Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 1651 - 1700 OF 15390 RESULTS

Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties
ACS Medicinal Chemistry Letters,
Yong Wang; Wendy Lee; Yi-Chen Chen; Yuhui Zhou; Emile G. Plise; Madyson M. Migliozzi; James J. Crawford
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Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Journal of the American Chemical Society, ISSN: 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
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Utility of measurable residual disease for predicting treatment outcomes with BCR- and BCL2-Targeted therapies in patients with CLL
Leukemia and Lymphoma, ISSN: 10428194
William G. Wierda; Thomas J. Kipps; Othman Al-Sawaf; Brenda Chyla; Juliana M L Biondo; Yong Mun; Yanwen Jiang; John F. Seymour
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs
Organic Process Research and Development, ISSN: 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
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Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies
Veterinary Clinical Pathology, ISSN: 02756382
William Siska; A. Eric Schultze; Daniela Ennulat; Kathleen Biddle; Michael Logan; Adedeji; Tara Arndt; Adam Aulbach
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Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding (Nature Biotechnology, (2021), 39, 12, (1556-1562), 10.1038/s41587-021-00966-9)
Nature Biotechnology, ISSN: 15461696 10870156
Kerstin U. Ludwig; Ricarda M. Schmithausen; David Li; Max L. Jacobs; Ronja Hollstein; Katja Blumenstock; Jana Liebing; Mikołaj Słabicki; Amir Ben-Shmuel; Ofir Israeli; Shay Weiss; Thomas S. Ebert; Nir Paran; Wibke Rüdiger; Gero Wilbring; David Feldman; Bärbel Lippke; Nina Ishorst; Lara M. Hochfeld; Eva C. Beins; Ines H. Kaltheuner; Maximilian Schmitz; Aliona Wöhler; Manuel Döhla; Esther Sib; Marius Jentzsch; Eva-Maria C. Moench; Jacob D. Borrajo; Jonathan Strecker; Julia Reinhardt; Brian Cleary; Matthias Geyer; Michael Hölzel; Rhiannon Macrae; Markus M. Nöthen; Per Hoffmann; Martin Exner; Aviv Regev; Feng Zhang; Jonathan L. Schmid-Burgk
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Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species
mAbs, ISSN: 19420870
Zephania Kwong Glover; Aaron T. Wecksler; Baikuntha Aryal; Shrenik Mehta; Melissa Pegues; Wayman Chan; Mari Lehtimaki; Allen Luo; Alavattam Sreedhara; V Ashutosh Rao
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C-Terminal Lysine Processing of IgG in Human Suction Blister Fluid: Implications for Subcutaneous Administration
Molecular Pharmaceutics, ISSN: 15438392 15438384
Luladey Ayalew; Phyllis Chan; Zhilan Hu; Amy Shen; Duenas; Whitney P. Kirschbrown; Arthur J. Schick; Yan Chen; Michael Kim
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IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models
PLoS ONE,
Jose Heredia; Clara Sorenson; Sean Flanagan; Victor Nunez; Charles Jones III; Angela Martzall; Laurie Leong; Andres Paler Martinez; Alexis Scherl; Hans D. Brightbill; Nico Ghilardi; Ning Ding
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Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers
Organic Letters, ISSN: 15237060
Rick W. Dorn; Brendan J. Wall; Sarah B. Ference; Sean R. Norris; Joseph W. Lubach; Aaron J. Rossini; Brett VanVeller
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Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies
Toxicologic Pathology, ISSN: 01926233
William Siska; A. Eric Schultze; Daniela Ennulat; Kathleen Biddle; Michael Logan; Adedeji; Tara Arndt; Adam Aulbach
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Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
Nature Biotechnology, ISSN: 10870156
