Genentech: Publications

September 1, 2010

Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients who are biological naïve with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE))

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Paul Emery; Deodhar; William F. Rigby; John D. Isaacs; Bernard Combe; Artur J. Racewicz; Latinis; Abud-Mendoza; Leszek Szczepanski; Roschmann; Annie Chen; Gillian Armstrong; Douglass; Helen Tyrrell

View on Scopus

September 1, 2010

European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent

Genes and Immunity, ISSN: 14664879 14765470

Ilana B. Richman; Sharon A. Chung; Kimberly E. Taylor; Kosoy; Tian; Ward Ortmann; Joanne Nititham; Annette T. Lee; Rutman; Michelle Petri; Manzi; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell

View on Scopus

September 1, 2010

Parallel stacking of caffeine with riboflavin in aqueous solutions: The potential mechanism for hydrotropic solubilization of riboflavin

International Journal of Pharmaceutics, ISSN: 03785173

Yong Cui

View on Scopus

September 1, 2010

X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Andreas Kuglstatter; Manjiri Ghate; Stan Tsing; Armando G. Villaseñor; David Shaw; Jim W. Barnett; Michelle F. Browner

View on Scopus

September 1, 2010

Comparative analysis of techniques to purify plasma membrane proteins

Journal of Biomolecular Techniques, ISSN: 15240215 19434731

Michael P. Weekes; Robin Antrobus; Jennie R. Lill; Lidia M. Duncan; Simon Hör; Paul J. Lehner

View on Scopus

September 1, 2010

Clinical and biological data integration for biomarker discovery

Drug Discovery Today, ISSN: 13596446

Marco Sorani; Ward Ortmann; Erik P. Bierwagen; Timothy W. Behrens

View on Scopus

September 1, 2010

Design and powering of cystic fibrosis clinical trials using rate of FEV1 decline as an efficacy endpoint

Journal of Cystic Fibrosis, ISSN: 15691993

Michael W. Konstan; Wagener; Ashley Yegin; Stefanie J. Millar; David J. Pasta; Donald R. VanDevanter

View on Scopus

September 1, 2010

Proteomic profiling of cancer-opportunities, challenges, and context

Journal of Pathology, ISSN: 00223417 10969896

David Arnott; Michael R. Emmert-Buck

View on Scopus

September 1, 2010

Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs

American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605 15221504

Silvia Cardenas; Mario Scuri; Lennie Samsell; Barbara Ducatman; Pablo Bejarano; Alexander Auais; Melissa Doud; Kalai Mathee; Giovanni Piedimonte

View on Scopus

August 26, 2010

New insights into apoptosis signaling by Apo2L/TRAIL

Oncogene, ISSN: 09509232 14765594

François Gonzalvez; Avi Ashkenazi

View on Scopus

August 24, 2010

Structural basis for high-affinity HER2 receptor binding by an engineered protein

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Eigenbrot; Ultsch; Anatoly Dubnovitsky; Lars Abrahmsén; Torleif Härd

View on Scopus

August 20, 2010

Double TIP-ping

Science, ISSN: 00368075 10959203

Harinder Singh; Ignacio A. Demarco

View on Scopus

August 20, 2010

Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature

PLoS ONE, ISSN: 19326203

Andrew Scott; Michael B. Powner; Pranita Gandhi; Claire Clarkin; David H. Gutmann; Randall S. Johnson; Napoleone Ferrara; Marcus Fruttiger

View on Scopus

August 20, 2010

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Henry R. Maun; Xiaohui Wen; Andreas Lingel; Frederic J. De Sauvage; Lazarus; Suzie J. Scales; Sarah G. Hymowitz

View on Scopus

August 20, 2010

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Yaowu He; Andreas Wortmann; Les J. Burke; Janet C. Reid; Mark N. Adams; Ibtissam Abdul-Jabbar; James P. Quigley; Richard Leduc; Daniel Kirchhofer; John D. Hooper

