Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12001 - 12050 OF 15396 RESULTS

January 1, 1999

Kinase Receptor Activation (KIRA): a rapid and accurate alternative to endpoint bioassays.

Developments in biological standardization, ISSN: 03015149

Michael D Sadick

January 1, 1999

How much insulin-like growth factor-I (IGF-I) circulates?: impact of standardization on IGF-I assay accuracy.

Developments in biological standardization, ISSN: 03015149

Quarmby; Quan

January 1, 1999

Pharmacokinetics of insulin-like growth factor I in hypopituitarism: Correlation with binding proteins

American Journal of Physiology - Endocrinology and Metabolism, ISSN: 01931849

Nelly Mauras; Quarmby; Duane C. Bloedow

January 1, 1999

Role of baseline parameters in determining indirect pharmacodynamic responses

Journal of Pharmaceutical Sciences, ISSN: 00223549

Sun; William J. Jusko

January 1, 1999

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

Cytokine, ISSN: 10434666

Xie; Ilona N. Holcomb; Bethanne Deuel; Patrick Dowd; Arthur Huang; Alicia Vagts; Foster; Jie Liang; Brush; Qimin Gu; Kenneth J. Hillan; Goddard; Austin L. Gurney

January 1, 1999

Allergic bronchopulmonary aspergillosis in cystic fibrosis: Reported prevalence, regional distribution, and patient characteristics

Chest, ISSN: 00123692

David E. Geller; Kaplowitz; Michael Light; Andrew A. Colin

January 1, 1999

A human antibody that binds to the γ-carboxyglutamic acid domain of factor IX is a potent antithrombotic in vivo

Thrombosis and Haemostasis, ISSN: 03406245

Refino; Jacques Himber; Louis Burcklen; Paul Moran; Peek; Shelley Suggett; Devaux; Daniel Kirchhofer

January 1, 1999

Role of vascular endothelial growth factor in the regulation of angiogenesis

Kidney International, ISSN: 00852538

Napoleone Ferrara

January 1, 1999

A real time quantitative PCR-based method for the detection and quantification of simian virus 40

Biologicals, ISSN: 10451056

Shi; Jeniffer Ho; Lenore A Norling; Margaret Roy; Yuan Xu

January 1, 1999

Real time quantitative PCR as a method to evaluate simian virus 40 removal during pharmaceutical protein purification

Biologicals, ISSN: 10451056

Shi; Lenore A Norling; Allen S.L. Lau; Sherrie Krejci; Alison J. Laney; Yuan Xu

January 1, 1999

Functional roles for PECAM-1 (CD31) and VE-cadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels

American Journal of Pathology, ISSN: 00029440

Suya Yang; Jennifer Graham; Jeanne Kahn; Eric A. Schwartz; Mary E. Gerritsen

January 1, 1999

The biology of human epidermal growth factor receptor 2.

Current Oncology Reports, ISSN: 15233790

Sundaresan; Elicia M. Penuel; Mark X. Sliwkowski

January 1, 1999

Development and testing of a thermoluminescence dosemeter for mixed neutron-photon-beta radiation fields

Radiation Protection Dosimetry, ISSN: 01448420

Zummo; Liu

January 1, 1999

Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection

Journal of Virology, ISSN: 0022538X

Tsutomu Murakami; Tian-Yuan Zhang; Yoshio Koyanagi; Yuetsu Tanaka; Jin Kim; Yoichi Suzuki; Shigeru Minoguchi; Hirokazu Tamamura; Michinori Waki; Akiyoshi Matsumoto; Nobutaka Fujii; Hisatoshi Shida; James A. Hoxie; Stephen C. Peiper; Naoki Yamamoto

January 1, 1999

Commentary: Role of the pathologist in the identification and characterization of therapeutic molecules

Toxicologic Pathology, ISSN: 01926233

Anne Ryan

January 1, 1999

Anatomic localization of 24- and 96-h particle retention in canine airways

Journal of Applied Physiology, ISSN: 87507587

Kreyling; Blanchard; Godleski; Haeussermann; Heyder; Hutzler; Schulz; Sweeney; Takenaka; Ziesenis

January 1, 1999

Lyophilization of protein formulations in vials: Investigation of the relationship between resistance to vapor flow during primary drying and small-scale product collapse

Journal of Pharmaceutical Sciences, ISSN: 00223549

David E. Overcashier; Thomas W. Patapoff; Chung C. Hsu

January 1, 1999

Correlation of CT findings with clinical evaluations in 261 patients with symptomatic bronchiectasis

American Journal of Roentgenology, ISSN: 0361803X

David A. Lynch; John Newell; Valerie Hale; Debra Dyer; Kevin Corkery; Fox; Patricia Gerend; Robert B. Fick Jr.