Sean Simmons; Gila Lithwick-Yanai; Xian Adiconis; Florian Oberstrass; Nika Iremadze; Kathryn R. Geiger-Schuller; Pratiksha I. Thakore; Chris J. Frangieh; Omer Barad; Gilad Almogy; Orit Rozenblatt-Rosen; Aviv Regev; Doron Lipson; Joshua Z. Levin
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Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults with Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials
JAMA Neurology, ISSN: 21686149
Ostrowitzki; Tobias Bittner; Kaycee M. Sink; Howard M. Mackey; Christina Rabe; Lawrence S. Honig; Emanuele Cassetta; Michael Woodward; Mercè Boada; Christopher H. Van Dyck; Timo Grimmer; Dennis J. Selkoe; Andres Schneider; Kathleen Blondeau; Nan Hu; Angelica Quartino; David Clayton; Michael J. Dolton; Yifan Dang; Beth Ostaszewski; Sandra M. Sanabria-Bohorquez; Michael Rabbia; Balazs Toth; Udo Eichenlaub; Jillian Smith; Lee Honigberg; Rachelle S. Doody
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Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
Nature Aging,
Borislav Dejanovic; Tiffany Wu; Ming-Chi Tsai; David Graykowski; Vineela D. Gandham; Christopher M. Rose; Corey Bakalarski; Hai Ngu; Yuanyuan Wang; Shristi Pandey; Mitchell G. Rezzonico; Brad A. Friedman; Rose Edmonds; Ann De Mazière; Raphael Rakosi-Schmidt; Tarjinder Singh; Judith Klumperman; Oded Foreman; Michael C. Chang; Luke Xie; Morgan Sheng; Jesse E. Hanson
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MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC
Thoracic Cancer, ISSN: 17597706
Logan C. Tyler; Anh T. Le; Nan Chen; Hala Nijmeh; Liming Bao; Wilson; David Chen; Brian Simmons; Kristen M. Turner; Dean Perusse; Shailaja Kasibhatla; Jason Christiansen; Arkadiusz Z. Dudek; Robert C Doebele
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Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial
Nature Medicine, ISSN: 10788956
Jamie E. Chaft; Filiz Oezkan; Mark G. Kris; Paul A. Bunn Jr.; Ignacio I. Wistuba; David J. Kwiatkowski; Dwight H. Owen; Yan Tang; Bruce E. Johnson; Jay M. Lee; Gerard Lozanski; Maciej Pietrzak; Michal Seweryn; Woo Yul Byun; Katja Schulze; Alan Nicholas; Ann Johnson; Jessica Grindheim; Stephanie Hilz; David S. Shames; Chris Rivard; Eric Toloza; Eric B. Haura; Ciaran J. McNamee; G. Alexander Patterson; Saiama N. Waqar; Valerie W. Rusch; David Carbone; Saiama N. Waqar; Elaine Shum; Misako Nagasaka; Marianna Koczywas; Edward B. Garon; David J. Finley; D. Ross Camidge; Jennifer W. Carlisle; Justin D. Blasberg
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Erratum to Gene Set Enrichment Analyses Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy. Am J Ophthalmol 2022;233:111-123 (American Journal of Ophthalmology (2022) 233 (111–123), (S0002939421003366), (10.1016/j.ajo.2021.06.014))
American Journal of Ophthalmology, ISSN: 00029394
Lucia Sobrin; Gayatri Susarla; Lynn K. Stanwyck; John M. Rouhana; Ashley Li; Samuela Pollack; Robert P. Igo; Richard A. Jensen; Xiaohui Li; Maggie C.Y. Ng; Albert V Smith; Jane Z. Kuo; Kent D. Taylor; Barry I. Freedman; Donald W. Bowden; Alan Penman; Ching J. Chen; Jamie E. Craig; Sharon G. Adler; Emily Y. Chew; Mary Frances Cotch; Brian L. Yaspan; Paul Mitchell; Jie Jin Wang; Barbara E.K. Klein; Tien Y. Wong; Jerome I. Rotter; Kathryn Burdon; Sudha K. Iyengar; Ayellet V. Segrè
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A phase 1b study of atezolizumab in combination with guadecitabine for the treatment of acute myeloid leukemia
Leukemia and Lymphoma, ISSN: 10428194
Thomas Prebet; Aaron D. Goldberg; Joseph G. Jurcic; Samer Khaled; Monique Dail; Yuning Feng; Cherie Green; Chunze Li; Connie Ma; Bruno C. Medeiros; Mark Yan; Michael R. Grunwald
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Precipitation Behavior of Highly Soluble Amphiphilic Drugs in Solution: Physical Instability of Drugs in Solution
