Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11001 - 11050 OF 15396 RESULTS

Functional consequences of a gene duplication and fusion event in an arginine kinase
Journal of Experimental Biology, ISSN: 00220949
Deanne M. Compaan; W. Ross Ellington
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Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells
British Journal of Haematology, ISSN: 00071048
Toshiaki Hayashi; Treon; Hideshima; Tai; Masaharu Akiyama; Paul Richardson; Chauhan; Iqbal S. Grewal; Anderson
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Anti-angiogenesis: Biology is the foundation for therapy
Drug Discovery Today, ISSN: 13596446
Hans-Peter Gerber
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DNA-dependent acetylation of p53 by the transcription coactivator p300
Journal of Biological Chemistry, ISSN: 00219258
David Dornan; Harumi Shimizu; Neil D. Perkins; Ted R. Hupp
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Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors
AIDS, ISSN: 02699370
Matthew J. Gonzales; Thomas D Wu; Jonathan Taylor; Ilana Belitskaya; Rami Kantor; Dennis Israelski; Sunwen Chou; Andrew R. Zolopa; W. Jeffrey Fessel; Robert W. Shafer
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Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor
Journal of Biological Chemistry, ISSN: 00219258
Yutaka Hasegawa; James R. Erickson; Graham J. Goddard; Shuangxing Yu; Shuying Liu; Kwai Wa Cheng; Astrid Eder; Koji Bandoh; Junken Aoki; Renata Jarosz; Andrew D. Schrier; Kevin R. Lynch; Gordon B. Mills; Xianjun Fang
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Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments
Journal of Virology, ISSN: 0022538X
Thomas D Wu; Celia A. Schiffer; Matthew J. Gonzales; Jonathan Taylor; Rami Kantor; Sunwen Chou; Dennis Israelski; Andrew R. Zolopa; W. Jeffrey Fessel; Robert W. Shafer
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Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-γ
Journal of Pharmaceutical Sciences, ISSN: 00223549
Serena D. Webb; Cleland; John F. Carpenter; Theodore W. Randolph
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Ethics and the AIDS pandemic in the developing world
Journal of the International Association of Physicians in AIDS Care, ISSN: 15451097 15570886
Mark J. Ahn; Ashraf Grimwood; Heidi Schwarzwald; Allen Herman
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Asparagine deamidation in recombinant human lymphotoxin: Hindrance by three-dimensional structures
Journal of Pharmaceutical Sciences, ISSN: 00223549
Minli Xie; Shahrokh; Miryam Kadkhodayan; William J. Henzel; Powell; Ronald T. Borchardt; Richard L. Schowen
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Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system
Genes and Development, ISSN: 08909369
Kim Newton; Andreas Strasser
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Tenecteplase: Stability and bioactivity of thawed or diluted solutions used in peripheral thrombolysis
Journal of Vascular and Interventional Radiology, ISSN: 10510443
Charles P. Semba; Weck; Mahmood K Razavi; Lisa Tuomi; Thomas W. Patapoff
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N-benzoyl amino acids as LFA-1/ICAM inhibitors 1: Amino acid structure-activity relationship
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Burdick; Kenneth J. Paris; Kenneth J Weese; Mark S. Stanley; Beresini; Clark; Robert S. McDowell; James C. Marsters Jr.; Thomas Gadek
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The VIVA trial: Vascular endothelial growth factor in ischemia for vascular angiogenesis
Circulation, ISSN: 00097322
Timothy D. Henry; Brian H. Annex; George McKendall; Michael A. Azrin; John J. Lopez; Frank J. Giordano; Shah; James T. Willerson; Raymond L. Benza; Daniel S. Berman; C.Michael Gibson; Alex Bajamonde; Amy Chen Rundle; Jennifer T. Fine; Edward R. McCluskey
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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
Journal of Experimental Medicine, ISSN: 00221007
Marie-Laure Santiago-Raber; Roberto Baccala; Katarina M. Haraldsson; Divaker Choubey; Stewart; Dwight H. Kono; Argyrios N. Theofilopoulos
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Nucleic acid capture assay, a new method for direct quantitation of nucleic acids
Nucleic Acids Research, ISSN: 13624962
Siao Ping Tsai; Anne Wong; Elaine Mai; Pamela Chan; Grace Mausisa; Vasser; Jhurani; Mogens H. Jakobsen; Wai Lee T. Wong; Jean-Philippe Stephan
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HIF-1α is essential for myeloid cell-mediated inflammation
Cell, ISSN: 00928674