January 1, 1999

Safety and antitumor activity of recombinant soluble Apo2 ligand

Journal of Clinical Investigation, ISSN: 00219738

Avi Ashkenazi; Roger Pai; Fong; Susan Leung; David Lawrence; Scot A. Marsters; Christine Blackie; Ling Chang; Amy E. McMurtrey; Andrea Hebert; Laura DeForge; Iphigenia Koumenis; Lewis; Louise A. Harris; Bussiere; Koeppen; Shahrokh; Ralph H. Schwall

January 1, 1999

Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5

Molecular Cell, ISSN: 10972765

Sarah G. Hymowitz; Hans W. Christinger; Fuh; Ultsch; Mark P. O'Connell; Robert F. Kelley; Avi Ashkenazi; De Vos

January 1, 1999

Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes

Chemistry and Biology, ISSN: 10745521

Wuyuan Lu; Michael Randal; Anthony A. Kossiakoff; Stephen B. H. Kent

January 1, 1999

Pharmacokinetics and pharmacodynamics of sibrafiban, an orally administered IIb/IIIa antagonist, in patients with acute coronary syndrome.

Journal of Clinical Pharmacology, ISSN: 00912700

Modi; Novotny; Reimann; Christopher P. Cannon; Braunwauld

January 1, 1999

Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)

Journal of Leukocyte Biology, ISSN: 07415400

Grimaldi; Nai-Xuan Yu; Gabrielle Grunig; Brian W. P. Seymour; Françoise Cottrez; Douglas S. Robinson; Nancy Hosken; Walter G. Ferlin; Xiaoyan Wu; Hortensia Soto; Anne O'Garra; Maureen C. Howard; Coffman

January 1, 1999

The effect of growth hormone treatment on stature in Aarskog syndrome

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X

Anna Petryk; Samuel Richten; Judy P. Sy; Sandra L. Blethen

January 1, 1999

Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways

Molecular Biology of the Cell, ISSN: 10591524

Elicia M. Penuel; G. Steven Martin

January 1, 1999

Hepatocyte growth factor inhibits amiloride-sensitive Na+ channel function in cystic fibrosis airway epithelium in vitro

Pulmonary Pharmacology and Therapeutics, ISSN: 10945539

Shen; Widdicombe; Mrsny

January 1, 1999

A comparison of the national registry of myocardial infarction 2 with the cooperative cardiovascular project

Journal of the American College of Cardiology, ISSN: 07351097

Nathan R. Every; Paul D. Frederick; Michael Robinson; Jonathan Sugarman; Laura J. Bowlby; Hal V. Barron

January 1, 1999

Safety assessment of single-bolus administration of TNK tissue- plasminogen activator in acute myocardial infarction: The ASSENT-1 trial

American Heart Journal, ISSN: 00028703

Frans Van De Werf; Christopher P. Cannon; Anne Luyten; Katrijn Houbracken; Carolyn H. McCabe; Berioli; Bluhmki; Hans Sarelin; Wang-Clow; Fox; Eugene Braunwald

January 1, 1999

IgE inhibition as a therapy for allergic disease

International Archives of Allergy and Immunology, ISSN: 10182438

Paula Jardieu; Robert B. Fick Jr.

January 1, 1999

Effect of local anti-VEGF antibody treatment on tumor microvessel permeability

Microvascular Research, ISSN: 00262862

Hera C. Lichtenbeld; Napoleone Ferrara; Rakesh K. Jain; Lance L. Munn

January 1, 1999

Deficient T cell fate specification in mice with an induced inactivation of Notch1

Immunity, ISSN: 10747613

Freddy Radtke; Anne Wilson; Gerlinde Stark; Michele Bauer; Joost Van Meerwijk; H. Robson MacDonald; Michel Aguet

January 1, 1999

The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody

Pharmaceutical Research, ISSN: 07248741

Andya; Maa; Henry R. Costantino; Phuong-Anh Nguyen; Nancy Dasovich; Sweeney; Chung C. Hsu; Steven J. Shire

January 1, 1999

In vitro evaluation of microparticles and polymer gels for use as nasal platforms for protein delivery

Pharmaceutical Research, ISSN: 07248741

Claudia Witschi; Mrsny

January 1, 1999

Characterization of active-site aromatic residues in xylanase a from Streptomyces lividans