Journal of Pharmaceutical Sciences, ISSN: 00223549
Chloe Hu; José G. Napolitano; Shengli Ma; Frank Hrovat; Mark Ragains; David Russell; Aadithya Kannan; Ian C. Shieh; Dennis H. Leung; Ajit S. Narang
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Omalizumab treatment reduces asthma exacerbations regardless of airway bronchodilator reversibility
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Samuel DeLeon; Franco Barsanti; Cécile T.J. Holweg; Bongin Yoo; Blaine Creasy; Michael E. Wechsler
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Pharmacokinetics of the Port Delivery System with Ranibizumab in the Ladder Phase 2 Trial for Neovascular Age-Related Macular Degeneration
Ophthalmology and Therapy, ISSN: 21938245
Charles C. Wykoff; Peter A. Campochiaro; Dante Joseph Pieramici; Arshad M. Khanani; Shamika Gune; Mauricio Maia; Kagedal; Han Ting Ding; Katie F. Maass
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Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma
Nature Medicine, ISSN: 10788956
Zhu; Abbas Alexander; Marina Ruiz de Galarreta; Yinghui Guan; Shan Lu; Koeppen; Wenjun Zhang; Chih-Hung Hsu; Aiwu Ruth He; Baek-Yeol Ryoo; Thomas Yau; Ahmed Kaseb; Adam M. Burgoyne; Farshid Dayyani; Spahn; Wendy Verret; Richard S. Finn; Han Chong Toh; Amaia Lujambio; Wang
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The Association between Persistence and Adherence to Disease-Modifying Therapies and Healthcare Resource Utilization and Costs in Patients with Multiple Sclerosis
Journal of Health Economics and Outcomes Research, ISSN: 23272236
Gabriel Pardo; Elmor D. Pineda; Carmen D. Ng; Daniel Sheinson; Nicole G. Bonine
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Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?
Clinical and Translational Science, ISSN: 17528062 17528054
Songmao Zheng; Prell; Jennifer Sheng; Yow-Ming C. Wang; Lora Hamuro
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Myths about diversity in clinical trials reduce return on investment for industry
Nature Medicine, ISSN: 1546170X 10788956
Mohammed Suhail Chaudhry; Spahn; Shilpen Patel; Charles S. Fuchs; Jennifer O. Lauchle; Nikheel S. Kolatkar; Nicole A. Richie; Quita Highsmith; Meghan McKenzie; Ruma Bhagat
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Extension of the Alternative Intravenous Dosing Regimens of Atezolizumab into Combination Settings through Modeling and Simulation
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Stephanie N. Liu; Mathilde Marchand; Xiaoyan Liu; Gladys Ingle; Maiya; Graupner; Markus C. Elze; Phyllis Chan; Joy C. Hsu; Alyse Lin; Shweta Vadhavkar; Benjamin Wu; Rene Bruno
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Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq (Nature Biotechnology, (2022), 40, 6, (896-905), 10.1038/s41587-021-01160-7)
Nature Biotechnology, ISSN: 15461696 10870156
Oana Ursu; James T. Neal; Emily Shea; Pratiksha I. Thakore; Livnat Jerby-Arnon; Lan Nguyen; Danielle Dionne; Celeste Diaz; Julia Bauman; Mariam Mounir Mosaad; Christian Fagre; April Lo; Maria McSharry; Andrew O. Giacomelli; Seav Huong Ly; Orit Rozenblatt-Rosen; William C. Hahn; Andrew J. Aguirre; Alice H. Berger; Aviv Regev; Jesse S. Boehm
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Applying interpretable machine learning workflow to evaluate exposure–response relationships for large-molecule oncology drugs
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Gengbo Liu; James Lu; Hong Seo Lim; Jin Yan Jin; Dan Lu
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Defining the Efficacy of Omalizumab in Nasal Polyposis: A POLYP 1 and POLYP 2 Subgroup Analysis
American Journal of Rhinology and Allergy, ISSN: 19458932 19458924
Cecelia Damask; Meng Chen; Cécile T.J. Holweg; Bongin Yoo; Lauren A. Millette; Christine Franzese
