Genentech: Publications

March 1, 2010

Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis

Neurosurgery, ISSN: 0148396X

Mutsumi Nagai; Cigdem Erkuran Yilmaz; Daniel Kirchhofer; Charles T. Esmon; Nigel Mackman; D. Neil Granger

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March 1, 2010

Inferring the functional effects of mutation through clusters of mutations in homologous proteins

Human Mutation, ISSN: 10597794 10981004

Peng Yue; William F. Forrest; Joshua S. Kaminker; Scott Lohr; Zemin Zhang; Guy Cavet

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March 1, 2010

Binding to the extracellular matrix and proteolytic processing: Two key mechanisms regulating vascular endothelial growth factor action

Molecular Biology of the Cell, ISSN: 10591524

Napoleone Ferrara

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March 1, 2010

Genetic dissection of the function of hindbrain axonal commissures

PLoS Biology, ISSN: 15449173 15457885

Nicolas Renier; Martijn Schonewille; Fabrice Giraudet; Aleksandra Badura; Marc Tessier-Lavigne; Paul Avan; Chris I. de Zeeuw; Alain Chedotal

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March 1, 2010

The IL-17 family cytokines in immunity and disease

Journal of Clinical Immunology, ISSN: 02719142 15732592

Rajita Pappu; Vladimir Ramirez-Carrozzi; Naruhisa Ota; Wenjun Ouyang; Yan Hu

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March 1, 2010

Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab

Clinical Cancer Research, ISSN: 10780432

Howard M. Stern; Mary Padilla; Klaus W. Wagner; Lukas Amler; Avi Ashkenazi

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March 1, 2010

The zebrafish as a model organism for the study of apoptosis

Apoptosis, ISSN: 13608185 1573675X

Eimon; Avi Ashkenazi

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February 25, 2010

ALK1 signaling regulates early postnatal lymphatic vessel development

Blood, ISSN: 15280020 00064971

Kyle Niessen; Gu Zhang; John B.B. Ridgway; Hao Chen; Minhong Yan

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February 19, 2010

IFN-α-induced upregulation of CCR5 leads to expanded HIV tropism in vivo

PLoS Pathogens, ISSN: 15537374 15537366

Cheryl A. Stoddart; Mary E. Keir; Joseph M. McCune

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February 19, 2010

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

Cell, ISSN: 00928674

Baris Bingol; Chi-Fong Wang; David Arnott; Dongmei Cheng; Junmin Peng; Morgan Sheng

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February 18, 2010

Rere controls retinoic acid signalling and somite bilateral symmetry

Nature, ISSN: 00280836 14764687

Gonçalo C. Vilhais-Neto; Mitsuji Maruhashi; Karen T. Smith; Mireille Vasseur-Cognet; Andrew S. Peterson; Jerry L. Workman; Olivier Pourquié

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February 18, 2010

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy

Blood, ISSN: 15280020 00064971

Saul J. Priceman; James L. Sung; Zory Shaposhnik; Jeremy B. Burton; Antoni X. Torres-Collado; Diana L. Moughon; Mai Johnson; Aldons J. Lusis; Donald A. Cohen; M. Luisa Iruela-Arispe; Lily Wu

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February 15, 2010

Activation of epithelial STAT3 regulates intestinal homeostasis

Cell Cycle, ISSN: 15514005 15384101

Clemens Neufert; Geethanjali Pickert; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Alexei Nikolaev; Wenjun Ouyang; Markus F. Neurath; Christoph Becker

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February 15, 2010

Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

Journal of Experimental Medicine, ISSN: 00221007 15409538

Natasha K Crellin; Sara Trifari; Charles D. Kaplan; Tom Cupedo; Hergen Spits

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February 15, 2010

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Prescott G. Woodruff; Joseph R. Arron; John V. Fahy

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February 15, 2010

A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies

Clinical Cancer Research, ISSN: 10780432

D. Ross Camidge; Roy S. Herbst; Michael S. Gordon; Gail Eckhardt; Razelle Kurzrock; Blythe Durbin; Josephine Ing; Tanyifor M. Tohnya; Jason Sager; Avi Ashkenazi; Gordon L. Bray; David Mendelson

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February 12, 2010

Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display

Journal of Molecular Biology, ISSN: 00222836

Nathaniel C. Gordon; Samantha Lien; Jeremy Johnson; Heidi J. A. Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Quan; Melissa A. Starovasnik; Sarah G. Hymowitz; Robert F. Kelley

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February 11, 2010

Chronic DLL4 blockade induces vascular neoplasms

Nature, ISSN: 00280836 14764687

Minhong Yan; Christopher Callahan; Joseph Beyer; Krishna P. Allamneni; Gu Zhang; John B.B. Ridgway; Kyle Niessen; Greg D. Plowman

