Scientists / Publications

Publications

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DISPLAYING 2701 - 2750 OF 15477 RESULTS

Fast, Robust, and Sensitive Identification of Residual Host Cell Proteins in Recombinant Monoclonal Antibodies Using Sodium Deoxycholate Assisted Digestion
Analytical Chemistry, ISSN: 15206882 00032700
Delia Li; Adam Farchone; Qing Zhu; Frank D. Macchi; Donald Walker; David A. Michels; Feng Yang
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Quantitative mapping of transcriptome and proteome dynamics during polarization of human ipsc-derived neurons
eLife, ISSN: 2050084X
Feline W Lindhout; Robbelien Kooistra; Sybren Portegies; Lotte J. Herstel; Riccardo Stucchi; Basten L. Snoek; Maarten Altelaar; Harold MacGillavry; Corette J. Wierenga; Casper C Hoogenraad
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Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Yoshiro Itatani; Takamasa Yamamoto; Cuiling Zhong; Alfredo A. Molinolo; Jane Ruppel; Priti Hegde; M. Mark Taketo; Napoleone Ferrara
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Unstable mechanisms of resistance to inhibitors of escherichia coli lipoprotein signal peptidase
mBio, ISSN: 21507511 21612129
Homer Pantua; Elizabeth Skippington; Marie-Gabrielle Braun; Cameron Noland; Jingyu Diao; Yutian Peng; Susan L. Gloor; Donghong Yan; Jing Kang; Anand K. Katakam; Janina Reeder; Georgette M. Castanedo; Keira Garland; László Kömüves; Meredith Sagolla; Cary D. Austin; Jeremy Murray; Yiming Xu; Zora Modrusan; Min Xu; Emily J. Hanan; Sharookh B. Kapadia
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Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study
Haematologica, ISSN: 15928721 03906078
Christopher R. Bolen; Magdalena Klanova; Marek Trneny; Laurie H. Sehn; Jie He; Jing Tong; Joseph N. Paulson; Eugene Kim; Umberto Vitolo; Alice Di Rocco; Guenter Fingerle-Rowson; Tina Nielsen; Lenz; Mikkel Z. Oestergaard
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Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Suzie J. Scales; Nidhi Gupta; Ann De Mazière; George Posthuma; Cecilia Chiu; Andrew A Pierce; Kathy Hötzel; Jianhua Tao; Oded Foreman; Georgios Koukos; Francesca Oltrabella; Judith Klumperman; Wei Yu Lin; Andrew S. Peterson
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Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Nidhi Gupta; Xinhua Wang; Xiaohui Wen; Paul Moran; Maciej Paluch; Hass; Amy Heidersbach; Benjamin Haley; Daniel Kirchhofer; Randall J. Brezski; Andrew S. Peterson; Suzie J. Scales
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A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation
AAPS Journal, ISSN: 15507416
Michael J. Dolton; Po-Chang Chiang; Fang Ma; Jin Yan Jin; Yuan Chen
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Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Stanley B. Cohen; Katie Tuckwell; Tamiko R. Katsumoto; Rui Zhao; Joshua Galanter; Chin H. Lee; Julie Rae; Balazs Toth; Nandhini Ramamoorthi; Jason A. Hackney; Alberto Berman; Nemanja Damjanov; Dmytro Fedkov; Slawomir Jeka; Leslie Chinn; Michael J. Townsend; Alyssa M. Morimoto; Mark C. Genovese
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Bioactivation of a,b-unsaturated carboxylic acids through acyl glucuronidation
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Teresa Mulder; Sudheer Bobba; Kevin Johnson; Jessica M. Grandner; Wei Wang; Chenghong Zhang; Jingwei Cai; Edna F. Choo; Cyrus Khojasteh; Donglu Zhang
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Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The STAIRWAY Phase 2 Randomized Clinical Trial
JAMA Ophthalmology, ISSN: 21686173 21686165
Arshad M. Khanani; Sunil Patel; Philip J. Ferrone; Aaron Osborne; Jayashree Sahni; Susanna M. Grzeschik; Karen Basu; Jason S. Ehrlich; Zdenka Haskova; Pravin U. Dugel
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Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Rong Shi; Tong Lu; Grace Ku; Hao Ding; Tomohisa Saito; Leonid Gibiansky; Priya Agarwal; Xiaobin Li; Jin Yan Jin; Sandhya Girish; Dale Miles; Chunze Li; Dan Lu
