Scientists / Publications

Publications

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DISPLAYING 9301 - 9350 OF 15394 RESULTS

Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions: Study of citrate binding to a fab
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Chithkala Harinarayan; Ken Skidmore; Kao; Andrew Zydney; Robert Van Reis
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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W. Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T. Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A. Greenberg; Kevin G. Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J. Watts; Xuri Lia
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Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nature Chemical Biology, ISSN: 15524469 15524450
Yingnan Zhang; Brent A. Appleton; Wiesmann; Ted Lau; Michael Costa; Rami N. Hannoush; Sachdev S. Sidhu
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Xiaolan Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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Tissue factor-dependent coagulation contributes to α- naphthylisothiocyanate-induced cholestatic liver injury in mice
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547
James P. Luyendyk; Glenn H. Cantor; Daniel Kirchhofer; Nigel Mackman; Bryan L. Copple; Ruipeng Wang
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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
Journal of Immunology, ISSN: 00221767 15506606
Julie Zikherman; Michelle Hermiston; David Steiner; Kiminori Hasegawa; Andrew A. Chan; Arthur Weiss
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A census of human transcription factors: Function, expression and evolution
Nature Reviews Genetics, ISSN: 14710056 14710064
Juan M. Vaquerizas; Sarah K. Kummerfeld; Sarah A. Teichmann; Nicholas M. Luscombe
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Inhibitory properties of trapping agents: Glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms
Drug Metabolism Letters, ISSN: 18723128
Chenghong Zhang; Susan C. Wong; Erlie Marie Delarosa; Jane R. Kenny; Jason S. Hallday; Cornelis E. Hop; S. Cyrus Khojasteh
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Pharmacodynamics of 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]- 3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: Understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Harvey Wong; Marcia Belvin; Sylvia Herter; Klaus P. Hoeflich; Lesley J. Murray; Leo Wong; Edna F. Choo
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Interleukin-22-producing innate immune cells: New players in mucosal immunity and tissue repair?
Nature Reviews Immunology, ISSN: 14741733
Eric Vivier; Hergen Spits; Tom Cupedo
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Association of C-terminal ubiquitin hydrolase BRCAl-associated protein 1 with cell cycle regulator host cell factor 1
Molecular and Cellular Biology, ISSN: 02707306
Shahram Misaghi; Søren Ottosen; Anita Izrael-Tomasevic; David Arnott; Lamkanfi; James Lee; Jinfeng Liu; Karen M. O'Rourke; Vishva M. Dixit; Angus C. Wilson
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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Autophagy, an Achilles′ heel AKTing against cancer?
Autophagy, ISSN: 15548635 15548627
Michael Degtyarev; Ann De Mazière; Judith Klumperman; Kui Lin
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A Novel, Q-PCR based approach to measuring endogenous retroviral clearance by capture protein a chromatography
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Min Zhang; Scott Lute; Lenore A Norling; Connie Hong; Aurelia Safta; Deborah O'Connor; Lisa J. Bernstein; Hua Wang; Gregory S. Blank; Kurt Brorson; Qi Chen
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Follow: The Raptiva (efalizumab) Pregnancy Registry
Journal of the American Academy of Dermatology, ISSN: 01909622
David Margolis; Elizabeth Andrews; Winifred Werther
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Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAF V600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Sylvia Herter; Janet Y. Tien; Leo Wong; Berry; Jocelyn Chan; Carol O'Brien; Zora Modrusan; Somasekar Seshagiri; Lackner; Howard M. Stern; Edna F. Choo; Lesley J. Murray; Lori S. Friedman; Marcia Belvin
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Death receptor signal transducers: Nodes of coordination in immune signaling networks
