Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9451 - 9500 OF 15394 RESULTS

Quantitation of polysorbate 20 in protein solutions using mixed-mode chromatography and evaporative light scattering detection
Journal of Chromatography A, ISSN: 00219673
Daniel Hewitt; Taylor Zhang; Kao
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Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Danielle A. Sliter; Kazuishi Kubota; Donald S. Kirkpatrick; Kamil J. Alzayady; Steven P. Gygi; Richard J. H. Wojcikiewicz
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Near infrared spectroscopic characterisation of secondary structure content of proteins
Journal of Near Infrared Spectroscopy, ISSN: 09670335
Leon N. Hsu; Tanya P. Lin; Samir Sane
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Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Gopi Shankar; Viswanath Devanarayan; Lakshmi Amaravadi; Yu Chen Barrett; Ronald Bowsher; Deborah Finco-Kent; Michele Fiscella; Boris Gorovits; Susan Kirschner; Michael Moxness; Thomas Parish; Quarmby; Holly W. Smith; Wendell Smith; Linda A. Zuckerman; Koren
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The Filamentous Actin Cross-Linking/Bundling Activity of Mammalian Formins
Journal of Molecular Biology, ISSN: 00222836
Osigwe Esue; Elizabeth S. Harris; Henry N. Higgs; Denis Wirtz
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Generation of a prostate from a single adult stem cell
Nature, ISSN: 00280836 14764679
Kevin G. Leong; Bu-Er Wang; Leisa Johnson; Gao
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A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation
Developmental Cell, ISSN: 15345807
Alexander V. Loktev; Qihong Zhang; John S. Beck; Charles C. Searby; Todd E. Scheetz; J.Fernando Bazan; Diane C. Slusarski; Val C. Sheffield; Peter K Jackson; Maxence V. Nachury
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Distinct Thresholds Govern Myc's Biological Output In Vivo
Cancer Cell, ISSN: 15356108
Daniel J. Murphy; Melissa Junttila; Laurent Pouyet; Anthony N. Karnezis; Ksenya Shchors; Duyen A. Bui; Lamorna Brown Swigart; Leisa Johnson; Gerard I. Evan
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The conjugate addition-Peterson olefination reaction for the preparation of cross-conjugated cyclopentenone, PPAR-γ ligands
Organic and Biomolecular Chemistry, ISSN: 14770520
Mazhar Iqbal; Patricia Duffy; Paul Evans; George Cloughley; Bernard B. Allan; Agustí Lledó; Xavier Verdaguer; Antoni Riera
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Validation of column-based chromatograhy processes for the purification of proteins
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Brandeth; Chris Bussineau; Michelle D. Butler; Tony Christensen; Doris Conrad; Becky Devine; Ranga Godavarti; Eric Grund; Norbert Hentschel; Philip M. Lester; Jennifer McNay; Michael Muegge; Stephen Notarnicola; Rahul Patel; Laurie Scaggs
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Independent development of hydrolysate-containing and hydrolysate-free cho cell culture processes yields different optimal conditions
AIChE Annual Meeting, Conference Proceedings,
Diane M. Wuest; Polina Rapoport; Deborah E. Pascoe
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Chirality vs. HOMFLY and Kauffman polynomials
Journal of Knot Theory and its Ramifications, ISSN: 02182165
Sandy Ganzell; Amy V. Kapp
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Erratum: PCSK9 function and physiology (Journal of Lipid Research)
Journal of Lipid Research, ISSN: 00222275 15397262
Andrew S. Peterson; Loren G. Fong; Stephen G. Young
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Effects of cell culture conditions on antibody N-glycosylation- What causes high mannose 5 glycoform
AIChE Annual Meeting, Conference Proceedings,
Efren Pacis; Feng Li; Darren Brown; Robert Bayer
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Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome
Virology Journal, ISSN: 1743422X
Mark R. Schleiss; Alistair McGregor; K Yeon Choi; Shailesh V. Date; Xiaohong Cui; Michael A. McVoy
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Startle reactivity in children at risk for migraine
Clinical Neurophysiology, ISSN: 13882457
Roman Duncko; Lihong Cui; Jeffrey Hille; Christian Grillon; Kathleen R. Merikangas
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Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival
Clinical Cancer Research, ISSN: 10780432
Hongkui Jin; Renhui Yang; Ross; Fong; Richard A. D. Carano; Klara Totpal; David Lawrence; Zhong Zheng; Koeppen; Howard M. Stern; Ralph H. Schwall; Avi Ashkenazi
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Are health-care relationships important for mammography adherence in Latinas?
