Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8851 - 8900 OF 15394 RESULTS

Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
Journal of Neuroscience, ISSN: 02706474 15292401
Yanling Wang; Catherine A. Dye; Vikaas Sohal; Jason E. Long; Rosanne C. Estrada; Tomas Roztocil; Thomas Lufkin; Karl Deisseroth; Scott C. Baraban; John L. R. Rubenstein
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Differential effects of divalent manganese and magnesium on the kinase activity of Leucine-Rich Repeat Kinase 2 (LRRK2)
Biochemistry, ISSN: 00062960 15204995
Brian Lovitt; Erica Vanderporten; Zejuan Sheng; Haitao Zhu; Jake Drummond; Yichin Liu
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A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
Cancer Cell, ISSN: 15356108
Ruihuan Chen; Merry C. Nishimura; Stephanie M. Bumbaca; Samir Kharbanda; William F. Forrest; Ian Kasman; Joan M. Greve; Robert Soriano; Laurie L. Gilmour; Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A. Edgar; Jeffery J. Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C. David James; Scott R. VandenBerg; Joseph F. Costello; Scott Moorefield; Cynthia J. Cowdrey; Michael D. Prados; Phillips
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Cancer therapy reform
Science, ISSN: 00368075 10959203
Levinson
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Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Laetitia Malphettes; Yevgeniy Freyvert; Chang; Pei-Qi Liu; Edmond Chan; Jeffrey C. Miller; Zhe Zhou; Nguyen; Christina Tsai; Andrew Snowden; Trevor N. Collingwood; Philip D. Gregory; Gregory J. Cost
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An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G
Current Opinion in Structural Biology, ISSN: 0959440X
Devin B. Tesar; Pamela J. Bjorkman
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The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility
Journal of Immunology, ISSN: 00221767 15506606
Sharon Celeste Morley; Chen Wang; Wan-Lin Lo; Chan-Wang J. Lio; Bernd H. Zinselmeyer; Mark J. Miller; Eric J. Brown; Paul M. Allen
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Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
Nature Cell Biology, ISSN: 14657392
Yaron Pereg; Bob Y. Liu; Karen M. O'Rourke; Meredith Sagolla; Anwesha Dey; László Kömüves; French; Vishva M. Dixit
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Characteristics of rhVEGF release from topical hydrogel formulations
Pharmaceutical Research, ISSN: 07248741 1573904X
Junyan A. Ji; Jun Liu; Steven J. Shire; Tim J. Kamerzell; Sung Hong; Karen L Billeci; Ye Shen; Y. John Wang
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A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
Developmental Biology, ISSN: 1095564X 00121606
Setsu Endoh-Yamagami; Kameel M. Karkar; Scott R. May; Inma Cobos; Myo T. Thwin; Jason E. Long; Amir M. Ashique; Konstantinos Zarbalis; John L. R. Rubenstein; Andrew S. Peterson
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Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother
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Novel method for genotyping hepatitis B virus on the basis of taqMan real-time PCR
Journal of Clinical Microbiology, ISSN: 00951137
Sebastian Malmström; Ida Enquist; Magnus Lindh
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Cytosol as battleground: Ubiquitin as a weapon for both host and pathogen
Trends in Cell Biology, ISSN: 09628924
Cathleen A. Collins; Eric J. Brown
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Estimating duration in partnership studies: Issues, methods and examples
Sexually Transmitted Infections, ISSN: 13684973 14723263
Bart Burington; James P. Hughes; William L. H. Whittington; Brad Stoner; Geoff Garnett; Sevgi O. Aral; King K. Holmes
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Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET
Nuclear Medicine and Biology, ISSN: 09698051
Jeff N. Tinianow; Herman S. Gill; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Luis; Richard L. Vandlen; Martine Darwish; Jagath R. Junutula; Simon P. Williams; Jan Marik
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Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
Annals of Neurology, ISSN: 03645134 15318249
Amit Bar-Or; Lama Fawaz; Boli Fan; Peter J. Darlington; Aja Rieger; Christine Ghorayeb; Peter A Calabresi; Waubant; Stephen L. Hauser; Jiameng Zhang; Craig H. Smith
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Spatial control of EGF receptor activation by reversible dimerization on living cells
Nature, ISSN: 00280836 14764687
Inhee Chung; Robert W. Akita; Richard L. Vandlen; Derek Toomre; Schlessinger; Ira Mellman
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Cross-species comparison of the metabolism and excretion of zoniporide: Contribution of aldehyde oxidase to interspecies differences