Nature Immunology, ISSN: 15292908 15292916
Nicholas S. Wilson; Vishva M. Dixit; Avi Ashkenazi
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The art of making an exit
Science, ISSN: 00368075 10959203
Fredric Carlsson; Eric J. Brown
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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
Journal of Medicinal Chemistry, ISSN: 00222623
Frederick Cohen; Bruno Alicke; Linda O. Elliott; Flygare; Tatiana Goncharov; Stephen F. Keteltas; Matthew C Franklin; Stacy Frankovitz; Jean-Philippe Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne J. Fairbrother
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Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab
Journal of Clinical Oncology, ISSN: 0732183X
Alan Sandler; Joan H. Schiller; Robert Gray; Isaiah Dimery; Julie Brahmer; Meghna Samant; Lisa I. Wang; David H. Johnson
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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, ISSN: 00368075 10959203
Jenny Bostrom; Shang-Fan Yu; David Kan; Brent A. Appleton; Chingwei V. Lee; Karen L Billeci; Wenyan Man; Franklin V. Peale Jr.; Ross; Wiesmann; Fuh
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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hua Tian; Christopher Callahan; Kelly J. DuPree; Darbonne; Christina Ahn; Suzie J. Scales; Frederic J. De Sauvage
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Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
Cancer Research, ISSN: 00085472 15387445
Andrew G. Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley S. Chang; Erin Christensen; Suzanna Clark; Frederic J. De Sauvage; Dan L. Eaton; Kristi Elkins; J. Michael Elliott; Gretchen D. Frantz; Reina N. Fuji; Gray; Kristin Harden; Gladys S. Ingle; Noelyn Kljavin; Koeppen; Nelson; Saileta Prabhu; Helga Raab; Ross; Jean-Philippe Stephan; Suzie J. Scales; Spencer; Richard L. Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production
Journal of Immunology, ISSN: 00221767 15506606
Carla A. Da Silva; Cecile Chalouni; Adam Williams; Dominik Hartl; Chun G. Lee; Jack A. Elias
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Neuropilins in tumor biology
Clinical Cancer Research, ISSN: 10780432
Anil Bagri; Marc Tessier-Lavigne; Ryan J. Watts
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Yas3p, an opi1 family transcription factor, regulates Cytochrome P450 expression in response to n-alkanes inYarrowia lipolytica
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kiyoshi Hirakawa; Satoshi Kobayashi; Takuro Inoue; Setsu Endoh-Yamagami; Ryouichi Fukuda; Akinori Ohta
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Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms
Oncogene, ISSN: 09509232 14765594
Hollmén; Jorma Määttä; Bald; Mark X. Sliwkowski; Elenius
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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
Journal of Medicinal Chemistry, ISSN: 00222623
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V. Rahavendran; Heather Skor; Robert Hunter; Stephanie Shi; Koleen J. Herlihy; Hans Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Lewis
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William L. Ince; Novotny; Oliver Rosen
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The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase in study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Herbert Hurwitz; Jing Yi; William Ince; Novotny; Oliver Rosen
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Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
J. Michael Elliott; Lionel Rouge; Wiesmann; Justin M. Scheer
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dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants
EMBO Journal, ISSN: 02614189 14602075
Ryuya Fukunaga; Jennifer A. Doudna
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Two-state selection of conformation-specific antibodies
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Junjun Gao; Sachdev S. Sidhu; James A. Wells
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Adherence and persistence with omalizumab and fluticasone/salmeterol within a managed care population
Allergy and Asthma Proceedings, ISSN: 10885412 15396304
Michael S. Broder; Eunice Chang; Caron Ory; Tripthi V. Kamath; Sandhya Sapra
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Extrapituitary and Pituitary Pathological Findings in Horses with Pituitary Pars Intermedia Dysfunction: A Retrospective Study
