Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8801 - 8850 OF 15487 RESULTS

Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605 15221504
Silvia Cardenas; Mario Scuri; Lennie Samsell; Barbara Ducatman; Pablo Bejarano; Alexander Auais; Melissa Doud; Kalai Mathee; Giovanni Piedimonte
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New insights into apoptosis signaling by Apo2L/TRAIL
Oncogene, ISSN: 09509232 14765594
François Gonzalvez; Avi Ashkenazi
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Structural basis for high-affinity HER2 receptor binding by an engineered protein
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Eigenbrot; Ultsch; Anatoly Dubnovitsky; Lars Abrahmsén; Torleif Härd
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Double TIP-ping
Science, ISSN: 00368075 10959203
Harinder Singh; Ignacio A. Demarco
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Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature
PLoS ONE, ISSN: 19326203
Andrew Scott; Michael B. Powner; Pranita Gandhi; Claire Clarkin; David H. Gutmann; Randall S. Johnson; Napoleone Ferrara; Marcus Fruttiger
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Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Henry R. Maun; Xiaohui Wen; Andreas Lingel; Frederic J. De Sauvage; Lazarus; Suzie J. Scales; Sarah G. Hymowitz
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Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Yaowu He; Andreas Wortmann; Les J. Burke; Janet C. Reid; Mark N. Adams; Ibtissam Abdul-Jabbar; James P. Quigley; Richard Leduc; Daniel Kirchhofer; John D. Hooper
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Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Edoardo Fiorillo; Valeria Orrú; Stephanie M. Stanford; Yingge Liu; Mogjiborahman Salek; Novella Rapini; Aaron D. Schenone; Patrizia Saccucci; Lucia G. Delogu; Federica Angelini; Maria Luisa Manca Bitti; Christian Schmedt; Andrew A. Chan; Oreste Acuto; Nunzio Bottini
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Cloning, expression and functional characterization of cytochrome P450 3A37 from Turkey liver with high aflatoxin B1 epoxidation activity
Chemical Research in Toxicology, ISSN: 0893228X 15205010
Sumit Rawal; Shirley S. M. Yip; Roger A. Coulombe Jr.
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Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer
Cancer Research, ISSN: 15387445 00085472
Ciara Metcalfe; Ashraf E. K. Ibrahim; Michael Graeb; Marc De La Roche; Thomas Schwarz-Romond; Marc Fiedler; Douglas J. Winton; Anthony Corfield; Mariann Bienz
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β-catenin balances immunity
Science, ISSN: 00368075 10959203
Ira Mellman; Björn E. Clausen
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Imbalanced pattern completion vs. separation in cognitive disease: Network simulations of synaptic pathologies predict a personalized therapeutics strategy
BMC Neuroscience, ISSN: 14712202
Jesse E. Hanson; Daniel V. Madison
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Diverse somatic mutation patterns and pathway alterations in human cancers
Nature, ISSN: 00280836 14764687
Zhengyan Kan; Bijay S. Jaiswal; Stinson; Vasantharajan Janakiraman; Deepali Bhatt; Howard M. Stern; Peng Yue; Matthias Peter; Richard Bourgon; Jianbiao Zheng; Martin Moorhead; Subhra Chaudhuri; Lynn P. Tomsho; Brock A. Peters; Kanan Pujara; Shaun Cordes; David P. Davis; Victoria E. H. Carlton; Yuan; Li Li; Weiru Wang; Eigenbrot; Joshua S. Kaminker; Eberhard; Waring; Stephan C. Schuster; Zora Modrusan; Zemin Zhang; David Stokoe; Frederic J. De Sauvage; Malek Faham; Somasekar Seshagiri
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Preface
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Feroz Jameel; Susan Hershenson
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High-Concentration Antibody Formulations
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Steven J. Shire; Jun Liu; Wolfgang Friess; Susanne Jörg; Hanns-Christian Mahler
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Experimental Detection and Characterization of Protein Aggregates
Aggregation of Therapeutic Proteins,
Vikas Sharma; Devendra S. Kalonia
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Reversible Self-Association of Pharmaceutical Proteins: Characterization and Case Studies
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Vikas Sharma; Harminder Bajaj; Devendra S. Kalonia
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The Structure of Biological Therapeutics
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Sheryl Martin-Moe; Tim Osslund; Y. John Wang; Tahir Mahmood; Rohini Deshpande; Susan Hershenson
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Considerations for Successful Lyophilization Process Scale-Up, Technology Transfer, and Routine Production
Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals,
Samir Sane; Chung C. Hsu
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Construction, MD simulation, and hydrodynamic validation of an all-atom model of a monoclonal IgG antibody
Biophysical Journal, ISSN: 15420086 00063495
J. Paul Brandt; Thomas W. Patapoff; Sergio R. Aragon
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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Journal of Experimental Medicine, ISSN: 15409538 00221007
Petr Broz; Kim Newton; Lamkanfi; Sanjeev Mariathasan; Vishva M. Dixit; Denise M. Monack
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Vive la science! Vive le hérisson!
