Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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July 27, 2022

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

Cardiovascular Research, ISSN: 17553245

Marco Witkowski; Mario Witkowski; Julian Friebel; Jennifer A. Buffa; Xinmin S. Li; Zeneng Wang; Naseer Sangwan; Lin Li; Joseph A. DiDonato; Caroline Tizian; Arash Haghikia; Daniel Kirchhofer; François Mach; Lorenz Räber; Christian M. Matter; W H Wilson Tang; Ulf Landmesser; Thomas F. Lüscher; Ursula Rauch; Stanley L. Hazen

July 21, 2022

Designing antibodies as therapeutics

Cell, ISSN: 10974172 00928674

Paul J. Carter; Arvind Rajpal

July 18, 2022

Stress-induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration

EMBO Journal, ISSN: 14602075 02614189

Elena Tortosa; Arundhati Sengupta Ghosh; Qingling Li; Weng Ruh Wong; Trent Hinkle; Wendy N. Sandoval; Christopher M. Rose; Casper C Hoogenraad

July 17, 2022

Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies

Cells, ISSN: 20734409

Sayantanee Paul; Shiqi Xie; Xiaosai Yao; Anwesha Dey

July 14, 2022

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Journal of Medicinal Chemistry,

Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang

July 14, 2022

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Journal of Medicinal Chemistry, ISSN: 15204804

Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang

July 14, 2022

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang

July 1, 2022

Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer

Cancer immunology research, ISSN: 23266074

Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. Gonzalez-Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga

July 1, 2022

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-tune Virtual Microdissection

Journal of Visualized Experiments, ISSN: 1940087X

Veronica Ibarra-Lopez; Sangeeta Jayakar; Yeqing Angela Yang; Ciara Martin; Zora Modrusan; Sandra Rost

July 1, 2022

Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non-Small Cell Lung Cancer Trials Using Real-World Data

Clinical Cancer Research, ISSN: 10780432

Ton; Navdeep Pal; Huong Trinh; Sami Mahrus; Michael T. Bretscher; Robson J. M. Machado; Natalia Sadetsky; Nayan Chaudhary; Michael W. Lu; Gregory J. Riely

July 1, 2022

Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer

Cancer immunology research,

Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. Gonzalez-Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga

July 1, 2022

Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)

Clinical and Translational Allergy,

Stanley J. Szefler; Graham Roberts; Adalberto S. Rubin; Stefan Zielen; Piotr Kuna; Oral Alpan; Judith Anzures-Cabrera; Qiang Chen; Cécile T.J. Holweg; Janusz Kaminski; Wendy Putnam; Matthews; Nikhil Kamath

July 1, 2022

Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study

Haematologica, ISSN: 15928721 03906078

Lale Kostakoglu; Federico Mattiello; Maurizio Martelli; Laurie H. Sehn; David Belada; Chiara Ghiggi; Neil Chua; Eva González-Barca; Xiaonan Hong; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Christopher R. Bolen; Andrea Knapp; Gila Sellam; Tina Nielsen; Deniz Sahin; Umberto Vitolo; Marek Trneny

July 1, 2022

A phase IV, multicentre, open-label study of emicizumab prophylaxis in people with haemophilia A with or without FVIII inhibitors undergoing minor surgical procedures

Haemophilia, ISSN: 13652516 13518216

Miguel Escobar; Amy Dunn; Doris Quon; Benjamin L. Trzaskoma; Lucy Lee; Richard H. Ko; Shannon L. Carpenter

July 1, 2022

Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies

Cells, ISSN: 20734409

Sayantanee Paul; Shiqi Xie; Xiaosai Yao; Anwesha Dey

July 1, 2022

Immune contexture of paediatric cancers

European Journal of Cancer, ISSN: 18790852 09598049

Meghna Das Thakur; Carl Franz; Laura Brennan; Jurriaan Brouwer-Visser; Rachel Tam; Konstanty Korski; Koeppen; James Ziai; Galina Babitzki; Dominique Ranchere-Vince; Alexandre Vasiljevic; Frédérique Dijoud; Perrine Marec-Bérard; Isabelle Rochet; Michael A. Cannarile; Aurélien Marabelle