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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
Nature Cell Biology, ISSN: 14657392
Yun Zhang; Joana Liu Donaher; Sunny Das; Xin Li; Ferenc Reinhardt; Jordan A. Krall; Arthur W. Lambert; Prathapan Thiru; Heather R. Keys; Mehreen Khan; Matan Hofree; Molly M. Wilson; Ozlem Yedier-Bayram; Nathan A. Lack; Tamer T. Onder; Tugba Bagci-Onder; Michael Tyler; Itay Tirosh; Aviv Regev; Jacqueline A. Lees; Robert A. Weinberg
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Continuous Method Validation: Beyond One-Time Studies to Characterize Analytical Methods
Statistics in Biopharmaceutical Research,
Paul Faya; Steven Novick; John W. Seaman; John J. Peterson; Tony Pourmohamad; Dwaine Banton; Yanbing Zheng
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CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
Nature, ISSN: 00280836
Rebecca C. Larson; Michael C. Kann; Stefanie R. Bailey; Nicholas J. Haradhvala; Paula Montero Llopis; Amanda A. Bouffard; Irene Scarfó; Mark B. Leick; Korneel Grauwet; Trisha R. Berger; Kai Stewart; Praju Vikas Anekal; Max Jan; Julia Joung; Andrea Schmidts; Tamara Ouspenskaia; Travis Law; Aviv Regev; Gad Getz; Marcela V. Maus
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Blood-based tumor mutational burden as a biomarker for atezolizumab in non-small cell lung cancer: the phase 2 B-F1RST trial
Nature Medicine, ISSN: 10788956
Edward S. Kim; Velcheti; Tarek Mekhail; Cindy Yun; Sarah M. Shagan; Hu; Young Kwang Chae; Leal; Dowell; Michaela L. Tsai; Dakhil; Philip Stella; Yanling Jin; David S. Shames; Erica Schleifman; David Fabrizio; See Phan; Mark A. Socinski
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Journal of Medicinal Chemistry, ISSN: 00222623
Alexander M. Taylor; Christopher Bailey; Lisa D. Belmont; Robert Campbell; Nico Cantone; Alexandre Côté; Terry Crawford; Richard T Cummings; Kevin Dement; Martin Duplessis; Megan Flynn; Andrew C. Good; Hon-Ren Huang; Shivangi Joshi; Yves Leblanc; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Florence Poy; F. Anthony Romero; Peter Sandy; Yong Tang; Vickie Tsui; Laura E. Zawadzke; Robert J. Sims; James E. Audia; Steve Bellon; Steven Magnuson; Brian K Albrecht; Andrea G Cochran
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Population pharmacokinetic analysis of etrolizumab in patients with moderately-to-severely active ulcerative colitis
CPT: Pharmacometrics and Systems Pharmacology,
Anita Moein; Tong Lu; Siv Jönsson; Jakob Ribbing; Nastya Kassir; Wenhui Zhang; Gizette Sperinde; Rong Zhang; Meina Tang; Young S. Oh; Rene Bruno; Rui Zhu
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Synthesis of 3-Aryl-Substituted 4-Aminopyrazoles from Acetophenones
Synthesis (Germany), ISSN: 1437210X 00397881
Andreas Stumpf; Di Xu; Tyler A. Tuck; Haiming Zhang
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Effect of emicizumab prophylaxis on bone and joint health markers in people with haemophilia A without factor VIII inhibitors in the HAVEN 3 study
Haemophilia, ISSN: 13652516 13518216
Anna Kiialainen; Markus Niggli; Kempton; Giancarlo Castaman; Tiffany Chang; Paz-Priel; Adamkewicz; Gallia Levy
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Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Justin Feigelman; Siddharth Sukumaran; Manoj C. Rodrigo; Tracy Staton; Fang Cai; Rebecca N. Bauer; David F. Choy; Cynthia L. Stokes; Heleen Scheerens; Ramanujan
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Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial
Nature Medicine, ISSN: 10788956
Solange Peters; Rafal Dziadziuszko; Alessandro Morabito; Enriqueta Felip; Shirish M. Gadgeel; Parneet Cheema; Manuel Cobo; Zoran Andric; Carlos H. Barrios; Masafumi Yamaguchi; Eric Dansin; Pongwut Danchaivijitr; Melissa L. Johnson; Silvia Novello; Michael Mathisen; Sarah M. Shagan; Erica Schleifman; Jin Wang; Mark Yan; Mocci; David Voong; David Fabrizio; David S. Shames; Todd Riehl; David R. Gandara; Tony Mok