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Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Philippe Gevaert; Theodore A. Omachi; Jonathan Corren; Joaquim Mullol; Joseph Han; Stella E. Lee; Derrick G. Kaufman; Monica Ligueros-Saylan; Monet Howard; Rui Zhu; Ryan Owen; Kit Wong; Lutaf Islam; Claus Bachert
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Survival outcomes in an older US population with advanced melanoma and central nervous system metastases: SEER-Medicare analysis
Cancer Medicine, ISSN: 20457634
Natalia Sadetsky; Alexandra Hernandez; Chris J. Wallick; Edward McKenna; Andy Surinach; Dawn Colburn
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A cross-industry forum on benchmarking critical quality attribute identification and linkage to process characterization studies
Biologicals, ISSN: 10958320 10451056
Sarah Demmon; Swapnil Bhargava; Doreen Ciolek; Jennifer Halley; Nomalie Jaya; Marisa K. Joubert; Edward Koepf; Phillip Smith; Melody Trexler-Schmidt; Philip Tsai
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In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk
Archives of Toxicology, ISSN: 14320738 03405761
Leah M. Norona; Aaron Fullerton; Chris Lawson; Leslie Leung; Jochen Brumm; Tomomi Kiyota; Jonathan M. Maher; Cyrus Khojasteh; William R. Proctor
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Diabetologia, ISSN: 14320428 0012186X
Wendy K. Chung; Karel Erion; Jose C. Florez; Andrew T. Hattersley; Marie-France Hivert; Christine G. Lee; Mark I. McCarthy; John J. Nolan; Jill M. Norris; Ewan Pearson; Louis Philipson; Allison T. McElvaine; William T. Cefalu; Stephen S. Rich; Paul W. Franks
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Clinical Activity and Safety of Atezolizumab in a Phase 1 Study of Patients With Relapsed/Refractory Small-Cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Chiang; Lecia Van Dam Sequist; Gilbert; Paul Conkling; Thompson; Marcoux; Scott Gettinger; Marcin Kowanetz; Luciana L. Molinero; Carol E. O'Hear; Marcella Fassò; Lam; Michael S. Gordon
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Phase 1b study of anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) in patients with platinum-sensitive recurrent ovarian cancer
Gynecologic Oncology, ISSN: 10956859 00908258
Kevin L. Moore; Michael J. Birrer; James C. Marsters Jr.; Wang; Younjeong Choi; Stephanie Royer-Joo; Lemahieu; Katy Armstrong; Julie Cordova; Divya Samineni; Schuth; Vaze; Daniel Maslyar; Eric W. Humke; Hamilton; Joyce F. Liu
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The Hippo Pathway as a Driver of Select Human Cancers
Trends in Cancer, ISSN: 24058033
Aishwarya Kulkarni; Matthew T. Chang; Joseph H.A. Vissers; Anwesha Dey; Kieran F. Harvey
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Budget Impact of 12-Month Fixed Treatment Duration Venetoclax in Combination with Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia Patients in the United States
PharmacoEconomics, ISSN: 11792027 11707690
Sang Kyu Cho; Beenish S. Manzoor; Kavita Sail; Hélène Parisé; Arliene Ravelo; Sheila Shapouri; Tatyana Kapustyan; Simon Sharmokh; Suchin Virabhak; Matthew S. Davids; Scott Johnson
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Contribution of monocarboxylate transporter 6 to the pharmacokinetics and pharmacodynamics of bumetanide in mice
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Robert S. Jones; Donna Ruszaj; Mark D. Parker; Marilyn E. Morris
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Hallmarks of aging Drosophila intestinal stem cells
Mechanisms of Ageing and Development, ISSN: 18726216 00476374
Imilce A. Rodriguez-Fernandez; Helen Tauc; Heinrich Jasper
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An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Vincent Debruycker; Andrew Hutchin; Matthieu Masureel; Emel Ficici; Chloé Martens; Pierre Legrand; Richard A. Stein; Hassane S. Mchaourab; José D. Faraldo-Gómez; Han Remaut; Cedric Govaerts
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Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation
Cell Reports Medicine, ISSN: 26663791
Derek K. Smith; Lance Kates; Durinck; Nisha Patel; Eric Stawiski; Noelyn Kljavin; Oded Foreman; Bence Sipos; Mark J. Solloway; Bernard B. Allan; Andrew S. Peterson
