Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10251 - 10300 OF 15396 RESULTS

A high throughput electrochemiluminescent cell-binding assay for therapeutic anti-CD20 antibody selection
Journal of Immunological Methods, ISSN: 00221759
Yanmei Lu; Wai Lee T. Wong; Meng
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Developmental neurobiology: A destructive switch for neurons
Nature, ISSN: 14764687 00280836
Peter K Jackson
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Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
Oncogene, ISSN: 09509232 14765594
Shulewitz; Soloviev; Thomas D Wu; Koeppen; Paul G. Polakis; Sakanaka
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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo
Biochemical Journal, ISSN: 02646021
Harumi Shimizu; David Saliba; Maura Wallace; Lee Finlan; Patrick R. R. Langridge-Smith; Ted R. Hupp
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Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
Cell Cycle, ISSN: 15514005 15384101
Norman L. Lehman; Emmy W. Verschuren; Jerry Y. Hsu; Athena M. Cherry; Peter K Jackson
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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
Journal of Experimental Medicine, ISSN: 00221007 00221007
Shabaana A. Khader; Santiago Partida-Sanchez; Guy Bell; Dawn M. Jelley-Gibbs; Susan L. Swain; John E. Pearl; Nico Ghilardi; Frederic J. De Sauvage; Frances E. Lund; Andrea M. Cooper
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Death-receptor activation halts clathrin-dependent endocytosis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; David Lawrence; Andrew A. Peden; Eugene Varfolomeev; Klara Totpal; Ann De Mazière; Judith Klumperman; David Arnott; Victoria Pham; Richard H. Scheller; Avi Ashkenazi
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The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Allen Nguyen; Arthur Reyes; Min Zhang; Paul McDonald; Wai Lee T. Wong; Lisa A. Damico; Dennis
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A serum-free Vero production platform for a chimeric virus vaccine candidate
Cytotechnology, ISSN: 09209069 15730778
Inn H. Yuk; Gina B. Lin; Hui Ju; Inesse Sifi; Yvonne Lam; Armida Cortez; Danny Liebertz; J. Michael Berry; Richard M. Schwartz
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Uncontrolled asthma: A review of the prevalence, disease burden and options for treatment
Respiratory Medicine, ISSN: 09546111
Stephen P. Peters; Gary Ferguson; Yamo Deniz; Colin Reisner
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Inhibin-B levels in healthy young adult men and prepubertal boys: Is obesity the cause for the contemporary decline in sperm count because of fewer sertoli cells?
Journal of Andrology, ISSN: 01963635
Stephen J. Winters; Chenxi Wang; Eiman Abdelrahaman; Venus Hadeed; Mary Ann Dyky; Adam Brufsky
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Gender differences in IgE-mediated allergic asthma in the epidemiology and natural history of asthma: Outcomes and treatment regimens (TENOR) study
Journal of Asthma, ISSN: 02770903 15324303
June H. Lee; Tmirah Haselkorn; Bradley E. Chipps; Dave P. Miller; Sally E. Wenzel
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Wlds Protection Distinguishes Axon Degeneration following Injury from Naturally Occurring Developmental Pruning
Neuron, ISSN: 08966273
Eric D. Hoopfer; Todd McLaughlin; Ryan J. Watts; Oren Schuldiner; Dennis D.M. O'Leary; Liqun Luo
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Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
Oncogene, ISSN: 09509232 14765594
Adrian M. Jubb; Sreedevi Chalasani; Gretchen D. Frantz; Ron Smits; Grabsch; Kavi; Maughan; Kenneth J. Hillan; Philip Quirke; Koeppen
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Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
Journal of the American College of Cardiology, ISSN: 07351097
Robert L. McNamara; Yongfei Wang; Jeph Herrin; Jeptha P. Curtis; Elizabeth H. Bradley; David J. Magid; Eric D. Peterson; Martha Blaney; Paul D. Frederick; Harlan M. Krumholz
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Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
Cancer Immunology, Immunotherapy, ISSN: 03407004
Adams; David E. Allison; Kelly Flagella; Presta; Janet Clarke; Noel Dybdal; Kathleen McKeever; Mark X. Sliwkowski
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Deletion of exon I of SMAD7 in mice results in altered B cell responses
Journal of Immunology, ISSN: 00221767
Ronggui Li; Alexander Rosendahl; Greger Brodin; Alec M. Cheng; Aive Ahgren; Christina Sundquist; Sarang Kulkarni; Tony Pawson; Carl-Henrik Heldin; Rainer L. Heuchel
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Door-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI)
American Heart Journal, ISSN: 00028703 10976744
Elizabeth H. Bradley; Jeph Herrin; Yongfei Wang; Robert L. McNamara; Martha J. Radford; David J. Magid; John G. Canto; Martha Blaney; Harlan M. Krumholz
