Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8851 - 8900 OF 15487 RESULTS

July 8, 2010

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

Nature, ISSN: 00280836 14764687

Ira Surolia; Stephan P. Pirnie; Vasant Chellappa; Kendra N. Taylor; Annaiah Cariappa; Jesse Moya; Haoyuan Liu; Daphne W. Bell; David R. Driscoll; Sven Diederichs; Khaleda Haider; Ilka Netravali; Sheila Le; Roberto Elia; Ethan Dow; Annette T. Lee; Jan Freudenberg; Philip L. De Jager; Yves Chretien; Ajit Varki; Marcy E. MacDonald; Tammy Gillis; Timothy W. Behrens; Donald Bloch; Deborah Collier; Joshua Korzenik; Daniel K. Podolsky; David A. Hafler; Mandakolathur Murali; Bruce Sands; John H. Stone; Peter K. Gregersen; Shiv Pillai

July 2, 2010

Response

Science, ISSN: 10959203 00368075

Levinson

July 2, 2010

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Janet Jackman; Yongmei Chen; Arthur Huang; Moffat; Justin M. Scheer; Leong; Wyne P. Lee; Juan Zhang; Navneet Sharma; Yanmei Lu; Suhasini Iyer; Robert L. Shields; Nancy Y. Chiang; Michele Bauer; Diana Jakubiak; Merone Roose-Girma; Richard L. Vandlen; Yansura; Yan Wu; Lawren C. Wu

July 1, 2010

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

Nature Immunology, ISSN: 15292908 15292916

Hyota Takamatsu; Noriko Takegahara; Yukinobu Nakagawa; Michio Tomura; Masahiko Taniguchi; Roland H. Friedel; Helen Rayburn; Marc Tessier-Lavigne; Yutaka Yoshida; Tatsusada Okuno; Masayuki Mizui; Sujin Kang; Satoshi Nojima; Tohru Tsujimura; Yuji Nakatsuji; Ichiro Katayama; Toshihiko Toyofuku; Hitoshi Kikutani; Atsushi Kumanogoh

July 1, 2010

Pre-sterilized, single use filling systems for liquid bio-pharmaceuticals

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

July 1, 2010

The adaptor protein Sh2d3c is critical for marginal zone B cell development and function

Journal of Immunology, ISSN: 00221767 15506606

Amin Al-Shami; Carrie Wilkins; Jeannette Crisostomo; Dhaya Seshasayee; Flavius Martin; Nianhua Xu; Adisak Suwanichkul; Stephen J. Anderson; Tamás Oravecz

July 1, 2010

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

Journal of Immunology, ISSN: 15506606 00221767

Sheela Ramanathan; Stephanie Dubois; Julien Gagnon; Chantal Leblanc; Sanjeev Mariathasan; Gerardo Ferbeyre; Robert Rottapel; Pamela S. Ohashi; Subburaj Ilangumaran

July 1, 2010

Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Arick Brown; Charity Bechtel; Jerome Bill; Hui F. Liu; Jun Liu; Daniel J. McDonald; Satyan Pai; Asha Radhamohan; Ryan Renslow; Brooke Thayer; Stefan T. Yohe; Chris Dowd

July 1, 2010

Increased targeting of donor switch region and IgE in Sγ1-deficient B cells

Journal of Immunology, ISSN: 00221767 15506606

Shahram Misaghi; Christopher Garris; Yonglian Sun; Allen Nguyen; Juan Zhang; Andrew Sebrell; Kate Senger; Donghong Yan; Maria N. Lorenzo; Sherry Heldens; Wyne P. Lee; Min Xu; Jiansheng Wu; Laura DeForge; Tao Sai; Vishva M. Dixit; Ali A. Zarrin

July 1, 2010

SEC assay for polyvinylsulfonic impurities in 2-(N-morpholino) ethanesulfonic acid using a charged aerosol detector

Chromatographia, ISSN: 00095893 16121112

Taylor Zhang; Daniel Hewitt; Kao

July 1, 2010

Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy

Biotechnology Progress, ISSN: 87567938 15206033

Cary F. Opel; Jincai Li; Ashraf Amanullah

July 1, 2010

Process transfer to contract manufacturing organizations: A case study on process development support past regulatory approval

Pharmaceutical Engineering, ISSN: 02738139

Amy Webb; David H. Reifsnyder; Bender

July 1, 2010

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

Journal of Clinical Investigation, ISSN: 00219738 15588238

Scott N. Mueller; Vijay K. Vanguri; Sang-Jun Ha; Erin E. West; Mary E. Keir; Jonathan N. Glickman; Arlene H. Sharpe; Rafi Ahmed

July 1, 2010

Modulation of inflammasome activity for the treatment of auto-inflammatory disorders

Journal of Clinical Immunology, ISSN: 02719142 15732592

Naik; Vishva M. Dixit

July 1, 2010

Inline ultrafiltration

Biotechnology Progress, ISSN: 87567938 15206033

Christopher A. Teske; Lebreton

July 1, 2010

Use of disposable reactors to generate inoculum cultures for E. coli production fermentations

