Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9601 - 9650 OF 15394 RESULTS

July 1, 2008

Preclinical models of psoriasis

Veterinary Pathology, ISSN: 03009858 15442217

Dimitry Danilenko

July 1, 2008

Metabolism and disposition of dasatinib after oral administration to humans

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Lisa J. Christopher; Donghui Cui; Chiyuan Wu; Roger Luo; James Manning; Samuel J. Bonacorsi; Michael Lago; Alban Allentoff; Francis Y. F. Lee; Betty McCann; Susan Galbraith; Donald P. Reitberg; Kan He; Anthony Barros; Anne Blackwood-Chirchir; W. Griffith Humphreys; Ramaswamy A. Iyer

July 1, 2008

Identification of regions required for apical membrane localization of human multidrug resistance protein 2

Molecular Pharmacology, ISSN: 0026895X 15210111

Paul E. Bandler; Christopher J. Westlake; Caroline E. Grant; Susan P. C. Cole; Roger G. Deeley

July 1, 2008

From the bench to the bedside: Dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents

Current Opinion in Drug Discovery and Development, ISSN: 13676733

Zhonghua Pei

July 1, 2008

Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating β-catenin signaling

Cancer Research, ISSN: 00085472

Rama Pai; Debra Dunlap; Jing Qing; Iman Mohtashemi; Kathy Hötzel; French

July 1, 2008

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Ping Kang; Deepak Dalvie; Evan Smith; Sue Zhou; Alan Deese; James A. Nieman

June 30, 2008

3D micro-CT imaging of the postmortem brain

Journal of Neuroscience Methods, ISSN: 01650270

De Crespigny; Hani Bou-Reslan; Merry C. Nishimura; Phillips; Richard A. D. Carano; Helen D'Arceuil

June 27, 2008

DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1

Cell, ISSN: 00928674

Alice Ly; Anatoly Nikolaev; Geetha Suresh; Yufang Zheng; Marc Tessier-Lavigne; Elke Stein

June 23, 2008

Aurora A: Target Invalidated?

Chemistry and Biology, ISSN: 10745521

Andrea G Cochran

June 18, 2008

Molecular mechanisms controlling midline crossing by precerebellar neurons

Journal of Neuroscience, ISSN: 02706474 02706474

Thomas Di Meglio; Kim T. Nguyen-Ba-Charvet; Marc Tessier-Lavigne; Constantino Sotelo; Alain Chedotal

June 17, 2008

DEAF-1 regulates immunity gene expression in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Darien E. Reed; Xinhua M. Huang; James A. Wohlschlegel; Michael Levine; Kate Senger

June 15, 2008

Improvement in patient-reported outcomes in a rituximab trial in patients with severe rheumatoid arthritis refractory to anti-tumor necrosis factor therapy

Arthritis Care and Research, ISSN: 21514658

Edward Keystone; Gerd R. Burmester; Richard A. Furie; James E. Loveless; Paul Emery; Joel M. Kremer; Paul P. Tak; Michael S. Broder; Elaine B. Yu; Matthew W. Cravets; Fabio Magrini; Jost

June 15, 2008

Final survival and safety results from a multicenter, open-label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer

Cancer, ISSN: 0008543X 10970142

David Spigel; Ming Lin; Vincent O'Neill; John Hainsworth

June 13, 2008

Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion

BMC Systems Biology, ISSN: 17520509

Xiaodong Huang; Jean Y.J. Wang; Xin Lu

June 13, 2008

Bridging Toll-like- and B Cell-Receptor Signaling: Meet Me at the Autophagosome

Immunity, ISSN: 10747613

John G. Monroe; Mary E. Keir

June 11, 2008

Genomic analysis of Drosophila neuronal remodeling: A role for the RNA-binding protein boule as a negative regulator of axon pruning

Journal of Neuroscience, ISSN: 02706474 02706474

Eric D. Hoopfer; Andrea Penton; Ryan J. Watts; Liqun Luo

June 10, 2008

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

Experimental Cell Research, ISSN: 00144827

Mirjana Liovic; Brian B. Lee; Marjana Tomic-Canic; Mariella D'Alessandro; Viacheslav N. Bolshakov; E. Birgitte Lane

June 10, 2008

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

Experimental Cell Research, ISSN: 00144827

Mirjana Liovic; Brian Lee; Marjana Tomic-Canic; Mariella D'Alessandro; Viacheslav N. Bolshakov; E. Birgitte Lane