Journal of General Internal Medicine, ISSN: 08848734 15251497
Vanessa B. Sheppard; Judy Wang; Bin Yi; Toni Michelle Harrison; Shibao Feng; Elmer E. Huerta; Jeanne S. Mandelblatt
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Automated monitoring of mammalian cell cultures via an auto-sampler and an integrated multi-functional off-line analyzer
AIChE Annual Meeting, Conference Proceedings,
Gayle E. Derfus; Daniel Abramzon; Meg Tung; Robert Kiss; Ashraf Amanullah
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The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
Molecular and Cellular Biology, ISSN: 02707306
Veerendra Munugalavadla; Sasidhar Vemula; Emily Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J. Niziolek; Clifford Takemoto; Alexander G. Robling; Feng-Chun Yang; Reuben Kapur
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High throughput ADME screening: Practical considerations, impact on the portfolio and enabler of in silico ADME models
Current Drug Metabolism, ISSN: 13892002
Cornelis E. Hop; Mark J. Cole; Ralph E. Davidson; David B. Duignan; James Federico; John S. Janiszewski; Kelly Jenkins; Suzanne Krueger; Rebecca Lebowitz; Theodore E. Liston; Walter Mitchell; Mark Snyder; Stefan J. Steyn; John R. Soglia; Christine Taylor; Troutman; John Umland; Michael West; Kevin M. Whalen; Veronica Zelesky; Sabrina X. Zhao
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Some features of the kinetics and equilibrium of drug binding to plasma proteins
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255
Leonid M. Berezhkovskiy
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Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006
American Heart Journal, ISSN: 00028703 10976744
William J. Rogers; Paul D. Frederick; Edna Stoehr; John G. Canto; Joseph P. Ornato; C.Michael Gibson; Charles V. Pollack Jr.; Joel M. Gore; Nisha C. Chandra; Eric D. Peterson; William J. French
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Recombinant protein production in escherichia coli
AIChE Annual Meeting, Conference Proceedings,
Jane Gunson; Mike Laird
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How Do You Classify Asthma by Severity?
Clinical Asthma,
James E. Fish
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Monitoring and control of cell culture bioreactors using on-line scanning dielectric spectroscopy
AIChE Annual Meeting, Conference Proceedings,
Cary F. Opel; Ashraf Amanullah
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Automated de novo protein sequencing of monoclonal antibodies
Nature Biotechnology, ISSN: 10870156 15461696
Nuno Bandeira; Victoria Pham; Pavel A. Pevzner; David Arnott; Jennie R. Lill
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Harnessing the power of statistical design and the efficiency of a high throughput system for Cho media development
AIChE Annual Meeting, Conference Proceedings,
Sonali Nigam; Robb Shawley; Martin Gawlitzek; Louis Cheung; Christina Bevilacqua
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Triple light chain antibodies in thiomabs
AIChE Annual Meeting, Conference Proceedings,
Natalia Gomez; Abigail R Vinson; Jun Ouyang; Inn H. Yuk
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Establishing the credibility of a biotech simulation model
Proceedings - Winter Simulation Conference, ISSN: 08917736
Lenrick Johnston; Lee Schruben; Arden Yang; David Zhang
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Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays
Molecular Cancer Therapeutics, ISSN: 15357163
Zachary Boyd; Jenny Q. Wu; Carol O'Brien; Jill M. Spoerke; Heidi Savage; Fielder; Lukas Amler; Yibing Yan; Lackner
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Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
Drug Resistance Updates, ISSN: 13687646
Farbod Shojaei; Napoleone Ferrara
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MFAM29A promotes microtubule amplification via recruitment of the NEDDI-γ-tubuIin complex to the mitotic spindle
Journal of Cell Biology, ISSN: 00219525 00219525
Hui Zhu; Judith A. Coppinger; Chang-Young Jang; John R. Yates; Guowei Fang