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Structure of the essential inner membrane lipopolysaccharide–PbgA complex
Nature, ISSN: 14764687 00280836
Thomas Clairfeuille; Kerry R. Buchholz; Qingling Li; Erik Verschueren; Peter S. Liu; Dewakar Sangaraju; Summer Park; Cameron Noland; Kelly M. Storek; Nicholas N. Nickerson; Lynn Martin; Trisha Dela Vega; Anh Miu; Janina Reeder; Maria Ruiz-Gonzalez; Danielle L. Swem; Guanghui Han; Daniel P. DePonte; Mark S. Hunter; Cornelius Gati; Sheerin Shahidi-Latham; Min Xu; Nicholas J. Skelton; Benjamin D. Sellers; Elizabeth Skippington; Wendy N. Sandoval; Emily J. Hanan; Jian Payandeh; Steven T. Rutherford
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Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media
Journal of Biotechnology, ISSN: 18734863 01681656
Salina Louie; Jayanthi Lakkyreddy; Brian M. Castellano; Benjamin Haley; Anh Nguyen Dang; Cynthia Lam; Danming Tang; Steven E. Lang; Snedecor; Shahram Misaghi
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Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics
Bioconjugate Chemistry, ISSN: 15204812 10431802
Martine Darwish; Whitney Shatz; Brandon Leonard; Kelly M. Loyet; Kathy Barrett; Janice L. Wong; Hong Li; Ryan Abraham; May Lin; Yvonne Franke; Christine Tam; Kyle Mortara; Inna Zilberleyb; Craig D. Blanchette
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Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity
ACS Medicinal Chemistry Letters, ISSN: 19485875
James J. Crawford; Wendy Lee; Adam R. Johnson; Kelly Delatorre; Jacob Z. Chen; Eigenbrot; Julia Heidmann; Satoko Kakiuchi-Kiyota; Arna Katewa; James R. Kiefer; Lichuan Liu; Joseph W. Lubach; Misner; Hans E. Purkey; Karin Reif; Jennifer Vogt; Harvey Wong; Christine Yu; Wendy B. Young
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Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Elisia Villemure; Steven T. Staben
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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells
EMBO Molecular Medicine, ISSN: 17574684 17574676
Sascha Kahlfuss; Ulrike Kaufmann; Axel R Concepcion; Lucile Noyer; Dimitrius Raphael; Martin Vaeth; Jun Yang; Priya Pancholi; Mate Maus; James Muller; Lina Kozhaya; Alireza Khodadadi-Jamayran; Zhengxi Sun; Patrick Shaw; Derya Unutmaz; Peter B Stathopulos; Cori Feist; Scott B Cameron; Stuart E Turvey; Stefan Feske
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Impact of initial treatment and prognostic factors on postprogression survival in BRAF-mutated metastatic melanoma treated with dacarbazine or vemurafenib ± cobimetinib: A pooled analysis of four clinical trials
Journal of Translational Medicine, ISSN: 14795876
Paolo A. Ascierto; Antoni Ribas; James Larkin; McArthur; Karl Lewis; Axel Hauschild; Keith Flaherty; Edward McKenna; Qian Zhu; Yong Mun; Brigitte Dréno
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Method screening strategies of stereoisomers of compounds with multiple chiral centers and a single chiral center
Journal of Chromatography A, ISSN: 18733778 00219673
Jessica Lin; Charlotte Tsang; Raymond Lieu; Kelly Zhang
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Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
JCI insight, ISSN: 23793708
Kasia Owczarczyk; Matthew Cascino; Cecile Holweg; Tew; Ward Ortmann; Timothy W. Behrens; Thomas Schindler; Langford; William St.Clair; Peter A. Merkel; Spiera; Seo; Cees Kallenberg; Specks; Noha Lim; John H. Stone; Paul Brunetta; Marco Prunotto
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Immunoaffinity LC-MS/MS is more suitable than ELISA to quantify a PEGylated molecule in cynomolgus monkey serum
Bioanalysis, ISSN: 17576199 17576180
Yanqiu Liu; Luna Liu; Nancy Yu; Lu Dai; Cinzia Stella; Vincent Chang; Surinder Kaur; Keyang Xu; Eric Wakshull
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Point-of-care and utility in clinical trials: Making quicker decisions to transform patient care and drug development
Bioanalysis, ISSN: 17576199 17576180
Saloumeh Kadkhodayan Fischer
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Regions of conformational flexibility in the proprotein convertase PCSK9 and design of antagonists for LDL cholesterol lowering
