Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9201 - 9250 OF 15394 RESULTS

Wnt signaling is regulated by endoplasmic reticulum retention
PLoS ONE, ISSN: 19326203
J. Susie Zoltewicz; Amir M. Ashique; Youngshik Choe; Gena Lee; Stacy Taylor; Khanhky Phamluong; Mark J. Solloway; Andrew S. Peterson
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CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin; Thomas F.J. Martin
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CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin
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Scalable total synthesis and biological evaluation of haouamine A and its atropisomer
Journal of the American Chemical Society, ISSN: 00027863
Noah Z. Burns; Irina N. Krylova; Rami N. Hannoush; Phil S. Baran
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Reassessment of corticospinal tract regeneration in Nogo-deficient mice
Journal of Neuroscience, ISSN: 02706474 15292401
Jae K. Lee; Andrea F. Chan; Sen M. Luu; Yuhong Zhu; Carole Ho; Marc Tessier-Lavigne; Binhai Zheng
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Journal of Experimental Medicine, ISSN: 00221007 15409538
Geethanjali Pickert; Clemens Neufert; Moritz Leppkes; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Hans-Anton Lehr; Sebastian Hirth; Benno Weigmann; Stefan Wirtz; Wenjun Ouyang; Markus F. Neurath; Christoph Becker
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Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells
Nature Immunology, ISSN: 15292908 15292916
Sara Trifari; Charles D. Kaplan; Elise H. Tran; Natasha K Crellin; Hergen Spits
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Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
Journal of Experimental Medicine, ISSN: 00221007 15409538
Wei Cao; Laura Bover; Minkwon Cho; Xiaoxia Wen; Shino Hanabuchi; Musheng Bao; David B. Rosen; Yi-Hong Wang; Joanne L. Shaw; Qiumei Du; Chun Li; Naoko Arai; Zhengbin Yao; Lewis L. Lanier; Yong-Jun Liu
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Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice
Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836
Jian-Guo Wang; Manly; Daniel Kirchhofer; Rafal Pawlinski; Nigel Mackman
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Homeless women's personal networks: Implications for understanding risk behavior
Human Organization, ISSN: 00187259
Joan Tucker; David Kennedy; Gery Ryan; Suzanne Wenzel; Daniela Golinelli; James L. Zazzali
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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
Nature Structural and Molecular Biology, ISSN: 15459993 15459985
Ivan Bosanac; Henry R. Maun; Suzie J. Scales; Xiaohui Wen; Andreas Lingel; J.Fernando Bazan; Frederic J. De Sauvage; Sarah G. Hymowitz; Lazarus
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Removal of endogenous retrovirus-like particles from CHO-cell derived products using Q sepharose fast flow chromatography
Biotechnology Progress, ISSN: 87567938
Daniel M. Strauss; Scott Lute; Kurt Brorson; Gregory S. Blank; Qi Chen; Bin Yang
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Development of prophylactic and therapeutic vaccines using the ISCOMATRIX adjuvant
Immunology and Cell Biology, ISSN: 08189641 14401711
Eugene Maraskovsky; Max Schnurr; Nicholas S. Wilson; Neil C Robson; Jeff Boyle; Debbie Drane
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MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema
Molecular Endocrinology, ISSN: 08888809
Francine M. Gregoire; Fang Zhang; Holly J. Clarke; Thomas A. Gustafson; Dorothy D. Sears; Svetlana Favelyukis; James Lenhard; Dennis Rentzeperis; L. Edward Clemens; Yi Mu; Brian E. Lavan
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Second International Conference on Accelerating Biopharmaceutical Development March 9-12, 2009, Coronado, CA, USA
Biotechnology Progress, ISSN: 87567938
Janice M. Reichert; Nitya M. Jacob; Ashraf Amanullah
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Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus
PLoS ONE, ISSN: 19326203
Abbas Alexander; Kristen Wolslegel; Dhaya Seshasayee; Zora Modrusan; Hilary F. Clark
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Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration
Molecular and Cellular Neuroscience, ISSN: 10447431
Séverine Marcos; Stéphanie Backer; Frédéric Causeret; Marc Tessier-Lavigne; Evelyne Bloch-Gallego
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Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways
Cerebral Cortex, ISSN: 10473211 14602199
Jason E. Long; Inma Cobos; Gregory B. Potter; John L. R. Rubenstein
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Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma
Journal of Pathology, ISSN: 00223417 10969896
Laura A. Strickland; Ross; Simon P. Williams; Ross; Maria Romero; Spencer; Erickson; Julie Sutcliffe; Caroline Verbeke; Paul G. Polakis; Nicholas Van Bruggen; Koeppen
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Player RanKings: Using coefficient of variation to measure MLB players' worth
Quality Progress, ISSN: 0033524X
Julia E. Seaman; Elaine Allen
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Measurements of birth defect prevalence: Which is most useful as a comparator group for pharmaceutical pregnancy registries?
