Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10801 - 10850 OF 15396 RESULTS

March 1, 2004

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac

Nature Genetics, ISSN: 10614036

Stephen T. Thibault; Matthew A. Singer; Wesley Y. Miyazaki; Brett Milash; Nicholas A. Dompe; Carol M. Singh; Ross Buchholz; Madelyn Demsky; Robert Fawcett; Helen L. Francis-Lang; Lisa Ryner; Lai Man Cheung; Angela Chong; Cathy Erickson; William W. Fisher; Kimberly Greer; Stephanie R. Hartouni; Elizabeth Howie; Lakshmi Jakkula; Daniel Joo; Keith Killpack; Alex Laufer; Julie Mazzotta; Ronald D. Smith; Lynn M. Stevens; Christiana Stuber; Lory R. Tan; Richard Ventura; Alesa Woo; Irena Zakrajsek; Lora Zhao; Feng Chen; Candace Swimmer; Casey Kopczynski; Geoffrey Duyk; Margaret L. Winberg; Jonathan Margolis

March 1, 2004

Application of Frequency-Modulated Spectroscopy in Vacuum Seal Integrity Testing of Lyophilized Biological Products

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Tanya P. Lin; Chung C. Hsu; Bruce Kabakoff; Thomas W. Patapoff

March 1, 2004

Association between HER-2/neu and Vascular Endothelial Growth Factor Expression Predicts Clinical Outcome in Primary Breast Cancer Patients

Clinical Cancer Research, ISSN: 10780432

Gottfried E. Konecny; Meng; Untch; Wang; Ingo Bauerfeind; Melinda Epstein; Petra Stieber; Jean-Michel Vernes; Johnny Gutierrez; Kyu Hong; Malgorzata Beryt; Hermann Hepp; Dennis J. Slamon; Pegram

March 1, 2004

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Drug Development Research, ISSN: 02724391

Reed J. Harris; Reven J. Shire; Charles Winter

March 1, 2004

Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

Journal of Immunology, ISSN: 00221767

Nico Ghilardi; Noelyn Kljavin; Qi Chen; Sophie Lucas; Austin L. Gurney; Frederic J. De Sauvage

March 1, 2004

Computational and experimental studies on Human Misshapen/NIK-related kinase MINK-1

Current Medicinal Chemistry, ISSN: 09298673

Kunbin Qu; Yanmei Lu; Nan Lin; Rajinder Singh; Xiang Xu; Donald G. Payan; Dong Xu

March 1, 2004

Gata2 specifies serotonergic neurons downstream of sonic hedgehog

Development (Cambridge), ISSN: 09501991

Sarah E. Craven; Kim-Chew Lim; Weilan Ye; James Douglas Engel; Frederic J. De Sauvage; Arnon Rosental

March 1, 2004

Dynamic Expression of Lef/Tcf Family Members and β-Catenin during Chick Gastrulation, Neurulation, and Early Limb Development

Developmental Dynamics, ISSN: 10588388

Maike Schmidt; Margaret Patterson; Elizabeth Farrell; Andrea Münsterberg

February 27, 2004

Definition of the Consensus Motif Recognized by γ-Adaptin Ear Domains

Journal of Biological Chemistry, ISSN: 00219258

Rafael Mattera; Brigitte Ritter; Sachdev S. Sidhu; Peter S. McPherson; Juan S. Bonifacino

February 27, 2004

Human De-Etiolated-Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase

Science, ISSN: 00368075

Ingrid E. Wertz; Karen M. O'Rourke; Zemin Zhang; David Dornan; David Arnott; Raymond J. Deshaies; Vishva M. Dixit

February 26, 2004

Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor

Oncogene, ISSN: 09509232

Alyssa M. Morimoto; Nguyen Tan; Kristina West; McArthur; Guy C. Toner; William C. Manning; Beverly D. Smolich; Julie M. Cherrington

February 24, 2004

Recurrent events analysis in the presence of time-dependent covariates and dependent censoring

Journal of the Royal Statistical Society. Series B: Statistical Methodology, ISSN: 13697412

Maja Miloslavsky; Sündüz Keleş; Mark J. van der Laan; Butler

February 20, 2004

Tumor Necrosis Factor: An Apoptosis JuNKie?

