Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8951 - 9000 OF 15394 RESULTS

Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.
BMC Cancer, ISSN: 14712407
Erich P. Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington
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Pharmaceutical Medical Information Contact Centers: Results of Three Benchmarking Surveys
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Pete Guillot; Stacey M. Fung
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Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model
British Journal of Dermatology, ISSN: 13652133 00070963
Wang; Fujita; Prado; Tousson; Hsu; Arndt J Schottelius; Kelly; Yang; Wu; Chen; Xu; Elmets; Mountz; Edwards Iii
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Single-use technology and its carbon and water footprints, part 2: "Bioreactors - To be or not to be: That is the question"
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Satish K. Singh; Nataliya Afonina; Michel Awwad; Karoline Bechtold-Peters; Jeffrey T. Blue; Danny Chou; Cromwell; Hans-Juergen Krause; Hanns-Christian Mahler; Brian K. Meyer; Linda O. Narhi; Doug P. Nesta; Thomas Spitznagel
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A generic headspace GC method for residual solvents in pharmaceuticals: Benefits, rationale, and adaptations for new chemical entities
LCGC North America, ISSN: 15275949
Lulu Dai; Amanda C. Quiroga; Kelly Zhang; Heather B. Runes; Derrick T. Yazzie; Kavita Mistry; Nik P. Chetwyn; Michael W. Dong
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Cancer: MiRNA addiction - Depending on life's little things
Current Biology, ISSN: 09609822
David Dornan; Jeffrey Settleman
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Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia
Journal of Immunology, ISSN: 15506606 00221767
Lamkanfi; Anasuya Sarkar; Vande Walle; Alberto C. Vitari; Amal O. Amer; Mark D. Wewers; Kevin J. Tracey; Thirumala-Devi Kanneganti; Vishva M. Dixit
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The conserved bardet-biedl syndrome proteins assemble a coat that traffics membrane proteins to Cilia
Cell, ISSN: 00928674
Hua Jin; Susan Roehl White; Toshinobu Shida; Stefan Schulz; Mike Aguiar; Steven P. Gygi; J.Fernando Bazan; Maxence V. Nachury
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B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity
Annals of Neurology, ISSN: 15318249 03645134
Martin Weber; Thomas Prod'homme; Juan C. Patarroyo; Nicolas Molnarfi; Tara Karnezis; Klaus Lehmann-Horn; Dimitry Danilenko; Jeffrey Eastham-Anderson; Anthony J. Slavin; Christopher Linington; Claude C.A. Bernard; Flavius Martin; Scott S. Zamvil
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A two-stage algorithm for designing phase I cancer clinical trials for two new molecular entities
Contemporary Clinical Trials, ISSN: 15517144
Zheng Su
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Immunization responses in rheumatoid arthritis patients treated with rituximab: Results from a controlled clinical trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
Bingham; R. John Looney; Deodhar; Neal Halsey; Maria Greenwald; Christine Codding; Benjamin L. Trzaskoma; Flavius Martin; Sunil Agarwal; Ariella Kelman
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Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
Clinical Cancer Research, ISSN: 10780432
William P. Tew; Michael S. Gordon; John Murren; Jakob Dupont; Sandra Pezzulli; Carol Aghajanian; Paul Sabbatini; David Mendelson; Lawrence Schwartz; Scott Gettinger; Amanda Psyrri; Jesse M. Cedarbaum; David R. Spriggs
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Guidelines for reporting the use of capillary electrophoresis in proteomics
Nature Biotechnology, ISSN: 15461696 10870156
Paula J. Domann; Satoko Akashi; Coral Barbas; Lihua Huang; Wendy Lau; Cristina Legido-Quigley; Stephen McClean; Christian Neusü; David Perrett; Milena Quaglia; Erdmann Rapp; Lance Smallshaw; Norman W. Smith; W Franklin Smyth; Chris Taylor
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Cell culture monitoring via an auto-sampler and an integrated multi-functional off-line analyzer
Biotechnology Progress, ISSN: 87567938 15206033
Gayle E. Derfus; Daniel Abramzon; Meg Tung; David Chang; Robert Kiss; Ashraf Amanullah
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Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways
Expert Review of Molecular Diagnostics, ISSN: 14737159 17448352
Lackner
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Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Chee Ng; Shuang Bai; Takimoto; Meina Tao Tang; Anthony W. Tolcher
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Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry
Journal of Mass Spectrometry, ISSN: 10765174 10969888
Jennifer Zhang; Hongbin Liu; Viswanatham Katta
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Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection
Journal of Drug Targeting, ISSN: 1061186X 10292330
Daugherty; Mrsny
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AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
British Journal of Pharmacology, ISSN: 14765381 00071188
Joel R. Gever; Rothschild Soto; Robert A. Henningsen; Renee S. Martin; David Hackos; Sandip Panicker; Rubas; Ian B. Oglesby; Michael P. Dillon; Marcos E. Milla; Geoffrey Burnstock; Anthony P. D. W. Ford
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Purification and characterization of a motility initiating protein from caprine epididymal plasma
Journal of Cellular Physiology, ISSN: 00219541
Bijay S. Jaiswal; Kaushik Das; Sudipta Saha; Sandhya Rekha Dungdung; Gopal C. Majumder
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Poor disease control among insured users of high-dose combination therapy for asthma
Allergy and Asthma Proceedings, ISSN: 10885412 15396304
Michael S. Broder; Eunice Chang; Tripthi V. Kamath; Sandhya Sapra
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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells
Trends in Molecular Medicine, ISSN: 14714914
Liyun Sang; James M. Roberts; Hilary A. Coller
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Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
Arthritis and Rheumatism, ISSN: 00043591 15290131
Merrill; C. Michael Neuwelt; Daniel J. Wallace; Joseph C. Shanahan; Latinis; James C. Oates; Tammy O. Utset; Gordon; David A. Isenberg; Hsin-Ju Hsieh; David Zhang; Paul Brunetta
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Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: Insights into rational drug design and activity regulation
Chemical Biology and Drug Design, ISSN: 17470285 17470277
Alan K. Kutach; Armando G. Villaseñor; Diana Lam; Charles Belunis; Cheryl Janson; Stephen Lok; Li-Na Hong; Chao-Min Liu; Jerome Deval; Thomas J. Novak; Jim W. Barnett; Wei Chu; David Shaw; Andreas Kuglstatter
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Regulation of death receptor signaling by the ubiquitin system
Cell Death and Differentiation, ISSN: 13509047 14765403
Ingrid E. Wertz; Vishva M. Dixit
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Long-term safety of recombinant human growth hormone in children
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Jennifer J. Bell; Parker; Rita D. Swinford; Andrew R. Hoffman; Thomas J. Maneatis; Barbara M. Lippe
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Therapeutic strategies within the ubiquitin proteasome system
Cell Death and Differentiation, ISSN: 13509047 14765403
Adam G. Eldridge; Thomas O'Brien
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Bevacizumab safety in patients with central nervous system metastases
Clinical Cancer Research, ISSN: 10780432
Benjamin Besse; Susan F. Lasserre; Peter Compton; Jane E. Huang; Stella Augustus; Ulrich-Peter Rohr
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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
Cancer Cell, ISSN: 15356108
Jian-Bin Wang; Jon W. Erickson; Reina N. Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F. Wilson; Andre L.B. Ambrosio; Sandra M.G. Dias; Chi V. Dang; Richard A. Cerione
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Cold denaturation of monoclonal antibodies
mAbs, ISSN: 19420862
Kristi L. Lazar; Thomas W. Patapoff; Vikas Sharma
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A multigene predictor of outcome in glioblastoma
Neuro-Oncology, ISSN: 15228517 15235866
Howard Colman; Li Zhang; Erik P. Sulman; J. Matthew McDonald; Nasrin Latif Shooshtari; Andreana Rivera; Sonya Popoff; Catherine L. Nutt; David N. Louis; J. Gregory Cairncross; Mark R. Gilbert; Phillips; Minesh P. Mehta; Arnab Chakravarti; Christopher E. Pelloski; Krishna P.L. Bhat; Burt G. Feuerstein; Robert B. Jenkins; Kenneth D. Aldape
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Psychological effects of patient surge in large-scale emergencies: A quality improvement tool for hospital and clinic capacity planning and response
Prehospital and Disaster Medicine, ISSN: 19451938 1049023X
Lisa S. Meredith; James L. Zazzali; Sandra Shields; David P. Eisenman; Halla Alsabagh
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A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood-tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Cardiovascular events associated with ipratropium bromide in COPD
Chest, ISSN: 19313543 00123692
Sarika S. Ogale; Todd A. Lee; David H. Au; Denise M. Boudreau; Sean D. Sullivan
