Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10351 - 10400 OF 15396 RESULTS

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
ACS Chemical Biology, ISSN: 15548937
Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O. Elliott; Heidi J. A. Wallweber; David C Okawa; Flygare; Domagoj Vucic; Wayne J. Fairbrother; Deshayes
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Is tobacco use a problem among deaf college students?
American Annals of the Deaf, ISSN: 0002726X
Barbara A. Berman; Coen A. Bernaards; Elizabeth A. Eckhardt; Heidi B. Kleiger; Lauren Maucere; Leanne Streja; Glenn Wong; Shari Barkin; Roshan Bastani
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Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan
Journal of Managed Care Pharmacy, ISSN: 10834087
Scott D. Ramsey; Lauren Clarke; Tripthi V. Kamath; Deborah Lubeck
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The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Benjamin Wu; Amita Joshi; Song Ren; Chee Ng
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Apples and oranges: Comparing computer systems audits
Drug Information Journal, ISSN: 00928615
Jacques Mourrain
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Ranibizumab for Treatment of Neovascular Age-Related Macular Degeneration. A Phase I/II Multicenter, Controlled, Multidose Study
Ophthalmology, ISSN: 01616420
Jeffrey S. Heier; Andrew N. Antoszyk; Peter Reed Pavan; Steven R. Leff; Philip J. Rosenfeld; Thomas A. Ciulla; Richard F. Dreyer; Ronald C. Gentile; Judy P. Sy; Gary Hantsbarger; Naveed Shams
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Tolerability and Efficacy of Multiple Escalating Doses of Ranibizumab (Lucentis) for Neovascular Age-Related Macular Degeneration
Ophthalmology, ISSN: 01616420
Philip J. Rosenfeld; Jeffrey S. Heier; Gary Hantsbarger; Naveed Shams
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Potential inhibitors of chemokine function: Analysis of noncovalent complexes of CC chemokine and small polyanionic molecules by ESI FT-ICR mass spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 10440305
Yonghao Yu; Matthew D. Sweeney; Ola M. Saad; Julie A. Leary
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Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1
Annals of Oncology, ISSN: 15698041 09237534
Brid M. Ryan; Gottfried E. Konecny; Kahlert; Wang; Untch; Meng; Pegram; Podratz; John Crown; Dennis J. Slamon; Duffy
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Asthma in older adults: Observations from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Annals of Allergy, Asthma and Immunology, ISSN: 10811206
Raymond G. Slavin; Tmirah Haselkorn; June H. Lee; Zheng; Yamo Deniz; Sally E. Wenzel
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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
Cancer Cell, ISSN: 15356108
Phillips; Samir Kharbanda; Ruihuan Chen; William F. Forrest; Robert Soriano; Thomas D Wu; Anjan Misra; Janice M. Nigro; Howard Colman; Liliana Soroceanu; P. Mickey Williams; Zora Modrusan; Burt G. Feuerstein; Kenneth D. Aldape
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A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys
American Journal of Pathology, ISSN: 00029440
Yulia Vugmeyster; Dhaya Seshasayee; Wesley S. Chang; Anahid Storn; Howell; Susan Sa; Tenea Nelson; Flavius Martin; Iqbal S. Grewal; Ellen Gilkerson; Ben Wu; Jeffrey S. Thompson; Barbara N. Ehrenfels; Song Ren; An Song; Thomas R. Gelzleichter; Dimitry Danilenko
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Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid
Investigative Ophthalmology and Visual Science, ISSN: 01460404
Ivana K. Kim; Deeba Husain; Norman Michaud; Edward Connolly; Anne Marie Lane; Khayyam Durrani; Ali Hafezi-Moghadam; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller
