Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9551 - 9600 OF 15394 RESULTS

T cell-independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells
Journal of Experimental Medicine, ISSN: 00221007 00221007
Ferenc A. Scheeren; Maho Nagasawa; Kees Weijer; Tom Cupedo; Jörg Kirberg; Nicolas Legrand; Hergen Spits
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Growth hormone responsiveness: Peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): Data from the national cooperative growth study
Pediatric Endocrinology Reviews, ISSN: 15654753
Wayne V. Moore; Ken Dana; James W. Frane; Barbara M. Lippe
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Shifting patterns of inhaled antibiotic use in cystic fibrosis
Pediatric Pulmonology, ISSN: 87556863 10990496
Samuel M. Moskowitz; Stefanie J. Silva; Nicole Mayer-Hamblett; David J. Pasta; David R. Mink; Jenny A. Mabie; Michael W. Konstan; Wagener
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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Nature Genetics, ISSN: 10614036 15461718
Stacy L. Musone; Kimberly E. Taylor; Timothy T. Lu; Joanne Nititham; Ricardo C. Ferreira; Ward Ortmann; Nataliya Shifrin; Michelle Petri; M. Ilyas Kamboh; Manzi; Michael F. Seldin; Peter K. Gregersen; Timothy W. Behrens; Averil Ma; Pui-Yan Kwok; Lindsey A. Criswell
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The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Reza Khosravan; Michael J. Kukulka; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet
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Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255
Andrea N. Edginton; Frank-Peter Theil; Walter Schmitt; Stefan Willmann
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Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)
Lung Cancer, ISSN: 01695002
Josh J. Carlson; Carolina Reyes; Nina Oestreicher; Deborah Lubeck; Scott D. Ramsey; David L. Veenstra
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Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
Molecular Medicine, ISSN: 10761551
Chunyu Liu; Franak Batliwalla; Wentian Li; Annette T. Lee; Ronenn Roubenoff; Evan Beckman; Houman Khalili; Aarti Damle; Marlena Kern; Richard A. Furie; Najaf Amin; Robert M. Plenge; Marieke J.H. Coenen; Timothy W. Behrens; John P. Carulli; Peter K. Gregersen
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Hospitalized cardiovascular diseases in neovascular age-related macular degeneration
Archives of Ophthalmology, ISSN: 00039950 00039950
Bao-Anh Nguyen-Khoa; Earl L. Goehring; Winifred Werther; Emily W. Gower; Diana V. Do; Judith K. Jones
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IL-22 in mucosal immunity
Mucosal Immunology, ISSN: 19330219
Wenjun Ouyang; Patricia A. Valdez
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A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces
Journal of Molecular Biology, ISSN: 00222836
Ryan N. Gilbreth; Kaori Esaki; Akiko Koide; Sachdev S. Sidhu; Shohei Koide
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On the edge of validation - Cancer protease fibroblast activation protein
Mini-Reviews in Medicinal Chemistry, ISSN: 13895575
Beni B. Wolf; Quan; Thuy Tran; Wiesmann; Daniel P. Sutherlin
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TGFβ induces SIK to negatively regulate type I receptor kinase signaling
Journal of Cell Biology, ISSN: 00219525 00219525
Marcin Kowanetz; Peter Lönn; Michael Vanlandewijck; Katarzyna Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas
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The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC
Molecular Cell, ISSN: 10972765
Matthew K. Summers; Borlan Pan; Kiran Mukhyala; Peter K Jackson
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Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies
Cell, ISSN: 00928674
Kim Newton; Marissa L. Matsumoto; Ingrid E. Wertz; Donald S. Kirkpatrick; Jennie R. Lill; Jenille Tan; Dugger; Nathaniel C. Gordon; Sachdev S. Sidhu; Frederic A. Fellouse; László Kömüves; French; Ron Ferrando; Cynthia Lam; Deanne M. Compaan; Christine Yu; Ivan Bosanac; Sarah G. Hymowitz; Robert F. Kelley; Vishva M. Dixit
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Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
Blood, ISSN: 15280020 00064971
David D. Kim; Takashi Miwa; Yuko Kimura; Retoa Schwendener; Menno Van Lookeren Campagne; Wen-Chao Song
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Antibody Purification: Drivers of Change
Process Scale Purification of Antibodies,
Narahari Pujar; Duncan Low; O'Leary
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Potent and selective pyrazole-based inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Joshua D. Hansen; Jonas Grina; Bradley J. Newhouse; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Susan L. Gloor; Matthew Martinson; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero
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Bootstrap quantile estimation via importance resampling
Computational Statistics and Data Analysis, ISSN: 01679473
Jiaqiao Hu; Zheng Su
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Downstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities
Process Scale Purification of Antibodies,
Kelley; Gregory S. Blank; Ann L. Lee
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Advances in Technology and Process Development for Industrial-Scale Monoclonal Antibody Purification
Process Scale Purification of Antibodies,
Nuno Fontes; Robert Van Reis
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A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability
Journal of Medicinal Chemistry, ISSN: 00222623
Thomas E. Rawson; Matthias Rüth; Elizabeth M. Blackwood; Burdick; Laura B. Corson; Jennafer Dotson; Jason H. Drummond; Carter Fields; Guy J. Georges; Bernhard Goller; Jason S Halladay; Thomas Hunsaker; Tracy L. Kleinheinz; Hans-Willi Krell; Jun Li; Jun Liang; Anja Limberg; Angela McNutt; John Moffat; Gail L. Phillips; Yingqing Ran; Brian S. Safina; Ultsch; Leslie Walker; Wiesmann; Birong Zhang; Aihe Zhou; Bing-Yan Zhu; Petra Rüger; Andrea G Cochran
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Liposomal packaging generates Wnt protein with in vivo biological activity
PLoS ONE, ISSN: 19326203
Nathan T. Morrell; Philipp Leucht; Ludan Zhao; Jae-Beom Kim; Derk ten Berge; Karthik Ponnusamy; A. Lyonel Carre; Henryk Dudek; Marie Zachlederova; Michael McElhaney; Shirley A. Brunton; Janet Gunzner; Marinella G. Callow; Paul G. Polakis; Michael Costa; Xiaoyan M. Zhang; Jill A. Helms; Roel Nusse
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FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
Neural Development, ISSN: 17498104
Ugo Borello; Inma Cobos; Jason E. Long; Cornelis Murre; John L. R. Rubenstein
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Cognitive impairment after breast cancer treatment
Clinical journal of oncology nursing, ISSN: 10921095 1538067X
Tamsin Mulrooney
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Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
Development (Cambridge), ISSN: 09501991
Elizabeth A.V. Jones; Li Yuan; Christiane Bréant; Ryan J. Watts; Anne Eichmann
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Role of myeloid cells in tumor angiogenesis and growth
Trends in Cell Biology, ISSN: 09628924
Farbod Shojaei; Cuiling Zhong; Xiumin Wu; Lanlan Yu; Napoleone Ferrara
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Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: Dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding
Molecular and Cellular Biology, ISSN: 02707306
Georgina S. Butler; Richard A. Dean; Eric Tam; Christopher Overall
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High-throughput screening of chromatographic separations: IV. Ion-exchange
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Kelley; Mary Switzer; Patrick Bastek; Jack F. Kramarczyk; Kathleen Molnar; Tianning Yu; Jon L. Coffman
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New gait stimulation devices walk the coverage line. As microprocessor-controlled devices are improved to help patients maintain freedom and function, insurers are divided on coverage.
Managed Care, ISSN: 10623388
Thomas Morrow
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High-throughput screening of chromatographic separations: III. monoclonal antibodies on ceramic hydroxyapatite
Biotechnology and Bioengineering, ISSN: 00063592 10970290
David L. Wensel; Kelley; Jon L. Coffman
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Second Autologous Stem Cell Transplantation for Relapsed Lymphoma after a Prior Autologous Transplant
Biology of Blood and Marrow Transplantation, ISSN: 10838791 15236536
Sonali M. Smith; Koen van Besien; Jeanette Carreras; Asad Bashey; Mitchell S. Cairo; Cesar O. Freytes; Robert Peter Gale; Gregory A. Hale; Brandon Hayes-Lattin; Leona A. Holmberg; Armand Keating; Richard T. Maziarz; McCarthy; Willis H. Navarro; Santiago Pavlovsky; Harry C. Schouten; Matthew Seftel; Peter H. Wiernik; Julie Vose; Hillard M. Lazarus; Parameswaran Hari
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Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Molecular Biology of the Cell, ISSN: 10591524
Wanli Tang; Judy Qiju Wu; Yanxiang Guo; David V. Hansen; Jennifer A. Perry; Christopher D. Freel; Leta Nutt; Peter K Jackson; Sally Kornbluth
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Application of high-performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed in Escherichia coli