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Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models
Clinical Cancer Research, ISSN: 10780432
Deepak Sampath; Lee M. Greenberger; Carl Beyer; Malathi Hari; Hao Liu; Michelle Baxter; Yang Sharon; Carol Rios; Carolyn Discafani
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Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis
Pharmaceutical Research, ISSN: 07248741 1573904X
Chee Ng; Bert L. Lum; Veronica Gimenez; Steve Kelsey; David E. Allison
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Patient-perceived impact of resective epilepsy surgery
Neurology, ISSN: 00283878
Peter Chin; Berg; Spencer; Lee; Shinnar; Sperling; Langfitt; Walczak; Pacia; Bazil; Vassar; Vickrey
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Basic helix-loop-helix gene hes6 delineates the sensory hair cell lineage in the inner ear
Developmental Dynamics, ISSN: 10588388 10970177
Dong Qian; Kristen Radde-Gallwitz; Michael Kelly; Björn Tyrberg; Jaesang Kim; Gao; Ping Chen
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B cell immunobiology in disease: Evolving concepts from the clinic
Annual Review of Immunology, ISSN: 07320582
Flavius Martin; Andrew A. Chan
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Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Evette S. Radisky; Justin M. Lee; Chia-Jung Karen Lu; Daniel E. Koshland Jr.
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Safety of efalizumab in adults with chronic moderate to severe plaque psoriasis: A phase IIIb, randomized, controlled trial
International Journal of Dermatology, ISSN: 00119059 13654632
Kim Papp; Reni Bressinck; Scott Fretzin; Bernard Goffe; Steven Kempers; Kenneth B. Gordon; Ivor Caro; Patricia Walicke; Xiaolin Wang; Alan Menter
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The role of rituximab in the treatment of canine lymphoma: An ex vivo evaluation
Veterinary Journal, ISSN: 10900233
Joseph A Impellizeri; Howell; Kathleen McKeever; Steven E Crow
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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
Journal of Clinical Investigation, ISSN: 00219738 15588238
David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent Mckenzie; Melanie A. Kleinschek; Alexander M. Owyang; Jeanine Mattson; Wendy M. Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J. Cua; Robert A. Kastelein; Donna Rennick
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Assessing the impact of cancer: Development of a new instrument for long-term survivors
Psycho-Oncology, ISSN: 10579249 10991611
Brad J. Zebrack; Patricia A. Ganz; Coen A. Bernaards; Laura Petersen; Laura Abraham
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The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIb randomized, double-blind, placebo-controlled, dose-ranging trial
Arthritis and Rheumatism, ISSN: 00043591
Paul Emery; Roy Fleischmann; Anna Filipowicz-Sosnowska; Joy Schechtman; Leszek Szczepanski; Arthur Kavanaugh; Artur J. Racewicz; Ronald Van Vollenhoven; Nicole F. Li; Sunil Agarwal; Eva W. Hessey; Tim Shaw
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Tumor-driven paracrine platelet-derived growth factor receptor α signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma
Clinical Cancer Research, ISSN: 10780432
Max L. Tejada; Lanlan Yu; Jianying Dong; Kenneth Jung; Meng; Franklin V. Peale Jr.; Gretchen D. Frantz; Linda Hall; Xiao Huan Liang; Hans-Peter Gerber; Napoleone Ferrara
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De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand
Analytical Biochemistry, ISSN: 10960309 00032697
Victoria Pham; William J. Henzel; David Arnott; Sarah G. Hymowitz; Wendy N. Sandoval; Bao-Tran Truong; Henry B. Lowman; Jennie R. Lill
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The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000-2002. Findings From the National Registry of Myocardial Infarction-4
Journal of the American College of Cardiology, ISSN: 07351097
Jeptha P. Curtis; Edward L. Portnay; Yongfei Wang; Robert L. McNamara; Jeph Herrin; Elizabeth H. Bradley; David J. Magid; Martha Blaney; John G. Canto; Harlan M. Krumholz
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Comments on plasmalemmal vesicle associated protein-1 as a novel marker implicated in brain tumor angiogenesis [3]
Clinical Cancer Research, ISSN: 10780432
Laura A. Strickland; Koeppen
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The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus
Arthritis Research and Therapy, ISSN: 14786354 14786362
Anthony P. Manderson; Francesco Carlucci; Peter J. Lachmann; Lazarus; Richard J. Festenstein; H. Terence Cook; Mark J. Walport; Marina Botto
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Office-based low-field extremity magnetic resonance imaging: Is the glass half empty or half full?
