Genentech: Publications

December 15, 2006

Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

International Journal of Cancer, ISSN: 00207136 10970215

Alexei V. Salnikov; Nils-Erik Heldin; Linda B. Stuhr; Helge Wiig; Hans-Peter Gerber; Rolf K. Reed; Kristofer Rubin

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December 13, 2006

Making antibodies in bacteria

Making and Using Antibodies: A Practical Handbook,

Frederic A. Fellouse; Sachdev S. Sidhu

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December 5, 2006

An exclusion mechanism in ion exchange chromatography

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Chithkala Harinarayan; Jay Mueller; Anders Ljunglöf; Fahrner; James M. Van Alstine; Van Reis

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December 1, 2006

Concluding summary: Proceedings of the AAPS Biotec Open Forum on "Aggregation of Protein Therapeutics"

AAPS Journal, ISSN: 15507416

Steven J. Shire; Cromwell; Jun Liu

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December 1, 2006

Sustained benefit in rheumatoid arthritis following one course of rituximab: Improvements in physical function over 2 years

Rheumatology, ISSN: 14620324 14620332

Vibeke Strand; Balbir-Gurman; Karel Pavelka; Paul Emery; Nicole F. Li; Ming Yin; Lehane; Sunil Agarwal

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December 1, 2006

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling

Molecular and Cellular Proteomics, ISSN: 15359476

Pierre-Olivier Angrand; Inmaculada Segura; Pamela Völkel; Sonja Ghidelli; Rebecca Terry; Miro Brajenovic; Kristina Vintersten; Rüdiger Klein; Giulio Superti-Furga; Gerard Drewes; Bernhard Kuster; Tewis Bouwmeester; Amparo Acker-Palmer

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December 1, 2006

Genetics of autoimmune diseases - Disorders of immune homeostasis

Nature Reviews Genetics, ISSN: 14710056 14710064

Peter K. Gregersen; Timothy W. Behrens

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December 1, 2006

Glucuronidation in the chimpanzee (Pan troglodytes): Studies with acetaminophen, oestradiol and morphine

Xenobiotica, ISSN: 00498254 13665928

Harvey Wong; James E. Grace Jr.; Matthew Wright; Browning; Grossman; Bai; David D. Christ

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December 1, 2006

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: Potential application in humorally mediated autoimmune disease

International Immunology, ISSN: 09538178 14602377

Stefka B. Petkova; Shreeram Akilesh; Thomas J. Sproule; Gregory J. Christianson; Hana Al Khabbaz; Aaron C. Brown; Presta; Meng; Derry C. Roopenian

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December 1, 2006

Estimation of baculovirus titer based on viable cell size

Nature Protocols, ISSN: 17542189 17502799

Vasantharajan Janakiraman; William F. Forrest; Somasekar Seshagiri

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December 1, 2006

Making independence work: Monitoring the bevacizumab colorectal cancer clinical trial

Data Monitoring in Clinical Trials: A Case Studies Approach,

Janet Wittes; Holmgren; Heidi Christ-Schmidt; Alex Bajamonde

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December 1, 2006

Herpes zoster vaccine brings relief for the elderly.

Managed Care, ISSN: 10623388

Thomas Morrow

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December 1, 2006

Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus

PLoS Medicine, ISSN: 15491277 15491676

Jason W. Bauer; Emily C. Baechler; Michelle Petri; Franak Batliwalla; Dianna Crawford; Ward Ortmann; Karl J. Espe; Wentian Li; Dhavalkumar D. Patel; Peter K. Gregersen; Timothy W. Behrens

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December 1, 2006

High prevalence of skin test positivity in severe or difficult-to-treat asthma

Journal of Asthma, ISSN: 02770903 15324303

Tmirah Haselkorn; Larry Borish; Dave P. Miller; Weiss; Dennis A. Wong

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December 1, 2006

Targeting the Hedgehog pathway in cancer

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Lee L. Rubin; Frederic J. De Sauvage

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December 1, 2006

Sensitive detection of KIT D816V in patients with mastocytosis

Clinical Chemistry, ISSN: 00099147

Tan; David Westerman; McArthur; Kevin Lynch; Waring; Dobrovic

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December 1, 2006

Development and validation of a preference weight multiattribute health outcome measure for rheumatoid arthritis