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Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study
Biotechnology Progress, ISSN: 87567938
Danming Tang; Jane Gunson; Eric Tran; Cynthia Lam; Amy Shen; Snedecor; Gavin Barnard; Shahram Misaghi
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Characterization of exposure–response relationships of ipatasertib in patients with metastatic castration-resistant prostate cancer in the IPATential150 study
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Naoki Kotani; Justin Wilkins; Janet R. Wade; Steve Dang; Dhruvitkumar S. Sutaria; Kenta Yoshida; Sameer Sundrani; Hao Ding; Josep Garcia; Heather Hinton; Rucha Sane; Pascal Chanu
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Comparison of the MOdified NARanjo Causality Scale (MONARCSi) for Individual Case Safety Reports vs. a Reference Standard
Drug Safety, ISSN: 01145916
Shaun Comfort; Bruce A. Donzanti; Darren Dorrell; Sunita Dhar; Chris Eden; Francis Donaldson
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Rapid multi-attribute characterization of intact bispecific antibodies by a microfluidic chip-based integrated icIEF-MS technology
Electrophoresis, ISSN: 01730835
Maggie A. Ostrowski; Scott Mack; Milady Ninonuevo; John Yan; Mariam ElNaggar; Erik Gentalen; David A. Michels
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A phase-II study of atezolizumab in combination with obinutuzumab or rituximab for relapsed or refractory mantle cell or marginal zone lymphoma or Waldenström’s macroglobulinemia
Leukemia and Lymphoma, ISSN: 10292403 10428194
Panayiotis Panayiotidis; Gayane Tumyan; Catherine Thieblemont; Vadim V. Ptushkin; Ana Marin-Niebla; Ramon García-Sanz; Le Gouill; Anastasios Stathis; Alessia Bottos; Habib Hamidi; Pablo Katz; Thomas Perretti; Jenna C. Willis; Christian Buske
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Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial
Nature Medicine, ISSN: 1546170X 10788956
Solange Peters; Rafal Dziadziuszko; Alessandro Morabito; Enriqueta Felip; Shirish M. Gadgeel; Parneet Cheema; Manuel Cobo; Zoran Andric; Carlos H. Barrios; Masafumi Yamaguchi; Eric Dansin; Pongwut Danchaivijitr; Melissa L. Johnson; Silvia Novello; Michael Mathisen; Sarah M. Shagan; Erica Schleifman; Jin Wang; Mark Yan; Mocci; David Voong; David Fabrizio; David S. Shames; Todd Riehl; David R. Gandara; Tony Mok
View on Scopus
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Jane Gunson; Eric Tran; Cynthia Lam; Amy Shen; Snedecor; Gavin Barnard; Shahram Misaghi
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Comparison of logP and logD correction models trained with public and proprietary data sets
Journal of Computer-Aided Molecular Design, ISSN: 0920654X
Ignacio Aliagas; Alberto Gobbi; Man-Ling Lee; Benjamin D. Sellers
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Allelic variation in HLA-DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro
Clinical and Translational Science, ISSN: 17528054
Christian Hammer; Jane Ruppel; Lynn Kamen; Julie Hunkapiller; Ira Mellman; Quarmby
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Antibody-Drug Conjugates for Immunology
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Peter Dragovich
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CLEC5a-directed bispecific antibody for effective cellular phagocytosis
mAbs, ISSN: 19420870 19420862
Vivekananda Kedage; Diego Ellerman; Mingjian Fei; Wei-Ching Liang; Gu Zhang; Eric Cheng; Juan Zhang; Yongmei Chen; Haochu Huang; Wyne P. Lee; Yan Wu; Minhong Yan
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