Genentech: Publications

November 1, 2009

Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung

Pediatric Pulmonology, ISSN: 87556863 10990496

Fernando Urrego; Mario Scuri; Alexander Auais; Lida Mohtasham; Giovanni Piedimonte

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November 1, 2009

Targeting inhibitor of apoptosis proteins for therapeutic intervention

Future Medicinal Chemistry, ISSN: 17568919

Chudi O. Ndubaku; Frederick Cohen; Eugene Varfolomeev; Domagoj Vucic

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November 1, 2009

Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance

Journal of Virology, ISSN: 0022538X

Madhavi Kolli; Eric Stawiski; Colombe Chappey; Celia A. Schiffer

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November 1, 2009

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4- (methylsulfonyl)benzamide), an orally bioavailable systemic hedgehog signalling pathway inhibitor

Xenobiotica, ISSN: 00498254 13665928

Harvey Wong; Jacob Z. Chen; Bilin Chou; Jason S Halladay; Jane R. Kenny; Hank La; James C. Marsters Jr.; Emile G. Plise; Patrick J. Rudewicz; Kirk D. Robarge; Young G. Shin; Susan C. Wong; Chenghong Zhang; S. Cyrus Khojasteh

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November 1, 2009

Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

mAbs, ISSN: 19420862

Claire L. Dobson; Sarah Main; Philip Newton; Matthieu Chodorge; Karen Cadwallader; Robin Humphreys; Albert; Tristan J. Vaughan; Ralph R. Minter; Bryan M. Edwards

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November 1, 2009

Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides

Pharmaceutical Research, ISSN: 07248741 1573904X

Andrew Kosky; Vasumathi Dharmavaram; Gayathri Ratnaswamy; Mark C. Manning

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November 1, 2009

Carboxylate-dependent gelation of a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Osigwe Esue; Sonoko Kanai; Jun Liu; Thomas W. Patapoff; Steven J. Shire

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November 1, 2009

Charge-based analysis of antibodies with engineered cysteines: From multiple peaks to a single main peak

mAbs, ISSN: 19420862

Xiaoying Chen; Mary D. H. Nguyen; Fred Jacobson; Jun Ouyang

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November 1, 2009

Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: Insights from imaging

Clinical Cancer Research, ISSN: 10780432

James P.B. O'Connor; Richard A. D. Carano; Andrew R. Clamp; Ross; Calvin Ho; Alan Jackson; Geoff J. M. Parker; Chris J. Rose; Franklin V. Peale Jr.; Michel Friesenhahn; Claire L. Mitchell; Yvonne Watson; Caleb Roberts; Lynn Hope; Sue Cheung; Hani Bou-Reslan; MaryAnn Go; Glenn Pacheco; Xiumin Wu; Tim C. Cao; Ross; Giovanni A. Buonaccorsi; Karen Davies; Jurjees Hasan; Paula Thornton; Olivia Del Puerto; Napoleone Ferrara; Nicholas Van Bruggen; Gordon C. Jayson

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November 1, 2009

A novel alginate hollow fiber bioreactor process for cellular therapy applications

Biotechnology Progress, ISSN: 87567938

Corinne A. Hoesli; Minh Luu; James M. Piret

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October 30, 2009

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

Cell, ISSN: 00928674

Julie A. Siegenthaler; Amir M. Ashique; Konstantinos Zarbalis; Katelin P. Patterson; Jonathan H. Hecht; Maureen A. Kane; Alexandra E. Folias; Youngshik Choe; Scott R. May; Tsutomu Kume; Joseph L. Napoli; Andrew S. Peterson; Samuel J. Pleasure

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October 29, 2009

Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623

Michael B. Plewe; Scott L. Butler; Klaus R. Dress; Qiyue Hu; Ted W. Johnson; Jon E. Kuehler; Atsuo Kuki; Hieu Lam; Wen Liu; Dawn Nowlin; Qinghai Peng; Sadayappan V. Rahavendran; Steven P. Tanis; Khanh T. Tran; Hai Wang; Anle Yang; Junhu Zhang

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October 26, 2009

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

Journal of Experimental Medicine, ISSN: 00221007 15409538

David K. Finlay; Linda V. Sinclair; Carmen Feijoo; Caryll M. Waugh; Thijs Hagenbeek; Hergen Spits; Doreen A. Cantrell

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October 26, 2009

Masking MALT1: The paracaspase's potential for cancer therapy

Journal of Experimental Medicine, ISSN: 00221007 15409538

Domagoj Vucic; Vishva M. Dixit

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October 23, 2009

Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma

Science, ISSN: 00368075 10959203

Robert Yauch; Gerrit J. P. Dijkgraaf; Bruno Alicke; Thomas Januario; Christina Ahn; Thomas Holcomb; Kanan Pujara; Stinson; Christopher Callahan; Tracy Tzu-Ling Tang; J.Fernando Bazan; Zhengyan Kan; Somasekar Seshagiri; Christine L. Hann; Stephen Gould; Low; Charles M. Rudin; Frederic J. De Sauvage