Birth Defects Research Part A - Clinical and Molecular Teratology, ISSN: 15420752 15420760
Angela E. Scheuerle; Vani X. Vannappagari; Mary K. Miller
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Targeted depletion of lymphotoxin-α-expressing T H 1 and T H 17 cells inhibits autoimmune disease
Nature Medicine, ISSN: 10788956 1546170X
Eugene Y. Chiang; Ganesh Kolumam; Xin Yu; Michelle Francesco; Ivelja; Ivan Peng; Gribling; Jean Shu; Wyne P. Lee; Refino; Mercedesz Balazs; Andres Paler Martinez; Allen Nguyen; Judy Young; Kai H. Barck; Richard A. D. Carano; Ron Ferrando; Laurie Diehl; Devavani Chatterjea; Jane L. Grogan
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Unbound brain concentration determines receptor occupancy: A correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Xingrong Liu; Olga Vilenski; Joyce Kwan; Subbu Apparsundaram; Robert Weikert
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Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Rafael Ponce; Leslie Abad; Lakshmi Amaravadi; Thomas R. Gelzleichter; Elizabeth Gore; Green; Shalini Gupta; Danuta Herzyk; Christopher Hurst; Inge A. Ivens; Thomas Kawabata; Curtis Maier; Barbara Mounho; Bonita Rup; Gopi Shankar; Holly W. Smith; Peter Thomas; Daniel Wierda
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Differential role of the Ca2+ sensor synaptotagmin VII in macrophages and dendritic cells
Immunobiology, ISSN: 01712985
Steven M. Becker; Lélia Delamarre; Ira Mellman; Norma W. Andrews
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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
Clinical Cancer Research, ISSN: 10780432
Klaus P. Hoeflich; Carol O'Brien; Zachary Boyd; Guy Cavet; Steve Guerrero; Kenneth Jung; Thomas Januario; Heidi Savage; Elizabeth A. Punnoose; Tom Truong; Wei Zhou; Berry; Lesley J. Murray; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner
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Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study
Journal of Immunological Methods, ISSN: 00221759
Kelly M. Loyet; Rong Deng; Wei-Ching Liang; Yan Wu; Henry B. Lowman; Laura DeForge
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Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Laurent Salphati; Emile G. Plise; Guangmin Li
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Novel therapeutic targets along the Th17 pathway
European Journal of Immunology, ISSN: 00142980 15214141
Wenjun Ouyang; Ellen H. Filvaroff; Yan Hu; Jane L. Grogan
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Finding and achieving value in cancer care
JNCCN Journal of the National Comprehensive Cancer Network, ISSN: 15401405 15401413
Clifford Goodman; Joseph S. Bailes; Stephen B. Edge; A. Mark Fendrick; Scott Gottlieb; Robert Mass; Lee N. Newcomer; Lynn Zonakis
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Development of novel drugs targeting inhibitors of apoptosis
Future Oncology, ISSN: 14796694 17448301
Flygare; Domagoj Vucic
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Engineering human IgG1 affinity to human neonatal Fc receptor: Impact of affinity improvement on pharmacokinetics in primates
Journal of Immunology, ISSN: 00221767 15506606
Yik Andy Yeung; Maya Leabman; Jonathan S. Marvin; Julia Qiu; Adams; Samantha Lien; Melissa A. Starovasnik; Henry B. Lowman
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Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab
Clinical Cancer Research, ISSN: 10780432
Evelyn Yao; Wei Zhou; Si Tuen Lee-Hoeflich; Tom Truong; Matthias Peter; Jeffrey Eastham-Anderson; Nicholas Lewin-Koh; Bert Gunter; Marcia Belvin; Lesley J. Murray; Lori S. Friedman; Mark X. Sliwkowski; Klaus P. Hoeflich
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Multi-round virus filter integrity test sensitivity
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Chris Dowd
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Toward an effective targeted chemotherapy for multiple myeloma
Clinical Cancer Research, ISSN: 10780432
Andrew G. Polson; Mark X. Sliwkowski
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Interaction of IF2 with the ribosomal GTPase-associated center during 70S initiation complex formation
