Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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April 15, 1994

Vascular endothelial growth factor: A cytokine modulating endothelial function in rheumatoid arthritis

Journal of Immunology, ISSN: 00221767

Alisa Koch; Lisa A. Harlow; G. Kenneth Haines; Edward P. Amento; Elaine N. Unemori; Wai Lee T. Wong; Richard M. Pope; Napoleone Ferrara

April 12, 1994

Neurotrophin 4/5 is a trophic factor for mammalian facial motor neurons

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Vassilis E. Koliatsos; Michelle H. Cayouette; Lucy R. Berkemeier; Richard E. Clatterbuck; Donald L. Price; Rosenthal

April 12, 1994

Neurotrophin 3 stimulates the differentiation of motoneurons from avian neural tube progenitor cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Lea Averbuch-Heller; Merav Pruginin; Nitza Kahane; Tsoulfas; Parada; Rosenthal; Chaya Kalcheim

April 8, 1994

Retention and degradation of proteins containing an uncleaved glycosylphosphatidylinositol signal

Journal of Biological Chemistry, ISSN: 00219258

Mark C. Field; Paul Moran; Wenlu Li; Gilbert-Andre Keller; Caras

April 4, 1994

Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist

Tetrahedron Letters, ISSN: 00404039

Robert R. Webb II; Peter L. Barker; Mark Baier; Mark E. Reynolds; Kirk D. Robarge; Brent Blackburn; Maureen Tischler; Kenneth J Weese

April 1, 1994

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

Journal of Neuroscience, ISSN: 02706474

Karen L. Allendoerfer; Robert J. Cabelli; Escandon; David R. Kaplan; Nikolics; Carla J. Shatz

April 1, 1994

Signal transduction versus buffering activity in Ca2+-binding proteins

Nature Structural Biology, ISSN: 10728368

Nicholas J. Skelton; Johan Kördel; Mikael Akke; Sture Forsén; Walter J. Chazin

April 1, 1994

A faster-acting and more potent form of tissue plasminogen activator

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Keyt; Nicholas F. Paoni; Refino; Lea Berleau; Hung V. Nguyen; Alice M. Chow; Lai; Luis Peña; Cheryl Pater; John R. Ogez; Etcheverry; David Botstein; William F. Bennett

April 1, 1994

Protein Folding Activities of Escherichia coli Protein Disulfide Isomerase

Biochemistry, ISSN: 15204995 00062960

John C. Joly; James R. Swartz

April 1, 1994

Ecotin Is a Potent Anticoagulant and Reversible Tight-Binding Inhibitor of Factor Xa

Biochemistry, ISSN: 15204995 00062960

Jana L. Seymour; Robert N. Lindquist; Dennis; Lazarus; Moffat; Yansura; Dorothea Reilly; Wessinger

March 25, 1994

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

Cell, ISSN: 00928674

Crowley; Spencer; Merry Nishimura; Grace Chan; Sharon Pitts-Meek; Mark P. Armaninl; Lanway H. Ling; McMahon; David L. Shelton; Levinson; Phillips

March 18, 1994

Expression of the duffy antigen in K562 cells: Evidence that it is the human erythrocyte chemokine receptor

Journal of Biological Chemistry, ISSN: 00219258

Asok Chaudhuri; Valerie Zbrzezna; Julia Polyakova; A. Oscar Pogo; Joseph Hesselgesser; Richard Horuk

March 15, 1994

Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy

Journal of Immunology, ISSN: 00221767

V. Courtney Broaddus; Alice M. Boylan; John M. Hoeffel; K.Jin Kim; Michael D Sadick; Anan Chuntharapai; Hébert

March 14, 1994

Two new procedures for the introduction of benzyl-type protecting groups for thiols

Tetrahedron Letters, ISSN: 00404039

Lutz S. Richter; James C. Marsters Jr.; Thomas Gadek

March 4, 1994

Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells

Journal of Biological Chemistry, ISSN: 00219258

Liisa Pertovaara; Arja Kaipainen; Tuija Mustonen; Arto Orpana; Napoleone Ferrara; Olli Saksela; Kari Alitalo

March 1, 1994

Functional analysis of the cysteine residues of activin A

Molecular Endocrinology, ISSN: 08888809

Anthony J. Mason

March 1, 1994

Characterization of Humanized Anti-TAC, an Antibody Directed Against the Interleukin 2 Receptor, Using Electrospray Ionization Mass Spectrometry by Direct Infusion, LC/MS, and MS/MS