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February 10, 2010

Fast and SNP-tolerant detection of complex variants and splicing in short reads

Bioinformatics, ISSN: 13674803 14602059

Thomas D Wu; Serban Nacu

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February 3, 2010

Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 Message

Toxicological Sciences, ISSN: 10960929 10966080

Phuong Minh Nguyen; Miki Susanto Park; Marilynn Chow; Jae H. Chang; Lisa Wrischnik; William K. Chan

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February 1, 2010

Ixabepilone: Providing new hope for women with breast cancer after anthracycline and taxane failure

Clinical journal of oncology nursing, ISSN: 10921095 1538067X

Alisha Stein

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February 1, 2010

Outlier options: Consider simple parametric tests to find an outlier's significance

Quality Progress, ISSN: 0033524X

Julia E. Seaman; I. Elaine Allen

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February 1, 2010

Editorial overview

Current Opinion in Immunology, ISSN: 09527915

Ira Mellman; Peter Cresswell

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February 1, 2010

Modular architecture of Munc13/calmodulin complexes: Dual regulation by Ca 2 and possible function in short-term synaptic plasticity

EMBO Journal, ISSN: 02614189 14602075

Fernando Rodríguez-Castãeda; Mitcheell Maestre-Martínez; Nicolas Coudevylle; Kalina Dimova; Harald Junge; Noa Lipstein; Donghan Lee; Stefan Becker; Nils Brose; Olaf Jahn; Teresa Carlomagno; Christian Griesinger

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February 1, 2010

Bioavailability in healthy adults of efavirenz capsule contents mixed with a small amount of food

American Journal of Health-System Pharmacy, ISSN: 15352900 10792082

Sanjeev Kaul; Ping Ji; Michael W. Lu; Kim L. Nguyen; Tong Shangguan; Dennis Grasela

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February 1, 2010

Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture

PLoS Computational Biology, ISSN: 1553734X 15537358

Ju Han; Hang Chang; Orsi Giricz; Genee Y. Lee; Frederick L. Baehner; Joe W. Gray; Mina J. Bissell; Paraic A. Kenny; Bahram Parvin

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February 1, 2010

Targeting the tumor microenvironment with Src kinase inhibition

Clinical Cancer Research, ISSN: 10780432

Alicia S Chung; Napoleone Ferrara

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February 1, 2010

BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Gregory J. Cost; Yevgeniy Freyvert; Annamaria Vafiadis; Yolanda Santiago; Jeffrey C. Miller; Edward J. Rebar; Trevor N. Collingwood; Andrew Snowden; Philip D. Gregory

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February 1, 2010

Pathways mediating VEGF-independent tumor angiogenesis

Cytokine and Growth Factor Reviews, ISSN: 13596101

Napoleone Ferrara

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February 1, 2010

Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following Rituximab treatment in systemic lupus erythematosus

Lupus, ISSN: 09612033

Tew; Rabbee; Kristen Wolslegel; Hsin-Ju Hsieh; John G. Monroe; Timothy W. Behrens; Paul Brunetta; Mary E. Keir

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February 1, 2010

Active, but not passive cigarette smoking was inversely associated with mammographic density

Cancer Causes and Control, ISSN: 09575243 15737225

Lesley Butler; Ellen B. Gold; Shannon M. Conroy; Carolyn J. Crandall; Gail A. Greendale; Nina Oestreicher; Charles P. Quesenberry Jr.; Laurel A. Habel

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February 1, 2010

Small-molecule pan-IAP antagonists: A patent review

Expert Opinion on Therapeutic Patents, ISSN: 13543776

Flygare; Wayne J. Fairbrother

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February 1, 2010

Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Greenberg; Reed; Joel M. Kremer; Tindall; Arthur Kavanaugh; Zheng; Bishai; Hochberg

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February 1, 2010

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

Cancer Research, ISSN: 00085472 15387445

Kyle A. Edgar; Jeffery J. Wallin; Megan Berry; Leslie Lee; Wei Wei Prior; Deepak Sampath; Lori S. Friedman; Marcia Belvin

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January 29, 2010

Understanding and mitigating conductivity transitions in weak cation exchange chromatography

Journal of Chromatography A, ISSN: 00219673

Jace Fogle; Jenny Hsiung

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January 25, 2010

Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo

PLoS ONE, ISSN: 19326203

Osigwe Esue; Laura Rupprecht; Sean X. Sun; Denis Wirtz

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January 22, 2010

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

Cell, ISSN: 00928674

Beate M. Lichtenberger; Poi Kiang Tan; Heide Niederleithner; Napoleone Ferrara; Peter Petzelbauer; Maria Sibilia

