Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8951 - 9000 OF 16484 RESULTS

January 22, 2012

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Nature Medicine, ISSN: 1546170X 10788956

Clara Montagut; Alba Dalmases; Beatriz Bellosillo; Marta Crespo; Silvia Pairet; Mar Iglesias; Marta Salido; Manuel Gallen; Scot A. Marsters; Siao Ping Tsai; André Minoche; Somasekar Seshagiri; Sergi Serrano; Heinz Himmelbauer; Joaquim Bellmunt; Ana Rovira; Jeffrey Settleman; Francesc Bosch; Joan Albanell

January 19, 2012

Heteroarylation of azine N-oxides

Organic Letters, ISSN: 15237052 15237060

Francis Gosselin; Scott Savage; Nicole Blaquiere; Steven T. Staben

January 17, 2012

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

Developmental Cell, ISSN: 15345807 18781551

Linda N. Geng; Zizhen Yao; Lauren Snider; Abraham P. Fong; Jennifer N. Cech; Janet M. Young; Silvere M. vanderMaarel; Walter L. Ruzzo; Robert Gentleman; Rabi Tawil; Stephen J. Tapscott

January 16, 2012

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

NeuroImage, ISSN: 10538119 10959572

Benjamin M. Ellingson; Timothy Cloughesy; Whitney B. Pope; Taryar M. Zaw; Phillips; Shadi Lalezari; Phioanh L. Nghiemphu; Hassana Ibrahim; Kourosh M. Naeini; Robert J. Harris; Albert Lai

January 16, 2012

NMDA receptors and BAX are essential for Aβ impairment of LTP

Scientific Reports, ISSN: 20452322

Kimberly Moore Olsen; Morgan Sheng

January 15, 2012

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: Implications for androgen- deprivation therapy

Cancer Research, ISSN: 00085472 15387445

Yuting Sun; Bu-Er Wang; Kevin G. Leong; Peng Yue; Li Li; Suchit Jhunjhunwala; Darrell Chen; Kyounghee Seo; Zora Modrusan; Gao; Jeffrey Settleman; Leisa Johnson

January 15, 2012

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Li Ren; Ellen R. Laird; Alexandre J. Buckmelter; Victoria Dinkel; Susan L. Gloor; Jonas Grina; Bradley J. Newhouse; Kevin Rasor; Gregg Hastings; Stefan Gradl; Joachim Rudolph

January 15, 2012

Pyrazolopyridine inhibitors of B-Raf V600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Steve Wenglowsky; David Moreno; Joachim Rudolph; Yingqing Ran; Kateri Ahrendt; Alisha Arrigo; Ben Colson; Susan L. Gloor; Gregg Hastings

January 15, 2012

Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Baselga; Javier Cortés; Sung-Bae Kim; Seock-Ah Im; Roberto Hegg; Im; Laslo Roman; José Luiz Pedrini; Tadeusz Pienkowski; Adam Knott; Emma Clark; Benyunes; Graham Ross; Sandra M. Swain

January 15, 2012

A secreted protein microarray platform for extracellular protein interaction discovery

Analytical Biochemistry, ISSN: 10960309 00032697

Sree R. Ramani; Irene Tom; Nicholas Lewin-Koh; Bernd Wranik; Laura DePalatis; Jianjun Zhang; Dan L. Eaton; Lino C. Gonzalez Jr.

January 14, 2012

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

BMC Cancer, ISSN: 14712407

Carolyn D. Britten; Antoinette S. Gomes; Zev A. Wainberg; David Elashoff; Rafael Amado; Yan Xin; Ronald W. Busuttil; Dennis J. Slamon; Richard S. Finn

January 13, 2012

Separation-Based Analytical Methods for Measuring Protein Aggregation

Analysis of Aggregates and Particles in Protein Pharmaceuticals,

Jun Liu; Barthélemy Demeule; Steven J. Shire

January 12, 2012

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C

PLoS ONE, ISSN: 19326203

Robert Mintzer; Sreemathy Ramaswamy; Kinjalkumar Shah; Rami N. Hannoush; Christine D. Pozniak; Frederick Cohen; Xianrui Zhao; Emile G. Plise; Joe Lewcock; Christopher E. Heise

January 11, 2012

Genetic analysis of DSCAM'S role as a netrin-1 receptor in vertebrates

Journal of Neuroscience, ISSN: 02706474 15292401

Elena Palmesino; Patrick C. G. Haddick; Marc Tessier-Lavigne; Artur Kania

January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

January 11, 2012

Single electron transfer (SET) activity of the dialkyl-amido sodium zincate [(TMEDA)·Na(μ-TMP)(μ-tBu)Zn(tBu)] towards TEMPO and chalcone