Thorsten Cramer; Yuji Yamanishi; Björn E. Clausen; Irmgard Förster; Rafal Pawlinski; Nigel Mackman; Volker H. Haase; Rudolf Jaenisch; Maripat Corr; Victor Nizet; Gary S. Firestein; Hans-Peter Gerber; Napoleone Ferrara; Randall S. Johnson
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The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jennifer Lecouter; Rui Lin; Max L. Tejada; Gretchen D. Frantz; Franklin V. Peale Jr.; Kenneth J. Hillan; Napoleone Ferrara
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A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse
International Immunology, ISSN: 09538178
Koji Eshima; Conchi Mora; F. Susan Wong; E. Allison Green; Iqbal S. Grewal; Richard A. Flavell
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A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300 CD4+ T cells
Clinical Immunology, ISSN: 15216616
Alberdina W. De Boer; Norman Markowitz; H.Clifford Lane; Louis D. Saravolatz; Susan L. Koletar; Haig Donabedian; Carl Yoshizawa; A-M. Duliege; Gwendolyn Fyfe; Ronald T. Mitsuyasu
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Intravenous mouse infection model for studying the pathology of Enterococcus faecalis infections
Infection and Immunity, ISSN: 00199567
Claudia Gentry-Weeks; Monica Estay; Cindy Loui; Dale Baker
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α-1-acid glycoprotein as an independent predictor for treatment effects and a prognostic factor of survival in patients with non-small cell lung cancer treated with docetaxel
Clinical Cancer Research, ISSN: 10780432
Rene Bruno; Robert Olivares; Jocelyne Berille; Philip Chaikin; Nicole Vivier; Luz Hammershaimb; Gerald R. Rhodes; James R. Rigas
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Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from ATP site inhibitors block tumor growth
Cancer Research, ISSN: 00085472
Nerissa Mendoza; Fong; James C. Marsters Jr.; Koeppen; Ralph H. Schwall; Dineli Wickramasinghe
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Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the erbin PDZ domain
Journal of Biological Chemistry, ISSN: 00219258
Nicholas J. Skelton; Michael F. T. Koehler; Zobel; Wai Lee T. Wong; Sherry Yeh; Pisabarro; Jianping Yin; Lasky; Sachdev S. Sidhu
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High-throughput protein sequencing
Analytical Chemistry, ISSN: 00032700
Victoria Pham; Jake Tropea; Suzy Wong; James Quach; William J. Henzel
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Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides
Nucleic Acids Research, ISSN: 03051048
Thomas D. Schaal; William Mallet; Dustin McMinn; Nam V. Nguyen; Michelle M. Sopko; Sam John; Bhavin S. Parekh
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Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1
Science, ISSN: 00368075
Jennifer Lecouter; Dirk R. Moritz; Bing Li; Gail L. Phillips; Xiao Huan Liang; Hans-Peter Gerber; Kenneth J. Hillan; Napoleone Ferrara
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Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
Neuron, ISSN: 08966273
Mala Murthy; Dan Garza; Richard H. Scheller; Thomas L. Schwarz
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A profile hidden Markov model for signal peptides generated by HMMER
Bioinformatics, ISSN: 13674803
Zemin Zhang; William I. Wood
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Differential scanning calorimetric, circular dichroism, and Fourier transform infrared spectroscopic characterization of the thermal unfolding of xylanase A from Streptomyces lividans
Proteins: Structure, Function and Bioinformatics, ISSN: 08873585
Roberge; Ruthven N.A.H. Lewis; François Shareck; Rolf Morosoli; Dieter Kluepfel; Claude Dupont; Ronald N. McElhaney
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Adhesion molecules as therapeutic targets for autoimmune diseases and transplant rejection
Expert Opinion on Biological Therapy, ISSN: 14712598
Russell L Dedrick; Bodary; Marvin Garovoy
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A unified model for apical caspase activation
Molecular Cell, ISSN: 10972765
Kelly M. Boatright; Martin Renatus; Fiona L. Scott; Sabina Sperandio; Hwain Shin; Irene M. Pedersen; Jean-Ehrland Ricci; Wade A. Edris; Daniel P. Sutherlin; Douglas R. Green; Guy S. Salvesen
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Impairment of myocardial perfusion in both culprit and nonculprit arteries in acute myocardial infarction: A LIMIT AMI substudy
American Journal of Cardiology, ISSN: 00029149
Sabina A. Murphy; Christopher Chen; Steven G. Gourlay; Raymond J. Gibbons; Hal V. Barron; C.Michael Gibson
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Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?
