Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9351 - 9400 OF 15394 RESULTS

PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kathleen A. O'Hagan; Sinead Cocchiglia; Alexander V. Zhdanov; Murtaza M. Tambawala; Eoin P. Cummins; Mona Monfared; Terence A. Agbor; John F. Garvey; Dmitri B. Papkovsky; Cormac T. Taylor; Bernard B. Allan
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Human CD4 + T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
Journal of Experimental Medicine, ISSN: 00221007 15409538
Christopher J. Haines; Thierry D. Giffon; Li-Sheng Lu; Lu; Marc Tessier-Lavigne; Douglas T. Ross; David B. Lewis
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Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii- I nfected dendritic cells
Journal of Experimental Medicine, ISSN: 00221007 15409538
Romina S. Goldszmid; Isabelle Coppens; Avital Lev; Pat Caspar; Ira Mellman; Alan Sher
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The impact of protein exclusion on the purity performance of ion exchange resins
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Zeid; Chithkala Harinarayan; Robert Van Reis
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Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells
Journal of Immunology, ISSN: 00221767 15506606
Iyadh Douagi; Cornelia Gujer; Christopher Sundling; William C. Adams; Anna Smed-Sörensen; Robert A. Seder; Gunilla B. Karlsson Hedestam; Karin Loré
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α-actinin and filamin cooperatively enhance the stiffness of actin filament networks
PLoS ONE, ISSN: 19326203
Osigwe Esue; Yiider Tseng; Denis Wirtz
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Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Markus Eser; Lluis Masip; Hiroshi Kadokura; George Georgiou; Jonathan Beckwith
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The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts
Experimental Eye Research, ISSN: 00144835
Claudia M. Garcia; Ying-Bo Shui; Meera Kamath; Justin DeVillar; Randall S. Johnson; Hans-Peter Gerber; Napoleone Ferrara; Michael L. Robinson; David C. Beebe
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Atrophins' emerging roles in development and neurodegenerative disease
Cellular and Molecular Life Sciences, ISSN: 1420682X 15691632
Yiguo Shen; Andrew S. Peterson
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Role of benzyl alcohol in the prevention of heat-induced aggregation and inactivation of hen egg white lysozyme
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411
Monu Kumari Goyal; Ipsita Roy; Uttam Chand Banerjee; Vikas Sharma; Arvind Kumar Bansal
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Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice
Pharmaceutical Research, ISSN: 07248741 1573904X
Suneet Shukla; Hani Zaher; Anika Hartz; Björn Bauer; Joseph A. Ware; Suresh V. Ambudkar
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Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
Journal of Comparative Neurology, ISSN: 00219967 10969861
Jason E. Long; Christo Swan; Winnie S. Liang; Inma Cobos; Gregory B. Potter; John L. R. Rubenstein
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Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma
Respiratory Medicine, ISSN: 09546111
Tmirah Haselkorn; James E. Fish; Bradley E. Chipps; Dave P. Miller; Hubert Chen; Weiss
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Construction and application of a zebrafish array comparative genomic hybridization platform
Genes Chromosomes and Cancer, ISSN: 10452257 10982264
Jennifer L. Freeman; Craig Ceol; Hui Feng; David M. Langenau; Cassandra Belair; Howard M. Stern; Anhua Song; Barry H. Paw; A. Thomas Look; Yi Zhou; Leonard I. Zon; Charles Lee
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Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population
Arthritis and Rheumatism, ISSN: 00043591 15290131
Ikue Ito; Aya Kawasaki; Satoshi Ito; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Akito Tsutsumi; Geoffrey Hom; Robert R. Graham; Yoshinari Takasaki; Hiroshi Hashimoto; Jun Ohashi; Timothy W. Behrens; Takayuki Sumida; Naoyuki Tsuchiya
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Breaking into bone biology: Target practice
Nature Medicine, ISSN: 10788956 1546170X
Yongwon Choi; Matthew C. Walsh; Joseph R. Arron
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Drug-drug interactions mediated through P-glycoprotein: Clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Fenner; Troutman; Kempshall; Cook; Joseph A. Ware; Smith; Caroline A. Lee
