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DISPLAYING 1051 - 1100 OF 15486 RESULTS

Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney; Martyn Partridge; Mike Morgan; Anne Millar; Mark Stafford-Watson; Gabriella Cooper
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IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition
Cell Death and Disease,
Bruno Alicke; Eugene Varfolomeev; Shi Hui Kaylee Lee; Alexandra Frommlet; Savita Ubhayakar; John G. Quinn; Wayne J. Fairbrother; Robert Jones; Stephen Gould; Domagoj Vucic
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IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine nonalcoholic steatohepatitis models
PLoS ONE, ISSN: 19326203
Jose Heredia; Clara Sorenson; Sean Flanagan; Victor Nunez; Charles Jones III; Angela Martzall; Laurie Leong; Andres Paler Martinez; Alexis Scherl; Hans D. Brightbill; Nico Ghilardi; Ning Ding
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Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells
Current Protocols, ISSN: 26911299
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
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Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
Nature Aging, ISSN: 26628465
Borislav Dejanovic; Tiffany Wu; Ming-Chi Tsai; David Graykowski; Vineela D. Gandham; Christopher M. Rose; Corey Bakalarski; Hai Ngu; Yuanyuan Wang; Shristi Pandey; Mitchell G. Rezzonico; Brad A. Friedman; Rose Edmonds; Ann De Mazière; Raphael Rakosi-Schmidt; Tarjinder Singh; Judith Klumperman; Oded Foreman; Michael C. Chang; Luke Xie; Morgan Sheng; Jesse E. Hanson
View on Scopus
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney; Martyn Partridge; Mike Morgan; Anne Millar; Mark Stafford-Watson; Gabriella Cooper
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Prevalence and Progression of Macular Atrophy in Eyes with Neovascular Age-Related Macular Degeneration in the Phase 2 Ladder Trial of the Port Delivery System with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Glenn J. Jaffe; Briana Cameron; David Kardatzke; Jane Ives; Giulio Barteselli; Shamika Gune
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Sources of Cancer Neoantigens beyond Single-Nucleotide Variants
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Aude-Hélène Capietto; Reyhane Hoshyar; Lélia Delamarre
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Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial
Nature Medicine, ISSN: 1546170X 10788956
Solange Peters; Rafal Dziadziuszko; Alessandro Morabito; Enriqueta Felip; Shirish M. Gadgeel; Parneet Cheema; Manuel Cobo; Zoran Andric; Carlos H. Barrios; Masafumi Yamaguchi; Eric Dansin; Pongwut Danchaivijitr; Melissa L. Johnson; Silvia Novello; Michael Mathisen; Sarah M. Shagan; Erica Schleifman; Jin Wang; Mark Yan; Mocci; David Voong; David Fabrizio; David S. Shames; Todd Riehl; David R. Gandara; Tony Mok
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Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies
Veterinary Clinical Pathology, ISSN: 1939165X 02756382
William Siska; A. Eric Schultze; Daniela Ennulat; Kathleen Biddle; Michael Logan; Adedeji; Tara Arndt; Adam Aulbach
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Population pharmacokinetic analysis of etrolizumab in patients with moderately-to-severely active ulcerative colitis
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Anita Moein; Tong Lu; Siv Jönsson; Jakob Ribbing; Nastya Kassir; Wenhui Zhang; Gizette Sperinde; Rong Zhang; Meina Tang; Young S. Oh; Rene Bruno; Rui Zhu
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Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Justin Feigelman; Siddharth Sukumaran; Manoj C. Rodrigo; Tracy Staton; Fang Cai; Rebecca N. Bauer; David F. Choy; Cynthia L. Stokes; Heleen Scheerens; Ramanujan
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Growth-rate model predicts in vivo tumor response from in vitro data
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Rocky Diegmiller; Laurent Salphati; Bruno Alicke; Wilson; Thomas J. Stout; Marc Hafner
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Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?