Clinical Endocrinology, ISSN: 03000664
Alan D. Rogol; Sandra L. Blethen; Judy P. Sy; Johannes D. Veldhuis
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Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
Immunity, ISSN: 10747613
Dhaya Seshasayee; Patricia A. Valdez; Minhong Yan; Vishva M. Dixit; Daniel B. Tumas; Iqbal S. Grewal
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Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Hongkui Jin; Renhui Yang; Wei Li; Annie Ogasawara; Ralph H. Schwall; Eberhard; Zhong Zheng; David W. Kahn; Nicholas F. Paoni
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Isolating Substrates for an Engineered α-Lytic Protease by Phage Display
Journal of Protein Chemistry, ISSN: 02778033
Samantha Lien; Geoffrey L. Francis; Lloyd D. Graham; John C. Wallace
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Turn stability in β-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns
Protein Science, ISSN: 09618368
Tamas Blandl; Andrea G Cochran; Nicholas J. Skelton
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UV Raman spectrum of 1,3-dimethylcyclopentenyl cation adsorbed in zeolite H-MFI
Journal of the American Chemical Society, ISSN: 00027863
Yek Tann Chua; Peter C. Stair; John B. Nicholas; Weiguo Song; James F. Haw
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Distribution of toll-like receptor 1 and toll-like receptor 2 in human lymphoid tissue
Immunology, ISSN: 00192805
Maria Teresa Ochoa; Annaliza Legaspi; Zena Hatziris; Godowski; Robert L. Modlin; Peter A. Sieling
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Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
Nature, ISSN: 00280836
Claudia Kemper; Andrew A. Chan; Jonathan M. Green; Kelly A. Brett; Kenneth M. Murphy; John P. Atkinson
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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
Journal of Biological Chemistry, ISSN: 00219258
Aggarwal; Nico Ghilardi; Xie; Frederic J. De Sauvage; Austin L. Gurney
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Stability of cyclic β-hairpins: Asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair
Journal of the American Chemical Society, ISSN: 00027863
Russell; Tamas Blandl; Nicholas J. Skelton; Andrea G Cochran
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Exploring protein-protein interactions with phage display
ChemBioChem, ISSN: 14394227
Sachdev S. Sidhu; Wayne J. Fairbrother; Deshayes
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An overview of quantitative PCR assays for biologicals: quality and safety evaluation.
Developments in Biologicals, ISSN: 14246074
Yuan Xu; Kurt Brorson
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The Crystal Structures of EDA-A1 and EDA-A2: Splice Variants with Distinct Receptor Specificity
Structure, ISSN: 09692126
Sarah G. Hymowitz; Deanne M. Compaan; Minhong Yan; Heidi J. A. Wallweber; Vishva M. Dixit; Melissa A. Starovasnik; De Vos
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Tissue microarrays in drug discovery
Nature Reviews Drug Discovery, ISSN: 14741776
Guido Sauter; Ronald Simon; Kenneth J. Hillan
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Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations
AAPS Journal, ISSN: 15507416
Andya; Chung C. Hsu; Steven J. Shire
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EGFR signal transactivation in cancer cells
Biochemical Society Transactions, ISSN: 03005127
Oliver M. Fischer; Stefan Hart; Andreas Gschwind; Axel Ullrich
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EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats
Molecular and Cellular Neuroscience, ISSN: 10447431
Xu; Li; Brown; Gerlai; Fahnestock; Racine
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