View on Scopus

August 20, 2010

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Edoardo Fiorillo; Valeria Orrú; Stephanie M. Stanford; Yingge Liu; Mogjiborahman Salek; Novella Rapini; Aaron D. Schenone; Patrizia Saccucci; Lucia G. Delogu; Federica Angelini; Maria Luisa Manca Bitti; Christian Schmedt; Andrew A. Chan; Oreste Acuto; Nunzio Bottini

View on Scopus

August 16, 2010

Cloning, expression and functional characterization of cytochrome P450 3A37 from Turkey liver with high aflatoxin B1 epoxidation activity

Chemical Research in Toxicology, ISSN: 0893228X 15205010

Sumit Rawal; Shirley S. M. Yip; Roger A. Coulombe Jr.

View on Scopus

August 15, 2010

Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer

Cancer Research, ISSN: 15387445 00085472

Ciara Metcalfe; Ashraf E. K. Ibrahim; Michael Graeb; Marc De La Roche; Thomas Schwarz-Romond; Marc Fiedler; Douglas J. Winton; Anthony Corfield; Mariann Bienz

View on Scopus

August 13, 2010

β-catenin balances immunity

Science, ISSN: 00368075 10959203

Ira Mellman; Björn E. Clausen

View on Scopus

August 13, 2010

Imbalanced pattern completion vs. separation in cognitive disease: Network simulations of synaptic pathologies predict a personalized therapeutics strategy

BMC Neuroscience, ISSN: 14712202

Jesse E. Hanson; Daniel V. Madison

View on Scopus

August 12, 2010

Diverse somatic mutation patterns and pathway alterations in human cancers

Nature, ISSN: 00280836 14764687

Zhengyan Kan; Bijay S. Jaiswal; Stinson; Vasantharajan Janakiraman; Deepali Bhatt; Howard M. Stern; Peng Yue; Matthias Peter; Richard Bourgon; Jianbiao Zheng; Martin Moorhead; Subhra Chaudhuri; Lynn P. Tomsho; Brock A. Peters; Kanan Pujara; Shaun Cordes; David P. Davis; Victoria E. H. Carlton; Yuan; Li Li; Weiru Wang; Eigenbrot; Joshua S. Kaminker; Eberhard; Waring; Stephan C. Schuster; Zora Modrusan; Zemin Zhang; David Stokoe; Frederic J. De Sauvage; Malek Faham; Somasekar Seshagiri

View on Scopus

August 5, 2010

Preface

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Feroz Jameel; Susan Hershenson

View on Scopus

August 5, 2010

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Feroz Jameel; Susan Hershenson

View on Scopus

August 5, 2010

High-Concentration Antibody Formulations

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Steven J. Shire; Jun Liu; Wolfgang Friess; Susanne Jörg; Hanns-Christian Mahler

View on Scopus

August 5, 2010

Experimental Detection and Characterization of Protein Aggregates

Aggregation of Therapeutic Proteins,

Vikas Sharma; Devendra S. Kalonia

View on Scopus

August 5, 2010

Reversible Self-Association of Pharmaceutical Proteins: Characterization and Case Studies

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Vikas Sharma; Harminder Bajaj; Devendra S. Kalonia

View on Scopus

August 5, 2010

The Structure of Biological Therapeutics

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Sheryl Martin-Moe; Tim Osslund; Y. John Wang; Tahir Mahmood; Rohini Deshpande; Susan Hershenson

View on Scopus

August 5, 2010

Considerations for Successful Lyophilization Process Scale-Up, Technology Transfer, and Routine Production

Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,

Samir Sane; Chung C. Hsu

View on Scopus

August 4, 2010

Construction, MD simulation, and hydrodynamic validation of an all-atom model of a monoclonal IgG antibody

Biophysical Journal, ISSN: 15420086 00063495

J. Paul Brandt; Thomas W. Patapoff; Sergio R. Aragon

View on Scopus

August 2, 2010

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

Journal of Experimental Medicine, ISSN: 15409538 00221007

Petr Broz; Kim Newton; Lamkanfi; Sanjeev Mariathasan; Vishva M. Dixit; Denise M. Monack

View on Scopus

August 1, 2010

Vive la science! Vive le hérisson!