Analytical Chemistry, ISSN: 15206882 00032700

Derf A. Lewis; Andrew W. Guzzetta; William S. Hancock; Maureen Costello

March 1, 1994

Modification of CD4 Immunoadhesin with Monomethoxy poly (ethylene glycol) Aldehyde via Reductive Alkylation

Bioconjugate Chemistry, ISSN: 15204812 10431802

Steven M. Chamow; Peers; Timothy P. Kogan; Michael C. Venuti; Thomas Gadek; Reed J. Harris; Joyce Mordenti; Steven Shak; Avi Ashkenazi

February 25, 1994

Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin

Journal of Biological Chemistry, ISSN: 00219258

Debyra J. Groskreutz; Mark X. Sliwkowski; Cornelia M. Gorman

February 15, 1994

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways

Journal of Immunology, ISSN: 00221767

Grace H.W. Wong; David V. Goeddel

February 15, 1994

Neutralizing monoclonal antibodies to human IL-8 receptor A map to the NH2-terminal region of the receptor

Journal of Immunology, ISSN: 00221767

Anan Chuntharapai; James Lee; Burnier; William I. Wood; Hébert; Jin Kim

February 1, 1994

Protein Sorting by High Performance Liquid Chromatography. 2. Separation of Isophosphorylates of Recombinant Human DNase I on a Polyethylenimine Column

Analytical Chemistry, ISSN: 15206882 00032700

John Frenz; Quan; Cacia; Democko; Robert L. Bridenbaugh; McNerney

February 1, 1994

Cis,cis-Muconate Lactonizing Enzyme from Trichosporon cutaneum: Evidence for a Novel Class of Cycloisomerases in Eucaryotes

Biochemistry, ISSN: 15204995 00062960

Paul Mazur; Wolfgang A. Pieken; Scott R. Budihas; Suzanne E. Williams; Susan Wong; John W. Kozarich

February 1, 1994

Cis,cis-Muconate Lactonizing Enzyme from Trichosporon cutaneum: Evidence for a Novel Class of Cycloisomerases in Eucaryotes

Biochemistry, ISSN: 15204995 00062960

Paul Mazur; Wolfgang A. Pieken; Scott R. Budihas; Suzanne E. Williams; Susan C. Wong; John W. Kozarich

January 28, 1994

Cloning of FRK, a novel human intracellular SRC-like tyrosine kinaseencoding gene

Gene, ISSN: 03781119

James Lee; Zhengyu Wang; Shiuh-Ming Luoh; William I. Wood; David T. Scadden

January 14, 1994

Identification and characterization of a novel tyrosine kinase from megakaryocytes

Journal of Biological Chemistry, ISSN: 00219258

Brian D. Bennett; Sally Cowley; Shuxian Jiang; Roanna London; Bijia Deng; Jadwiga Grabarek; Jerome E. Groopman; David V. Goeddel; Hava Avraham

January 4, 1994

Structure from function: Screening structural models with functional data

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Jin; Fred E. Cohen; James A. Wells

January 1, 1994

The interferon-γ receptor extracellular domain. Non-identical requirements for ligand binding and signaling

Journal of Biological Chemistry, ISSN: 00219258

Axelrod; Gibbs; David V. Goeddel

January 1, 1994

The precision of anthropometric assessment of body fat distribution in children

Annals of Human Biology, ISSN: 03014460

Mueller; Kaplowitz

January 1, 1994

Development of a single-shot subunit vaccine for HIV-1

AIDS Research and Human Retroviruses, ISSN: 08892229

Cleland; Powell; Lim; Barron; Berman; Eastman; Nunberg; Wrin; Vennari

January 1, 1994

Growth hormone-binding protein levels: Studies of children with short stature

Metabolism: Clinical and Experimental, ISSN: 00260495

Nelly Mauras; Carlsson; Suzanne Murphy; Thomas J. Merimee

January 1, 1994

Analytical considerations in the development of protein purification processes.

Bioprocess technology, ISSN: 08887470

Vincent R. Anicetti; William S. Hancock

January 1, 1994

rse, A novel receptor-type tyrosine kinase with homology to Ax1/Ufo, is expressed at high levels in the brain

Journal of Biological Chemistry, ISSN: 00219258

Melanie R Mark; David T. Scadden; Wang; Qimin Gu; Goddard; Godowski

January 1, 1994

Pharmaco-toxicological expert report. Pulmozyme(®) rhDNase, Genentech, Inc.

