Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 13651 - 13700 OF 15397 RESULTS

December 1, 1993

The development of stable protein formulations: A close look at protein aggregation, deamidation, and oxidation

Critical Reviews in Therapeutic Drug Carrier Systems, ISSN: 07434863

Cleland; Powell; Steven J. Shire

December 1, 1993

Successful immunization of rhesus monkeys with the extracellular domain of p185(HER2): A potential approach human breast cancer

Vaccine Research, ISSN: 10567909

Brian M. Fendly; Claire Kotts; Wai Lee T. Wong; Figari; Harel; Staib; Monique E. Carver; David Vetterlein; Mitchell; Shepard

December 1, 1993

An essential role for interferon γ in resistance to mycobacterium tuberculosis infection

Journal of Experimental Medicine, ISSN: 15409538 00221007

JoAnne L. Flynn; John Chan; Karla J. Triebold; Dyana K. Dalton; Stewart; Bloom

December 1, 1993

Neurotrophic factor therapy of Alzheimer's disease

Clinical Neuroscience, ISSN: 10656766

Klaus D. Beck; Franz Hefti

December 1, 1993

Cytokine reversal of morphine-induced suppression of the antibody response

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565

Bussiere; Adler; Rogers; Eisenstein

December 1, 1993

Disseminated tuberculosis in interferon γ Gene-disrupted mice

Journal of Experimental Medicine, ISSN: 15409538 00221007

Andrea M. Cooper; Dyana K. Dalton; Stewart; John P. Griffin; David G. Russell; Ian M. Orme

November 1, 1993

Response to influenza infection in mice with a targeted disruption in the interferon γ gene

Journal of Experimental Medicine, ISSN: 15409538 00221007

Mary Beth Graham; Dyana K. Dalton; Giltinan; Vivian L. Braciale; Stewart; Thomas J. Braciale

November 1, 1993

Identification of Carbohydrate Structures in Glycoprotein Peptide Maps by the Use of LC/MS with Selected Ion Extraction with Special Reference to Tissue Plasminogen Activator and a Glycosylation Variant Produced by Site Directed Mutagenesis

Analytical Chemistry, ISSN: 15206882 00032700

Andrew W. Guzzetta; Basa; William S. Hancock; Keyt; William F. Bennett

October 15, 1993

Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line

Journal of Biological Chemistry, ISSN: 00219258

Kurt A. Morgenstern; William J. Henzel; Baker; Susan C. Wong; Andrzej Pastuszyn; Walter Kisiel

October 1, 1993

Isolation and properties of a soluble sialidase from the culture fluid of chinese hamster ovary cells

Glycobiology, ISSN: 09596658

Warner; Joseph Chang; Ferrari; Reed J. Harris; McNerney; Bennett; Burnier; Mary B. Sliwkowski

September 27, 1993

Monoclonal antibody based ELISAs for measurement of activins in biological fluids

Journal of Immunological Methods, ISSN: 00221759

Wai Lee T. Wong; Shaily Garg; Woodruff; Bald; Brian M. Fendly; James A. Lofgren

September 24, 1993

Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters

Journal of Biological Chemistry, ISSN: 00219258

Shen; Roger A. Barthelson; William Skach; Dieter C. Gruenert; Elliott Sigal; Mrsny; Widdicombe

September 20, 1993

1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy

FEBS Letters, ISSN: 00145793

Wayne J. Fairbrother; Dorothea Reilly; Timothy J. Colby; Richard Horuk

September 17, 1993

Clinical and preclinical studies presented at the keystone symposium on arthritis, related diseases, and cytokines

Lymphokine and Cytokine Research, ISSN: 02776766

Peter Ralph

September 10, 1993

A novel domain within the 55 kd TNF receptor signals cell death

Cell, ISSN: 00928674

Louis A. Tartaglia; T. Merrill Ayres; Grace H.W. Wong; David V. Goeddel

September 1, 1993

Effect of intravenous infusion of growth hormone-releasing hormone on the morphology of rat pituitary somatotrophs