EMBO Reports, ISSN: 1469221X 14693178
Jeremy Reiter; Frederic J. De Sauvage
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Avoiding infusion therapy prime benefit of new MS drug: The search for an acceptable oral MS drug may be over if fingolimod (Gilenia) survives an FDA review this fall
Managed Care, ISSN: 10623388
Thomas Morrow
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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Nature Immunology, ISSN: 15292908 15292916
Daniel J. Hodson; Michelle L. Janas; Alison Galloway; Sarah E. Bell; Simon Andrews; Cheuk M. Li; Richard Pannell; Christian W. Siebel; H. Robson MacDonald; Kim De Keersmaecker; Adolfo A. Ferrando; Gerald Grutz; Martin Turner
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Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy
Clinical Cancer Research, ISSN: 10780432 15573265
Anil Bagri; Berry; Bert Gunter; Mallika Singh; Ian Kasman; Lisa A. Damico; Hong Xiang; Maike Schmidt; Fuh; Beth A Hollister; Oliver Rosen; Greg D. Plowman
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Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Athena W. Wong; Tomasz K. Baginski; Dorothea Reilly
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A plate-based assay to measure cellular ERK substrate phosphorylation: Utility for drug discovery of the MAPK-signaling cascade
Assay and Drug Development Technologies, ISSN: 1540658X
Sreemathy Ramaswamy; Ivana Yen; Steve Sideris; Shiva Malek; Christopher E. Heise
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Neural RNA-Binding Protein Musashi1 Controls Midline Crossing of Precerebellar Neurons through Posttranscriptional Regulation of Robo3/Rig-1 Expression
Neuron, ISSN: 08966273
Ken-ichiro Kuwako; Kyoko Kakumoto; Takao Imai; Mana Igarashi; Takao Hamakubo; Shin-ichi Sakakibara; Marc Tessier-Lavigne; Hirotaka James Okano; Hideyuki Okano
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The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes
Journal of Virology, ISSN: 0022538X 10985514
Sanjay Chandriani; Yiyang Xu; Don Ganem
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The Type 1 Diabetes PhysioLab® Platform: A validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
Clinical and Experimental Immunology, ISSN: 00099104 13652249
Shoda; Kreuwel; Kapil Gadkar; Zheng; Whiting; Mark Atkinson; Jeffrey A. Bluestone; Mathis; Young; Ramanujan
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A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress
Cancer Research, ISSN: 00085472 15387445
David Peterson; James Lee; Xingye Lei; William F. Forrest; David P. Davis; Peter K Jackson; Lisa D. Belmont
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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody
Molecular Cell, ISSN: 10972765
Marissa L. Matsumoto; Katherine E. Wickliffe; Ken Dong; Christine Yu; Ivan Bosanac; Daisy J. Bustos; Lilian Phu; Donald S. Kirkpatrick; Sarah G. Hymowitz; Michael Rape; Robert F. Kelley; Vishva M. Dixit
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Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
Modern Pathology, ISSN: 08933952 15300285
Xingxing Zang; Peggy S. Sullivan; Robert A. Soslow; Rebecca Waitz; Victor E. Reuter; Andrew Wilton; Howard T. Thaler; Manonmani Arul; Susan F. Slovin; Joyce Wei; David R. Spriggs; Jakob Dupont; James P. Allison
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Distal regions of the human IFNG locus direct cell type-specific expression
Journal of Immunology, ISSN: 00221767 15506606
Patrick L. Collins; Shaojing Chang; Melodie Henderson; Mohammed Soutto; Georgia M. Davis; Allyson G. McLoed; Michael J. Townsend; Laurie H. Glimcher; Douglas P. Mortlock; Aune
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High-yield expression of human vascular endothelial growth factor VEGF 165 in Escherichia coli and purification for therapeutic applications
Protein Expression and Purification, ISSN: 10465928