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An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Amita Joshi; Bauer; Peter Kuebler; Mark White; Cecilia Leddy; Peter Compton; Marvin Garovoy; Paul Kwon; Patricia Walicke; Russell L Dedrick
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Self-association of therapeutic proteins: Implications for product development
Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability,
Cromwell; Chantal Felten; Heather Flores; Jun Liu; Steven J. Shire
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Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
Neuro-Oncology, ISSN: 15228517
Michael D. Prados; Kathleen R. Lamborn; Susan Chang; Eric Burton; Nicholas Butowski; Mary Malec; Ami Kapadia; Jane Rabbit; Margaretta S. Page; Ann Fedoroff; Dong Xie; Kelley
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Concordance between central and local laboratory HER2 testing from a community-based clinical study
Clinical Breast Cancer, ISSN: 15268209
Josina C. Reddy; Reimann; Steven M. Anderson; Pam Klein
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Somatic mutations lead to an oncogenic deletion of Met in lung cancer
Cancer Research, ISSN: 00085472
Monica Kong-Beltran; Somasekar Seshagiri; Jiping Zha; Wenjing Zhu; Kaumudi Bhawe; Nerissa Mendoza; Thomas Holcomb; Kanan Pujara; Stinson; Ling Fu; Christophe Severin; Linda Rangell; Ralph H. Schwall; Lukas Amier; Dineli Wickramasinghe; Robert Yauch
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Erratum: Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution (Journal of Pharmaceutical Sciences [2005] 94 [1928-1940] DOI: 10.1002/jps.20347)
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jun Liu; Mary D. H. Nguyen; Andya; Steven J. Shire
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Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma
Mayo Clinic Proceedings, ISSN: 00256196
Martha Lacy; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Kimberly L. Gollbach; Suzanne R. Hayman; Shaji Kumar; John A. Lust; S. Vincent Rajkumar; Stephen J. Russell; Witzig; Steven R. Zeldenrust; David Dingli; P. Lief Bergsagel; Rafael Fonseca; Craig B. Reeder; A. Keith Stewart; Vivek Roy; Robert J. Dalton; Alan B. Carr; Deepak Kademani; Eugene E. Keller; Christopher F. Viozzi; Robert A. Kyle
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Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Thomas B. Casale; William W. Busse; Joel N. Kline; Zuhair K. Ballas; Mark H. Moss; Robert G. Townley; Masoud Mokhtarani; Vicki Seyfert-Margolis; Adam Asare; Kirk Bateman; Yamo Deniz
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Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers
Pharmaceutical Research, ISSN: 07248741
Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus
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Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
International Journal of Infectious Diseases, ISSN: 12019712
Steven P. LaRosa; Steven M. Opal; Barbara Utterback; Sau Chi Betty Yan; Jeffrey D. Helterbrand; Andrew J.H. Simpson; Wipada Chaowagul; Nicholas J. White; Charles J. Fisher Jr.
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Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma
AIDS Research and Human Retroviruses, ISSN: 08892229
Seth Rakoff-Nahoum; Peter Kuebler; Jonas J. Heymann; Megan E. Sheehy; Gabriel M. Ortiz; Graham S. Ogg; Jason D. Barbour; Jack Lenz; Alan D. Steinfeld; Douglas F. Nixon
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Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities
Proteomics, ISSN: 16159853 16159861
Denise C. Krawitz; William F. Forrest; G. Tony Moreno; Joshua Kittleson; Kathleen M. Champion
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The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes
Structure, ISSN: 09692126
Brent A. Appleton; Ping Wu; Wiesmann
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Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer.