July 1, 2022

Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Aprajita S. Yadav; Faith Stevison; Mika Kosaka; Susan C. Wong; Jane R. Kenny; John K. Amory; Nina Isoherranen

July 1, 2022

Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)

Clinical and Translational Allergy, ISSN: 20457022

Stanley J. Szefler; Graham Roberts; Adalberto S. Rubin; Stefan Zielen; Piotr Kuna; Oral Alpan; Judith Anzures-Cabrera; Qiang Chen; Cécile T.J. Holweg; Janusz Kaminski; Wendy Putnam; Matthews; Nikhil Kamath

July 1, 2022

Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering

Advanced Healthcare Materials, ISSN: 21922659 21922640

Beyza Bulutoglu; Aylin Acun; Sarah L. Deng; Safak Mert; Elise Lupon; Alexandre G. Lellouch; Curtis L. Cetrulo; Basak E. Uygun; Martin L. Yarmush

July 1, 2022

Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Jia Liu; Karthik Nagapudi; Ricky Wu; Michael J. Dolton; Niloufar Salehi; Gregory Amidon

July 1, 2022

Best Practices for Aggregate Quantitation of Antibody Therapeutics by Sedimentation Velocity Analytical Ultracentrifugation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

George M. Bou-Assaf; Ivan L. Budyak; Michael D. Brenowitz; Eric S. Day; David Hayes; John J. Hill; Ranajoy Majumdar; Paola Ringhieri; Peter Schuck; Jasper C. Lin

July 1, 2022

Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Shawn Zhang; Karthik Nagapudi; Mike Shen; Joshua Lomeo; Yuri Qin; Aiden Zhu; Purnendu K. Nayak; Debby P. Chang; Rami N. Hannoush

July 1, 2022

Investigation of Quantitative X-ray Microscopy for Assessment of API and Excipient Microstructure Evolution in Solid Dosage Processing

AAPS PharmSciTech, ISSN: 15309932

Aiden Zhu; Chen Mao; Paul E. Luner; Joshua Lomeo; Chi So; Stephanie Marchal; Shawn Zhang

July 1, 2022

Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study

Clinical and Translational Gastroenterology,

Coimbra; Rimola; Miriam Cuatrecasas; Gert De Hertogh; Gert A. Van Assche; Vanslembrouck; Henning Glerup; Agnete Hedemann Nielsen; Rikke Hagemann-Madsen; Yoram Bouhnik; Magaly Zappa; Dominique Cazals-Hatem; Geert R.A.M. D'Haens; Jaap Stoker; Sybren Meijer; Gerhard Rogler; Andreas Boss; Achim Weber; Rui Zhao; Mary E. Keir; Alexis Scherl; De Crespigny; Timothy T. Lu; Julián Panés

July 1, 2022

Standardized Processing for Formalin-Fixed, Paraffin-Embedded Cell Pellet Immunohistochemistry Controls

Journal of Visualized Experiments, ISSN: 1940087X

Charles Havnar; Kathy Hötzel; Carmina Espiritu; Amy A. Lo; Webster

July 1, 2022

Correction to: Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer (Advances in Therapy, (2022), 39, 3, (1375-1392), 10.1007/s12325-022-02047-y)

Advances in Therapy, ISSN: 18658652 0741238X

Jesse Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen

July 1, 2022

ortho-Quinone drugs go pro

Nature Chemistry, ISSN: 17554330

Thomas H. Pillow

July 1, 2022

Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques

Toxicologic Pathology, ISSN: 15331601 01926233

Justin D. Vidal; Manoj Bhaskaran; Mary Carsillo; Steve Denham; Olivia Dubay; Steven T. Laing; Balasubramanian Manickam; Stephanie Phillips; Jonathan Werner; Armando R. Irizarry Rovira

