Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 14451 - 14500 OF 15397 RESULTS

January 1, 1990

Hydroxyl hydrogen conformations in trypsin determined by the neutron diffraction solvent difference map method: Relative importance of steric and electrostatic factors in defining hydrogen-bonding geometries

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Anthony A. Kossiakoff; Shpungin; Sintchak

January 1, 1990

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor α: Relevance to genetic predisposition to systemic lupus erythematosus

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Chaim O. Jacob; Zdenka Fronek; Gail D. Lewis; May Koo; John A. Hansen; Hugh O. McDevitt

January 1, 1990

Functionally distinct insulin receptors generated by tissue-specific alternative splicing

EMBO Journal, ISSN: 02614189

Luitgard Mosthaf; Grako; Dull; Lisa Coussens; Axel Ullrich; Donald A. McClain

January 1, 1990

Chapter 31. The Impact of Biotechnology on Drug Discovery

Annual Reports in Medicinal Chemistry, ISSN: 00657743

Michael C. Venuti

January 1, 1990

Expression of cloned proteins in mammalian cells: regulation of cell-associated parameters.

Bioprocess technology, ISSN: 08887470

Mather; Tsao

January 1, 1990

A precise and rapid microtitre plate clot lysis assay: Methodology, kinetic modeling and measurement of catalytic constants for plasminogen activation during fibrinolysis

Thrombosis and Haemostasis, ISSN: 03406245

Andrew J.S. Jones; Meunier

January 1, 1990

Hormone phage: An enrichment method for variant proteins with altered binding properties

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Bass; Ronald Greene; James A. Wells

January 1, 1990

Serotonin Receptor “Families” in the Central Nervous System: An Overview

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Peroutka; ANNE W. SCHMIDT; Andrew J. Sleight; MELISSA A. HARRINGTON

January 1, 1990

Folding of eukaryotic proteins produced in Escherichia coli.

Genetic engineering, ISSN: 01963716

Robert F. Kelley; Winkler

January 1, 1990

Acidic fibroblast growth factor (HBGF‐1) stimulates DNA synthesis in primary rat hepatocyte cultures

Journal of Cellular Physiology, ISSN: 10974652 00219541

Houck; Reza Zarnegar; Stephanie J. Muga; George K. Michalopoulos

January 1, 1990

5’ -Phosphorylation of oligonucleotides with phosphorous acid in automated dna synthesis

Nucleosides and Nucleotides, ISSN: 07328311

James C. Marsters Jr.; Ng; Jhurani; Vasser; Norbert Bischofberger

January 1, 1990

Regional Distribution of α‐[3H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Binding Sites in Rat Brain: Effect of Chemical Modification of SH– Groups in Tissue Sections

Journal of Neurochemistry, ISSN: 14714159 00223042

Michel Baudry; Daniel Monaghan; Carl Cotman; C.Anthony Altar

January 1, 1990

Quality control of rDNA-derived human tissue-type plasminogen activator.

Bioprocess technology, ISSN: 08887470

Andrew J.S. Jones; Robert L. Garnick

January 1, 1990

Preparation and Characterization of Conjugates of Recombinant CD4 and Deglycosylated Ricin A Chain Using Different Cross-Linkers

Bioconjugate Chemistry, ISSN: 15204812 10431802

Victor Ghetie; Mark A. Till; Maria-Ana Gnette; Thomas Tucker; James P. Porter; Patzer; James A. Richardson; Jonathan W. Uhr; Ellen S. Vitetta

January 1, 1990

Structural characterization by mass spectrometry of native and recombinant human relaxin

Biomedical and Environmental Mass Spectrometry, ISSN: 10969888 10529306

Stults; James H. Bourell; Eleanor Canova-Davis; Victor Ling; Laramee; Winslow; Patrick Griffin; Rinderknecht; Richard L. Vandlen

January 1, 1990

Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4-CD8- T lymphocytes from MRL lpr mice

