Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12451 - 12500 OF 15396 RESULTS

Redesigning antibodies
FASEB Journal, ISSN: 08926638
Presta
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Hepatic clearance and metabolism of tnk-tpa, a long half-life variant of rt-PA
Fibrinolysis and Proteolysis, ISSN: 13690191
Geralyn G. Deguzman; Richardson; Keyt; Zioncheck
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TNK-tissue plasminogen activator compared with frontloaded tpa in acute myocardial infarction: clinical update
Fibrinolysis and Proteolysis, ISSN: 13690191
Bruce A. Kevt
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Deep-lung delivery of therapeutic proteins
CHEMTECH, ISSN: 00092703
John R. Patton
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Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6
Journal of Immunology, ISSN: 00221767
Richards; Christine Kerr; Minoru Tanaka; Takahiko Hara; Atsushi Miyajima; Diane Pennica; Fernando Botelho; Langdon
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Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat
Cardiovascular Research, ISSN: 00086363
Lesley A. Brown; Richard A.D. Rutherford; Derek J.R. Nunez; John Wharton; David G Lowe; Martin R. Wilkins
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Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis
Journal of Immunology, ISSN: 00221767
Encarnacion Montecino-Rodriguez; Ross Clark; Powell-Braxton; Kenneth Dorshkind
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Minimization of a protein binding domain
FASEB Journal, ISSN: 08926638
Andrew Braisted
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Mannose phosphorylat10n on secretory glycoproteins
FASEB Journal, ISSN: 08926638
Nase; Nishikawa; Walter Gregory; Akash Nanda; John Frenz; Stuart Kornfeld
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High-dose aldesleukin in renal cell carcinoma: Long-term survival update
Cancer Journal from Scientific American, ISSN: 10814442
Richard I. Fisher; Steven A. Rosenberg; Mario Sznol; David R. Parkinson; Gwendolyn Fyfe
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The resurgence of analytical ultracentrifugation: An old technique applied to a new technology
Proceedings of SPIE - The International Society for Optical Engineering, ISSN: 0277786X
Steven J. Shire; Jun Liu
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Fourier-transform infrared spectroscopic analysis of the secondary structure of recombinant humanized immunoglobulin G
Pharmaceutical Sciences, ISSN: 13566881
Henry R. Costantino; Andya; Steven J. Shire; Chung C. Hsu
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Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation
FASEB Journal, ISSN: 08926638
Yung-Hsiang Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner
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Engineering hyperactive human dnase i with over 4000-fold higher activity in human serum by altering its functional mechan1sm
FASEB Journal, ISSN: 08926638
Clark Q. Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus
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Rapid analytical tryptic mapping of a recominant chimeric monoclonal antibody and method validation challenges
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Kannan; Michael G. Mulkerrin; Zhang; Gray; Steinharter; Sewerin; Baffi; Reed J. Harris; Karunatilake
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Data handling issues in a gmp environment
FASEB Journal, ISSN: 08926638
Nolan
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Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Kathy Moorhouse; Wassim Nashabeh; James Deveney; Nancy Bjork; Michael G. Mulkerrin; Thomas C. Ryskamp
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Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation
FASEB Journal, ISSN: 08926638
Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner
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Crystal structure at 1.7 Å resolution f VEGF in complex with domain 2 of the Fit-1 receptor
Cell, ISSN: 00928674
Wiesmann; Fuh; Hans W. Christinger; Eigenbrot; James A. Wells; De Vos
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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling
Science, ISSN: 00368075
Marta Muzio; Jian Ni; Ping Feng; Vishva M. Dixit
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Interaction of human IgE with soluble forms of IgE high affinity receptors
Pharmaceutical Research, ISSN: 07248741
Jun Liu; Jane Ruppel; Steven J. Shire
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Caspases: Intracellular signaling by proteolysis
Cell, ISSN: 00928674
Guy S. Salvesen; Vishva M. Dixit
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A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand Ephrin-A5/AL-1
Cell and Tissue Research, ISSN: 0302766X
Caras
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Hepatocyte-derived cell lines express a functional receptor for cardiotrophin-1
European Cytokine Network, ISSN: 11485493
Olivier Robledo; Catherine Guillet; Sylvie Chevalier; Maryvonne Fourcin; Josy Froger; Annick Pouplard-Barthelaix; Diane Pennica; Hugues Gascan
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Structural plasticity in a remodeled protein-protein interface
Science, ISSN: 00368075
Shane Atwell; Ultsch; De Vos; James A. Wells
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The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects
European Respiratory Journal, ISSN: 09031936
Anderson; Spring; Moore; Rodwell; Spalding; Gonda; Chan; Andrew J. Walsh; Clark
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Capillary electrophoresis based immunoassays: A critical review
Electrophoresis, ISSN: 01730835
Dieter Schmalzing; Wassim Nashabeh
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The use of sequential high-performance liquid chromatography and capillary zone electrophoresis to separate the glycosylated peptides from recombinant tissue plasminogen activator to a detailed level of microheterogeneity