Cancer treatment and research, ISSN: 09273042
Arndt J Schottelius; Harald Dinter
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IL-27 limits IL-2 production during Th1 differentiation
Journal of Immunology, ISSN: 00221767
Alejandro V. Villarino; Jason S. Stumhofer; Christiaan J. M. Saris; Robert A. Kastelein; Frederic J. De Sauvage; Christopher A. Hunter
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Counterpoint: Why biogenerics are a strawman
Nature Biotechnology, ISSN: 15461696 10870156
Robert L. Garnick
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Large-scale trends in the evolution of gene structures within 11 animal genomes
PLoS Computational Biology, ISSN: 15537358 1553734X
Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin
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Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)
Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933
Bertina; Van Tilburg; Haverkate; Bouma; Von Dem Borne; Meijers; William Campbell; Dan L. Eaton; Dirk F. Hendriks; Willemse
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Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology
American Journal of Pathology, ISSN: 00029440
Lucia E. Rosas; Anjali A. Satoskar; Kimberly M. Roth; Tracy L. Keiser; Joseph Barbi; Christopher A. Hunter; Frederic J. De Sauvage; Abhay R. Satoskar
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Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Michelle A. Lowes; Francesca Chamian; Maria V. Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; Rachel Nussbaum; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut Wittkowski; Kim Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M. Steinman; James G. Krueger
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TGF-β regulates the mechanical properties and composition of bone matrix
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Guive Balooch; Mehdi Balooch; Ravi K. Nalla; Stephen Schilling; Ellen H. Filvaroff; Grayson W. Marshall; Sally J. Marshall; Robert O. Ritchie; Rik Derynck; Tamara Alliston
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Identification of the minimal protein domain required for priming activity of munc13-1
Current Biology, ISSN: 09609822
David R. Stevens; Zheng-Xing Wu; Ulf Matti; Harald Junge; Claudia Schirra; Ute Becherer; Sonja M. Wojcik; Nils Brose; Jens Rettig
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Angiogenesis as a therapeutic target
Nature, ISSN: 00280836 14764679
Napoleone Ferrara; Robert S. Kerbel
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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
Clinical Cancer Research, ISSN: 10780432
Robert Yauch; Thomas Januario; Eberhard; Guy Cavet; Wenjing Zhu; Ling Fu; Thinh Q. Pham; Robert Soriano; Stinson; Somasekar Seshagiri; Zora Modrusan; Chin-Yu Lin; Vincent O'Neill; Lukas Amler
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MORT1/FADD is involved in liver regeneration
World Journal of Gastroenterology, ISSN: 10079327
Marcus Schuchmann; Felix Rückert; Jose F. Garcia-Lazaro; Andrea Karg; Jürgen Burg; Natalia Knorr; Jürgen Siebler; Eugene Varfolomeev; David Wallach; Wolfgang Schreiber; Ansgar W. Lohse; Peter R. Galle
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Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; Xiaohui Wen; Lewis Gazzard; Nelson; Richard H. Scheller; Suzie J. Scales
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Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII
Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836
Williamson; Pyke; Sampath Sridhara; Robert F. Kelley; Morris A. Blajchman; Bryan J. Clarke
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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi
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P63 is an essential proapoptotic protein during neural development
Neuron, ISSN: 08966273
W. Bradley Jacobs; Gregory Govoni; Daniel Ho; Jasvinder K. Atwal; Fanie Barnabe-Heider; William M. Keyes; Alea A. Mills; Freda D. Miller; David R. Kaplan
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A smooth operator for LPS responses
Nature Immunology, ISSN: 15292908 15292916
Godowski
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TWEAK attenuates the transition from innate to adaptive immunity
Cell, ISSN: 00928674
Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
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Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Rosenfield; Nancy Devine; Joanne Julius Hunold; Nelly Mauras; Thomas Moshang Jr.; Allen W. Root
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Analysis of protein therapeutics by capillary electrophoresis: Applications and challenges
Developments in Biologicals, ISSN: 14246074
Stacey Ma
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Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance- associated protein 2 (rMrp2)
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Chee Ng; Yun-De Xiao; Bert L. Lum; Yong-Hae Han
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Expression of HIF-1α in human tumours [5]
Journal of Clinical Pathology, ISSN: 00219746
Adrian M. Jubb; Kenneth J. Hillan
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Rituximab in combination with fludarabine chemotherapy in low-grade or follicular lymphoma
Journal of Clinical Oncology, ISSN: 0732183X
Myron S. Czuczman; Koryzna; Mohr; Stewart; Donohue; Blumenson; Bernstein; McCarthy; Alam; Hernandez-Ilizaliturri; Skipper; Brown; Chanan-Khan; Klippenstein; Loud; Mike K Rock; Benyunes; Grillo-Lopez; Bernstein
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Development and the boundaries of the firm: A knowledge-based examination in drug development
Academy of Management 2005 Annual Meeting: A New Vision of Management in the 21st Century, AOM 2005,
Jeffrey T. Macher; Christopher S. Boerner
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