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Lebreton; Arick Brown; Robert Van Reis
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Wolman disease/cholesteryl ester storage disease: Efficacy of plant-produced human lysosomal acid lipase in mice
Journal of Lipid Research, ISSN: 00222275 15397262
Hong Du; Terri L. Cameron; Stephen J. Garger; Gregory P. Pogue; Lee A. Hamm; Earl White; Kathleen M. Hanley; Gregory A. Grabowski
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High-resolution, in vivo magnetic resonance imaging of Drosophila at 18.8 Tesla
PLoS ONE, ISSN: 19326203
Brian Null; Corey W. Liu; Maj Hedehus; Steven Conolly; Ronald W. Davis
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The Hunt for Cyclin
Cell, ISSN: 00928674
Peter K Jackson
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Safety of efalizumab therapy in patients with moderate to severe psoriasis: An open-label extension of a phase IIIb trial
Drug Safety, ISSN: 01145916
Tiffani K. Hamilton; Alan Menter; Ivor Caro; Peter Compton; Jeffrey Sobell; Kim Papp
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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Nature Biotechnology, ISSN: 15461696 10870156
Jagath R. Junutula; Helga Raab; Suzanna Clark; Sunil Bhakta; Douglas Leipold; Sylvia Weir; Chen; Michelle Simpson; Siao Ping Tsai; Dennis; Yanmei Lu; Meng; Carl Ng; Yang; Chien C. Lee; Duenas; Gorrell; Viswanatham Katta; Amy H. Kim; Kevin McDorman; Kelly Flagella; Rayna Venook; Ross; Spencer; Wai Lee Wong; Henry B. Lowman; Richard L. Vandlen; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; William Mallet
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A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
Cancer Research, ISSN: 00085472
Si Tuen Lee-Hoeflich; Lisa Crocker; Evelyn Yao; Thinh Q. Pham; Xander Munroe; Klaus P. Hoeflich; Mark X. Sliwkowski; Howard M. Stern
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Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells
Cancer Research, ISSN: 00085472
Farbod Shojaei; Napoleone Ferrara
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Discovery of novel, potent benzamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model
Journal of Medicinal Chemistry, ISSN: 00222623
Lisa D. Julian; Zhulun Wang; Tracy Bostick; Seb Caille; Rebekah Choi; Michael DeGraffenreid; Yongmei Di; Xiao He; Randall W. Hungate; Juan C. Jaen; Jinsong Liu; Mario Monshouwer; Dustin McMinn; Yosup Rew; Athena Sudom; Daqing Sun; Hua Tu; Stefania Ursu; Nigel Walker; Xuelei Yan; Qiuping Ye; Jay P. Powers
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Sγ3 switch sequences function in place of endogenous Sγ1 to mediate antibody class switching
Journal of Experimental Medicine, ISSN: 00221007 00221007
Ali A. Zarrin; Peter H. Goff; Kate Senger; Frederick W. Alt
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Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice
Journal of Neuroscience, ISSN: 02706474 02706474
Oswald Steward; Binhai Zheng; Marc Tessier-Lavigne; Maura Hofstadter; Kelli Sharp; Kelly Matsudaira Yee
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Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer
Cancer Research, ISSN: 00085472
Carol O'Brien; Guy Cavet; Ajay Pandita; Xiaolan Hu; Lauren Haydu; Sankar Mohan; Toy; Rivers; Zora Modrusan; Lukas Amler; Lackner
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The effects of anesthetic agent and carrier gas on blood glucose and tissue uptake in mice undergoing dynamic FDG-PET Imaging: Sevoflurane and Isoflurane Compared in Air and in Oxygen
Molecular Imaging and Biology, ISSN: 15361632 18602002
Judith E. Flores; Leanne McFarland; Alexander N. Vanderbilt; Annie Ogasawara; Simon P. Williams
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Molecular imaging in drug development
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Jürgen K. Willmann; Nicholas Van Bruggen; Ludger M. Dinkelborg; Sanjiv S. Gambhir
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Synthesis, characterization, and biological evaluation of integrin αvβ3-targeted PAMAM dendrimers
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Peter K. Eck; Celeste A. S. Regino; Marcelino Bernardo; Karen J. Wong; Diane E. Milenic; Peter Choyke; Martin W. Brechbiel
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Adaptive resampling algorithms for estimating bootstrap distributions
Journal of Statistical Planning and Inference, ISSN: 03783758
Jiaqiao Hu; Zheng Su
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Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer
Cancer Research, ISSN: 00085472
Carol O'Brien; Guy Cavet; Ajay Pandita; Hu; Lauren Haydu; Sankar Mohan; Toy; Rivers; Zora Modrusan; Lukas Amler; Lackner
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