Endocrine Pathology, ISSN: 10463976 15590097

Lucia Stefaneanu; Kalman Kovacs; Eva Horvath; G.Clark Ross; J.Cronin Michael

August 25, 1993

Interferon-γ induces receptor dimerization in solution and on cells

Journal of Biological Chemistry, ISSN: 00219258

Andrew C. Greenlund; Schreiber; David V. Goeddel; Diane Pennica

July 24, 1993

Efficacy and safety of short-term administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosis

The Lancet, ISSN: 01406736

Ranasinha; Assoufi; Geddes; Hodson; Empey; Steven Shak; David H. Christiansen; Henry J. Fuchs

July 15, 1993

Transforming Growth Factor-β Primes Macrophages to Express Inflammatory Gene Products in Response to Particulate Stimuli by an Autocrine/Paracrine Mechanism

Journal of Immunology, ISSN: 00221767

Paul W. Noble; Peter M. Henson; Catherine Lucas; Mora-Worms; Phillipe C. Carré; David W. H. Riches

July 10, 1993

Induction of HIV-1-neutralising and syncytium-inhibiting antibodies in uninfected recipients of HIV-1IIIB rgp120 subunit vaccine

The Lancet, ISSN: 01406736

David Schwartz; Mary Lou Clements; Geoffrey Gorse; Robert Belshe; Allen Izu; A-M. Duliege; Berman; Tom Twaddell; Donald M. Stablein; Richard Sposto; Robert F. Siliciano; Matthews

July 1, 1993

Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies

Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851

Gail D. Lewis; Figari; Brian M. Fendly; Wai Lee Wong; Paul J. Carter; Cornelia M. Gorman; Shepard

July 1, 1993

Simplification of High-Energy Collision Spectra of Peptides by Amino-Terminal Derivatization

Analytical Chemistry, ISSN: 15206882 00032700

Stults; Johnny Lai; Shannon McCune; Wetzel

July 1, 1993

Making tissue-type plasminogen activator more fibrin specific

Protein Engineering, Design and Selection, ISSN: 17410126

Nicholas F. Paoni; Alice M. Chow; Luis Peña; Keyt; Zoller; William F. Bennett

July 1, 1993

Tryptic Mapping of Recombinant Proteins by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Todd M. Billeci; Stults

July 1, 1993

Human IgE receptor α-chain IgG chimera blocks passive cutaneous anaphylaxis reaction in vivo

Journal of Immunology, ISSN: 00221767

Haak-Frendscho; John B.B. Ridgway; Robert L. Shields; Robbins; Cornelia M. Gorman; Paula Jardieu

June 20, 1993

Crystals of human growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization

Journal of Molecular Biology, ISSN: 00222836

Ultsch; De Vos

June 15, 1993

Selection of an anti-IGF-1 Fab from a Fab phage library created by mutagenesis of multiple CDR loops

Gene, ISSN: 03781119

Lisa J. Garrard; Henner

June 8, 1993

Glycosylphosphatidylinositol anchored proteins are preferentially targeted to the basolateral surface in Fischer rat thyroid epithelial cells

Journal of Cell Biology, ISSN: 00219525

Chiara Zurzolo; Michael P. Lisanti; Caras; Lucio Nitsch; Rodriguez-Boulan

June 1, 1993

Prevention of metastasis by inhibition of the urokinase receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Crowley; Robert L. Cohen; Brian K. Lucas; Liu; Shuman; Levinson

June 1, 1993

Combinatorial mediators of inflammation?

Current Biology, ISSN: 09609822

Lasky

June 1, 1993

Loss in expression of the retinoblastoma gene product in human gliomas is associated with advanced disease

Journal of Neuro-Oncology, ISSN: 0167594X 15737373

Wolfgang Hamel; Manfred Westphal; Shepard

June 1, 1993

O-linked fucose and other post-translational modifications unique to EGF modules

Glycobiology, ISSN: 09596658

Reed J. Harris; Spellman

June 1, 1993

Human macrophage inflammatory protein cr (MIP-1α) and MIP-1β chemoklnes attract distinct populations of lymphocytes

Journal of Experimental Medicine, ISSN: 15409538 00221007

Thomas J. Schall; Bacon; Camp; Kaspari; David V. Goeddel

May 20, 1993

Theoretical considerations for the design and development of a drug: Influence of pharmacokinetics and dosage regimen on receptor interactions