Journal of Rheumatology, ISSN: 0315162X

Chiun-Fang Chiou; Maria E. Suarez-Almazor; Cathy D. Sherbourne; Chih-Hung Chang; Carolina Reyes; Michelle Dylan; Joshua Ofman; Daniel J. Wallace; Wesley Mizutani; Michael Weisman

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December 1, 2006

Bringing science to cancer therapy

Yale Journal of Biology and Medicine, ISSN: 00440086

Ira Mellman

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December 1, 2006

TENOR risk score predicts healthcare in adults with severe or difficult-to-treat asthma

European Respiratory Journal, ISSN: 09031936

Mary K. Miller; June H. Lee; Paul D. Blanc; David J. Pasta; Gujrathi; Hal V. Barron; Sally E. Wenzel; Weiss

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November 20, 2006

Selectivity improvements in highly charged UF membranes

Desalination, ISSN: 00119164

Alex Xenopoulos; Charkoudian; Robert Van Reis

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November 20, 2006

Protein NMR Spectroscopy: Principles and Practice

Protein NMR Spectroscopy: Principles and Practice,

John Cavanagh; Wayne J. Fairbrother; Arthur G. Palmer III; Mark Rance; Nicholas J. Skelton

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November 16, 2006

Boc is a receptor for sonic hedgehog in the guidance of commissural axons

Nature, ISSN: 14764687 00280836

Ami Okada; Frédéric Charron; Steves Morin; David S. Shin; Karen G. Wong; Pierre J. Fabre; Marc Tessier-Lavigne; Susan K. McConnell

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November 15, 2006

Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest

EMBO Journal, ISSN: 02614189 14602075

George B. Kyei; Isabelle Vergne; Jennifer Chua; Esteban Roberts; James Harris; Jagath R. Junutula; Vojo Deretic

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November 10, 2006

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Nature, ISSN: 14764687 00280836

Wiesmann; Kenneth J. Katschke Jr.; Jianping Yin; Karim Y. Helmy; Micah Steffek; Wayne J. Fairbrother; Scott A. McCallum; Lizette Sturgeon; Laura DeForge; Hass; Menno Van Lookeren Campagne

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November 1, 2006

Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects

Human Heredity, ISSN: 00015652

Hsin-Ju Hsieh; Christina G.S. Palmer; Janet S. Sinsheimer

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November 1, 2006

Inhibitory effect of carboxylic acid group on hERG binding

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Bing-Yan Zhu; Zhaozhong J. Jia; Penglie Zhang; Ting Su; Wenrong Huang; Erick Goldman; Daniel B. Tumas; Vic Kadambi; Priya Eddy; Uma Sinha; Robert M. Scarborough; Yonghong Song

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November 1, 2006

Human immunodeficiency virus persistence and production in T-cell development

Clinical and Vaccine Immunology, ISSN: 15566811

Kevin B. Gurney; Christel H. Uittenbogaart

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November 1, 2006

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo

PLoS Biology, ISSN: 15457885 15457885

Noah W. Gray; Robby M. Weimer; Ingrid Bureau; Karel Svoboda

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November 1, 2006

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

Molecular and Cellular Biology, ISSN: 02707306

Zhaoyu Jin; Wafik S. El-Deiry

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November 1, 2006

Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease

Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586

Joan M. Greve; Chico; Hope Goldman; Bunting; Franklin V. Peale Jr.; Daugherty; Nicholas Van Bruggen; Simon P. Williams

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November 1, 2006

Preclinical pharmacokinetics and metabolism of 6-(4- (2,5-Difluorophenyl)oxazol-5-yk)-3-isopropyl-[1,2,4]-triazolo[4,3- a]pyridine, a novel and selective p38α inhibitor: Identification of an active metaboline in preclinical species and human liver microsomes

Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X

Amit S. Kalgutkar; Heather L. Hatch; Frederick Kosea; Hang T. Nguyen; Edna F. Choo; Kim F. McClure; Timothy J. Taylor; Kirk R. Henne; Alexander V. Kuperman; Mark A. Dombroski; Michael A. Letavic

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November 1, 2006

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

Cellular Signalling, ISSN: 08986568

Simon Rousseau; Ignacio Dolado; Victoria Beardmore; Natalia Shpiro; Rodolfo Marquez; Angel R. Nebreda; J. Simon C. Arthur; Lauren C Case; Marc Tessier-Lavigne; Matthias Gaestel; Ana Cuenda; Philip Cohen