Biochemical Society Transactions, ISSN: 14708752 03005127
Daniel Kirchhofer; Burdick; Nicholas J. Skelton; Yingnan Zhang; Ultsch
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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Filip Roudnicky; Jitao David Zhang; Bo Kyoung Kim; Nikhil J. Pandya; Yanjun Lan; Lisa Sach-Peltason; Heloise Ragelle; Pamela Strassburger; Sabine Gruener; Mirjana Lazendic; Sabine Uhles; Franco Revelant; Oliv Eidam; Gregor Sturm; Verena Kueppers; Klaus Christensen; Leonard D. Goldstein; Manuel Tzouros; Balazs Banfai; Zora Modrusan; Martin Graf; Christoph Patsch; Mark Burcin; Claas A. Meyer; Peter D. Westenskow; Chad A. Cowan
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Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis following First-Line Therapy in Patients with Metastatic Colorectal Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Xiaoju Max Ma; Bendell; Herbert Hurwitz; Christine Ju; John J. Lee; Alex Lovejoy; Christoph Mancao; Alan Nicholas; Richard Price; Nicolas Sommer; Nalin Tikoo; Lijing Yao; Stephanie J. Yaung; John F. Palma
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EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL
Retina, ISSN: 15392864 0275004X
Vlad Bantseev; Chris Schuetz; Helen Booler; Joshua Horvath; Kristof Hovaten; Signe Erickson; Ellison Bentley; T. Michael Nork; William R. Freeman; Jay M. Stewart; Giulio Barteselli
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Regulation of cell death and immunity by xiap
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Philipp J. Jost; Domagoj Vucic
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NADPH-independent inactivation of CYP2B6 and NADPH-dependent inactivation of CYP3A4/5 by PBD: Potential implication for assessing covalent modulators for time-dependent inhibition
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Mika Kosaka; Donglu Zhang; Simon Wong; Zhengyin Yan
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Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Byung-Gil Lee; Fabian Merkel; Matteo Allegretti; Markus Hassler; Christopher Cawood; Léa Lecomte; Francis J. O’Reilly; Ludwig R. Sinn; Pilar Gutierrez-Escribano; Marc Kschonsak; Sol Bravo; Takanori Nakane; Juri Rappsilber; Luis Aragon; Martin Beck; Jan Löwe; Christian H. Haering
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In Situ-Forming Glucose-Responsive Hydrogel from Hyaluronic Acid Modified with a Boronic Acid Derivative
Macromolecular Chemistry and Physics, ISSN: 15213935 10221352
Emily Holz; Karthikan Rajagopal
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RAS-targeted therapies: is the undruggable drugged?
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Amanda R. Moore; Scott C. Rosenberg; Frank McCormick; Shiva Malek
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Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] Caprylate in Rats
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Gauri Deshmukh; Jia Liu; Karthik Nagapudi; Jacob Z. Chen; Nicole R. Valle; Ruina Li; Emile G. Plise; Matthew Durk
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Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks
Journal of Digital Imaging, ISSN: 1618727X 08971889
Skander Jemaa; Jill Fredrickson; Richard A. D. Carano; Tina Nielsen; De Crespigny; Thomas Bengtsson
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Timing of Peak Vision Gains in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Rahul N. Khurana; Louis K. Chang; Bann-Mo Day; Avanti Ghanekar; Ivaylo Stoilov
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Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Jotte; Federico Cappuzzo; Ihor Vynnychenko; Daniil Stroyakovskiy; Rodriguez-Abreu; Maen Hussein; Ross A. Soo; Henry J Conter; Kozuki; Kuan-Chieh Huang; Graupner; Sun; Tien Hoang; Helen Jessop; Mark L. McCleland; Ballinger; Alan Sandler; Mark A. Socinski
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A Review on Mixing-Induced Protein Particle Formation: The Puzzle of Bottom-Mounted Mixers
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Benson Gikanga; Maa
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