Biochemistry, ISSN: 00062960
Haiou Qin; Christina Grigoriadou; Barry S. Cooperman
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Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis
Cell Stem Cell, ISSN: 19345909
Inga Hofmann; Elizabeth H. Stover; Dana E. Cullen; Junhao Mao; Kelly J. Morgan; Benjamin H. Lee; Michael G. Kharas; Peter G. Miller; Melanie G. Cornejo; Rachel Okabe; Scott A. Armstrong; Nico Ghilardi; Stephen Gould; Frederic J. De Sauvage; Andrew P. McMahon; D. Gary Gilliland
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Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of Hepatitis C virus
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Julie Qi Hang; Yanli Yang; Seth F. Harris; Vincent J.P. Leveque; Hannah J. Whittington; Sonal Rajyaguru; Gloria Ao-Leong; Matthew F. McCown; April Wong; Anthony M. Giannetti; Sophie Le Pogam; Francisco Talamás; Nick Cammack; Nájera; Klumpp
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Targeting interferon alpha subtypes in serum: A comparison of analytical approaches to the detection and quantitation of proteins in complex biological matrices
Journal of Proteome Research, ISSN: 15353893
Anita Izrael-Tomasevic; Lilian Phu; Qui Phung; Jennie R. Lill; David Arnott
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Axotomy-induced smad1 activation promotes axonal growth in adult sensory neurons
Journal of Neuroscience, ISSN: 02706474 15292401
Hongyan Zou; Carole Ho; Karen G. Wong; Marc Tessier-Lavigne
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An analytical system for the characterization of highly heterogeneous mixtures of N-linked oligosaccharides
Analytical Biochemistry, ISSN: 10960309 00032697
Briggs; Rodney Keck; Stacey Ma; Wendy Lau; Andrew J.S. Jones
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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Trends in Pharmacological Sciences, ISSN: 01656147
Suzie J. Scales; Frederic J. De Sauvage
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Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: Human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG Cells
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Dermot F. McGinnity; George Zhang; Jane R. Kenny; Geraldine A. Hamilton; Sara Otmani; Karen R. Stams; Suzzette Haney; Patrick Brassil; David M Stresser; Robert J. Riley
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Analysis of charge heterogeneities in mAbs using imaged CE
Electrophoresis, ISSN: 01730835 15222683
Xiaoping Z. He; Amy H. Que; Jim J. Mo
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Review of recent genome-wide association scans in lupus
Journal of Internal Medicine, ISSN: 09546820 13652796
Robert R. Graham; Geoffrey Hom; Ward Ortmann; Timothy W. Behrens
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Assessment of a sixteen-week training program on strength, pain, and function in rheumatoid arthritis patients
Journal of Clinical Rheumatology, ISSN: 10761608
Hilary G. Flint-Wagner; Jeffrey Lisse; Timothy G. Lohman; Scott B. Going; Terri Guido; Ellen Cussler; Donald Gates; David E. Yocum
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Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Timothy Eley; Feng R. Luo; Shruti Agrawal; Ashish Sanil; James Manning; Tong Li; Anne Blackwood-Chirchir; Richard Bertz
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PET of glial metabolism using 2-18F-fluoroacetate
Journal of Nuclear Medicine, ISSN: 01615505
Jan Marik; Annie Ogasawara; Baby Martin-McNulty; Ross; Judith E. Flores; Herman S. Gill; Jeff N. Tinianow; Alexander N. Vanderbilt; Merry C. Nishimura; Franklin V. Peale Jr.; Cinthia V Pastuskovas; Joan M. Greve; Nicholas Van Bruggen; Simon P. Williams
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Non-invasive monitoring provides fast payback
Chemical Processing, ISSN: 00092630
Chris Stubbs
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Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides
Chemical Biology and Drug Design, ISSN: 17470277
Kai Zheng; Jennifer S. Laurence; Krzysztof Kuczera; Gennady Verkhivker; C. Russell Middaugh; Teruna J. Siahaan
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