Journal of Immunology, ISSN: 00221767

Ralph C. Budd; Genine Winslow; Sharon Inokuchi; John B. Imboden

January 1, 1990

The mtr locus is a two-gene operon required for transcription attenuation in the trp operon of Bacillus subtilis

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Paul Gollnick; Shuichi Ishino; Mitzi I. Kuroda; Henner; Yanofsky

January 1, 1990

Endothelial and leukocyte forms of IL-8: Conversion by thrombin and interactions with neutrophils

Journal of Immunology, ISSN: 00221767

Hébert; Francis W. Luscinskas; Jeanne-Marie Kiely; Luis; Darbonne; Bennett; Liu; Obin; Gimbrone Jr.; Baker

January 1, 1990

PDGF ligand and receptor gene expression during repair of arterial injury

Journal of Cell Biology, ISSN: 00219525

Mark W. Majesky; Michael A. Reidy; Daniel F. Bowen-Pope; Charles E. Hart; Josiah N. Wilcox; Schwartz

January 1, 1990

Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Tetsuya Gatanaga; Chenduen Hwang; William J. Kohr; Fabio Cappuccini; Joseph A. Lucci III; Edward W. B. Jeffes; Rigdon Lentz; John Tomich; Robert S. Yamamoto; Gale A. Granger

January 1, 1990

Transforming growth factor‐α

Molecular Reproduction and Development, ISSN: 10982795 1040452X

Rik Derynck

January 1, 1990

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2

Science, ISSN: 00368075

Ruth Lupu; Ramon Colomer; Gerhard Zugmaier; Jay Sarup; Michael H. Shepard; Dennis J. Slamon; Marc E. Lippman

January 1, 1990

Transforming Growth Factor‐β Effect on Soft Tissue Repair

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Arthur J. Ammann; L. Steven Beck; Leo Deguzman; Sue E. Hirabayashi; Wyne P. Lee; Lorrie L. Mcfatridge; Tue H. Nguyen; Yvette Xu; THOMAS A. MUSTOE

January 1, 1990

Structure and function of lipopolysaccharide binding protein

Science, ISSN: 00368075

Ralf R. Schumann; Leong; Gail W. Flaggs; Patrick W. Gray; Samuel D. Wright; John C. Mathison; Peter S. Tobias; Richard J. Ulevitch

January 1, 1990

The autocrine production of transforming growth factor-β1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA

Journal of Immunology, ISSN: 00221767

Catherine Lucas; Bald; Brian M. Fendly; Mora-Worms; Figari; Patzer; Michael A. Palladino

January 1, 1990

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

Nature, ISSN: 00280836

Sarvetnick; Shizuru; Liggitt; Martin; Burly Mclntyre; Anita Gregory; Tristram Parslow; Stewart

January 1, 1990

Induced expression using yeast copper metallothionein promoter

Methods in Enzymology, ISSN: 15577988 00766879

Etcheverry

January 1, 1990

Inducible expression of regulatory genes in Bacillus subtilis

Methods in Enzymology, ISSN: 15577988 00766879

Henner

January 1, 1990

Systems for heterologous gene expression

Methods in Enzymology, ISSN: 15577988 00766879

David V. Goeddel

January 1, 1990

Use of heterologous and homologous signal sequences for secretion of heterologous proteins from yeast

Methods in Enzymology, ISSN: 15577988 00766879

Ronald A. Hitzeman; Christina Y. Chen; Dowbenko; Renz; Liu; Roger Pai; Simpson; William J. Kohr; Arjun Singh; Chisholm; Robert W. Hamilton; Chung N. Chang