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Deepak Dalvie; Chenghong Zhang; Weichao Chen; Teresa Smolarek; R. Scott Obach; Cho-Ming Loi
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Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin e for the treatment of melanoma and breast cancer
Current Opinion in Molecular Therapeutics, ISSN: 14648431
Louie Naumovski; Jagath R. Junutula
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A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
James Tumlin; Jesse Goldman; David M. Spiegel; David Roer; K. Adu Ntoso; Martha Blaney; Joan R. Jacobs; Barbara S. Gillespie; Susan M. Begelman
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Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
Molecular and Cellular Biology, ISSN: 02707306
Xiaohui Wen; Cary K. Lai; Marie Evangelista; Hongo; Frederic J. De Sauvage; Suzie J. Scales
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Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-α antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Rong Deng; Kelly M. Loyet; Samantha Lien; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Henry B. Lowman; Fielder; Saileta Prabhu
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Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions
Nature Methods, ISSN: 15487091 15491676
Anita A. Koshy; Ashley Fouts; Melissa B. Lodoen; Ozan Alkan; Helen M. Blau; John C. Boothroyd
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Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jin I. Lee; Damien M. O'Halloran; Jeffrey Eastham-Anderson; Bi-Tzen Juang; Julia A. Kaye; O. Scott Hamilton; Bluma Lesch; Andrei Goga; Noelle D. L'Etoile
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Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Desiree H. Fong; Christopher T. Lemke; Jiyoung Hwang; Bing Xiong; Albert M. Berghuis
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Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Nature, ISSN: 00280836 14764687
Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek
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The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in netrin-mediated axon attraction and branching
Developmental Cell, ISSN: 18781551 15345807
Joe C. Hao; Carolyn E. Adler; Leslie Mebane; Frank B. Gertler; Cornelia I. Bargmann; Marc Tessier-Lavigne
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Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the abl-related gene (Arg) tyrosine kinase and N-WASp
Biochemistry, ISSN: 00062960 15204995
Matthew M. Miller; Stefanie Lapetina; Stacey M. MacGrath; Mindan K. Sfakianos; Thomas D. Pollard; Anthony J. Koleske
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Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors
Cancer, ISSN: 0008543X 10970142
Faye M. Johnson; Shruti Agrawal; Howard A. Burris; Lee Rosen; Navneet Dhillon; David Hong; Anne Blackwood-Chirchir; Feng R. Luo; Oumar Sy; Sanjeev Kaul; Alberto A. Chiappori
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Using precipitation by polyamines as an alternative to chromatographic separation in antibody purification processes
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Junfen Ma; Hai Hoang; Thomas Myint; Thanmaya Peram; Fahrner; Judy H. Chou
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Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Xiao Ding; Bilin Chou; Richard A. Graham; Sravanthi Cheeti; Percey; Matassa; Reuschel; Meng; Liu; Voelker; Bert L. Lum; Patrick J. Rudewicz; Cornelis E. Hop
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A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles
Molecular Biology of the Cell, ISSN: 10591524
Jorge Z. Torres; Kenneth H. Ban; Peter K Jackson
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Restriction of receptor movement alters cellular response: Physical force sensing by EphA2
Science, ISSN: 00368075 10959203
Khalid Salaita; Pradeep Nair; Rebecca S. Petit; Richard M. Neve; Debopriya Das; Joe W. Gray; Jay T. Groves
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CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus
Blood, ISSN: 15280020 00064971
Daniel A. Zlotoff; Arivazhagan Sambandam; Theodore D. Logan; J. Jeremiah Bell; Benjamin A. Schwarz; Avinash Bhandoola
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Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor
Biochemistry, ISSN: 00062960 15204995
Christopher M. Koth; Norzehan Abdul-Manan; Christopher A. Lepre; Peter J. Connolly; Sanghee Yoo; Arun K. Mohanty; Judith A. Lippke; Jacque Zwahlen; Joyce T. Coll; John D. Doran; Miguel Garcia-Guzman; Jonathan M. Moore
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Phospho-regulation of DDA3 function in mitosis
Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104
Chang-Young Jang; Judith A. Coppinger; John R. Yates; Guowei Fang
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Mature dendritic cells use endocytic receptors to capture and present antigens
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Craig D. Platt; Jessica K. Ma; Cecile Chalouni; Melanie Ebersold; Hani Bou-Reslan; Richard A. D. Carano; Ira Mellman; Lélia Delamarre
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Practical applications of quality risk management
BioProcess International, ISSN: 15426319
Mire-Sluis; Emma Ramnarine; Joseph Siemiatkoski; Dan Weese; Patrick Swann; Richard O'Keeffe; Joe Kutza; Julia Edwards; Lorna McLeod
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Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation
DMM Disease Models and Mechanisms, ISSN: 17548403 17548411
Nathalie Ortega; Ke Wang; Napoleone Ferrara; Zena Werb; Thiennu H. Vu
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Membrane transporters in drug development
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Kathleen M. Giacomini; Huang; Donald J. Tweedie; Leslie Z. Benet; Kim L.R. Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M. Hillgren; Keith Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B. Kim; Caroline A. Lee; Mikko Niemi; Polli; Yuichi Sugiyama; Peter W. Swaan; Joseph A. Ware; Stephen H. Wright; Sook Wah Yee; Zamek-Gliszczynski; Lei Zhang
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Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Deepak Sampath; Megan Berry; Georgette M. Castanedo; Zhigang Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Richard Goldsmith; Timothy P. Heffron; Leslie Lee; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Wiesmann; Susan C. Wong; Bing-Yan Zhu
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Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale
Trends in Molecular Medicine, ISSN: 14714914
Anil Bagri; Hosein Kouros-Mehr; Kevin G. Leong; Greg D. Plowman
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Visualization techniques for assessing design factors that affect the interaction between pharmaceutical vials and stoppers
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Philippe Lam; Al Stern
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Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy
Journal of Clinical Investigation, ISSN: 15588238 00219738
John F. O'Toole; Yangjian Liu; Erica E. Davis; Christopher J. Westlake; Massimo Attanasio; Edgar A. Otto; Dominik Seelow; Gudrun Nürnberg; Christian Becker; Matti Nuutinen; Mikko Kärppä; Jaakko Ignatius; Johanna Uusimaa; Salla Pakanen; Elisa Jaakkola; Lambertus P. Van Den Heuvel; Henry Fehrenbach; Roger Wiggins; Meera Goyal; Weibin Zhou; Matthias T. F. Wolf; Eric Wise; Juliana Helou; Susan J. Allen; Carlos A Murga-Zamalloa; Shazia Ashraf; Moumita Chaki; Saskia Heeringa; Gil Chernin; Bethan E. Hoskins; Hassan Chaib; Joseph G. Gleeson; Takehiro Kusakabe; Takako Suzuki; R. Elwyn Isaac; Lynne M. Quarmby; Bryan Tennant; Hisashi Fujioka; Hannu Tuominen; Ilmo Hassinen; Hellevi Lohi; Judith L. Van Houten; Agnes Rotig; John A. Sayer; Boris Rolinski; Peter Freisinger; Sethu M. Madhavan; Martina Herzer; Florence Madignier; Holger Prokisch; Peter Nürnberg; Peter K Jackson; Hemant Khanna; Nicholas Katsanis; Friedhelm Hildebrandt
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Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival
Journal of Neuro-Oncology, ISSN: 0167594X 15737373
Sean McBride; Daniel A. Perez; Mei-Yin Polley; Scott R. VandenBerg; Justin S. Smith; Shichun Zheng; Kathleen R. Lamborn; John K. Wiencke; Susan Chang; Michael D. Prados; Mitchel S. Berger; David Stokoe; Daphne A. Haas-Kogan
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Triple light chain antibodies: Factors that influence its formation in cell culture
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Natalia Gomez; Abigail R Vinson; Jun Ouyang; Mary D. H. Nguyen; Xiaoying Chen; Vikas Sharma; Inn H. Yuk
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Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation
Metabolic Engineering, ISSN: 10967176 10967184
Adam L. Meadows; Rahi Karnik; Harry Lam; Sean Forestell; Snedecor
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Molecular mechanism of the synaptotagmin-SNARE interaction in Ca 2+-triggered vesicle fusion
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Marija Vrljic; Pavel Strop; James A. Ernst; R Bryan Sutton; Steven Chu; Axel T. Brünger
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Metabolic flux analysis and pharmaceutical production
Metabolic Engineering, ISSN: 10967176 10967184
Brett A. Boghigian; Gargi Seth; Robert Kiss; Blaine A. Pfeifer
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