Biotechnology Progress, ISSN: 87567938 15206033

Ekta Mahajan; Timothy Matthews; Ryan Hamilton; Mike Laird

July 1, 2010

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

Journal of Clinical Investigation, ISSN: 00219738 15588238

Sheng Cao; Usman Yaqoob; Amitava Das; Uday Shergill; Kumaravelu Jagavelu; Robert C. Huebert; Chittaranjan Routray; Soha Abdelmoneim; Meher Vasdev; Edward Leof; Michael R. Charlton; Ryan J. Watts; Debabrata Mukhopadhyay; Vijay H. Shah

July 1, 2010

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain

Neuron, ISSN: 08966273

Naoko Kaneko; Oscar Marín; Masato Koike; Yuki Hirota; Yasuo Uchiyama; Jane Y. Wu; Qiang Lu; Marc Tessier-Lavigne; Arturo Alvarez-Buylla; Hideyuki Okano; John L. R. Rubenstein; Kazunobu Sawamoto

July 1, 2010

Cost analysis review of stroke centers, telestroke, and rt-PA

American Journal of Managed Care, ISSN: 10880224

Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung

July 1, 2010

The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment

Clinical Cancer Research, ISSN: 10780432 15573265

Ivor Caro; Low

July 1, 2010

Characterization of a monoclonal antibody cell culture production process using a quality by design approach

Molecular Biotechnology, ISSN: 10736085

Brian Horvath; Melissa Mun; Mike Laird

July 1, 2010

Targeting the tumour vasculature: Insights from physiological angiogenesis

Nature Reviews Cancer, ISSN: 1474175X 14741768

Alicia S Chung; John Lee; Napoleone Ferrara

July 1, 2010

Year-to-year changes in lung function in individuals with cystic fibrosis

Journal of Cystic Fibrosis, ISSN: 15691993

Liou; Eric Elkin; David J. Pasta; Joan R. Jacobs; Michael W. Konstan; Morgan; Wagener

July 1, 2010

Reply to S.N. Wolff

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Suman Bhattacharya; Gwendolyn Fyfe; Robert Gray; Daniel J. Sargent

July 1, 2010

Zinc Finger Nucleases as tools to understand and treat human diseases

BMC Medicine, ISSN: 17417015

David P. Davis; David Stokoe

July 1, 2010

Response

Chest, ISSN: 19313543 00123692

Sarika Ogale; Todd A. Lee; Sean D. Sullivan

July 1, 2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy

Arthritis and Rheumatism, ISSN: 00043591 15290131

Jing Cui; Saedis Saevarsdottir; Brian Thomson; Leonid Padyukov; Annette H. M. Van Der Helm-van Mil; Joanne Nititham; Laura B. Hughes; Niek De Vries; Soumya Raychaudhuri; Lars Alfredsson; Johan Askling; Wedren; Bo Ding; Candace Guiducci; Gert Jan Wolbink; J. Bart A. Crusius; Irene E. Van Der Horst-Bruinsma; Marieke Herenius; Michael E. Weinblatt; Nancy A. Shadick; Jane Worthington; Franak Batliwalla; Marlena Kern; Ann W. Morgan; Anthony G. Wilson; John D. Isaacs; Kimme Hyrich; Michael F. Seldin; Larry W. Moreland; Timothy W. Behrens; Allaart; Lindsey A. Criswell; Tom W. J. Huizinga; Paul P. Tak; S. Louis Bridges Jr.; Toes; Anne Barton; Lars Klareskog; Peter K. Gregersen; Elizabeth W. Karlson; Robert M. Plenge

July 1, 2010

Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis

Cytokine, ISSN: 10434666

Judy Young; Xin Yu; Kristen Wolslegel; Allen Nguyen; Catherine Kung; Eugene Y. Chiang; Ganesh Kolumam; Nathan Wei; Wai Lee T. Wong; Laura DeForge; Michael J. Townsend; Jane L. Grogan

July 1, 2010

US cost burden of ischemic stroke: A systematic literature review

American Journal of Managed Care, ISSN: 10880224

Bart M. Demaerschalk; Ha-Mill Hwang; Grace Leung

July 1, 2010

Unique challenges and opportunities for enabling and supporting preclinical and translational areas of biologic development in India - A perspective

American Pharmaceutical Outsourcing, ISSN: 15296318

Ashwin Datt; Sara Kenkare-Mitra

July 1, 2010

Prosthetic hand provides nearly normal function: It might seem to be straight out of science fiction, but there's solid science and engineering behind it

Managed Care, ISSN: 10623388

Thomas Morrow

June 29, 2010

Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol- 4,5-bisphosphate distribution is required for MAPK signaling

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Lindsay S. Garrenton; Christopher J. Stefan; Michael A. McMurray; Scott D. Emr; Jeremy Thorner

June 22, 2010

Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Benjamin Haley; Bryon Foys; Michael Levine