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January 19, 2010

Utilization of lysozyme charge ladders to examine the effects of protein surface charge distribution on binding affinity in ion exchange systems

Langmuir, ISSN: 07437463

Wai Keen Chung; Steven T. Evans; Alexander S. Freed; James J. Keba; Zachary C. Baer; Kaushal Rege; Steven M. Cramer

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January 19, 2010

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

Developmental Cell, ISSN: 15345807

Ann C. Zovein; Alfonso Luque; Kirsten A. Turlo; Jennifer J. Hofmann; Kathleen M. Yee; Michael S. Becker; Reinhard Fässler; Ira Mellman; Timothy F. Lane; M. Luisa Iruela-Arispe

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January 19, 2010

Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells

PLoS ONE, ISSN: 19326203

Bob Y. Liu; Soloviev; Peter Chang; John Lee; Xiaodong Huang; Cuiling Zhong; Napoleone Ferrara; Paul G. Polakis; Sakanaka

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January 19, 2010

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

Developmental Cell, ISSN: 15345807

Eric Camerer; Adrian Barker; Daniel N. Duong; Rajkumar Ganesan; Hiroshi Kataoka; Ivo Cornelissen; Molly R. Darragh; Arif Hussain; Yao-Wu Zheng; Yoga Srinivasan; Christopher Brown; Shan-Mei Xu; Jean B. Regard; Chen-Yong Lin; Charles S. Craik; Daniel Kirchhofer; Shaun R. Coughlin

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January 18, 2010

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

Journal of Experimental Medicine, ISSN: 00221007 15409538

Hongkang Xi; Kenneth J. Katschke Jr.; Karim Y. Helmy; Paige A. Wark; Noelyn Kljavin; Hilary F. Clark; Jeffrey Eastham-Anderson; Theresa Shek; Merone Roose-Girma; Nico Ghilardi; Menno Van Lookeren Campagne

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January 15, 2010

Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis

Journal of Immunology, ISSN: 00221767 15506606

Nadine Kassner; Manuela Krueger; Hideo Yagita; Andrzej Dzionek; Andreas Hutloff; Richard Kroczek; Alexander Scheffold; Sascha Rutz

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January 15, 2010

Reversing HOXA9 oncogene activation by PI3K inhibition: Epigenetic mechanism and prognostic significance in human glioblastoma

Cancer Research, ISSN: 00085472 15387445

Bruno M. Costa; Justin S. Smith; Ying Chen; Justin Chen; Phillips; Kenneth D. Aldape; Giuseppe Zardo; Janice M. Nigro; C. David James; Jane Fridlyand; Rui M. Reis; Joseph F. Costello

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January 15, 2010

Corrigendum to "GDC-0449-A potent inhibitor of the hedgehog pathway" [Bioorg. Med. Chem. Lett. 19 (2009) 5576] (DOI:10.1016/j.bmcl.2009.08.049)

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie

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January 11, 2010

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3

Journal of Cell Biology, ISSN: 00219525 00219525

Yunling Xu; Li Yuan; Judy Mak; Luc Pardanaud; Maresa Caunt; Ian Kasman; Bruno Larrivee; Raquel del Toro; Steven Suchting; Alexander Medvinsky; Jillian Silva; Jian Yang; Jean-Léon Thomas; Alexander W. Koch; Kari Alitalo; Anne Eichmann; Anil Bagri

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January 8, 2010

Industrial case study: Evaluation of a mixed-mode resin for selective capture of a human growth factor recombinantly expressed in E. coli

Journal of Chromatography A, ISSN: 00219673

Kimberly A. Kaleas; Charles H. Schmelzer; Shelly A. Pizarro

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January 8, 2010

Four-component synthesis of fully substituted 1,2,4-triazoles

Angewandte Chemie - International Edition, ISSN: 14337851

Steven T. Staben; Nicole Blaquiere

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January 7, 2010

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Nature, ISSN: 00280836 14764687

Martin Schwickart; Xiaodong Huang; Jennie R. Lill; Jinfeng Liu; Ron Ferrando; French; Heather Maecker; Karen M. O'Rourke; J.Fernando Bazan; Jeffrey Eastham-Anderson; Peng Yue; David Dornan; David C.S. Huang; Vishva M. Dixit

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January 1, 2010

Targeting inhibitor of apoptosis (IAP) proteins in cancer

Apoptosis: Modern Insights into Disease from Molecules to Man,

Eugene Varfolomeev; Domagoj Vucic

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