Genentech: Publications

December 1, 2004

Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro

Angiogenesis, ISSN: 09696970

Yaning Wang; David T.W. Fei; Vanderlaan; An Song

December 1, 2004

Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer

Journal of Clinical Oncology, ISSN: 0732183X

David H. Johnson; Louis Fehrenbacher; Novotny; Roy S. Herbst; John J. Nemunaitis; David M. Jablons; Corey Langer; Russell F. DeVore III; Jacques Gaudreault; Lisa A. Damico; Holmgren; Fairooz F. Kabbinavar

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December 1, 2004

Roles of active site tryptophans in substrate binding and catalysis by α-1,3 galactosyltransferase

Glycobiology, ISSN: 09596658

Yingnan Zhang; Ashlesha Deshpande; Zhihong Xie; Ramanathan Natesh; K. Ravi Acharya; Keith Brew

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November 30, 2004

Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Jennifer Lecouter; Constance Zlot; Max L. Tejada; Franklin V. Peale Jr.; Napoleone Ferrara

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November 24, 2004

Impurity effects on the crystallization kinetics of ampicillin

Industrial and Engineering Chemistry Research, ISSN: 08885885

Ottens; Lebreton; Zomerdijk; Rijkers; Bruinsma; Van Der Wielen

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November 12, 2004

Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival

Journal of Biological Chemistry, ISSN: 00219258

Beatrix Schäfer; Beatrice Marg; Andreas Gschwind; Axel Ullrich

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November 11, 2004

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system

Nature, ISSN: 00280836

Xiaowel Lu; Ferdinand Le Noble; Li Yuan; Quingjan Jiang; Benjamin De Lafarge; Daisuke Sugiyama; Christiane Bréant; Filip Claes; Frederik De Smet; Jean-Léon Thomas; Monica Autiero; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann

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November 1, 2004

Vascular endothelial growth factor-induced nitric oxide-and PGI 2-dependent relaxation in human internal mammary arteries: A comparative study with KDR and Flt-1 selective mutants

Journal of Cardiovascular Pharmacology, ISSN: 01602446

Wei Wei; Hongkui Jin; Zhi-Wu Chen; Zioncheck; Anthony P. C. Yim; Guo-Wei He

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November 1, 2004

Tissue distribution, stability, and pharmacokinetics of APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice

Drug Metabolism and Disposition, ISSN: 00909556

Hong Xiang; Cindy B. Nguyen; Kelley; Noel Dybdal; Escandon

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November 1, 2004

Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product

Journal of General Virology, ISSN: 00221317

Fenaux; Opriessnig; Halbur; Yuan Xu; Barbara J. Potts; Meng

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November 1, 2004

The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis

Critical Care Medicine, ISSN: 00903493

Derek C. Angus; Pierre-Francois Laterre; Jeffrey D. Helterbrand; E. Wesley Ely; Daniel E. Ball; Rekha Garg; Lisa A. Weissfeld; Gordon R. Bernard

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November 1, 2004

Novel biologic agents for multiple sclerosis and their impact on managed care

Formulary, ISSN: 1082801X

Schumarry H. Chao; Craig H. Smith

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November 1, 2004

A new suite of automated bioreactors at Genentech: A case study employing standards, guidelines, and software: From requirements to validation

Pharmaceutical Engineering, ISSN: 02738139

Ronald E. Menéndez

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November 1, 2004

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

Molecular and Cellular Biology, ISSN: 02707306

David Dornan; Mirjam Eckert; Maura Wallace; Harumi Shimizu; Eleanor Ramsay; Ted R. Hupp; Kathryn L. Ball

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November 1, 2004

Efficacy of PUVA phototherapy compared with biologics

Cosmetic Dermatology, ISSN: 10413766

John Y. Koo; Rachel Wenner

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November 1, 2004

Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20

Journal of Immunological Methods, ISSN: 00221759

Kyu Hong; Presta; Yanmei Lu; Ashley Penn; Adams; Anan Chuntharapai; Yang; Wai Lee T. Wong; Meng

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November 1, 2004

Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: Intestinal absorption and liver metabolism

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565

Banmeet S. Anand; Suresh Katragadda; Ashim K. Mitra

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November 1, 2004

Current immunomodulatory therapies for multiple sclerosis

Formulary, ISSN: 1082801X

Craig H. Smith

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November 1, 2004

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

Journal of Immunology, ISSN: 00221767

David Artis; Alejandro V. Villarino; Michael Silverman; Weimian He; Elizabeth M. Thornton; Sharon Mu; Shamin Summer; Todd M. Covey; Elaine Huang; Hiroki Yoshida; Gary Koretzky; Michael Goldschmidt; Gary D. Wu; Frederic J. De Sauvage; Hugh R. P. Miller; Christiaan J. M. Saris; Phillip Scott; Christopher A. Hunter

