Genentech: Publications

January 1, 2020

The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies

Medicinal Research Reviews, ISSN: 10981128 01986325

Iris Dotan; Matthieu Allez; Silvio Danese; Mary E. Keir; Swati Tole; Jacqueline McBride

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January 1, 2020

Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

mAbs, ISSN: 19420870 19420862

Chunze Li; Cindy Zhang; Zao Li; Divya Samineni; Dan Lu; Wang; Shang-Chiung Chen; Rong Zhang; Priya Agarwal; Bernard M. Fine; Sandhya Girish

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January 1, 2020

Harnessing MerTK agonism for targeted therapeutics

mAbs, ISSN: 19420870 19420862

Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Jovencio Borneo; Yan Wu; Minhong Yan

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January 1, 2020

Integrated Two-Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non-Hodgkin Lymphoma

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Dan Lu; Tong Lu; Leonid Gibiansky; Xiaobin Li; Chunze Li; Priya Agarwal; Colby S. Shemesh; Rong Shi; Randall Dere; Jamie Hirata; Dale Miles; Pascal Chanu; Sandhya Girish; Jin Yan Jin

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January 1, 2020

A Multicompany Assessment of Submicron Particle Levels by NTA and RMM in a Wide Range of Late-Phase Clinical and Commercial Biotechnology-Derived Protein Products

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Mario Hubert; Dennis T. Yang; Stanley C. Kwok; Anacelia Rios; Tapan K. Das; Ankit Patel; Klaus Wuchner; Valentyn Antochshuk; Friederike Junge; George M. Bou-Assaf; Shawn Cao; Miguel Saggu; Luis Montrond; Nataliya Afonina; Parag Kolhe; Vakhtang Loladze; Linda O. Narhi

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January 1, 2020

Changes in organic anion transporting polypeptide uptake in HEK293 overexpressing cells in the presence and absence of human plasma

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Christine M. Bowman; Eugene C. Chen; Liuxi Chen; Yi-Chen Chen; Xiaorong Liang; Matthew Wright; Yuan Chen; Jialin Mao

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January 1, 2020

Rate of Adverse Events and Associated Health Care Costs for the Management of Inflammatory Bowel Disease in Germany

Clinical Therapeutics, ISSN: 1879114X 01492918

Thomas Wilke; Antje Groth; Gráinne H. Long; Amanda R. Tatro; Diana Sun

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January 1, 2020

Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial

Arthritis and Rheumatology, ISSN: 23265205 23265191

Jon T. Giles; Naveed Sattar; Sherine Gabriel; Paul M Ridker; Steffen Gay; Charles Warne; David Musselman; Laura Brockwell; Emma Shittu; Micki Klearman; Thomas Fleming

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January 1, 2020

Atezolizumab for children and young adults with previously treated solid tumours, non-Hodgkin lymphoma, and Hodgkin lymphoma (iMATRIX): a multicentre phase 1–2 study

The Lancet Oncology, ISSN: 14745488 14702045

Birgit Geoerger; C Michel Zwaan; Lynley V. Marshall; Jean Michon; Franck Bourdeaut; Michela Casanova; Nadège Corradini; Gianluca Rossato; Mufiza Farid-Kapadia; Colby S. Shemesh; Katherine E. Hutchinson; Francis Donaldson; Minlei Liao; Hubert Caron; Tanya Trippett

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January 1, 2020

Extended 5-year follow-up results of a phase Ib study (BRIM7) of vemurafenib and cobimetinib in BRAF-mutant melanoma A C

Clinical Cancer Research, ISSN: 15573265 10780432

Antoni Ribas; Adil Daud; Anna Pavlick; Rene Gonzalez; Karl Lewis; Omid Hamid; Thomas F. Gajewski; Igor Puzanov; Matthew Wongchenko; Isabelle Rooney; Jessie Hsu; Yibing Yan; Erica Park; McArthur