July 1, 2022

Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A

Journal of Comparative Effectiveness Research, ISSN: 20426305

Arash Mahajerin; Imi Faghmous; Peter Kuebler; Monet Howard; Tao Xu; Carlos Flores; Tiffany Chang; Francis Nissen

July 1, 2022

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition

Gut, ISSN: 14683288

Raghav Sundar; Kie-Kyon Huang; Vikrant Kumar; Kalpana Ramnarayanan; Deniz Demircioglu; Zhisheng Her; Xuewen Ong; Zul Fazreen Bin Adam Isa; Manjie Xing; Angie Lay-Keng Tan; David Wai Meng Tai; Su Pin Choo; Weiwei Zhai; Jia Qi Lim; Meghna Das Thakur; Luciana L. Molinero; Edward Cha; Marcella Fassò; Monica Niger; Filippo Pietrantonio; Jeeyun Lee; Anand D. Jeyasekharan; Aditi Qamra; Radhika Patnala; Arne Fabritius; Mark De Simone; Joe Yeong; Cedric Chuan Young Ng; Sun Young Rha; Yukiya Narita; Kei Muro; Yu Amanda Guo; Anders Jacobsen Skanderup; Jimmy Bok Yan So; Wei Peng Yong; Qingfeng Chen; Jonathan Göke; Patrick Tan

July 1, 2022

Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Naoki Kotani; Michael J. Dolton; Robin J Svensson; Jakob Ribbing; Lena E. Friberg; Shweta Vadhavkar; Dorothy S. Cheung; Tracy Staton; Gizette Sperinde; Jin Jin; Wendy Putnam; Angelica Quartino

July 1, 2022

Combination of Atezolizumab and Tazemetostat in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Results From a Phase Ib Study

Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650

M. Lia Palomba; Guillaume Cartron; Leslie L. Popplewell; Vincent Ribrag; Jason Westin; Huw; Shefali Agarwal; Mahesh Shivhare; Wan-Jen Hong; Aparna Raval; Alice C. Chang; Elicia M. Penuel; Morschhauser

July 1, 2022

Combination of Atezolizumab and Obinutuzumab in Patients with Relapsed/Refractory Follicular Lymphoma and Diffuse Large B‐Cell Lymphoma: Results from a Phase 1b Study

Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650

M. Lia Palomba; Brian G. Till; Steven I. Park; Morschhauser; Guillaume Cartron; Reinhard Marks; Mahesh Shivhare; Wan-Jen Hong; Aparna Raval; Alice C. Chang; Elicia M. Penuel; Leslie L. Popplewell

July 1, 2022

Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study

Clinical and Translational Gastroenterology, ISSN: 2155384X

Coimbra; Rimola; Miriam Cuatrecasas; Gert De Hertogh; Gert A. Van Assche; Vanslembrouck; Henning Glerup; Agnete Hedemann Nielsen; Rikke Hagemann-Madsen; Yoram Bouhnik; Magaly Zappa; Dominique Cazals-Hatem; Geert R.A.M. D'Haens; Jaap Stoker; Sybren Meijer; Gerhard Rogler; Andreas Boss; Achim Weber; Rui Zhao; Mary E. Keir; Alexis Scherl; De Crespigny; Timothy T. Lu; Julián Panés

July 1, 2022

Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer

Cancer immunology research, ISSN: 23266074 23266066

Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. González Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga

July 1, 2022

Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A

Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305

Arash Mahajerin; Imi Faghmous; Peter Kuebler; Monet Howard; Tao Xu; Carlos Flores; Tiffany Chang; Francis Nissen

July 1, 2022

Correction to: Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer (Advances in Therapy, (2022), 39, 3, (1375-1392), 10.1007/s12325-022-02047-y)

Advances in Therapy, ISSN: 18658652 0741238X

Jesse A. Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen

July 1, 2022

Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non-Small Cell Lung Cancer Trials Using Real-World Data