Cell, ISSN: 00928674

Eugene Varfolomeev; Avi Ashkenazi

February 20, 2004

Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates

Journal of Biological Chemistry, ISSN: 00219258

Paul R. Hinton; Mary G. Johlfs; Joanna M. Xiong; Kelly Hanestad; Kelly C. Ong; Chuck Bullock; Steve Keller; Meina Tao Tang; J. Yun Tso; Max Vásquez; Naoya Tsurushita

February 15, 2004

Combining Liquid Chromatography with MALDI Mass Spectrometry Using a Heated Droplet Interface

Analytical Chemistry, ISSN: 00032700

Boyan Zhang; Chris McDonald; Liang Li

February 10, 2004

Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity

Biochemistry, ISSN: 00062960

Robert F. Kelley; Yang; Eigenbrot; Paul Moran; Peek; Michael T. Lipari; Daniel Kirchhofer

February 9, 2004

Vancomycin disulfide derivatives as antibacterial agents

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

YongQi Mu; Matthew B. Nodwell; John Pace; Jeng-Pyng Shaw; J. Kevin Judice

February 1, 2004

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to the trans-Golgi Network and a Subpopulation of Late Endosomes

Molecular Biology of the Cell, ISSN: 10591524

Sharron X. Lin; William Mallet; Amy Y. Huang; Frederick R. Maxfield

February 1, 2004

EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer

Cancer Research, ISSN: 00085472

Mao; Luis; Ross; Johnny Silva; Christine Tan; Crowley; Clarissa Chui; Gretchen Franz; Peter Senter; Koeppen; Paul G. Polakis

February 1, 2004

Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; French; Minhong Yan; Gretchen D. Frantz; Vishva M. Dixit

February 1, 2004

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

International Immunology, ISSN: 09538178

Conchi Mora; Iqbal S. Grewal; F. Susan Wong; Richard A. Flavell

February 1, 2004

APRIL-Deficient Mice Have Normal Immune System Development

Molecular and Cellular Biology, ISSN: 02707306

Eugene Varfolomeev; Frank C. Kischkel; Flavius Martin; Dhaya Seshasayee; Hua Wang; David Lawrence; Christine Olsson; Lucrece Tom; Sharon Erickson; French; Peter Schow; Iqbal S. Grewal; Avi Ashkenazi

February 1, 2004

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; Xiaoqing Sun; Vishva M. Dixit

January 30, 2004

PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

Science, ISSN: 00368075

Kiminori Hasegawa; Flavius Martin; Guangming Huang; Daniel B. Tumas; Laurie Diehl; Andrew A. Chan

January 29, 2004

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

Oncogene, ISSN: 09509232

Beatrix Schäfer; Andreas Gschwind; Axel Ullrich

January 26, 2004

Quinine/Quinidine-Induced Thrombocytopenia: A Great Imitator

Archives of Internal Medicine, ISSN: 00039926

Josina C. Reddy; Shuman; Richard H. Aster

January 23, 2004

Factorial screening of antibody purification processes using three chromatography steps without protein A

Journal of Chromatography A, ISSN: 00219673

Deborah K. Follman; Fahrner

January 22, 2004

Recordings from Single Neocortical Nerve Terminals Reveal a Nonselective Cation Channel Activated by Decreases in Extracellular Calcium

Neuron, ISSN: 08966273

Stephen M. Smith; Jeremy B. Bergsman; Nobutoshi C. Harata; Richard H. Scheller; Richard W. Tsien

January 15, 2004

Alteplase for Treatment of Occluded Peripherally Inserted Central Catheters: Safety and Efficacy in 240 Patients

Journal of Vascular and Interventional Radiology, ISSN: 10510443

Rita Ng; Xin Li; Tri Tu; Charles P. Semba

January 9, 2004

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

Journal of Biological Chemistry, ISSN: 00219258

Astrid A. Ruefli-Brasse; Wyne P. Lee; Stephen D. Hurst; Vishva M. Dixit

January 8, 2004

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

Nature, ISSN: 00280836

Honglin Zhou; Ingrid E. Wertz; Karen M. O'Rourke; Ultsch; Somasekar Seshagiri; Mike Eby; Wei Xiao; Vishva M. Dixit

January 2, 2004

Structure-activity relationships by mass spectrometry: Identification of novel MMP-3 inhibitors

Bioorganic and Medicinal Chemistry, ISSN: 09680896

Denise A. Ockey; Jennafer Dotson; Martin Struble; Stults; James H. Bourell; Clark; Thomas Gadek

