Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9701 - 9750 OF 15394 RESULTS

Tumor necrosis factor: Renaissance as a cancer therapeutic?
Current Cancer Drug Targets, ISSN: 15680096
Dylan Daniel; Nicholas S. Wilson
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Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug
Xenobiotica, ISSN: 00498254 13665928
S. Cyrus Khojasteh; Douglas Leipold; Lai; Hank La; Matthew Baumgardner; Desino; Gudmundsson; Duane C. Bloedow; Bodary; Mark E. Reynolds; Thomas Gadek; Sara Kenkare-Mitra
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Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: Support for a crucial role of intron 1 polymorphisms
Arthritis and Rheumatism, ISSN: 00043591
Aya Kawasaki; Chieko Kyogoku; Jun Ohashi; Risa Miyashita; Koki Hikami; Makio Kusaoi; Katsushi Tokunaga; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Naoyuki Tsuchiya
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Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects
British Journal of Clinical Pharmacology, ISSN: 03065251 13652125
Reza Khosravan; Brian Grabowski; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet
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Combination intravitreal triamcinolone injection and cryotherapy for exudative retinal detachments in severe coats disease
Retina, ISSN: 0275004X
Chris S. Bergstrom; G. Baker Hubbard III
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The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis
Molecular Biology of the Cell, ISSN: 10591524
Elsa N. N'Diaye; Aylin C. Hanyaloglu; Kimberly K. Kajihara; Manojkumar A. Puthenveedu; Ping Wu; Mark Von Zastrow; Eric J. Brown
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Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during Zebrafish vasculogenesis
Developmental Dynamics, ISSN: 10588388 10970177
Ann De Mazière; Leon Parker; Suzanne Van Dijk; Weilan Ye; Judith Klumperman
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Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors
Current Cancer Drug Targets, ISSN: 15680096
Domagoj Vucic
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Subcutaneous efalizumab is not effective in the treatment of alopecia areata
Journal of the American Academy of Dermatology, ISSN: 01909622
Vera H. Price; Maria K. Hordinsky; Elise A. Olsen; Janet L. Roberts; Elaine C. Siegfried; Elyse S. Rafal; Neil J. Korman; Basel Altrabulsi; Hoi M. Leung; Marvin Garovoy; Ivor Caro; David A. Whiting
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Multi-step variance minimization in sequential tests
Statistics and Computing, ISSN: 09603174
Zheng Su; Jiaqiao Hu; Wei Zhu
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Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses
Virology, ISSN: 00426822 10960341
Isidro Hötzel
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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
New England Journal of Medicine, ISSN: 15334406 00284793
Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette T. Lee; Sharon A. Chung; Ricardo C. Ferreira; P. V. Krishna Pant; Dennis G. Ballinger; Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Tian; Iva Gunnarsson; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens
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Stem Cell Factor Functions as an Outgrowth-Promoting Factor to Enable Axon Exit from the Midline Intermediate Target
Neuron, ISSN: 08966273
Bryan B. Gore; Karen G. Wong; Marc Tessier-Lavigne
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Are Phase 2 screening trials in Oncology obsolete?