Analytical Biochemistry, ISSN: 00032697
Shiaw-Lin Wu
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Potent α4β1 peptide antagonists as potential anti-inflammatory agents
Journal of Medicinal Chemistry, ISSN: 00222623
Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Sherman Fong
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Potent α4β1 peptide antagonists as potential anti-inflammatory agents
Journal of Medicinal Chemistry, ISSN: 00222623
Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Fong
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Single step method for the accurate concentration determination of polysorbate 80
Journal of Chromatography A, ISSN: 00219673
Travis H. Tani; Jamie M. R. Moore; Thomas W. Patapoff
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Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines
Circulation, ISSN: 00097322
Eric Van Belle; Alain Rivard; Donghui Chen; Marcy Silver; Bunting; Napoleone Ferrara; James F. Symes; Christophe Bauters; Jeffrey M. Isner
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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
Cancer Research, ISSN: 00085472
Presta; Helen Chen; Shane J. O'Connor; Chisholm; Meng; Lynne Krummen; Winkler; Napoleone Ferrara
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Formulation Development and Primary Degradation Pathways for Recombinant Human Nerve Growth Factor
Analytical Chemistry, ISSN: 00032700
Eng; Victor Ling; Jonathan A. Briggs; Karen Souza; Eleanor Canova-Davis; Powell; Linda R. De Young
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A p47-phox pseudogene carries the most common mutation causing p47- phox-deficient chronic granulomatous disease
Journal of Clinical Investigation, ISSN: 00219738
Agnes Görlach; Pauline L. Lee; Joachim Roesler; Penelope J. Hopkins; Barbara Christensen; Eric D. Green; Stephen J. Chanock; John T. Curnutte
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Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation
Histochemistry and Cell Biology, ISSN: 09486143
Heyworth; John M. Robinson; Jiabing Ding; Beverly A. Ellis; John A. Badwey
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Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development
Advanced Drug Delivery Reviews, ISSN: 0169409X
Cleland; OluFunmi Johnson; Putney; Andrew J.S. Jones
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Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth homone)-insulin- like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Johannes D. Veldhuis; Daniel L. Metzger; Paul M. Martha Jr.; Nelly Mauras; James R. Kerrigan; Bruce Keenan; Alan D. Rogol; Steve M. Pincus
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New advances in microsphere-based single-dose vaccines
Advanced Drug Delivery Reviews, ISSN: 0169409X
Justin Hanes; Cleland; Langer
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Hemodynamic effects of intracoronary VEGF delivery: Evidence of tachyphylaxis and NO dependence of response
American Journal of Physiology - Heart and Circulatory Physiology, ISSN: 03636135
John J. Lopez; Roger J Laham; Joseph P. Carrozza; Motohisa Tofukuji; Frank W Sellke; Bunting; Michael Simons
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High performance tangential flow filtration
Biotechnology and Bioengineering, ISSN: 00063592
Robert Van Reis; Shishir Gadam; Leah N. Frautschy; Scott Orlando; Elizabeth M. Goodrich; Saksena; Ralf Kuriyel; Curran M. Simpson; Steven Pearl; Andrew Zydney
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Long-term benefit of one thrombolytic over another [13] (multiple letters)
Circulation, ISSN: 00097322
Barry Grobman; Roberts
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Inhibition of virus-induced age-dependent poliomyelitis by interferon-γ
Antiviral Research, ISSN: 01663542
William A. Cafruny; Thomas R. Haven; Steven R. Lawson; Grace H.W. Wong; Raymond R.R. Rowland
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rhDNase as an example of recurrent event analysis
Statistics in Medicine, ISSN: 02776715
Terry M. Therneau; Scott A. Hamilton
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rhDNase as an example of recurrent event analysis
Statistics in Medicine, ISSN: 02776715
Terry M. Therneau; Scott Hamilton
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Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy- 3-methylglutaryl-coenzyme A reductase
Journal of Biological Chemistry, ISSN: 00219258
William Harrison Engfelt; Janis E. Shackelford; Nahla Aboushadi; Nadini Jessani; Kim Masuda; Vincent G. Paton; Gilbert-Andre Keller; Skaidrite Krisans
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Insulin-like growth factor-binding protein-6 levels are elevated in serum of children with chronic renal failure: A report of the southwest pediatric nephrology study group
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
David R. Powell; Frances Liu; Bonita K. Baker; Hintz; Susan K. Durham; Eileen D. Brewer; James W. Frane; Burkhard Tonshoff; Otto Mehls; Anne-Margret Wingen; Sandra L. Watkins; Ronald J. Hogg; Lee
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Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
Journal of Biological Chemistry, ISSN: 00219258
Hans-Peter Gerber; Fabrizio Condorelli; Jeanie Park; Napoleone Ferrara
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Role of CED-4 in the activation of CED-3 [9]
Nature, ISSN: 00280836
Arul M. Chinnaiyan; Divya Chaudhary; Karen M. O'Rourke; Eugene V. Koonin; Vishva M. Dixit
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Phage display of a catalytic antibody to optimize affinity for transition-state analog binding
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Baca; Thomas S. Scanlan; Robert C. Stephenson; James A. Wells
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