January 1, 2004

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

Nature Reviews Drug Discovery, ISSN: 14741776

Napoleone Ferrara; Kenneth J. Hillan; Hans-Peter Gerber; Novotny

January 1, 2004

The discovery of receptor tyrosine kinases: Targets for cancer therapy

Nature Reviews Cancer, ISSN: 1474175X

Andreas Gschwind; Oliver M. Fischer; Axel Ullrich

January 1, 2004

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Cancer Cell, ISSN: 15356108

Matthew C Franklin; Kendall Carey; Vajdos; Daniel J. Leahy; De Vos; Mark X. Sliwkowski

January 1, 2004

Raman Spectroscopic Characterization of Drying-Induced Structural Changes in a Therapeutic Antibody: Correlating Structural Changes with Long-Term Stability

Journal of Pharmaceutical Sciences, ISSN: 00223549

Samir Sane; Wong; Chung C. Hsu

January 1, 2004

Substrate capacity consideration in developing kinase assays

Assay and Drug Development Technologies, ISSN: 1540658X

Laura DeForge; Andrea G. Cochan; Sherry Yeh; Brian S. Robinson; Karen L Billeci; Wai Lee T. Tong

January 1, 2004

Quantification of Tumor Tissue Populations by Multispectral Analysis

Magnetic Resonance in Medicine, ISSN: 07403194

Richard A. D. Carano; Adrienne L. Ross; Ross; Simon P. Williams; Koeppen; Ralph H. Schwall; Nicholas Van Bruggen

January 1, 2004

The HER receptor family: A rich target for therapeutic development

International Journal of Radiation Oncology Biology Physics, ISSN: 03603016

Robert Mass

January 1, 2004

Evaluation of procedures for amplification of small-size samples for hybridization on microarrays

Genomics, ISSN: 08887543

Sandra Klur; Toy; Mickey P. Williams; Ulrich Certa

January 1, 2004

Reflections on Rice's formulae for level crossings - History, extensions and use

Australian and New Zealand Journal of Statistics, ISSN: 13691473

Leadbetter; Spaniolo

January 1, 2004

Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor

Thrombosis and Haemostasis, ISSN: 03406245

Sabine Raab; Heike Beck; Andreas Gaumann; Ali Yüce; Hans-Peter Gerber; Karl Plate; Hans-Peter Hammes; Napoleone Ferrara; Georg Breier

January 1, 2004

Treatment of Pulmonary Arterial Hypertension with Sildenafil

Hospital Pharmacy, ISSN: 00185787

Stacey M. Fung; Mary J. Ferrill

January 1, 2004

Single lead ST-segment recovery: A simple, reliable measure of successful fibrinolysis after acute myocardial infarction

American Heart Journal, ISSN: 00028703

Mushabbar A. Syed; Steven Borzak; Abed Asfour; Madhavi Gunda; Omar Obeidat; Sabina A. Murphy; Raymond J. Gibbons; Steven G. Gourlay; Hal V. Barron; W.Douglas Weaver; Michael Hudson

January 1, 2004

Editorial introductions

Current Opinion in Nephrology and Hypertension, ISSN: 10624821

Barry M. Brenner; Marc R. Hammerman; Matthew R. Weir; Ronald C. Blantz; Pierre M. Ronco

January 1, 2004

Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Chantal M. Dolan; Kyle Fraher; Eugene R. Bleecker; Larry Borish; Bradley E. Chipps; Mary Lou Hayden; Weiss; Zheng; Charles A. Johnson; Sally E. Wenzel

January 1, 2004

APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA

Journal of Immunology, ISSN: 00221767

Kerstin N. Schmidt; Beatrice Leung; Mandy Kwong; Kol A. Zarember; Sanjeev Satyal; Tony A. Navas; Fay Wang; Godowski

January 1, 2004

Maintaining change control in part 11 - Compliant systems - A quality systems approach

American Pharmaceutical Review, ISSN: 10998012

Peter Bland

January 1, 2004

Ureagenesis: Evidence for a lack of hepatic regulation of acid-base equilibrium in humans

American Journal of Physiology - Renal Physiology, ISSN: 03636127

Markus Hosch; Juergen Muser; Henry N. Hulter; Reto Krapf

January 1, 2004

Neutralizing VEGF Bioactivity with a Soluble Chimeric VEGF-Receptor Protein flt(I-3) IgG Inhibits Testosterone-Stimulated Prostate Growth in Castrated Mice

Prostate, ISSN: 02704137

Ingela Franck Lissbrant; Peter Hammarsten; Erik Lissbrant; Napoleone Ferrara; Stina Häggström Rudolfsson; Anders Bergh

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