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January 1, 2020

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

Nature Genetics, ISSN: 15461718 10614036

Kushal Suryamohan; Sajesh P. Krishnankutty; Joseph Guillory; Matthew Jevit; Markus S. Schröder; Meng Wu; Boney Kuriakose; Oommen K. Mathew; Rajadurai C. Perumal; Ivan Koludarov; Leonard D. Goldstein; Kate Senger; Mandumpala Davis Dixon; Dinesh Velayutham; Derek Vargas; Subhra Chaudhuri; Megha Muraleedharan; Ridhi Goel; Ying-Jiun J. Chen; Aakrosh Ratan; Peter S. Liu; Brendan Faherty; Guillermo de la Rosa; Hiroki Shibata; Miriam Baca; Meredith Sagolla; James Ziai; Gus A. Wright; Domagoj Vucic; Sangeetha Mohan; Aju Antony; Stinson; Donald S. Kirkpatrick; Rami N. Hannoush; Durinck; Zora Modrusan; Eric Stawiski; Kristen Wiley; Terje Raudsepp; R. Manjunatha Kini; Arun Zachariah; Somasekar Seshagiri

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January 1, 2020

Polatuzumab vedotin in relapsed or refractory diffuse large B-cell lymphoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Laurie H. Sehn; Alex F. Herrera; Christopher R. Flowers; Manali K. Kamdar; Andrew McMillan; Mark Hertzberg; Sarit E. Assouline; Kim; Won Seog Kim; Muhit Ozcan; Jamie Hirata; Elicia M. Penuel; Joseph N. Paulson; Ji Cheng; Grace Ku; Matthew Matasar

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January 1, 2020

A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells

Cancer Research, ISSN: 15387445 00085472

Kenneth J. Finn; Scott E. Martin; Jeffrey Settleman

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January 1, 2020

Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv600 mutation–positive melanoma receiving adjuvant vemurafenib

Annals of Oncology, ISSN: 15698041 09237534

Paolo A. Ascierto; Karl Lewis; Anna Maria Di Giacomo; Lev Demidov; Mario Mandala; Igor Bondarenko; Christopher Herbert; Andrzej Mackiewicz; Piotr Rutkowski; Alexander Guminski; Brian Simmons; Chenglin Ye; Gregory Hooper; Matthew Wongchenko; Grant R. Goodman; Yibing Yan; Dirk Schadendorf

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January 1, 2020

Predictive and pharmacodynamic biomarkers of response to the phosphatidylinositol 3-kinase inhibitor taselisib in breast cancer preclinical models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Heather M. Moore; Heidi Savage; Carol O'Brien; Wei Zhou; Ethan S. Sokol; Michael E. Goldberg; Ciara Metcalfe; Lori S. Friedman; Lackner; Wilson

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January 1, 2020

Macular atrophy in neovascular age-related macular degeneration: A pilot post Hoc analysis of patients with pigment epithelial detachments

Retina, ISSN: 15392864 0275004X

Carl B. Rebhun; Carlos Moreira-Neto; Shamika Gune; Lauren Hill; Jay S. Duker; Nadia K. Waheed

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January 1, 2020

Burden of illness in geographic atrophy: A study of vision-related quality of life and health care resource use

Clinical Ophthalmology, ISSN: 11775483 11775467

Praveen J. Patel; Focke Ziemssen; Eugene Ng; Anushini Muthutantri; David Silverman; Elizabeth Tschosik; Ronald A. Cantrell

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January 1, 2020

In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Jinze Li; Mayur S. Mitra; Gautham K. Rao

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January 1, 2020

Survey of Customers Requesting Medical Information: Preferences and Information Needs of Patients and Health Care Professionals to Support Treatment Decisions

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Stacey M. Fung; Cheryl Sud; Matt Suchodolski

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January 1, 2020

Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

mAbs, ISSN: 19420870 19420862

Aimee Fourie-O’Donohue; Phillip Chu; Josefa Dela Cruz Chuh; Robert Tchelepi; Siao Ping Tsai; John C. Tran; William S. Sawyer; Dian Su; Carl Ng; Keyang Xu; Shang-Fan Yu; Thomas H. Pillow; Jack D. Sadowsky; Peter Dragovich; Yichin Liu; Katherine R. Kozak