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November 1, 2006

Reply to Challenges to the report of Nogo antibody effects in primates [4]

Nature Medicine, ISSN: 10788956 1546170X

Carole Ho; Marc Tessier-Lavigne

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November 1, 2006

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells

Blood, ISSN: 00064971 00064971

Chingwei V. Lee; Sarah G. Hymowitz; Heidi J. A. Wallweber; Nathaniel C. Gordon; Karen L Billeci; Siao Ping Tsai; Deanne M. Compaan; Jianping Yin; Qian Gong; Robert F. Kelley; Laura DeForge; Flavius Martin; Melissa A. Starovasnik; Fuh

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November 1, 2006

Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) β-receptor but not the PDGF α-receptor

Molecular Biology of the Cell, ISSN: 10591524

Susann Karlsson; Katarzyna Kowanetz; Åsa Sandin; Camilla Persson; Arne Östman; Carl-Henrik Heldin; Carina Hellberg

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November 1, 2006

The process engineer's role in technology transfers to CMOs

American Pharmaceutical Outsourcing, ISSN: 15296318

Bender

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November 1, 2006

Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study

Archives of Ophthalmology, ISSN: 00039950 00039950

Jeffrey S. Heier; David S. Boyer; Thomas A. Ciulla; Philip J. Ferrone; J. Michael Jumper; Ronald C. Gentile; Debbie Kotlovker; Carol Chung; Robert Kim

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November 1, 2006

Quality by design, validation, and PAT: Operational, statistical, and engineering perspectives

Pharmaceutical Engineering, ISSN: 02738139

Ron Branning; Lynn Torbeck; Cliff Campbell

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November 1, 2006

Alteplase for the treatment of central venous catheter occlusion in children: Results of a prospective, open-label, single-arm study (The Cathflo Activase Pediatric Study)

Journal of Vascular and Interventional Radiology, ISSN: 10510443

Martha Blaney; Violet Shen; John A. Kerner; Brian R. Jacobs; Sarah Gray; Jennifer Armfield; Charles P. Semba

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November 1, 2006

Technical considerations in the development of prefilled syringes for protein products

American Pharmaceutical Review, ISSN: 10998012

David E. Overcashier; Edwin K. Chan; Chung C. Hsu

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November 1, 2006

Reply to Challenges to the report of Nogo antibody effects in primates [4]

Nature Medicine, ISSN: 10788956 1546170X

Carole Ho; Marc Tessier-Lavigne

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November 1, 2006

Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study

Archives of Ophthalmology, ISSN: 00039950 00039950

Jeffrey S. Heier; David S. Boyer; Thomas A. Ciulla; Philip J. Ferrone; J. Michael Jumper; Ronald C. Gentile; Debbie Kotlovker; Carol Y. Chung; Robert Kim

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October 26, 2006

Corneal avascularity is due to soluble VEGF receptor-1

Nature, ISSN: 14764687 00280836

Balamurali K. Ambati; Miho Nozaki; Nirbhai Singh; Atsunobu Takeda; Pooja D. Jani; Tushar Suthar; Romulo J. C. Albuquerque; Elizabeth Richter; Eiji Sakurai; Michael T. Newcomb; Mark E. Kleinman; Ruth Caldwell; Qing Lin; Yuichiro Ogura; Angela Orecchia; Don A. Samuelson; Dalen W. Agnew; Judy St. Leger; W. Richard Green; Parameshwar J. Mahasreshti; David T. Curiel; Donna Kwan; Helene Marsh; Sakae Ikeda; Lucy J. Leiper; J. Martin Collinson; Sasha Bogdanovich; Tejvir S. Khurana; Masabumi Shibuya; Megan E. Baldwin; Napoleone Ferrara; Hans-Peter Gerber; Sandro De Falco; Jassir Witta; Judit Z. Baffi; Brian J. Raisler; Jayakrishna Ambati

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October 15, 2006

Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors [3]

Clinical Cancer Research, ISSN: 10780432

Loughrey; Waring; Dobrovic; George Demetri; Kovalenko; McArthur

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October 15, 2006

The Hedgehog signaling pathway in cancer

Clinical Cancer Research, ISSN: 10780432

Marie Evangelista; Hua Tian; Frederic J. De Sauvage

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October 15, 2006