January 1, 1990

Expression of heterologous genes in mammalian cells

Methods in Enzymology, ISSN: 00766879

Levison

January 1, 1990

Use of Escherichia coli trp promoter for direct expression of proteins

Methods in Enzymology, ISSN: 15577988 00766879

Yansura; Henner

January 1, 1990

Expression as trpE fusion

Methods in Enzymology, ISSN: 15577988 00766879

Yansura

January 1, 1990

Optimizing cell and culture environment for production of recombinant proteins

Methods in Enzymology, ISSN: 15577988 00766879

Mather

January 1, 1990

Expression of heterologous genes in Bacillus subtilis

Methods in Enzymology, ISSN: 15577988 00766879

Henner

January 1, 1990

Gene expression technology: Preface

Methods in Enzymology, ISSN: 00766879

David V. Goeddel

January 1, 1990

Molecular and Genetic Approach to Enhancing Protein Secretion

Methods in Enzymology, ISSN: 15577988 00766879

Chisholm; Christina Y. Chen; Simpson; Ronald A. Hitzeman

January 1, 1990

Macrophage deactivating factor and transforming growth factors-β1, -β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ

Journal of Immunology, ISSN: 00221767

Aihao Ding; Carl Nathan; Graycar; Rik Derynck; Dennis J. Stuehr; Srimal

January 1, 1990

Functional interaction among catalytic residues in subtilisin BPN′

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Paul J. Carter; James A. Wells

January 1, 1990

Crystal structure of subtilisin BPN′ variants containing disulfide bonds and cavities: Concerted structural rearrangements induced by mutagenesis

Proteins: Structure, Function and Bioinformatics, ISSN: 10970134 08873585

Katz; Anthony A. Kossiakoff

January 1, 1990

From virus to vaccine: Recombinant mammalian cell lines as substrates for the production of herpes simplex virus vaccines

Journal of Medical Virology, ISSN: 10969071 01466615

Lasky

January 1, 1990

Synergistic induction of polypeptides by tumor necrosis factor and interferon‐gamma in cells sensitive or resistant to tumor necrosis factor: Assessment by computer based analysis of two‐dimensional gels using the PDQUEST system

Electrophoresis, ISSN: 15222683 01730835

Beresini; Sugarman; Shepard; Lois B. Epstein

January 1, 1990

Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160

Nature, ISSN: 00280836

Berman; Timothy Gregory; Riddle; Nakamura; Mark Champe; James P. Porter; Florian M. Wurm; Robert D. Hershberg; E. Kathy Cobb; Eichberg

January 1, 1990

Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter

Nature Biotechnology, ISSN: 0733222X

Chaitan Khosla; Joseph E. Curtis; Pat Bydalek; James R. Swartz; James E. Baileya

January 1, 1990

Epidermal Growth Factor Receptor Cytoplasmic Domain Mutations Trigger Ligand-Independent Transformation

Molecular and Cellular Biology, ISSN: 02707306

Sharon Massoglia; Gray; Dull; Munemitsu; Hsing-Jien Kung; Schlessinger; Axel Ullrich

January 1, 1990

Recombinant murine interferon‐γ inhibits the fusion of mouse alveolar macrophages in vitro but stimulates the formation of osteoclastlike cells on implanted syngeneic bone particles in mice in vivo

Journal of Bone and Mineral Research, ISSN: 15234681 08840431

Agnès Vignery; Tracy Niven-Fairchild; Michael H. Shepard

January 1, 1990

Relaxin in the peri-implantation period

Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X

Dennis R. Stewart; Abbie Celniker; Clinton A. Taylor Jr.; Jeffrey R. Cragun; James W. Overstreet

January 1, 1990

Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor

Journal of Immunology, ISSN: 00221767

Virginia C. Broudy; Kaushansky; Sara G. Shoemaker; Aggarwal; John W. Adamson

January 1, 1990

Tissue plasminogen activator: The biochemistry and pharmacology of variants produced by mutagenesis

Annual Review of Pharmacology and Toxicology, ISSN: 00664251

Deborah L. Higgins; William F. Bennett

January 1, 1990

Engineering human prolactin to bind to the human growth hormone receptor

Science, ISSN: 00368075

Cunningham; Henner; James A. Wells

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