June 3, 2008

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Li-Chung Hsu; Syed R. Ali; Shauna McGillivray; Ping-Hui Tseng; Sanjeev Mariathasan; Eric W. Humke; Lars Eckmann; Jonathan J. Powell; Victor Nizet; Vishva M. Dixit; Michael Karin

June 2, 2008

To kill a tumor cell: The potential of proapoptotic receptor agonists

Journal of Clinical Investigation, ISSN: 00219738 15588238

Avi Ashkenazi; Roy S. Herbst

June 1, 2008

PCSK9 function and physiology

Journal of Lipid Research, ISSN: 00222275 15397262

Andrew S. Peterson; Loren G. Fong; Stephen G. Young

June 1, 2008

A golden era of opportunity in immunotherapy discovery and development

Immunological Reviews, ISSN: 01052896 1600065X

Andrew A. Chan

June 1, 2008

Vascular endothelial growth factors in pulmonary edema: An update

Journal of Thrombosis and Thrombolysis, ISSN: 09295305

Ioanna Kosmidou; Dimitrios Karmpaliotis; Ajay J. Kirtane; Hal V. Barron; C.Michael Gibson

June 1, 2008

Design opportunities for actively targeted nanoparticle vaccines

Nanomedicine, ISSN: 17435889

Tarek M. Fahmy; Stacey L. Demento; Michael J. Caplan; Ira Mellman; W. Mark Saltzman

June 1, 2008

High-resolution genomic and expression analyses of copy number alterations in breast tumors

Genes Chromosomes and Cancer, ISSN: 10452257 10982264

Matthias Peter; Jane Fridlyand; Li Li; Gad Getz; Rameen Beroukhim; Scott Lohr; Thomas D Wu; Guy Cavet; Zemin Zhang; John Chant

June 1, 2008

Dendritic cells: Driving the differentiation programme of T cells in viral infections

Immunology and Cell Biology, ISSN: 08189641 14401711

Frederick Masson; Adele Mount; Nicholas S. Wilson; Gabrielle T Belz

June 1, 2008

Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay

Journal of Immunological Methods, ISSN: 00221759

Yang; Carl Ng; Henry B. Lowman; Chestnut; Cheryl A. Schofield; Bryan Sandlund; James A. Ernst; Bennett; Quarmby

June 1, 2008

Ubiquitin-mediated regulation of TNFR1 signaling

Cytokine and Growth Factor Reviews, ISSN: 13596101

Ingrid E. Wertz; Vishva M. Dixit

June 1, 2008

Multiple sclerosis risk after optic neuritis: Final optic neuritis treatment trial follow-up

Archives of Neurology, ISSN: 00039942 15383687

Michael Brodsky; Sarkis Nazarian; Silvia Orengo-Nania; George J. Hutton; Edward G. Buckley; E. Wayne Massey; M. Tariq Bhatti; Melvin Greer; James Goodwin; Michael Wall; Peter J. Savino; Thomas Leist; Neil R. Miller; David Irani; Jonathan D. Trobe; Wayne Cornblath; David I. Kaufman; Eric Eggenberger; Mark J. Kupersmith; William T. Shults; Leslie McAllister; Steve Hamilton; Roy W. Beck; Mariya Dontchev; Robin L. Gal; Craig Kollman; John L. Keltner; Craig H. Smith

June 1, 2008

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

Cell Cycle, ISSN: 15514005 15384101

Eugene Varfolomeev; Domagoj Vucic

June 1, 2008

MetMAb, the one-armed 5d5 anti-c-met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

Cancer Research, ISSN: 00085472

Hongkui Jin; Renhui Yang; Zhong Zheng; Mally Romero; Ross; Hani Bou-Reslan; Richard A. D. Carano; Ian Kasman; Elaine Mai; Judy Young; Jiping Zha; Zemin Zhang; Ross; Ralph H. Schwall; Gail T. Colbern; Mark Merchant

June 1, 2008

Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl] -2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

C. Edwin Garner; Eric G. Solon; Chii-Ming Lai; Jianrong Lin; Gang Luo; Kevin Jones; Jingwu Duan; Carl P. Decicco; Thomas Maduskuie; Stephen E. Mercer; Lian-Shen Gan; Mingxin Qian; Shimoga Prakash; Huey-Shin Shen; Frank W. Lee

June 1, 2008

Netrin-1 inhibits sprouting angiogenesis in developing avian embryos

Developmental Biology, ISSN: 00121606

Karine Bouvrée; Bruno Larrivee; Xiang Lv; Li Yuan; Benjamin DeLafarge; Catarina Freitas; Thomas Mathivet; Christiane Bréant; Marc Tessier-Lavigne; Andréas Bikfalvi; Anne Eichmann; Luc Pardanaud