Clinical Cancer Research, ISSN: 15573265 10780432

Ton; Navdeep Pal; Huong Trinh; Sami Mahrus; Michael T. Bretscher; Robson J. M. Machado; Natalia Sadetsky; Nayan Chaudhary; Michael W. Lu; Gregory J. Riely

July 1, 2022

ortho-Quinone drugs go pro

Nature Chemistry, ISSN: 17554349 17554330

Thomas H. Pillow

June 28, 2022

Spectroscopy-Based Local Modeling Method for High-Throughput Quantification of Nucleic Acid Loading in Lipid Nanoparticles

Analytical Chemistry, ISSN: 00032700

Yuchen Fan; Zhenqi Shi; Shengli Ma; Sayyeda Zeenat A. Razvi; Yige Fu; Tao Chen; Jason Gruenhagen; Kelly Zhang

June 28, 2022

Spectroscopy-Based Local Modeling Method for High-Throughput Quantification of Nucleic Acid Loading in Lipid Nanoparticles

Analytical Chemistry, ISSN: 15206882 00032700

Yuchen Fan; Zhenqi Shi; Shengli Ma; Sayyeda Zeenat A. Razvi; Yige Fu; Tao Chen; Jason Gruenhagen; Kelly Zhang

June 22, 2022

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

eLife,

Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter

June 22, 2022

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

eLife, ISSN: 2050084X

Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter

June 15, 2022

Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice

Journal of Immunology, ISSN: 00221767

Katherine Bao; Juan Zhang; Alexis Scherl; James Ziai; Azi Hadadianpour; Daqi Xu; Christopher Dela Cruz; John Liu; Yuxin Liang; Lucinda Tam; Cesar A. Corzo; Merone Roose-Girma; Søren Warming; Zora Modrusan; Wyne P. Lee; Kam Hon Hoi; Ali A. Zarrin

June 15, 2022

Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice

Journal of Immunology, ISSN: 15506606 00221767

Katherine Bao; Juan Zhang; Alexis Scherl; James Ziai; Azi Hadadianpour; Daqi Xu; Christopher Dela Cruz; John Liu; Yuxin Liang; Lucinda Tam; Cesar A. Corzo; Merone Roose-Girma; Søren Warming; Zora Modrusan; Wyne P. Lee; Kam Hon Hoi; Ali A. Zarrin

June 8, 2022

Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)

Oncologist,

Seohyuk Lee; Chao Ma; Sui Zhang; Fang-Shu Ou; Tiffany M. Bainter; Donna Niedzwiecki; Leonard Saltz; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al B. Benson; Daniel Atienza; Hedy L. Kindler; Cary P. Gross; Melinda L. Irwin; Jeffrey A. Meyerhardt; Charles Fuchs

June 8, 2022

Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)

Oncologist, ISSN: 1549490X

Seohyuk Lee; Chao Ma; Sui Zhang; Fang-Shu Ou; Tiffany M. Bainter; Donna Niedzwiecki; Leonard Saltz; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al B. Benson; Daniel Atienza; Hedy L. Kindler; Cary P. Gross; Melinda L. Irwin; Jeffrey A. Meyerhardt; Charles Fuchs

June 7, 2022

Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry

Journal of Chromatography A, ISSN: 18733778 00219673

Sanket Dahotre; Lu Dai; Karissa Kjenstad; Cinzia Stella; Julien Camperi

June 7, 2022

Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490

Brandon Leonard; Kannan Sankar; Matthew G. Romei; Margaret J. Tse; Nina Do; Yanli Yang; Wadim L. Matochko; Jack Bevers; Sundeep Bollineni; Kiran Mukhyala; Kam Hon Hoi; Greg A. Lazar

June 7, 2022

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration

EMBO Reports, ISSN: 14693178 1469221X

Mila Daoud; Pia Nora Broxtermann; Fabian Schorn; J Paul Werthenbach; Jens Michael Seeger; Lars Schiffmann; Kerstin Brinkmann; Domagoj Vucic; Thomas Tüting; Cornelia Mauch; Dagmar Kulms; Paola Zigrino; Hamid Kashkar

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