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January 1, 2020

Intestinal Stem Cell Aging: Origins and Interventions

Annual Review of Physiology, ISSN: 15451585 00664278

Heinrich Jasper

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January 1, 2020

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires

mAbs, ISSN: 19420870 19420862

Yi-Chun Hsiao; Ying-Jiun J. Chen; Leonard D. Goldstein; Jia Wu; Zhonghua Lin; Kellen Schneider; Subhra Chaudhuri; Aju Antony; Kanika Bajaj Pahuja; Zora Modrusan; Dhaya Seshasayee; Somasekar Seshagiri; Isidro Hötzel

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January 1, 2020

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals

eLife, ISSN: 2050084X

Agata Wesolowska-Andersen; Grace Zhuo Yu; Vibe Nylander; Fernando Abaitua; Matthias Thurner; Jason M. Torres; Anubha Mahajan; Anna L. Gloyn; Mark I. McCarthy

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January 1, 2020

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

eLife, ISSN: 2050084X

Mable Lam; Scot A. Marsters; Avi Ashkenazi; Peter Walter

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January 1, 2020

A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction

PLoS ONE, ISSN: 19326203

Beyza Bulutoglu; Camilo Rey-Bedón; Safak Mert; Lipeng Tian; Yoon-Young Jang; Martin L. Yarmush; Berk Usta

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January 1, 2020

Risk stratification biomarkers for Staphylococcus aureus bacteraemia

Clinical and Translational Immunology, ISSN: 20500068

Yi Cao; Alessander O. Guimaraes; Melicent Peck; Oleg Mayba; Felicia Ruffin; Kyu Hong; Montserrat Carrasco-Triguero; Vance G. Fowler; Stacey A. Maskarinec; Carrie M. Rosenberger

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January 1, 2020

MicrobiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Justin Williams; Hector Corrada Bravo; Jennifer A. Tom; Joseph N. Paulson

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January 1, 2020

Visual Function Decline Resulting from Geographic Atrophy: Results from the Chroma and Spectri Phase 3 Trials

Ophthalmology Retina, ISSN: 24686530

Jeffrey S. Heier; Dante Joseph Pieramici; Usha Chakravarthy; Sunil Patel; Sunil Gupta; Andrew Lotery; Eleonora M. Lad; David Silverman; Erin C. Henry; Majid Anderesi; Elizabeth Tschosik; Sarah Gray; Daniela Ferrara; Robyn H. Guymer

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January 1, 2020

MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity

Science immunology, ISSN: 24709468

Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Hélène Capietto; Lélia Delamarre; Kevin B. Walsh; Weilan Ye

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January 1, 2020

Impact of genetic and nongenetic factors on body mass index and waist-hip ratio change in HIV-infected individuals initiating antiretroviral therapy

Open Forum Infectious Diseases, ISSN: 23288957

Catalina Barceló; Monia Guidi; Christian W. Thorball; Christian Hammer; Aziz Chaouch; Sebastian Haubitz; Bernasconi; Thierry Buclin; Philip E. Tarr; Chantal Csajka; Anagnostopoulos; Battegay; Bernasconi; Böni; Braun; Bucher; Alexandra Calmy; Cavassini; Ciuffi; Dollenmaier; Egger; Elzi; Fehr; Jacques Fellay; Hansjakob Furrer; Fux; Günthard; Haerry; Barbara Hasse; Hirsch; Hoffmann; Hösli; Huber; Christian Kahlert; Kaiser; Keiser; Klimkait; Kouyos; Kovari; Ledergerber; Martinetti; Martinez de Tejada; Marzolini; Metzner; Müller; Nicca; Paioni; Pantaleo; Perreau; Rauch; Rudin; Alexandra U. Scherrer; Schmid; Speck; Stöckle; Tarr; Trkola; Vernazza; Wandeler; Weber; Yerly

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January 1, 2020

Chapter 15: Drug Product Formulation Development and Formulation Robustness Criteria for a mAb in a Pre-filled Syringe

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Gregory Downing; Karen Rutherford

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January 1, 2020

Chapter 4: Production Strategies and Challenges with IgG-Based Bispecific Ab Formats

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Chen Gu; Diego Ellerman

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January 1, 2020

Chapter 24: Considerations and Challenges When Filling High-Concentration Monoclonal Antibody Formulations into Prefilled Syringes

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Wendy Shieu; Maa

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January 1, 2020

Chapter 11: Particles in Biopharmaceuticals: Causes, Characterization, and Strategy