Shelly A. Pizarro; Jane Gunson; Field; Rachel Dinges; Stefanie Khoo; Milind Dalal; Michael Lee; Kimberly A. Kaleas; Kathryn Moiseff; Susan Garnick; Dorothea Reilly; Mike Laird; Charles H. Schmelzer
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Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Hanbiao Yang; Robert T. Hendricks; Nidhi Arora; Dov Nitzan; Calvin Yee; Matthew C. Lucas; Yanli Yang; Amy Fung; Sonal Rajyaguru; Seth F. Harris; Vincent J.P. Leveque; Julie Qi Hang; Sophie Le Pogam; Deborah Reuter; Gisele A. Tavares
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Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing
Clinical Therapeutics, ISSN: 01492918 1879114X
Kay Stubenrauch; Uwe Wessels; Herbert Birnboeck; Francisco Ramirez; Angelika Jahreis; Julia Schleypen
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Effect of trastuzumab on health-related quality of life in patients with HER2-positive metastatic breast cancer: Data from three clinical trials
Clinical Breast Cancer, ISSN: 15268209
Hope S. Rugo; Melissa Brammer; Fan Zhang; Deepa Lalla
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Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer
Biological Chemistry, ISSN: 14316730 14374315
Henry R. Maun; Daniel Kirchhofer; Lazarus
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Managing Successful Product Portfolio Creation and R&D Pipelines
Pharmaceutical and Biomedical Project Management in a Changing Global Environment,
Sue E. Steven
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Vertebrate Hedgehog signaling: Cilia rule
BMC Biology, ISSN: 17417007
Christopher W. Wilson; Didier Y. R. Stainier
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Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin
Journal of Neuroscience, ISSN: 02706474 15292401
Ozlem Bozdagi; Xiaobin Wang; Jessica S. Nikitczuk; Tonya R. Anderson; Erik B. Bloss; Glenn L. Radice; Qiang Zhou; Deanna L. Benson; George W. Huntley
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Preparation and separation of antimicrobial agents derived from capreomycin
Tetrahedron Letters, ISSN: 00404039
D. David Hennings; Daniel J. Watson; Joseph P. Lyssikatos; Andrew Allen
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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy
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Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Faye Martin; Padmamalini Baskaran; Xiaolei Ma; Pete W. Dunten; Martina Schaefer; Johannes-Peter Stasch; Annie Beuve; Focco Van Den Akker
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Rituximab versus cyclophosphamide for ANCA-associated vasculitis
New England Journal of Medicine, ISSN: 15334406 00284793
John H. Stone; Merkel; Spiera; Seo; Langford; Hoffman; Cees Kallenberg; St.clair; Anthony Turkiewicz; Tchao; Lisa Webber; Linna Ding; Lourdes P. Sejismundo; Kathleen Mieras; David Weitzenkamp; Iklé; Vicki Seyfert-Margolis; Mark Mueller; Paul Brunetta; Allen; Fervenza; Duvuru Geetha; Keogh; Kissin; Monach; Peikert; Stegeman; Steven R. Ytterberg; Specks
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Predictive biomarkers of sensitivity to the phosphatidylinositol 3′ kinase inhibitor GDC-0941 in breast cancer preclinical models
Clinical Cancer Research, ISSN: 10780432 15573265
Carol O'Brien; Jeffery J. Wallin; Deepak Sampath; Debraj GuhaThakurta; Heidi Savage; Elizabeth A. Punnoose; Zhengyu Guan; Berry; Wei Wei Prior; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner
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IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
Journal of Immunology, ISSN: 00221767 15506606
Allen W. Ho; Fang Shen; Heather R. Conti; Nayan Patel; Erin E. Childs; Alanna C. Peterson; Nydiaris Herna´ndez-Santos; Jay K. Kolls; Lawrence P. Kane; Wenjun Ouyang; Sarah L. Gaffen
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Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
Journal of Neuroscience, ISSN: 02706474 15292401
Alexander Jaworski; Hua Long; Marc Tessier-Lavigne
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