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October 20, 2009

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Richard G. Jenner; Michael J. Townsend; Ian Jackson; Kaiming Sun; Russell D. Bouwman; Richard A. Young; Laurie H. Glimcher; Graham M. Lord

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October 20, 2009

A Role for C. elegans Eph RTK Signaling in PTEN Regulation

Developmental Cell, ISSN: 15345807

Sarah Brisbin; Jun Liu; Jeff Boudreau; Jimmy Peng; Marie Evangelista; Ian Chin-Sang

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October 20, 2009

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

Developmental Cell, ISSN: 15345807

Boris Strilić; Tomáš Kučera; Jan Eglinger; Michael R. Hughes; Kelly M. McNagny; Sachiko Tsukita; Elisabetta Dejana; Napoleone Ferrara; Eckhard Lammert

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October 19, 2009

Promising bone-related therapeutic targets for rheumatoid arthritis

Nature Reviews Rheumatology, ISSN: 17594790 17594804

Yongwon Choi; Joseph R. Arron; Michael J. Townsend

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October 16, 2009

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

Cell, ISSN: 00928674

Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye

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October 15, 2009

Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y+, proopiomelanocortin+, and tyrosine hydroxylase+ neurons in neonatal and adult mice

Journal of Comparative Neurology, ISSN: 00219967 10969861

Cindy Yee; Yanling Wang; Stewart Anderson; Marc Ekker; John L. R. Rubenstein

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October 15, 2009

Revving the throttle on an oncogene: CDK8 takes the driver seat

Cancer Research, ISSN: 00085472 15387445

Ron Firestein; William C. Hahn

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October 14, 2009

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes

Structure, ISSN: 09692126

Andreas Lingel; Thomas M. Weiss; Marc Niebuhr; Borlan Pan; Brent A. Appleton; Wiesmann; J.Fernando Bazan; Wayne J. Fairbrother

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October 14, 2009

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

Arthritis and Rheumatism, ISSN: 00043591 15290131

Jason W. Bauer; Michelle Petri; Franak Batliwalla; Thearith Koeuth; Joseph Wilson; Catherine A. Slattery; Angela Panoskaltsis-Mortari; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler

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October 14, 2009

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

PLoS ONE, ISSN: 19326203

Junichi Soh; Naoki Okumura; William W. Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S. Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I. Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; Minna; Wan L. Lam; Adi Gazdar

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October 12, 2009

Engineering surfaces for substrate-mediated gene delivery using recombinant proteins

Biomacromolecules, ISSN: 15257797

Jennifer C. Rea; Romie F. Gibly; Nicolynn E. Davis; Annelise E. Barron; Lonnie D. Shea

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October 9, 2009

DNA spike studies for demonstrating improved clearance on chromatographic media

Journal of Chromatography A, ISSN: 00219673

Michelle D. Butler; Brian Kluck; Tracy Bentley

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October 5, 2009

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Journal of Cell Biology, ISSN: 00219525 00219525

Lamkanfi; James L. Mueller; Alberto C. Vitari; Shahram Misaghi; Anna V. Fedorova; Deshayes; Wyne P. Lee; Hal M. Hoffman; Vishva M. Dixit

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October 5, 2009

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

Lupus, ISSN: 09612033

Michelle Petri; Singh; Tesfasyone; Russell L Dedrick; Fry; Preeti Lal; Williams; Jason W. Bauer; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler

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October 1, 2009

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins

PLoS Biology, ISSN: 15449173 15457885

Raffi Tonikian; Xiaofeng Xin; Christopher P. Toret; David Gfeller; Christiane Landgraf; Simona Panni; Serena Paoluzi; Luisa Castagnoli; Bridget Currell; Somasekar Seshagiri; Haiyuan Yu; Barbara Winsor; Marc Vidal; Mark Gerstein; Gary D. Bader; Rudolf Volkmer; Gianni Cesareni; Drubin; Philip M. Kim; Sachdev S. Sidhu; Charles Boone

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October 1, 2009

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions

PLoS Genetics, ISSN: 15537390 15537404

Lisa F. Barcellos; Suzanne L. May; Ramsay; Hong L. Quach; Lane; Joanne Nititham; Janelle A. Noble; Kimberly E. Taylor; Diana L. Quach; Sharon A. Chung; Jennifer A. Kelly; Kathy L. Moser; Timothy W. Behrens; Michael F. Seldin; Glenys Thomson; John B. Harley; Patrick M. Gaffney; Lindsey A. Criswell

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October 1, 2009

Axl as a potential therapeutic target in cancer: Role of Axl in tumor growth, metastasis and angiogenesis

Oncogene, ISSN: 09509232 14765594

Li; Ye; Christine Tan; Hongo; Jiping Zha; Liu; Dara Y. Kallop; Mary J. C. Ludlam; Lin Pei