Chemical Communications, ISSN: 1364548X 13597345

Armstrong; Balloch; James J. Crawford; Ben J. Fleming; Hogg; Alan R. Kennedy; Jan Klett; Mulvey; Charles T. O’Hara; Samantha A. Orr; Robertson

January 8, 2012

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: Results of a phase I randomized, placebo-controlled trial

Arthritis Research and Therapy, ISSN: 14786354 14786362

Brinda Emu; Diana Luca; Carolyn Offutt; Jane L. Grogan; Bernadette Rojkovich; Marna Williams; Meina Tao Tang; Jim J. Xiao; June H. Lee; John C. Davis

January 6, 2012

Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis

Science, ISSN: 10959203 00368075

Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin

January 6, 2012

Capillary size exclusion chromatography with picogram sensitivity for analysis of monoclonal antibodies purified from harvested cell culture fluid

Journal of Chromatography A, ISSN: 18733778 00219673

Jennifer C. Rea; G. Tony Moreno; Lisa Vampola; Yun Lou; Bjorn Van Haan; Guillaume Tremintin; Laura C. Simmons; Adrian Nava; Yajun Jennifer Wang; Dell Farnan

January 6, 2012

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold

Journal of Molecular Biology, ISSN: 10898638 00222836

Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel

January 5, 2012

Regulation of mitosis and taxane response by Daxx and Rassf1

Oncogene, ISSN: 09509232 14765594

Giovinazzi; Lindsay; Morozov; Escobar-Cabrera; Matthew K. Summers; Han; McIntosh; Ishov

January 1, 2012

Evaluation of time-dependent cytochrome P450 inhibition in a high-throughput, automated assay: Introducing a novel area under the curve shift approach

Drug Metabolism Letters, ISSN: 18723128

Sophie Mukadam; Suzanne Tay; Daniel Tran; Leslie Wang; Erlie Marie Delarosa; S. Cyrus Khojasteh; Jason S Halladay; Jane R. Kenny

January 1, 2012

Phase i clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma

Investigational New Drugs, ISSN: 15730646 01676997

Jason Konner; Rachel N. Grisham; Jae Park; Owen A. O'Connor; Gillian Cropp; Robert Johnson; Alison L. Hannah; Martee L. Hensley; Paul Sabbatini; Svetlana Miranov; Samuel Danishefsky; David Hyman; David R. Spriggs; Jakob Dupont; Carol Aghajanian

January 1, 2012

Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Mayumi Bowen; Nick Armstrong; Maa

January 1, 2012

Variable selection in multivariate modeling of drug product formula and manufacturing process

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Xiling Song; King Chuang; Venkatramani; Sueanne Lee; Gregory Gallegos; Thirunellai Venkateshwaran; Minli Xie

January 1, 2012

Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokinetics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

January 1, 2012

Erratum:Ungersma et al., vessel imaging with viable tumor analysis for quantification of tumor angiogenesis.(Magnetic Resonance in Medicine 2010 63 (1637-1647))

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Sharon E. Ungersma; Glenn Pacheco; Calvin Ho; Sharon Fong Yee; Ross; Nicholas Van Bruggen; Franklin V. Peale Jr.; Ross; Richard A. D. Carano

January 1, 2012

Bevacizumab maintenance in patients with advanced non-small-cell lung cancer, clinical patterns, and outcomes in the eastern cooperative oncology group 4599 study: Results of an exploratory analysis

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Ariel Lopez-Chavez; Todd Young; Sophie Fages; Larry Leon; Joan H. Schiller; Afshin Dowlati; Julie Brahmer; David H. Johnson; Alan Sandler

January 1, 2012

Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Cornelis E. Hop; Quynh Ho; Jason S Halladay; Sami Haddad; Jane R. Kenny

January 1, 2012

Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ozan S. Kumru; Jun Liu; Junyan A. Ji; Wilson Cheng; Y. John Wang; Tingting Wang; Sangeeta B. Joshi; C. Russell Middaugh; David B. Volkin

January 1, 2012

A phase i study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Sarah B. Goldberg; Jeffrey G. Supko; Joel W. Neal; Alona Muzikansky; Subba Digumarthy; Panos Fidias; Jennifer S. Temel; Rebecca S. Heist; Alice T. Shaw; Patricia O. McCarthy; Thomas J. Lynch; Sreenath Sharma; Jeffrey Settleman; Lecia V. Sequist

January 1, 2012

Determination of hepatic clearance with the account of drug-protein binding kinetics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

January 1, 2012

Effects of commercial air travel on patients with pulmonary hypertension

Chest, ISSN: 19313543 00123692

Nareg Roubinian; C. Gregory Elliott; Christopher F. Barnett; Paul D. Blanc; Joan Chen; Teresa De Marco; Hubert Chen