Pharmaceutical Research, ISSN: 07248741

Joyce Mordenti; Rescigno

April 23, 1993

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

Cell, ISSN: 00928674

Louis A. Tartaglia; Mike Rothe; Yan-Fen Hu; David V. Goeddel

April 16, 1993

Solid phase synthesis of peptide para -nitroanilides

Tetrahedron Letters, ISSN: 00404039

Burdick; Martin Struble; Burnier

April 1, 1993

Physical Properties of Recombinant Apolipoprotein(a) and Its Association with LDL to Form an Lp(a)-like Complex

Biochemistry, ISSN: 15204995 00062960

Martin L. Phillips; Audra V. Lembertas; Verne N. Schumaker; Lawn; Steven J. Shire; Zioncheck

March 26, 1993

Protein sorting by high-performance liquid chromatography. I. Biomimetic interaction chromatography of recombinant human deoxyribonuclease I on polyionic stationary phases

Journal of Chromatography A, ISSN: 00219673

Cacia; Quan; Vasser; Mary B. Sliwkowski; John Frenz

March 15, 1993

Proper glycosylation and phosphorylation of the type A natriuretic peptide receptor are required for hormone-stimulated guanylyl cyclase activity

Journal of Biological Chemistry, ISSN: 00219258

Koller; Michael T. Lipari; David V. Goeddel

March 1, 1993

A new yeast gene with a myosin-like heptad repeat structure

Molecular and General Genetics, ISSN: 00268925 16174623

Ralf Kölling; Nguyen; Ellson Y. Chen; David Botstein

March 1, 1993

Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy

Journal of the American College of Cardiology, ISSN: 07351097

Thomas C. Wall; Robert M. Califf; Stephen G. Ellis; Kristina Sigmon; Dean J. Kereiakes; Barry S. George; Joseph Samaha; David Sane; David Stump; Richard S. Stack; Eric Topol

March 1, 1993

Biochemical Characterization of the Extracellular Domain of the 75-Kilodalton Tumor Necrosis Factor Receptor

Biochemistry, ISSN: 15204995 00062960

Diane Pennica; Van Lam; Weber; William J. Kohr; Basa; Spellman; Avi Ashkenazi; Steven J. Shire; David V. Goeddel

February 28, 1993

An Alu sequence interupts a human 5-hydroxytryptamine1D receptor pseudogene

Gene, ISSN: 03781119

Tuan Nguyen; Adriano Marchese; James L. Kennedy; Arturas Petronis; Peroutka; Peter H. Wu; Brian F. O'Dowd

February 20, 1993

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

Journal of Molecular Biology, ISSN: 00222836

Eigenbrot; Michael Randal; Presta; Paul J. Carter; Anthony A. Kossiakoff

February 12, 1993

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

Cell, ISSN: 00928674

Kuldeep Neote; DiGregorio; John Mak; Richard Horuk; Thomas J. Schall

January 13, 1993

Extracellular matrix regulates expression of the TGF-β1 gene

Journal of Cell Biology, ISSN: 00219525

Charles H. Streuli; Christian Schmidhauser; Michael S. Kobrin; Mina J. Bissell; Rik Derynck

January 1, 1993

Appearance of additional ouabain binding sites on platelet surfaces following activation

Experimental Cell Research, ISSN: 00144827

Tracie Bork; Mrsny

January 1, 1993

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells: Interacting effects involving suppression, synergistic suppression, and blocking of suppression

Journal of Immunology, ISSN: 00221767

Hal E. Broxmeyer; Barbara Sherry; Scott Cooper; Li Lu; Rodney Maze; M. Patricia Beckmann; Cerami; Peter Ralph

January 1, 1993

Stability characterization and formulation development of alteplase, a recombinant tissue plasminogen activator.

Chinese Journal of Pharmaceutical Biotechnology, ISSN: 10780467

Tue H. Nguyen; Carole A. Ward

January 1, 1993

Binding of L-selectin to the vascular sialomucin CD34

Science, ISSN: 00368075

Baumhueter; Mark S. Singer; William J. Henzel; Stefan Hemmerich; Renz; Steven D. Rosen; Lasky

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