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October 1, 2009

GDC-0449-A potent inhibitor of the hedgehog pathway

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie

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October 1, 2009

Systematic genetic nomenclature for type VII secretion systems

PLoS Pathogens, ISSN: 15537366 15537374

Wilbert Bitter; Edith N. G. Houben; Daria Bottai; Priscille Brodin; Eric J. Brown; Jeffery S. Cox; Keith Derbyshire; Sarah M. Fortune; Lian-Yong Gao; Jun Liu; Nicolaas C. Gey Van Pittius; Alexander S. Pym; Eric J. Rubin; David R. Sherman; Stewart T. Cole; Roland Brosch

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October 1, 2009

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

Molecular Cancer Therapeutics, ISSN: 15357163

Bing Zheng; Reina N. Fuji; Kristi Elkins; Shang-Fan Yu; Franklin Fuh; Josefa Chuh; Christine Tan; Hongo; Helga Raab; Katherine R. Kozak; Marna Williams; Elena McDorman; Dan L. Eaton; Allen Ebens; Andrew G. Polson

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October 1, 2009

Biomanufacturing process analytical technology (PAT) application for downstream processing: Using dissolved oxygen as an indicator of product quality for a protein refolding reaction

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Shelly A. Pizarro; Rachel Dinges; Rachel Adams; Ailen M. Sánchez; Charles Winter

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October 1, 2009

Multiplex RT Q-PCR assay for simultaneous quantification of three viruses used for validation of virus clearance by biopharmaceutical production

Biologicals, ISSN: 10451056 10958320

Scott Lute; Hua Wang; Davonie Sanchez; Janet Barletta; Qi Chen; Kurt Brorson

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October 1, 2009

Understanding the mechanism of virus removal by Q sepharose fast flow chromatography during the purification of CHO-cell derived biotherapeutics

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Daniel M. Strauss; Scott Lute; Zinaida Tebaykina; Douglas D. Frey; Cintia Ho; Gregory S. Blank; Kurt Brorson; Qi Chen; Bin Yang

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October 1, 2009

The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3

Cell Cycle, ISSN: 15514005 15384101

Chang-Young Jang; Guowei Fang

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September 18, 2009

Structural Ties between Cholesterol Transport and Morphogen Signaling

Cell, ISSN: 00928674

J.Fernando Bazan; Frederic J. De Sauvage

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September 18, 2009

The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Hiroaki Uranishi; Andrei S. Zolotukhin; Susan Lindtner; Søren Warming; Gen-Mu Zhang; Jenifer Bear; Neal G. Copeland; Nancy A. Jenkins; George N. Pavlakis; Barbara K. Felber

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September 17, 2009

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

New England Journal of Medicine, ISSN: 15334406 00284793

Charles M. Rudin; Christine L. Hann; John Laterra; Robert Yauch; Christopher Callahan; Ling Fu; Thomas Holcomb; Stinson; Stephen Gould; Barbara Coleman; Patricia M. LoRusso; Daniel D. Von Hoff; Frederic J. De Sauvage; Low

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September 17, 2009

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

New England Journal of Medicine, ISSN: 15334406 00284793

Daniel D. Von Hoff; Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Robert Yauch; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Howard M. Mackey; Bert L. Lum; Darbonne; James C. Marsters Jr.; Frederic J. De Sauvage; Low

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September 15, 2009

Local Guidance of Emerging Vessel Sprouts Requires Soluble Flt-1

Developmental Cell, ISSN: 15345807

John C. Chappell; Sarah M. Taylor; Napoleone Ferrara; Victoria L. Bautch

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September 14, 2009

Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis mycelia and yeasts in vitro

Microbiology, ISSN: 13500872

Jomar P. Monteiro; Karl V. Clemons; Laurence F. Mirels; John A. Coller Jr.; Thomas D Wu; Jata Shankar; Catalina R. Lopes; David A. Stevens

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September 10, 2009

Estimating variance parameters from multivariate normal variables subject to limits of detection: MLE, REML, or Bayesian approaches?

Statistics in Medicine, ISSN: 02776715 10970258

Lei Nie; Haitao Chu; Shibao Feng

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September 9, 2009

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2

Journal of Medicinal Chemistry, ISSN: 00222623

Herman S. Gill; Jeff N. Tinianow; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Helga Raab; Justin M. Scheer; Richard L. Vandlen; Simon P. Williams; Jan Marik

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September 8, 2009

Science signaling podcast: 8 September 2009

Science Signaling, ISSN: 19450877 19379145

Sachdev S. Sidhu; Annalisa M. VanHook

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September 8, 2009

Rapid evolution of functional complexity in a domain family

Science Signaling, ISSN: 19450877 19379145

Andreas Ernst; Stephen L. Sazinsky; Shirley Hui; Bridget Currell; Moyez Dharsee; Somasekar Seshagiri; Gary D. Bader; Sachdev S. Sidhu

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September 1, 2009