January 1, 2012

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

PLoS ONE, ISSN: 19326203

French; Benjamin C. Lin; Manping Wang; Adams; Theresa Shek; Kathy Hötzel; Brad Bolon; Ron Ferrando; Craig Blackmore; Kurt A. Schroeder; Luis A Rodriguez; Maria Hristopoulos; Rayna Venook; Avi Ashkenazi; Luc Desnoyers

January 1, 2012

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Guiquan Jia; Erickson; David F. Choy; Mosesova; Lawren C. Wu; Owen D. Solberg; Aarti Shikotra; Richard Carter; Séverine Audusseau; Qutayba Hamid; Peter Bradding; John V. Fahy; Prescott G. Woodruff; Harris; Joseph R. Arron

January 1, 2012

Rheumatoid arthritis and the incidence of influenza and influenza-related complications: A retrospective cohort study

BMC Musculoskeletal Disorders, ISSN: 14712474

William A. Blumentals; Anna Arreglado; Pavel Napalkov; Stephen Toovey

January 1, 2012

An 'all-inclusive' 96-well cytochrome P450 induction method: Measuring enzyme: Activity, mrna levels, protein levels, and cytotoxicity from one well using: Cryopreserved human hepatocytes

Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719

Jason S Halladay; Susan C. Wong; S. Cyrus Khojasteh; Susan Grepper

January 1, 2012

The potential clinical relevance of visible particles in parenteral drugs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Lucette Doessegger; Hanns-Christian Mahler; Piotr Szczesny; Helmut Rockstroh; Georg Kallmeyer; Anja Langenkamp; Joerg Herrmann; Joseph Famulare

January 1, 2012

Key findings and clinical implications from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Bradley E. Chipps; Robert S. Zeiger; Larry Borish; Sally E. Wenzel; Ashley Yegin; Mary Lou Hayden; Dave P. Miller; Eugene R. Bleecker; F. Estelle R. Simons; Stanley J. Szefler; Weiss; Tmirah Haselkorn

January 1, 2012

Mechanisms of acquired resistance to targeted cancer therapies

Future Oncology, ISSN: 17448301 14796694

Lackner; Wilson; Jeffrey Settleman

January 1, 2012

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

Journal of Pathology, ISSN: 10969896 00223417

Mallika Singh; Suzana Couto; William F. Forrest; Anthony Lima; Jason H. Cheng; Rafael Molina; Jason E. Long; Patricia Hamilton; Angela McNutt; Ian Kasman; Michelle Nannini; Hani Bou-Reslan; Tim C. Cao; Calvin Ho; Kai H. Barck; Richard A. D. Carano; Oded Foreman; Jeffrey Eastham-Anderson; Adrian M. Jubb; Napoleone Ferrara; Leisa Johnson

January 1, 2012

The power of FDG PET to detect treatment effects is increased by glucose correction using a Michaelis constant

EJNMMI Research, ISSN: 2191219X

Simon P. Williams; Judith E. Flores; Andreas R. Baudy; Ruediger E. Port; Thomas Bengtsson

January 1, 2012

Quantitation of glucose uptake in tumors by dynamic FDG-PET has less glucose bias and lower variability when adjusted for partial saturation of glucose transport

EJNMMI Research, ISSN: 2191219X

Simon P. Williams; Judith E. Flores; Ruediger E. Port; Thomas Bengtsson

January 1, 2012

FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

EJNMMI Research, ISSN: 2191219X

Andreas R. Baudy; Taner Dogan; Judith E. Flores; Klaus P. Hoeflich; Fei Su; Nicholas Van Bruggen; Simon P. Williams

January 1, 2012

Symptom burden & quality of life among patients receiving second-line treatment of metastatic colorectal cancer

BMC Research Notes, ISSN: 17560500

Mark S. Walker; Elaine B. Yu; Jiandong Kerr; Yeun Mi Yim; Edward J. Stepanski; Lee S. Schwartzberg

January 1, 2012

On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenate

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

January 1, 2012

Phase II study of eribulin mesylate (E7389) in patients with metastatic castration-resistant prostate cancer stratified by prior taxane therapy

Annals of Oncology, ISSN: 15698041 09237534

De Bono; Molife; Guru Sonpavde; Pablo Maroto; Calvo; Cartwright; Loesch; Feit; Asha Das; Zang; Wanders; Agoulnik; Petrylak

January 1, 2012

Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis

mBio, ISSN: 21507511

Tien-Huei Hsu; Irene W. Althaus; Oded Foreman; Katherine R. Spindlera

January 1, 2012

Applying Nonexperimental Study Approach to Analyze Historical Batch Data

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yong Cui; Xiling Song; King Chuang; Minli Xie

January 1, 2012

Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain

Current Molecular Medicine, ISSN: 18755666 15665240

Shelby K. Wyatt; H. Charles Manning; Mingfeng Bai; Moneeb Ehtesham; Khubaib Y. Mapara; Reid C. Thompson; Darryl J. Bornhop

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