EMBO Reports, ISSN: 1469221X 14693178

Jeremy Reiter; Frederic J. De Sauvage

View on Scopus

August 1, 2010

Avoiding infusion therapy prime benefit of new MS drug: The search for an acceptable oral MS drug may be over if fingolimod (Gilenia) survives an FDA review this fall

Managed Care, ISSN: 10623388

Thomas Morrow

View on Scopus

August 1, 2010

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

Nature Immunology, ISSN: 15292908 15292916

Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner

View on Scopus

August 1, 2010

Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy

Clinical Cancer Research, ISSN: 10780432 15573265

Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman

View on Scopus

August 1, 2010

Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly

View on Scopus

August 1, 2010

A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade

Assay and Drug Development Technologies, ISSN: 1540658X

Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise

View on Scopus

August 1, 2010

Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression

Neuron, ISSN: 08966273

Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano

View on Scopus

August 1, 2010

The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes

Journal of Virology, ISSN: 0022538X 10985514

Sanjay Chandriani; Yiyang Xu; Don Ganem

View on Scopus

August 1, 2010

The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse

Clinical and Experimental Immunology, ISSN: 00099104 13652249

Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan

View on Scopus

August 1, 2010

A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress

Cancer Research, ISSN: 00085472 15387445

David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont

View on Scopus

August 1, 2010

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

Molecular Cell, ISSN: 10972765

Marissa L. Matsumoto; Katherine E. Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy J. Bustos; Lilian Phu; Donald S. Kirkpatrick; Sarah G. Hymowitz; Michael Rape; Robert F. Kelley; Vishva M. Dixit

View on Scopus

August 1, 2010

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

Modern Pathology, ISSN: 08933952 15300285

Xingxing Zang; Peggy S. Sullivan; Robert A. Soslow; Rebecca Waitz; Victor E. Reuter; Andrew Wilton; Howard T. Thaler; Manonmani Arul; Susan F. Slovin; Joyce Wei; David R. Spriggs; Jakob Dupont; James P. Allison

View on Scopus

August 1, 2010

Distal regions of the human IFNG locus direct cell type-specific expression

Journal of Immunology, ISSN: 00221767 15506606

Patrick L. Collins; Shaojing Chang; Melodie Henderson; Mohammed Soutto; Georgia M. Davis; Allyson G. McLoed; Michael J. Townsend; Laurie H. Glimcher; Douglas P. Mortlock; Aune

View on Scopus

August 1, 2010

High-yield expression of human vascular endothelial growth factor VEGF 165 in Escherichia coli and purification for therapeutic applications

Protein Expression and Purification, ISSN: 10465928

Shelly A. Pizarro; Jane Gunson; Field; Rachel Dinges; Stefanie Khoo; Milind Dalal; Michael Lee; Kimberly A. Kaleas; Kathryn Moiseff; Susan Garnick; Dorothea Reilly; Mike Laird; Charles H. Schmelzer

View on Scopus

August 1, 2010

Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Hanbiao Yang; Robert T. Hendricks; Nidhi Arora; Dov Nitzan; Calvin Yee; Matthew C. Lucas; Yanli Yang; Amy Fung; Sonal Rajyaguru; Seth F. Harris; Vincent J.P. Leveque; Julie Qi Hang; Sophie Le Pogam; Deborah Reuter; Gisele A. Tavares

View on Scopus

August 1, 2010

Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing

Clinical Therapeutics, ISSN: 01492918 1879114X

Kay Stubenrauch; Uwe Wessels; Herbert Birnboeck; Francisco Ramirez; Angelika Jahreis; Julia Schleypen

View on Scopus

August 1, 2010

Effect of trastuzumab on health-related quality of life in patients with HER2-positive metastatic breast cancer: Data from three clinical trials

Clinical Breast Cancer, ISSN: 15268209

Hope S. Rugo; Melissa Brammer; Fan Zhang; Deepa Lalla

View on Scopus

August 1, 2010