Statistics in Medicine, ISSN: 02776715 10970258
Holmgren
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Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin
Journal of Neuroscience, ISSN: 02706474 02706474
Dragoslav Zikich; Aviv Mezer; Frederique Varoqueaux; Anton Sheinin; Harald Junge; Esther Nachliel; Rely Melamed; Nils Brose; Menachem Gutman; Uri Ashery
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Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Farbod Shojaei; Mallika Singh; Jennifer D. Thompson; Napoleone Ferrara
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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior
Analytical Biochemistry, ISSN: 10960309 00032697
Quan; Emily W. Alcala; Irena Petkovska; Domenic Matthews; Eleanor Canova-Davis; Ron Taticek; Stacey Ma
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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
New England Journal of Medicine, ISSN: 15334406 00284793
Stephen L. Hauser; Waubant; Douglas L. Arnold; Timothy Vollmer; Jack Antel; Robert J. Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H. Smith
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Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Pierre A. Barthelemy; Helga Raab; Brent A. Appleton; Christopher J. Bond; Ping Wu; Wiesmann; Sachdev S. Sidhu
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Engineering and Overproduction of Polyketide Natural Products
Modern Biopharmaceuticals: Design, Development and Optimization,
Martha Lovato Tse; Chaitan Khosla
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pH dependent effect of glycosylation on protein stability
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Wei Wang; Kris Antonsen; Y. John Wang; Wang
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Racial variation in the incidence, care, and outcomes of severe sepsis: Analysis of population, patient, and hospital characteristics
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Amber E. Barnato; Sherri L. Alexander; Walter T. Linde-Zwirble; Derek C. Angus
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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Nature Genetics, ISSN: 10614036 15461718
John B. Harley; Marta E. Alarcón-Riquelme; Lindsey A. Criswell; Chaim O. Jacob; Robert P. Kimberly; Kathy L. Moser; Betty P. Tsao; Timothy J. Vyse; Carl D. Langefeld; Swapan K. Nath; Joel M. Guthridge; Beth L. Cobb; Daniel B. Mirel; Miranda C. Marion; Adrienne H. Williams; Jasmin Divers; Wei Wang; Summer G. Frank; Bahram Namjou; Stacey B. Gabriel; Annette T. Lee; Peter K. Gregersen; Timothy W. Behrens; Kimberly E. Taylor; Michelle M.A. Fernando; Raphael Zidovetzki; Patrick M. Gaffney; Jeffrey C. Edberg; John D. Rioux; Joshua O. Ojwang; Judith A. James; Merrill; Gary S. Gilkeson; Michael F. Seldin; Hong Yin; Emily C. Baechler; Quan-Zhen Li; Edward K. Wakeland; Gail R. Bruner; Kenneth M. Kaufman; Jennifer A. Kelly
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Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate?
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Janet Clarke; Christopher Hurst; Pauline L. Martin; John Vahle; Rafael Ponce; Barbara Mounho; Shawn Heidel; Laura Andrews; Theresa Reynolds; Joy A. Cavagnaro
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Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Jonathan Corren; Gail Shapiro; Reimann; Yamo Deniz; Dennis A. Wong; Daniel C. Adelman; Alkis Togias
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Transplantation: It may take two to tango and to treat
Immunology and Cell Biology, ISSN: 08189641 14401711
Flavius Martin
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Cleaning validation for biopharmaceutical manufacturing at Genentech
BioPharm International, ISSN: 1542166X
A. Hamid Mollah
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Economic evaluation of rituximab plus cyclophosphamide, vincristine and prednisolone for advanced follicular lymphoma
Leukemia and Lymphoma, ISSN: 10428194 10292403
John Hornberger; Carolina Reyes; Deborah Lubeck; Nancy Valente
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Interaction between bevacizumab and murine VEGF-A: A reassessment
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer Lecouter; Claudio Campa; Fuh; Henry B. Lowman; Napoleone Ferrara
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Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals
Anti-Cancer Drugs, ISSN: 09594973
Jie Ling; Scott Fettner; Bert L. Lum; Myriam Riek; Ashok Rakhit
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Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
Immunology and Cell Biology, ISSN: 08189641 14401711
Nicholas S. Wilson; Louise J. Young; Fiona Kupresanin; Shalin H. Naik; David Vremec; William R. Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle T Belz; Jose A. Villadangos
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Netrin-1 is a novel myelin-associated inhibitor to axon growth
Journal of Neuroscience, ISSN: 02706474 02706474
Karin Löw; Maya Culbertson; Frank Bradke; Marc Tessier-Lavigne; Mark H. Tuszynski
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SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