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Steven Messick; Miguel Saggu; Anacelia Ríos Quiroz

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January 1, 2020

Diabetic population-based model to estimate impact of ranibizumab on diabetic retinopathy severity in patients with diabetic macular edema

Clinical Ophthalmology, ISSN: 11775483 11775467

Rohit Varma; Neil M. Bressler; Quan V. Doan; Ivan J. Suñer; Mark Danese; Chantal M. Dolan; Abraham Lee; Jason S. Ehrlich; Yamina Rajput

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January 1, 2020

Predictors of early diabetic retinopathy regression with ranibizumab in the ride and rise clinical trials

Clinical Ophthalmology, ISSN: 11775483 11775467

Michael Singer; Mimi Liu; Patricio G. Schlottmann; Arshad M. Khanani; Miranda Hemphill; Lauren Hill; Lisa Tuomi; Zdenka Haskova

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January 1, 2020

Mechanistic modeling of soluble Aβ dynamics and target engagement in the brain by anti-Aβ mAbs in Alzheimer’s disease

Current Alzheimer Research, ISSN: 18755828 15672050

Gregory Z. Ferl; Reina N. Fuji; Jasvinder K. Atwal; Tony Sun; Ramanujan; Angelica Quartino

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January 1, 2020

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Human Brain Mapping, ISSN: 10970193 10659471

Christopher R. K. Ching; Derrek P. Hibar; Tiril P. Gurholt; Abraham Nunes; Sophia I. Thomopoulos; Christoph Abé; Ingrid Agartz; Rachel M. Brouwer; Dara M. Cannon; Sonja M C de Zwarte; Lisa T. Eyler; Pauline Favre; Tomas Hajek; Unn K. Haukvik; Josselin Houenou; Mikael Landén; Tristram A. Lett; Colm McDonald; Leila Nabulsi; Yash Patel; Melissa E. Pauling; Tomas Paus; Joaquim Radua; Marcio G. Soeiro-de-Souza; Giulia Tronchin; Neeltje E. M. Van Haren; Eduard Vieta; Henrik Walter; Ling-Li Zeng; Martin Alda; Jorge Almeida; Dag Alnæs; Silvia Alonso-Lana; Cara Altimus; Michael Bauer; Bernhard T. Baune; Carrie E. Bearden; Marcella Bellani; Francesco Benedetti; Michael Berk; Amy C. Bilderbeck; Hilary P. Blumberg; Erlend Bøen; Irene Bollettini; Caterina del Mar Bonnin; Paolo Brambilla; Erick J. Canales-Rodríguez; Xavier Caseras; Orwa Dandash; Udo Dannlowski; Giuseppe Delvecchio; Ana M. Díaz-Zuluaga; Danai Dima; Édouard Duchesnay; Torbjørn Elvsåshagen; Scott C. Fears; Sophia Frangou; Janice M. Fullerton; David C. Glahn; Jose M. Goikolea; Melissa J. Green; Dominik Grotegerd; Oliver Gruber; Bartholomeus C. M. Haarman; Chantal Henry; Fleur M. Howells; Victoria Ives-Deliperi; Andreas Jansen; Tilo T.J. Kircher; Christian Knöchel; Bernd Krämer; Beny Lafer; Carlos López-Jaramillo; Rodrigo Machado-Vieira; Bradley J. MacIntosh; Elisa M. T. Melloni; Philip B. Mitchell; Igor Nenadic; Fabiano Nery; Allison C. Nugent; Viola Oertel; Roel A. Ophoff; Miho Ota; Bronwyn J. Overs; Daniel L. Pham; Mary L. Phillips; Julian A. Pineda-Zapata; Sara Poletti; Mircea Polosan; Edith Pomarol-Clotet; Arnaud Pouchon; Yann Quidé; Maria M. Rive; Gloria Roberts; Henricus G. Ruhe; Raymond Salvador; Salvador Sarró; Theodore D. Satterthwaite; Aart H. Schene; Kang Sim; Jair C. Soares; Michael Stäblein; Dan J. Stein; Christian K. Tamnes; Georgios V. Thomaidis; Cristian Vargas Upegui; Dick J. Veltman; Michèle Wessa; Lars T. Westlye; Heather C. Whalley; Daniel H. Wolf; Mon-Ju Wu; Lakshmi N. Yatham; Carlos A. Zarate; Paul M. Thompson; Ole A. Andreassen