June 21, 2010

The functional capacity of the natural amino acids for molecular recognition

Molecular BioSystems, ISSN: 1742206X 17422051

Sara Birtalan; Robert D. Fisher; Sachdev S. Sidhu

June 17, 2010

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

Blood, ISSN: 15280020 00064971

Geraldine Strasser; Joshua S. Kaminker; Marc Tessier-Lavigne

June 15, 2010

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Melody Trexler-Schmidt; Sandy Sargis; Jason Chiu; Stefanie Sze-Khoo; Melissa Mun; Kao; Mike Laird

June 10, 2010

Reply to B.I. Rini et al

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Darren R. Feldman; Frank A. Scappaticci; Robert J. Motzer

June 1, 2010

The roles of bioactivity assays in lot release and stability testing

BioProcess International, ISSN: 15426319

Noel Rieder; Hélène Gazzano-Santoro; Mark Schenerman; Robert Strause; Chana Fuchs; Mire-Sluis; Lorna McLeod

June 1, 2010

Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus

Arthritis and Rheumatism, ISSN: 00043591 15290131

Paola G. Bronson; Leanne K. Komorowski; Ramsay; Suzanne L. May; Janelle A. Noble; Lane; Glenys Thomson; Frans H. Claas; Michael F. Seldin; Jennifer A. Kelly; John B. Harley; Kathy L. Moser; Patrick M. Gaffney; Timothy W. Behrens; Lindsey A. Criswell; Lisa F. Barcellos

June 1, 2010

Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum interference

Journal of Immunological Methods, ISSN: 00221759

Krista McCutcheon; Quarmby; An Song

June 1, 2010

Overloading ion-exchange membranes as a purification step for monoclonal antibodies

Biotechnology and Applied Biochemistry, ISSN: 08854513

Arick Brown; Jerome Bill; Timothy Tully; Asha Radhamohan; Chris Dowd

June 1, 2010

Asthma control and activity limitations: insights from the Real-world Evaluation of Asthma Control and Treatment (REACT) Study

Annals of Allergy, Asthma and Immunology, ISSN: 10811206 15344436

Tmirah Haselkorn; Hubert Chen; Dave P. Miller; James E. Fish; Stephen P. Peters; Weiss; Craig A. Jones

June 1, 2010

Template proteogenomics: Sequencing whole proteins using an imperfect database

Molecular and Cellular Proteomics, ISSN: 15359476

Natalie E. Castellana; Victoria Pham; David Arnott; Jennie R. Lill; Vineet Bafna

June 1, 2010

Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice

Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X

Nelson L'ntshotsholé Jumbe; Yan Xin; Douglas Leipold; Lisa Crocker; Dugger; Elaine Mai; Mark X. Sliwkowski; Fielder; Jay Tibbitts

June 1, 2010

Principal component analysis of general patterns of HIV-1 replicative fitness in different drug environments

Epidemics, ISSN: 17554365

João Martins; Colombe Chappey; Mojgan Haddad; Jeannette M. Whitcomb; Eric Stawiski; Christos J. Petropoulos; Sebastian Bonhoeffer

June 1, 2010

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

Nature Biotechnology, ISSN: 10870156 15461696

Mallika Singh; Anthony Lima; Rafael Molina; Patricia Hamilton; Anne C. Clermont; Vidusha Devasthali; Jennifer D. Thompson; Jason H. Cheng; Hani Bou-Reslan; Calvin Ho; Tim C. Cao; Chingwei V. Lee; Michelle Nannini; Fuh; Richard A. D. Carano; Koeppen; Ron Yu; William F. Forrest; Greg D. Plowman; Leisa Johnson

June 1, 2010

Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer

Cancer Research, ISSN: 00085472 15387445

Teemu T. Junttila; Kathryn Parsons; Christine Olsson; Yanmei Lu; Yan Xin; Julie Theriault; Lisa Crocker; Oliver Pabonan; Tomasz K. Baginski; Meng; Klara Totpal; Robert F. Kelley; Mark X. Sliwkowski

June 1, 2010

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

Journal of Clinical Investigation, ISSN: 00219738 15588238

Hans D. Brightbill; Surinc Er Jeet; Zhonghua Lin; Donghong Yan; Meijuan Zhou; Martha Tan; Allen Nguyen; Sherry Yeh; Donnie Delarosa; Leong; Wong; Chen; Ultsch; Luis; Sree R. Ramani; Janet Jackman; Lino C. Gonzalez Jr.; Dennis; Anan Chuntharapai; Laura DeForge; Meng; Min Xu; Eigenbrot; Wyne P. Lee; Refino; Mercedesz Balazs; Lawren C. Wu

June 1, 2010

Mining manufacturing data for discovery of high productivity process characteristics

Journal of Biotechnology, ISSN: 01681656 18734863

Salim Charaniya; Huong Le; Huzefa Rangwala; Mills; Kevin Johnson; George Karypis; Hu

June 1, 2010

First-year response to rhGH therapy in children with CKD: A National Cooperative Growth Study Report

Pediatric Nephrology, ISSN: 0931041X

John D. Mahan; Bradley A. Warady; James W. Frane; Rosenfeld; Rita D. Swinford; Barbara M. Lippe; Daniel Aaron Davis

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