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Pathophysiology and clinical implications of vascular endothelial growth factor
Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,
Napoleone Ferrara
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Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways
PLoS Medicine, ISSN: 15491277 15491676
Charles W. Lees; William J. Zacharias; Mark Tremelling; Colin L. Noble; Elaine R. Nimmo; Albert Tenesa; Jennine Cornelius; Leif Torkvist; John Kao; Susan Farrington; Hazel E. Drummond; Gwo-Tzer Ho; Ian Arnott; Henry D. Appelman; Laurie Diehl; Harry Campbell; Malcolm G. Dunlop; Miles Parkes; Sarah Howie; Deborah L. Gumucio; Jack Satsangi
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Bayesian adaptive design for targeted therapy development in lung cancer - A step toward personalized medicine
Clinical Trials, ISSN: 17407745 17407753
Xian Zhou; Suyu Liu; Edward S. Kim; Roy S. Herbst; J. Jack J. Lee
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Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?
Drug Discovery Today, ISSN: 13596446
Wendy N. Sandoval; Victoria Pham; Jennie R. Lill
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Crucial roles of robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing
Neural Development, ISSN: 17498104
Atsushi Tamada; Tatsuro Kumada; Yan Zhu; Tomoko Matsumoto; Yumiko Hatanaka; Keiko Muguruma; Zhe Chen; Yasuto Tanabe; Makio Torigoe; Kenta Yamauchi; Hiroshi Oyama; Kazuhiko Nishida; Fujio Murakami
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Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads
Osteoarthritis and Cartilage, ISSN: 10634584
Song; Joan M. Greve; Carter; Giori
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The development of avastin
Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,
Robert Mass
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Gene therapy offers HD patients relief from some symptoms
Managed Care, ISSN: 10623388
Thomas Morrow
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Overview and clinical applications of VEGF-A
Angiogenesis: An Integrative Approach From Science to Medicine,
Napoleone Ferrara
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Vascular endothelial growth factor antibodies for anti-angiogenic therapy
Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,
Hans-Peter Gerber; Megan E. Baldwin; Farbod Shojaei
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Erratum: FGF15 promotes neurnogenesis and opposes FGF8 function during neocortical development (Neural Development (2008) 3 (31))
Neural Development, ISSN: 17498104
Ugo Borello; Inma Cobos; Jason E. Long; John R. McWhirter; Cornelis Murre; John L. R. Rubenstein
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Chapter 6 Mouse Models to Investigate Anti-Cancer Effects of VEGF Inhibitors
Methods in Enzymology, ISSN: 00766879
Yongping Crawford; Napoleone Ferrara
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The semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development
Journal of Neuroscience, ISSN: 02706474 02706474
Ayal Ben-Zvi; Osnat Manor; Melitta Schachner; Avraham Yaron; Marc Tessier-Lavigne; Oded Behar
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
Cancer Research, ISSN: 00085472 15387445
Gail L. Phillips; Guangmin Li; Dugger; Lisa Crocker; Kathryn Parsons; Elaine Mai; Walter A. Blättler; John M. Lambert; Ravi Chari; Robert J. Lutz; Wai Lee T. Wong; Fred Jacobson; Koeppen; Ralph H. Schwall; Sara Kenkare-Mitra; Spencer; Mark X. Sliwkowski
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PirB is a functional receptor for myelin inhibitors of axonal regeneration
Science, ISSN: 00368075 10959203
Jasvinder K. Atwal; Julie Pinkston-Gosse; Josh Syken; Scott Stawicki; Yan Wu; Carla J. Shatz; Marc Tessier-Lavigne
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Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Avi Ashkenazi
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Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Manisha Tripathi; Srinivas Nandana; Hironobu Yamashita; Rajkumar Ganesan; Daniel Kirchhofer; Vito Quaranta
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