Human and Experimental Toxicology, ISSN: 01445952

Green

January 1, 1994

Agrin-like proteins of the neuromuscular junction

Neurochemistry International, ISSN: 01970186

László Patthy; Nikolics

January 1, 1994

Effect of Recombinant Human Insulin-like Growth Factor I and Early Total Parenteral Nutrition on Immune Depression Following Severe Head Injury

Archives of Surgery, ISSN: 15383644 00040010

Kenneth A. Kudsk; Christine Mowatt Larssen; Julie Bukar; Timothy Fabian; Sherryl Oellerich; Daniel L. Dent; Rex Brown

January 1, 1994

Immunological effects of insulin-like growth factor-I - Enhancement of immunoglobulin synthesis

Clinical and Experimental Immunology, ISSN: 00099104

Robbins; McCabe; Scheiner; Strasser; Ross Clark; Paula Jardieu

January 1, 1994

The Met Repressor‐Operator Complex: DNA Recognition by β‐Strands

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Somers; Rafferty; PHILLIPS; Strathdee; He; McNALLY; Manfield; Navratil; Old; Saint-Girons; Stockley; Phillips

January 1, 1994

Cytokine regulation of lactate dehydrogenase-elevating virus: inhibition of viral replication by interferon-γ

Antiviral Research, ISSN: 01663542

William A. Cafruny; Sarahann E. Bradley; James J. Broen; Grace H.W. Wong

January 1, 1994

Feasibility Study on Spray-Drying Protein Pharmaceuticals: Recombinant Human Growth Hormone and Tissue-Type Plasminogen Activator

Pharmaceutical Research, ISSN: 1573904X 07248741

Mumenthaler; Chung C. Hsu; Rodney Pearlman

January 1, 1994

Pharmacokinetics and pharmacodynamics of recombinant proteins and peptides

Journal of Controlled Release, ISSN: 01683659

Modi

January 1, 1994

ELISA for the neuropeptide degrading endopeptidase 3.4.24.11 in human serum and leukocytes

Peptides, ISSN: 01969781

Minzhong Zhang; Jochen Niehus; Thomas Schnellbacher; Silke Müller; Kristof Graf; Klaus D. Schultz; Claus R. Baumgarten; Catherine Lucas; Gert Kunkel

January 1, 1994

Major Degradation Products of Basic Fibroblast Growth Factor: Detection of Succinimide and Iso-aspartate in Place of Aspartate15

Pharmaceutical Research, ISSN: 1573904X 07248741

Shahrokh; Eberlein; Doug Buckley; Paranandi; Aswad; Stratton; Ron Mischak; Y. John Wang

January 1, 1994

Do antiidiotypic antibodies mimic antigen?

Research in Immunology, ISSN: 09232494

Amzel; Garcia; Desiderio

January 1, 1994

Validation of a Variable Direction Hysteresis Minimization Pharmacodynamic Approach: Cardiovascular Effects of Alfentanil

Pharmaceutical Research, ISSN: 1573904X 07248741

Modi; Veng-Pedersen

January 1, 1994

TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons

Neuron, ISSN: 08966273

Kris Poulsen; Armanini; Robert D. Klein; Mary Hynes; Phillips; Rosenthal

January 1, 1994

Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures

Journal of Neuroscience Research, ISSN: 10974547 03604012

Mary Hynes; Kris Poulsen; Armanini; Lucy R. Berkemeier; Phillips; Rosenthal

January 1, 1994

Protection against rat endotoxic shock by p55 tumor necrosis factor (tnf) receptor immunoadhesin: Comparison with anti-tnf monoclonal antibody

Journal of Infectious Diseases, ISSN: 15376613 00221899

Hongkui Jin; Renhui Yang; Scot A. Marsters; Bunting; Florian M. Wurm; Steven M. Chamow; Avi Ashkenazi

January 1, 1994

Inhibition of TNF by a TNF receptor immunoadhesin: Comparison to an anti- TNF monoclonal antibody

Journal of Immunology, ISSN: 00221767

Haak-Frendscho; Scot A. Marsters; Joyce Mordenti; Brady; Nancy Gillett; Chen; Avi Ashkenazi

January 1, 1994

Identification and characterization of batk, a predominantly brain‐specific non‐receptor protein tyrosine kinase related to Csk

Journal of Neuroscience Research, ISSN: 10974547 03604012

Sophia S. Kuo; Paul Moran; Gripp; Armanini; Phillips; Goddard; Caras

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