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A mouse knockout library for secreted and transmembrane proteins
Nature Biotechnology, ISSN: 15461696 10870156
Tracy Tzu-Ling Tang; Li Li; Zhijun Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark J. Solloway; Leon Parker; Weilan Ye; William F. Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Godowski; Kathleen H. Holt; Andrew S. Peterson; Brian P. Zambrowicz; Frederic J. De Sauvage
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Comparative biotransformation of pyrazinone-containing corticotropin- releasing factor receptor-1 antagonists: Minimizing the reactive metabolite formation
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xiaoliang Zhuo; Richard A. Hartz; Joanne J. Bronson; Harvey Wong; Vijay T. Ahuja; Vivekananda M. Vrudhula; John E. Leet; Stella Huang; John E. Macor; Yue-Zhong Shu
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Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642
Beat A. Kaufmann; Chad L. Carr; J. Todd Belcik; Aris Xie; Yue Qi; Scott Chadderdon; Evan S. Caplan; Jaspreet Khangura; Sherron Bullens; Bunting; Jonathan R. Lindner
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Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials
Journal of Rheumatology, ISSN: 0315162X
Ronald Van Vollenhoven; Paul Emery; Bingham; Edward Keystone; Roy Fleischmann; Daniel E. Furst; Katherine Macey; Marianne Sweetser; Ariella Kelman; Rao Ravi
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Specific interactions in high concentration antibody solutions resulting in high viscosity
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sandeep Yadav; Jun Liu; Steven J. Shire; Devendra S. Kalonia
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Safety and efficacy of combining sunitinib with bevacizumab + paclitaxel/carboplatin in non-small cell lung cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Mark A. Socinski; Frank A. Scappaticci; Meghna Samant; Margaret M. Kolb; Kozloff
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Secretory Cell Hyperplasia and Defects in Notch Activity in a Mouse Model of Leukocyte Adhesion Deficiency Type II
Gastroenterology, ISSN: 00165085
Christopher C.M. Waterhouse; Steven Johnson; Mia Phillipson; Lori Zbytnuik; Björn Petri; Margaret Kelly; John Lowe; Paul Kubes
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Signaling to NF-kappaB: regulation by ubiquitination.
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Ingrid E. Wertz; Vishva M. Dixit
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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the hedgehog pathway inhibitor GDC-0449 in dogs: An investigation using preclinical studies and physiologically based pharmacokinetic modeling
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Harvey Wong; Frank-Peter Theil; Yong Cui; James C. Marsters Jr.; S. Cyrus Khojasteh; Laurent Vernillet; Hank La; Xiling Song; Hong Wang; Eric Morinello; Yuzhong Deng; Cornelis E. Hop
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On the influence of protein binding on pharmacological activity of drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Leonid M. Berezhkovskiy
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Vision-Related Function after Ranibizumab Treatment by Better- or Worse-Seeing Eye. Clinical Trial Results from MARINA and ANCHOR
Ophthalmology, ISSN: 01616420
Neil M. Bressler; Tom S. Chang; Ivan J. Suñer; Jennifer T. Fine; Chantal M. Dolan; James Ward; Tsontcho Ianchulev
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PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Cell, ISSN: 00928674
Carlos Bais; Xiumin Wu; Jenny Yao; Suya Yang; Yongping Crawford; Krista McCutcheon; Christine Tan; Ganesh Kolumam; Jean-Michel Vernes; Jeffrey Eastham-Anderson; Peter Haughney; Marcin Kowanetz; Thijs Hagenbeek; Ian Kasman; Hani Bou-Reslan; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Yu-Ju Gloria Meng; Hongo; Jean-Philippe Stephan; Masabumi Shibuya; Napoleone Ferrara
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Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors
American Journal of Pathology, ISSN: 15252191 00029440
Seth B. Coffelt; Claire E. Lewis; Luigi Naldini; J. Martin Brown; Napoleone Ferrara; Michele De Palma
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Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization
Analytical Biochemistry, ISSN: 10960309 00032697
Brian D. Connolly; Thomas W. Patapoff; Y. John Wang; Jamie M. R. Moore; Tim J. Kamerzell
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Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels
American Journal of Pathology, ISSN: 15252191 00029440
Weon-Kyoo You; Ian Kasman; Dana D. Hu-Lowe; Donald M. McDonald
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