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October 25, 2004

Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: National registry of myocardial infarction

Archives of Internal Medicine, ISSN: 00039926

Frederick A. Spencer; Gregg C. Fonarow; Paul D. Frederick; R. Scott Wright; Nathan R. Every; Robert J. Goldberg; Joel M. Gore; Wei Dong; Richard C. Becker; William J. French

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October 19, 2004

Angiogenesis-dependent and independent phases of intimal hyperplasia

Circulation, ISSN: 00097322

Rohit Khurana; Zhenwu Zhuang; Shalini Bhardwaj; Masahiro Murakami; Ebo De Muinck; Seppo Yla-Herttuala; Napoleone Ferrara; John F. Martin; Ian Zachary; Michael Simons

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October 15, 2004

The crystal structure of A proliferation-inducing ligand, APRIL

Journal of Molecular Biology, ISSN: 00222836

Heidi J. A. Wallweber; Deanne M. Compaan; Melissa A. Starovasnik; Sarah G. Hymowitz

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October 15, 2004

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

Cancer Research, ISSN: 00085472

David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen D. Frantz; Patrick Dowd; Koeppen; Vishva M. Dixit; French

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October 14, 2004

Bevacizumab in colorectal cancer [2] (multiple letters)

New England Journal of Medicine, ISSN: 00284793

Guru Sonpavde; Waseem Sharieff; Herbert Hurwitz; Novotny; Fairooz F. Kabbinavar

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October 13, 2004

Differential requirements for semaphorin 3F and slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections

Journal of Neuroscience, ISSN: 02706474

Jean-François Cloutier; Amar Sahay; Ernie C. Chang; Marc Tessier-Lavigne; Catherine Dulac; Alex L. Kolodkin; David D. Ginty

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October 12, 2004

GEPIS - Quantitative gene expression profiling in normal and cancer tissues

Bioinformatics, ISSN: 13674803

Yan Zhang; Eberhard; Gretchen D. Frantz; Patrick Dowd; Thomas D Wu; Yan Zhou; Colin K. Watanabe; Shiuh-Ming Luoh; Paul G. Polakis; Kenneth J. Hillan; William I. Wood; Zemin Zhang

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October 6, 2004

Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction

JAMA - Journal of the American Medical Association, ISSN: 00987484

Elizabeth H. Bradley; Jeph Herrin; Yongfei Wang; Robert L. McNamara; Tashonna R. Webster; David J. Magid; Martha Blaney; Eric D. Peterson; John G. Canto; Charles V. Pollack Jr.; Harlan M. Krumholz

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October 1, 2004

Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin

Clinical Immunology, ISSN: 15216616

Yulia Vugmeyster; Toyoko Kikuchi; Michelle A. Lowes; Francesca Chamian; Mark Kagen; Patricia Gilleaudeau; Edmund Lee; Howell; Bodary; Wolfgang Dummer; James G. Krueger

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October 1, 2004

Production technologies for monoclonal antibodies and their fragments

Current Opinion in Biotechnology, ISSN: 09581669

Dana C. Andersen; Dorothea Reilly

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October 1, 2004

Signal peptide prediction based on analysis of experimentally verified cleavage sites

Protein Science, ISSN: 09618368

Zemin Zhang; William J. Henzel

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October 1, 2004

Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): Early termination due to increased toxicities

Clinical Cancer Research, ISSN: 10780432

Wells A. Messersmith; Daniel A. Laheru; Neil N. Senzer; Ross C. Donehower; Paula Grouleff; Theresa Rogers; Kelley; David A. Ramies; Bert L. Lum; Manuel Hidalgo

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October 1, 2004

Suppressor of fused regulates Gli activity through a dual binding mechanism

Molecular and Cellular Biology, ISSN: 02707306

Mark Merchant; Vajdos; Ultsch; Henry R. Maun; K. Ulrich Wendt; Jennifer Cannon; William Desmarais; Lazarus; De Vos; Frederic J. De Sauvage

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October 1, 2004

A pH-sensitive function and phenotype: Evidence that EutH facilitates diffusion of uncharged ethanolamine in Salmonella enterica