Protein Engineering, ISSN: 02692139

Roberge; François Shareck; Rolf Morosoli; Dieter Kluepfel; Claude Dupont

January 1, 1999

Effects of recombinant human growth hormone on height and skeletal maturation in growth hormone-deficient children with and without severe pretreatment bone age delay

Hormone Research, ISSN: 03010163

J. Paul Frindik; Stephen F. Kemp; Judy P. Sy

January 1, 1999

Research technologies: Fulfilling the promise

FASEB Journal, ISSN: 08926638

Ruth H. Angeletti; Lynda F. Bonewald; Karen De Jongh; Ronald Niece; John Rush; Stults

January 1, 1999

Herceptin®: Breaking new ground

Cancer Biotherapy and Radiopharmaceuticals, ISSN: 10849785

Robert L. Cohen

January 1, 1999

Concanavalin A protects hair cells against gentamicin ototoxicity in rat cochlear explant cultures

Journal of Neurobiology, ISSN: 00223034

Zheng; Gao

January 1, 1999

Inactivating mutations and overexpression of BCL 10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

Nature Genetics, ISSN: 10614036

Quangeng Zhang; Reiner Siebert; Minhong Yan; Bernd Hinzmann; Xiaoli Cui; Liquan Xue; Karen M. Rakestraw; Clayton W. Naeve; Georg Beckmann; Dennis D. Weisenburger; Warren G. Sanger; Hadwiga Nowotny; Michael Vesely; Evelyne Callet-Bauchu; Gilles Salles; Vishva M. Dixit; André Rosenthal; Brigitte Schlegelberger; Stephan W. Morris

January 1, 1999

Pharmacokinetics of fosinopril and hydrochlorothiazide in healthy elderly and young men

Clinical Drug Investigation, ISSN: 11732563

David R. Much; Howard D. Uderman; Barbara Ameer; John Brennan; Bruce C. Stouffer; Daisy Whigan; Arthur DeVault; Donald VanHarken

January 1, 1999

Ca2+-dependent activity of human DNase I and its hyperactive variants

Protein Science, ISSN: 09618368

Clark Q. Pan; Lazarus

January 1, 1999

Gibbon ape leukemia virus receptor functions of type III phosphate transporters from CHOK1 cells are disrupted by two distinct mechanisms

Journal of Virology, ISSN: 0022538X

G. Jilani Chaudry; Karen B. Farrell; Yuan-Tsang Ting; Christian Schmitz; Yolanda S. Lie; Christos J. Petropoulos; Maribeth V. Eiden

January 1, 1999

Regulation of activin A in cell proliferation and hormone secretion by human normal trophoblast cells

Chinese Science Bulletin, ISSN: 10016538

Yanling Wang; Mathe; Woodroff; Shuyi Luo; Linzhi Zhuang

January 1, 1999

Induction of apoptosis in cancer cells by tumor necrosis factor and butyrolactone, an inhibitor of cyclin-dependent kinases

Brazilian Journal of Medical and Biological Research, ISSN: 0100879X

Belizário; Steve Sherwood; Beçak

January 1, 1999

High-resolution mapping of discrete representational areas in rat somatosensory cortex using blood volume-dependent functional MRI

NeuroImage, ISSN: 10538119

James T. Palmer; De Crespigny; Simon P. Williams; Busch; Nicholas Van Bruggen

January 1, 1999

Purification and characterization of a novel 35-kDa protein from transformed cardiomyocytes

Cell Biology International, ISSN: 10656995

Sundararaman Chandrasekhar; Pamela N. Münster; William A. Henzel

January 1, 1999

Influence of calcium ions on the structure and stability of recombinant human deoxyribonuclease I in the aqueous and lyophilized states

Journal of Pharmaceutical Sciences, ISSN: 00223549

Bei Chen; Henry R. Costantino; Jun Liu; Chung C. Hsu; Steven J. Shire

January 1, 1999

Autotransplantation for Parkinson's disease goes a step further

Neuron, ISSN: 08966273

Choi-Lundberg; Rosenthal

January 1, 1999

Intracranial delivery of recombinant nerve growth factor: Release kinetics and protein distribution for three delivery systems

Pharmaceutical Research, ISSN: 07248741

W. Mark Saltzman; Michele W. Mak; Melissa J. Mahoney; Duenas; Cleland

January 1, 1999

Protein inhalation powders: Spray drying vs spray freeze drying

Pharmaceutical Research, ISSN: 07248741

Maa; Phuong-Anh Nguyen; Sweeney; Steven J. Shire; Chung C. Hsu

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