Clinical and Translational Science, ISSN: 17528062 17528054
Songmao Zheng; Prell; Jennifer Sheng; Yow-Ming C. Wang; Lora Hamuro
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Patient-reported outcomes provide prognostic information for survival in patients with diffuse large B-cell lymphoma: Analysis of 1239 patients from the GOYA study
Cancer Medicine, ISSN: 20457634
Huang Huang; Asim Datye; Ming Fan; Andrea Knapp; Tina Nielsen; Alessia Bottos; Joseph N. Paulson; Peter C. Trask; Fabio Efficace
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Differences in Glucose Readings Between Right Arm and Left Arm Using a Continuous Glucose Monitor
Journal of Diabetes Science and Technology, ISSN: 19322968
Sonoko Kawakatsu; Xiaohan Liu; Brandon Tran; Brittany P. Tran; Lucy Manzanero; Eric Shih; Allen Shek; Jeremy Lim
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Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells
Current Protocols, ISSN: 26911299
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
View on Scopus
Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells
Current Protocols,
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
View on Scopus
Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Drug Metabolism and Disposition,
Louis Lin; Matthew Wright; Cornelis E. Hop; Harvey Wong
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Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411
Purnendu K. Nayak; Karthikan Rajagopal; Debby P. Chang
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Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine,
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney
View on Scopus
Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases,
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
View on Scopus
Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Drug Metabolism and Disposition, ISSN: 1521009X
Louis Lin; Matthew Wright; Cornelis E. Hop; Harvey Wong
View on Scopus
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney
View on Scopus
Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases, ISSN: 15364844
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
View on Scopus
Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
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New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Kathleen M. Giacomini; Sook Wah Yee; Megan L. Koleske; Ling Zou; Pär Matsson; Eugene C. Chen; Deanna L. Kroetz; Miles A. Miller; Elnaz Gozalpour; Xiaoyan Chu
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology,
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology, ISSN: 14620332
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
View on Scopus
Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 15280020 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander M. Taylor; Christopher Bailey; Lisa D. Belmont; Robert Campbell; Nico Cantone; Alexandre Côté; Terry Crawford; Richard T Cummings; Kevin Dement; Martin Duplessis; Megan Flynn; Andrew C. Good; Hon-Ren Huang; Shivangi Joshi; Yves Leblanc; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Florence Poy; F. Anthony Romero; Peter Sandy; Yong Tang; Vickie Tsui; Laura E. Zawadzke; Robert J. Sims; James E. Audia; Steve Bellon; Steven Magnuson; Brian K Albrecht; Andrea G Cochran
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Determination of BET Specific Surface Area of Hydrate-Anhydrate Systems Susceptible to Phase Transformation Using Inverse Gas Chromatography
AAPS PharmSciTech,
Minhthi Bui; Karthik Nagapudi; Paroma Chakravarty
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports, ISSN: 22111247
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports,
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife, ISSN: 2050084X
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
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Importance of Green and Sustainable Chemistry in the Chemical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife,
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Single-cell analysis reveals clonally expanded tumor-associated CD57 +CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Michael Fehlings; Leesun Kim; Xiangnan Guan; Kobe Yuen; Alireza Tafazzol; Shomyseh Sanjabi; Oliver A. Zill; Deepali Rishipathak; Andrew Wallace; Alessandra Nardin; Siming Ma; Ana Milojkovic; Evan W. Newell; Sanjeev Mariathasan; Mahesh Yadav
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Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Journal of the American Chemical Society, ISSN: 15205126 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Tao Chen; Shijia Tang; Yige Fu; José G. Napolitano; Kelly Zhang
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
View on Scopus
Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 18733778 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping
Talanta, ISSN: 00399140
Julien Camperi; Sanket Dahotre; Davy Guillarme; Cinzia Stella
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers
Organic Letters, ISSN: 15237052 15237060
Rick W. Dorn; Brendan J. Wall; Sarah B. Ference; Sean R. Norris; Joseph W. Lubach; Aaron J. Rossini; Brett VanVeller
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