June 1, 2008

Targeting the extrinsic apoptosis pathway in cancer

Cytokine and Growth Factor Reviews, ISSN: 13596101

Avi Ashkenazi

June 1, 2008

Use of quantitative pharmacology in the development of HAE1, a high-affinity anti-ige monoclonal antibody

AAPS Journal, ISSN: 15507416

Wendy Putnam; Jing Li; Jonas Haggstrom; Chee Ng; Saloumeh Kadkhodayan Fischer; Melissa Cheu; Yamo Deniz; Henry B. Lowman; Fielder; Jennifer Visich; Amita Joshi; Nelson L'ntshotsholé Jumbe

May 26, 2008

In vitro Protein Refolding

Biotechnology: Second, Completely Revised Edition,

Cleland; Daniel I. C. Wang

May 26, 2008

Proteins and Peptides as Drugs: Sources and Methods of Purification

Biotechnology: Second, Completely Revised Edition,

Stuart E. Builder; Robert L. Garnick; James C. Hodgdon; John R. Ogez

May 15, 2008

On-line CE-LIF-MS technology for the direct characterization of N-linked glycans from therapeutic antibodies

Analytical Chemistry, ISSN: 00032700

Lynn Gennaro; Oscar Salas-Solano

May 15, 2008

IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via RrγRIIa

Blood, ISSN: 15280020 00064971

Anna Smed-Sörensen; Markus Moll; Tan-Yuri Cheng; Karin Loré; Anna-Carin Norlin; Leif Perbeck; D. Branch Moody; Anna-Lena Spetz; Johan K. Sandberg

May 14, 2008

Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling

PLoS ONE, ISSN: 19326203

Bu-Er Wang; Xi-De Wang; James A. Ernst; Paul G. Polakis; Gao

May 9, 2008

The hominoid-specific oncogene TBC1d3 activates ras and modulates epidermal growth factor receptor signaling and trafficking

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Marisa J. Wainszelbaum; Audra J. Charron; Chen Kong; Donald S. Kirkpatrick; Priya Srikanth; M. Alejandro Barbieri; Steven P. Gygi; Philip D. Stahl

May 8, 2008

Alternative Splicing of the Robo3 Axon Guidance Receptor Governs the Midline Switch from Attraction to Repulsion

Neuron, ISSN: 08966273

Zhe Chen; Bryan B. Gore; Hua Long; Le Ma; Marc Tessier-Lavigne

May 7, 2008

Proteins and Peptides as Drugs: Sources and Methods of Purification

Biotechnology: Second, Completely Revised Edition,

Stuart E. Builder; Robert L. Garnick; James C. Hodgdon; John R. Ogez

May 7, 2008

In vitro Protein Refolding

Biotechnology: Second, Completely Revised Edition,

Cleland; Daniel I. C. Wang

May 1, 2008

Manufacturing control systems bridge production and IT

Control Engineering, ISSN: 00108049

Ronald E. Menéndez; Darrell Tanner

May 1, 2008

Efalizumab: Results of a 3-year continuous dosing study for the long-term control of psoriasis

British Journal of Dermatology, ISSN: 00070963 13652133

Craig Leonardi; Alan Menter; Tiffani K. Hamilton; Ivor Caro; Xing; Alice Gottlieb

May 1, 2008

Topography of thalamic projections requires attractive and repulsive functions of netrin-1 in the ventral telencephalon

PLoS Biology, ISSN: 15449173 15457885

Ashton W. Powell; Takayuki Sassa; Yongqin Wu; Marc Tessier-Lavigne; Franck Polleux

May 1, 2008

Second-line and third-line chemotherapy for lung cancer: Use and cost

American Journal of Managed Care, ISSN: 10880224

Scott D. Ramsey; Renato G. Martins; David Blough; Lauri S. Tock; Deborah Lubeck; Carolina Reyes

May 1, 2008

Maturation modulates caspase-1-independent responses of dendritic cells to anthrax lethal toxin

Cellular Microbiology, ISSN: 14625814 14625822

Núria Reig; Aimin Jiang; Rachael Couture; Fayyaz S. Sutterwala; Yasunori Ogura; Richard A. Flavell; Ira Mellman; F. Gisou Van Der Goot

May 1, 2008

Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

Oncogene, ISSN: 09509232 14765594

Hauke S. Günther; Nils-Ole Schmidt; Phillips; Dirk Kemming; Samir Kharbanda; Robert Soriano; Zora Modrusan; Meissner; Manfred Westphal; Katrin Lamszus

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