subramanyam; Yow-Ming C. Wang

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.