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January 1, 2020

Modeling colorectal cancer progression through orthotopic implantation of organoids

Methods in Molecular Biology, ISSN: 19406029 10643745

Felipe de Sousa e Melo; Jonathan M. Harnoss; Noelyn Kljavin; Ryan Scott; Catherine Sohn; Kevin G. Leong; Frederic J. De Sauvage

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January 1, 2020

Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019)

Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776

Huifen Chen; Jack A. Terrett

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January 1, 2020

Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Ariel Muliadi; Alamelu Banda; Chen Mao

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January 1, 2020

Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer's Disease Treated with Escalating Doses for up to 133 Weeks

Journal of Alzheimer's Disease, ISSN: 18758908 13872877

Heather Guthrie; Lawrence S. Honig; Helen Lin; Kaycee M. Sink; Kathleen Blondeau; Angelica Quartino; Michael J. Dolton; Montserrat Carrasco-Triguero; Qinshu Lian; Tobias Bittner; David Clayton; Jillian Smith; Ostrowitzki

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January 1, 2020

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity

mAbs, ISSN: 19420870 19420862

Yue Sun; Alberto Estevez; Tilman Schlothauer; Aaron T. Wecksler

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January 1, 2020

Using artificial intelligence for improving stroke diagnosis in emergency departments: a practical framework

Therapeutic Advances in Neurological Disorders, ISSN: 17562864 17562856

Vida Abedi; Ayesha Khan; Durgesh Chaudhary; Debdipto Misra; Venkatesh Avula; Dhruv Mathrawala; Chadd Kraus; Kyle A. Marshall; Nayan Chaudhary; Xiao Li; Clemens M. Schirmer; Fabien Scalzo; Jiang Li; Ramin Zand

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January 1, 2020

Targeted IgMs agonize ocular targets with extended vitreal exposure

mAbs, ISSN: 19420870 19420862

Chen; Maciej Paluch; Julie A. Zorn; Sharmila Rajan; Brandon Leonard; Alberto Estevez; John Brady; Chiu; Wilson Phung; Amin Famili; Minhong Yan; Claudio Ciferri; Marissa L. Matsumoto; Greg A. Lazar; Susan R. Crowell; Hass; Nick Agard

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January 1, 2020

microbiomeDASim: Simulating longitudinal differential abundance for microbiome data

F1000Research, ISSN: 1759796X 20461402

Jennifer A. Tom; Joseph N. Paulson; Justin Williams; Hector Corrada Bravo

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January 1, 2020

Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinoma

OncoImmunology, ISSN: 2162402X 21624011

Alexandra Drakaki; Preet K. Dhillon; Heather A. Wakelee; Chui; Jinjoo Shim; Matthew Kent; Viraj Degaonkar; Tien Hoang; Virginia McNally; Patricia Luhn; Ralf Gutzmer

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January 1, 2020

Development of deep learning models to predict best-corrected visual acuity from optical coherence tomography

Translational Vision Science and Technology, ISSN: 21642591

Michael G. Kawczynski; Thomas Bengtsson; Jian Dai; J. Jill Hopkins; Simon S. Gao; Jeffrey R. Willis

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January 1, 2020

Circulating tumor DNA and biomarker analyse from the lotus randomized trial of first-line ipatasertib and paclitaxel for metastatic triple-negative breast cancer

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Sung-Bae Kim; Saura; Oliveira; Doron Lipson; Mark Kennedy; Mandy Greene; Virginia Breese; Aruna Mani; Xu; Rebecca Dent

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January 1, 2020

Long-Term Stability of Anti-Vascular Endothelial Growth Factor (a-VEGF) Biologics Under Physiologically Relevant Conditions and Its Impact on the Development of Long-Acting Delivery Systems

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Debby P. Chang; Shalini Burra; Eric S. Day; Joyce Chan; Laetitia Comps-Agrar; Thierry Nivaggioli; Karthikan Rajagopal

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