EMBO Journal, ISSN: 02614189 14602075
Vikki M. Weake; Kenneth K. Lee; Sebastián Guelman; Chia-Hui Lin; Christopher Seidel; Susan M. Abmayr; Jerry L. Workman
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Dual effects of Tween 80 on protein stability
International Journal of Pharmaceutics, ISSN: 03785173
Wei Wang; Y. John Wang; Wang
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Role for lysosomal enzyme β-hexosaminidase in the control of mycobacteria infection
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Ingrid Chou Koo; Yamini M. Ohol; Ping Wu; J. Hiroshi Morisaki; Jeffery S. Cox; Eric J. Brown
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Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer
Clinical Cancer Research, ISSN: 10780432
Peisheng Hu; Robyn S. Arias; Rebecca E. Sadun; Yu-Chih Nien; Nan Zhang; Helen Sabzevari; M. E. Christine Lutsiak; Leslie A. Khawli; Alan L. Epstein
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Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Lluis Masip; Daniel Klein-Marcuschamer; Shu Quan; James C. A. Bardwell; George Georgiou
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Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107
Journal of Clinical Oncology, ISSN: 0732183X
Grothey; Eric Hedrick; Robert Mass; Somnath Sarkar; Sam Suzuki; Ramesh K. Ramanathan; Herbert Hurwitz; Richard M. Goldberg; Daniel J. Sargent
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Synthetic antibodies for specific recognition and crystallization of structured RNA
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jing-Dong Ye; Valentina Tereshko; John K. Frederiksen; Akiko Koide; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Anthony A. Kossiakoff; Joseph A. Piccirilli
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Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models
Oncogene, ISSN: 09509232 14765594
Luc Desnoyers; Rama Pai; Ron Ferrando; Kathy Hötzel; Tom Le; Ross; Richard A. D. Carano; Aloma L. D'Souza; Jing Qing; Iman Mohtashemi; Avi Ashkenazi; French
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Accounting for Interim Analyses in the Assessment of Program Expected Net Present Value
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
Lee D. Kaiser; Jeffrey D. Helterbrand; Hal V. Barron
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Quantification of viable tumor microvascular characteristics by multispectral analysis
Magnetic Resonance in Medicine, ISSN: 15222594 07403194
Berry; Kai H. Barck; MaryAnn Go; Ross; Xiumin Wu; Simon P. Williams; Alvin Gogineni; Mary J. Cole; Nicholas Van Bruggen; Fuh; Franklin V. Peale Jr.; Napoleone Ferrara; Ross; Ralph H. Schwall; Richard A. D. Carano
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Improved health-related quality of life for patients with active rheumatoid arthritis receiving rituximab - Results of the dose-ranging assessment: International clinical evaluation of rituximab in rheumatoid arthritis (DANCER) trial
Journal of Rheumatology, ISSN: 0315162X
Philip J. Mease; Dennis A. Revicki; Jacek Szechinski; Maria Greenwald; Alan Kivitz; Leonor Barile-Fabris; Jatinderpal Kalsi; Jennifer Eames; Marjatta Leirisalo-Repo
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The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (SimCYP™) predicts in vivo metabolic inhibition
European Journal of Clinical Pharmacology, ISSN: 00316970
Ashok Rakhit; Michael P. Pantze; Scott Fettner; Hannah M. Jones; Jean-Eric Charoin; Myriam Riek; Bert L. Lum; Marta Hamilton
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In reply
Annals of Emergency Medicine, ISSN: 01960644
Andrew R. Erdman
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hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of β-catenin
Cancer Biology and Therapy, ISSN: 15384047 15558576
Min Yang; Marian L. Waterman; Rainer Brachmann
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Subspecialty differences in asthma characteristics and management
Mayo Clinic Proceedings, ISSN: 00256196
Hubert Chen; Charles A. Johnson; Tmirah Haselkorn; June H. Lee; Elliot Israel
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Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content
Biologicals, ISSN: 10451056 10958320
Rodney Keck; Namita Nayak; Laura Lerner; Shanta Raju; Stacey Ma; Thomas Schreitmueller; Steven M. Chamow; Kathy Moorhouse; Claire Kotts; Andrew J.S. Jones
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Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1
Clinical Cancer Research, ISSN: 10780432
Nina Korsisaari; Ross; Xiumin Wu; Marcin Kowanetz; Navneet Pal; Linda Hall; Jeffrey Eastham-Anderson; William F. Forrest; Nicholas Van Bruggen; Franklin V. Peale Jr.; Napoleone Ferrara
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Recommended changes to oncology clinical trial design: Revolution or evolution?
European Journal of Cancer, ISSN: 09598049
Ratain; Rachel W. Humphrey; Gary Gordon; Gwendolyn Fyfe; Peter C. Adamson; Thomas R. Fleming; Walter M. Stadler; Donald A. Berry; Carl C. Peck
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