Journal of Equine Veterinary Science, ISSN: 07370806
Christiana M. Glover; Lisa M. Miller; Noel Dybdal; Alfonso Lopez; Wendy M. Duckett; Dianne McFarlane
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The double-histone-acetyltransferase complex ATAC is essential for mammalian development
Molecular and Cellular Biology, ISSN: 02707306
Sebastián Guelman; Kenji Kozuka; Yifan Mao; Victoria Pham; Mark J. Solloway; John Wang; Jiansheng Wu; Jennie R. Lill; Jiping Zha
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Modeling electrostatic exclusion effects during ion exchange chromatography of monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Andrew Zydney; Chithkala Harinarayan; Robert Van Reis
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The effect of low intensity ultraviolet-c light on monoclonal antibodies
Biotechnology Progress, ISSN: 87567938
Christopher M. Lorenz; Bradley Wolk; Quan; Emily W. Alcala; Eng; Daniel J. McDonald; Timothy Matthews
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Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children
Pediatrics, ISSN: 00314005 10984275
Gabriele Renzetti; Gaetano Silvestre; Claudio D'Amario; Egidio Bottini; Fulvia Gloria-Bottini; Nunzio Bottini; Alexander Auais; Miriam K. Perez; Giovanni Piedimonte
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New methods allowing the detection of protein aggregates: A case study on trastuzumab
mAbs, ISSN: 19420862
Barthélemy Demeule; Caroline Palais; Gia Machaidze; Robert Gurny; Tudor Arvinte
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A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Christina J. Lee; Gargi Seth; Joni Tsukuda; Robert W. Hamilton
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Selective antibody precipitation using polyelectrolytes: A novel approach to the purification of monoclonal antibodies
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Paul McDonald; Corazon Victa; Jayme N. Carter-Franklin; Fahrner
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Trace level analysis of leached Protein A in bioprocess samples without interference from the large excess of rhMAb IgG
Journal of Immunological Methods, ISSN: 00221759
Judith Zhu-Shimoni; Feny Gunawan; Anne Thomas; Vanderlaan; Stults
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Chapter 5 DNA Targets of AID. Evolutionary Link Between Antibody Somatic Hypermutation and Class Switch Recombination
Advances in Immunology, ISSN: 00652776 15578445
Jason A. Hackney; Shahram Misaghi; Kate Senger; Christopher Garris; Yonglian Sun; Maria N. Lorenzo; Ali A. Zarrin
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Genetic deletion of JAM-C reveals a role in myeloid progenitor generation
Blood, ISSN: 15280020 00064971
Asja Praetor; Jacqueline McBride; Chiu; Linda Rangell; Lorena Cabote; Wyne P. Lee; James Cupp; Dimitry Danilenko; Fong
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Genetic deletion of JAM-C reveals a role in myeloid progenitor generation
Blood, ISSN: 15280020 00064971
Asja Praetor; Jacqueline McBride; Chiu; Linda Rangell; Lorena Cabote; Wyne P. Lee; James Cupp; Dimitry Danilenko; Sherman Fong
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IL-17 receptor signaling inhibits C/EBPb by sequential phosphorylation of the regulatory 2 domain
Science Signaling, ISSN: 19450877 19379145
Fang Shen; Nan Li; Padmaja Gade; Dhananjaya V. Kalvakolanu; Timothy Weibley; Brad Doble; James R. Woodgett; Troy D. Wood; Sarah L. Gaffen
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Perforin-mediated suppression of B-cell lymphoma
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Paul Bolitho; Shayna E. A. Street; Jennifer A. Westwood; Winfried Edelmann; Duncan MacGregor; Waring; William K. Murray; Dale I. Godfrey; Joseph A. Trapani; Ricky W. Johnstone; Mark J. Smyth
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Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes
Blood, ISSN: 15280020 00064971
Ralph Tiedt; Jörn Coers; Sandra Ziegler; Adrian Wiestner; Hui Hao-Shen; Caroline Bornmann; Johannes Schenkel; Svetlana Karakhanova; Frederic J. De Sauvage; Carl W. Jackson; Radek C. Skoda
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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Nature, ISSN: 00280836 14764687
Anatoly Nikolaev; Todd McLaughlin; Dennis D.M. O'Leary; Marc Tessier-Lavigne
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