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B and T lymphocyte attenuator regulates B cell receptor signaling by targeting Syk and BLNK
Journal of Immunology, ISSN: 15506606 00221767
Andrew C. Vendel; Jill Calemine-Fenaux; Anita Izrael-Tomasevic; Vandana Chauhan; David Arnott; Dan L. Eaton
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A phase I/II trial of trastuzumab plus erlotinib in metastatic HER2-positive breast cancer: A dual ErbB targeted approach
Clinical Breast Cancer, ISSN: 15268209
Carolyn D. Britten; Richard S. Finn; Linda Bosserman; Steven Wong; Michael F. Press; Mubashira Malik; Bert L. Lum; Dennis J. Slamon
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Essential and unique roles of PIP5K-γ and - α in Fcγ receptor-mediated phagocytosis
Journal of Cell Biology, ISSN: 15408140 00219525
Yuntao S. Mao; Masaki Yamaga; Xiaohui Zhu; Yongjie Wei; Hui-Qiao Sun; Jing Wang; Mia Yun; Yanfeng Wang; Gilbert Di Paolo; Michael J. Bennett; Ira Mellman; Charles S. Abrams; Pietro De Camilli; Christopher Y. Lu; Helen L. Yin
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Essential and unique roles of PIP5K-γ and - α in Fcγ receptor-mediated phagocytosis
Journal of Cell Biology, ISSN: 15408140 00219525
Yuntao S. Mao; Masaki Yamaga; Xiaohui Zhu; Yongjie Wei; Hui-Qiao Sun; Jing Wang; Mia Yun; Yanfeng Wang; Gilbert Di Paolo; Michael J. Bennett; Ira Mellman; Charles S. Abrams; Pietro De Camilli; Simon Craddock Lee; Helen L. Yin
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GPS navigation of the protein-stability landscape
Nature Biotechnology, ISSN: 10870156 15461696
Donald S. Kirkpatrick; Vishva M. Dixit
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A three-dimensional view of the molecular machinery of RNA interference
Nature, ISSN: 00280836 14764687
Martin Jinek; Jennifer A. Doudna
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Effect of polyols on polyethylene glycol (PEG)-induced precipitation of proteins: Impact on solubility, stability and conformation
International Journal of Pharmaceutics, ISSN: 03785173
Vineet Kumar; Vikas Sharma; Devendra S. Kalonia
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In situ precipitation and vacuum drying of interferon alpha-2a: Development of a single-step process for obtaining dry, stable protein formulation
International Journal of Pharmaceutics, ISSN: 03785173
Vineet Kumar; Vikas Sharma; Devendra S. Kalonia
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PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
EMBO Reports, ISSN: 1469221X 14693178
Elsa N. N'Diaye; Kimberly K. Kajihara; Ivy Hsieh; J. Hiroshi Morisaki; Jayanta Debnath; Eric J. Brown
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Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
Immunity, ISSN: 10747613
Kaufmann; Philipp J. Jost; Marc Pellegrini; Puthalakath; Gugasyan; Gerondakis; Erika Cretney; Mark J. Smyth; John Silke; Razq Hakem; Philippe Bouillet; Tak W. Mak; Vishva M. Dixit; Andreas Strasser
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Re-estimating the sample size of an on-going blinded trial based on the method of randomization block sums
Statistics in Medicine, ISSN: 02776715 10970258
Jitendra Ganju; Biao Xing
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By the scientists, for the scientists
Journal of Cell Biology, ISSN: 00219525 00219525
Ira Mellman
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Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
Journal of Clinical Oncology, ISSN: 0732183X
Fairooz F. Kabbinavar; Herbert Hurwitz; Jing Yi; Somnath Sarkar; Oliver Rosen
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Noncompetitive Inhibition of Hepatocyte Growth Factor-dependent Met Signaling by a Phage-derived Peptide
Journal of Molecular Biology, ISSN: 00222836
Eric Tam; Steven T. Runyon; Santell; Quan; Xiaoyi Yao; Daniel Kirchhofer; Nicholas J. Skelton; Lazarus
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PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
Cancer Cell, ISSN: 15356108
Yongping Crawford; Ian Kasman; Lanlan Yu; Cuiling Zhong; Xiumin Wu; Zora Modrusan; Joshua S. Kaminker; Napoleone Ferrara
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The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Wei Li; Dimitry Danilenko; Bunting; Rajkumar Ganesan; Susan Sa Ronald Ferrando; Thomas D Wu; Ganesh Kolumam; Wenjun Ouyang; Daniel Kirchhofer