Journal of Bacteriology, ISSN: 00219193

Joseph T. Penrod; Christopher C. Mace; John R. Roth

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October 1, 2004

Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae

Molecular Biology of the Cell, ISSN: 10591524

Matthias Versele; Björn Gullbrand; Shulewitz; Victor J. Cid; Shirin Bahmanyar; Raymond E. Chen; Patrick Barth; Tom Alber; Jeremy Thorner

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October 1, 2004

Capillary regression in vascular endothelial growth factor-deficient skeletal muscle

Physiological Genomics, ISSN: 15312267

Kechun Tang; Ellen C. Breen; Hans-Peter Gerber; Napoleone Ferrara; Peter D. Wagner

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October 1, 2004

Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice

Contraception, ISSN: 00107824

Girling; Heryanto; Patel; Peter A.W. Rogers

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October 1, 2004

Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis

Arthritis and Rheumatism, ISSN: 00043591

Kai H. Barck; Wyne P. Lee; Laurie Diehl; Ross; Gribling; Yifan Zhang; Kathy Nguyen; Nicholas Van Bruggen; Stephen D. Hurst; Richard A. D. Carano

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October 1, 2004

Selective impairment of TLR-mediated innate immunity in human newborns: Neonatal blood plasma reduces monocyte TNF-α induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848

Journal of Immunology, ISSN: 00221767

Ofer Levy; Kol A. Zarember; Rene M. Roy; Colette Cywes; Godowski; Michael R. Wessels

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September 30, 2004

Real time quantitative PCR as a method to evaluate xenotropic murine leukemia virus removal during pharmaceutical protein purification

Biotechnology and Bioengineering, ISSN: 00063592

Shi; Qi Chen; Lenore A Norling; Allen S.L. Lau; Sherrie Krejci; Yuan Xu

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September 17, 2004

Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in met binding and signaling

Journal of Biological Chemistry, ISSN: 00219258

Daniel Kirchhofer; Xiaoyi Yao; Peek; Eigenbrot; Michael T. Lipari; Karen L Billeci; Henry R. Maun; Paul Moran; Santell; Wiesmann; Lazarus

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September 15, 2004

Bioinformatics and cancer target discovery

Drug Discovery Today, ISSN: 13596446

Brian Desany; Zemin Zhang

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September 1, 2004

B-cell subsets in blood and lymphoid organs in Macaca fascicularis

Cytometry Part A, ISSN: 15524922

Yulia Vugmeyster; Howell; Anahid Bakshi; Flores; Hwang; Kathleen McKeever

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September 1, 2004

In vitro internalization, intracellular transport, and clearance of an anti-CD11a antibody (Raptiva) by human T-cells

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565

Greg P. Coffey; Stefanich; Susan Palmieri; Eckert; Josette Padilla-Eagar; Fielder; Susanne Pippig

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September 1, 2004

Receptor-mediated basic fibroblast growth factor signaling regulates cyclic pressure-induced human endothelial cell proliferation

Endothelium: Journal of Endothelial Cell Research, ISSN: 10623329

Hainsworth Y. Shin; Eric A. Schwartz; Rena Bizios; Mary E. Gerritsen

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September 1, 2004

Activation of caspases-8 and -10 by FLIPL

Biochemical Journal, ISSN: 02646021

Kelly M. Boatright; Cristina Deis; Jean-Bernard Denault; Daniel P. Sutherlin; Guy S. Salvesen

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September 1, 2004

Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells

Cancer Research, ISSN: 00085472

Ching Ching Leow; Maria Romero; Ross; Paul G. Polakis; Gao

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September 1, 2004

Caspase-8 serves both apoptotic and nonapoptotic roles

Journal of Immunology, ISSN: 00221767

Tae-Bong Kang; Tehila Ben-Moshe; Eugene Varfolomeev; Yael Pewzner-Jung; Nir Yogev; Anna Jurewicz; Ari Waisman; Ori Brenner; Rebecca Haffner; Erika Gustafsson; Parameswaran Ramakrishnan; Tsvee Lapidot; David Wallach

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September 1, 2004

Clinical benefits in patients with psoriasis after efalizumab therapy: Clinical trials versus practice

Cutis, ISSN: 00114162

Roberto R. Ricardo; Matthe Rhoa; Elaine K. Orenberg; Nicole F. Li; Amy Chen Rundle; Ivor Caro

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September 1, 2004

The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development

Molecular and Cellular Biology, ISSN: 02707306

Zhe Chen; Dennis J. Eastburn; Min Han

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September 1, 2004