Arthritis and Rheumatism, ISSN: 00043591
David E. Yocum; Philip G. Conaghan; Ewa Olech; Charles G. Peterfy
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Long-term continuous efalizumab therapy in patients with moderate to severe chronic plaque psoriasis: Updated results from an ongoing trial
Journal of the American Academy of Dermatology, ISSN: 01909622
Alice Gottlieb; Tiffani K. Hamilton; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Use of drotrecogin alfa (activated) in older patients with severe sepsis
Pharmacotherapy, ISSN: 02770008
Sherri L. Alexander; Frank R. Ernst
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Efalizumab retreatment in patients with moderate to severe chronic plaque psoriasis
Journal of the American Academy of Dermatology, ISSN: 01909622
Kim Papp; Bruce Miller; Kenneth B. Gordon; Ivor Caro; Paul Kwon; Peter Compton; Craig Leonardi
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Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13 II is required for viral infectivity in vivo
Journal of Virology, ISSN: 0022538X
Hajime Hiraragi; Seung-Jae Kim; Andrew J. Phipps; Micol Silic-Benussi; Vincenzo Ciminale; Lee Ratner; Patrick L. Green; Michael D. Lairmore
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Depressive symptoms in coronary artery disease patients after hypertension treatment
Annals of Pharmacotherapy, ISSN: 10600280
L. Douglas Ried; Michael J. Tueth; Taylor; Brian C. Sauer; Larry M. Lopez; Carl J. Pepine
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Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Suzana Tulac; Michael T. Overgaard; Amy E. Hamilton; Nelson L'ntshotsholé Jumbe; Ernest Suchanek; Linda C. Giudice
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A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery
Development (Cambridge), ISSN: 09501991
David A. Elliott; Mark J. Solloway; Natalie Wise; Christine Biben; Mauro W. Costa; Milena B. Furtado; Martin Lange; Sally Dunwoodie; Richard P. Harvey
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The clinical and economic burden of psoriasis
Managed Care Interface, ISSN: 10965645
Elisabeth H. Hazard; Spencer B. Cherry; Deepa Lalla; J. Michael Woolley; Helen Wilfehrt; Chiun-Fang Chiou
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Relapse, rebound, and psoriasis adverse events: An advisory group report
Journal of the American Academy of Dermatology, ISSN: 01909622
Wayne Carey; Scott Glazer; Alice Gottlieb; Mark Lebwohl; Craig Leonardi; Alan Menter; Kim Papp; Amy Chen Rundle; Darryl P. Toth
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Sinorhizobium meliloti bluB is necessary for production of 5,6-dimethylbenzimidazole, the lower ligand of B12
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Gordon R. O. Campbell; Michiko E. Taga; Kavita Mistry; Javier Lloret; Peter J. Anderson; John R. Roth; Graham C. Walker
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Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code
Journal of Molecular Biology, ISSN: 00222836
Frederic A. Fellouse; Pierre A. Barthelemy; Robert F. Kelley; Sachdev S. Sidhu
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Characterization of dual substrate binding sites in the homodimeric structure of Escherichia coli mRNA interferase MazF
Journal of Molecular Biology, ISSN: 00222836
Guang-Yao Li; Yonglong Zhang; Mitchell C.Y. Chan; Tapas K. Mal; Klaus P. Hoeflich; Masayori Inouye; Mitsuhiko Ikura
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Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Conrad Yap Edosada; Quan; Wiesmann; Thuy Tran; Daniel P. Sutherlin; Mark E. Reynolds; J. Michael Elliott; Helga Raab; Wayne J. Fairbrother; Beni B. Wolf
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CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette M. Castanedo; Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John B. Nicholas; Dineli Wickramasinghe; James C. Marsters Jr.; Daniel P. Sutherlin
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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
Cancer Research, ISSN: 00085472
Lauren Wallner; Jinlu Dai; June Escara-Wilke; Jian Zhang; Zhi Yao; Yi Lu; Mohit Trikha; Jeffrey A. Nemeth; Mohamed H. Zaki; Evan T. Keller
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