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Engineering as a means to improve the pharmacokinetics of injected therapeutic proteins
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
Dennis; Yik Andy Yeung; Henry B. Lowman; Robert F. Kelley
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In vitro-in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for antibody therapeutics
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
C. Andrew Boswell; Rong Deng; Kedan Lin; Wendy Putnam; Cherry Lei; Frank-Peter Theil; Amita Joshi; Fielder; Leslie A. Khawli
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Assessing Medical Information Needs via an Internet-Based Survey
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Stacey M. Fung; Laura Merriman; Maureen Cawley
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Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia
Blood, ISSN: 15280020 00064971
Kazuko Miyazaki; Norimasa Yamasaki; Hideaki Oda; Takeshi Kuwata; Yohei Kanno; Masaki Miyazaki; Yukiko Komeno; Jiro Kitaura; Zen-Ichiro Honda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; Toshio Kitamura; Takuro Nakamura; Hiroaki Honda
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Inflammasomes: Guardians of cytosolic sanctity
Immunological Reviews, ISSN: 01052896 1600065X
Lamkanfi; Vishva M. Dixit
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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Nature Immunology, ISSN: 15292908 15292916
Xin Yu; Kristin Harden; Lino C. Gonzalez Jr.; Michelle Francesco; Eugene Y. Chiang; Bryan Irving; Irene Tom; Ivelja; Refino; Hilary F. Clark; Dan L. Eaton; Jane L. Grogan
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Industrialization of mAb production technology: The bioprocessing industry at a crossroads
mAbs, ISSN: 19420862
Kelley
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In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models
Molecular Cancer Therapeutics, ISSN: 15357163
Kenneth Kolinsky; Shen; Yu-E. Zhang; Joseph Kohles; Ute Dugan; Zioncheck; David Heimbrook; Kathryn Packman; Higgins
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Applying simulation tools to evaluate and minimize operating costs of biotech manufacturing facilities
American Pharmaceutical Outsourcing, ISSN: 15296318
Frank Menkel; Rick Johnston; Arden Yang
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Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
Nature Immunology, ISSN: 15292908 15292916
Tom Cupedo; Natasha K Crellin; Natalie Papazian; Elwin J. Rombouts; Kees Weijer; Jane L. Grogan; Willem E. Fibbe; Jan J. Cornelissen; Hergen Spits
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Panitumumab monotherapy in patients with metastatic colorectal cancer and cetuximab infusion reactions: A series of four case reports
Clinical Colorectal Cancer, ISSN: 15330028
Alan Langerak; George River; Edith Mitchell; Puneet Cheema; Mona Shing
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Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
Immunobiology, ISSN: 01712985
Stefan Ehlers; Tanja Schreiber; Annette Dunzendorfer; John Lowe; Christoph Hölscher
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Quality by design: The next phase
BioProcess International, ISSN: 15426319
Mire-Sluis; Mark Schenerman; Rohin Mhatre; Siddharth Advant; John Dougherty; Steven Kozlowski; Wassim Nashabeh; Lorna McLeod
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Ion-specific modulation of protein interactions: Anion-induced, reversible oligomerization of a fusion protein
Protein Science, ISSN: 09618368 1469896X
Yatin Gokarn; R. Matthew Fesinmeyer; Atul Saluja; Shawn Cao; Jane Dankberg; Andrew Goetze; Richard L. Remmele Jr.; Linda O. Narhi; David N. Brems
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Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis
Molecules and Cells, ISSN: 10168478
Hui Zhu; Kayleen Fang; Guowei Fang
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Polar localization of virulence-related Esx-1 secretion in mycobacteria
PLoS Pathogens, ISSN: 15537366 15537374
Fredric Carlsson; Shilpa A. Joshi; Linda Rangell; Eric J. Brown
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Improved vision-related function after ranibizumab vs photodynamic therapy: A randomized clinical trial
Archives of Ophthalmology, ISSN: 00039950 15383601
Neil M. Bressler; Tom S. Chang; Jennifer T. Fine; Chantal M. Dolan; James Ward
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