Genentech: Publications

March 18, 2019

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

Cancer Cell, ISSN: 18783686 15356108

Jonathan Cooper; Filippo G Giancotti

March 15, 2019

Water molecules in protein–ligand interfaces. Evaluation of software tools and SAR comparison

Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X

Eva Nittinger; Paul Gibbons; Eigenbrot; Douglas R. Davies; Brigitte Maurer; Christine Yu; James R. Kiefer; Andreas Kuglstatter; Jeremy Murray; Daniel F. Ortwine; Yong Tang; Vickie Tsui

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March 15, 2019

Treatment Patterns and Outcomes in Patients with KRAS Wild-Type Metastatic Colorectal Cancer Treated in First Line with Bevacizumab- or Cetuximab-Containing Regimens

Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628

Arthur C. Houts; Sarika Ogale; Nicolas Sommer; Sacha Satram-Hoang; Mark S. Walker

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March 15, 2019

Progression-Free Survival in Patients Receiving Chemotherapy Alone (C) or Chemotherapy with Bevacizumab (CB) for First-Line Treatment of KRAS Mutant Metastatic Colorectal Cancer in Community Oncology Settings

Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628

Arthur C. Houts; Sarika Ogale; Yousuf Zafar; Joleen M. Hubbard; Sacha Satram-Hoang; Nicolas Sommer; Mark S. Walker

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March 14, 2019

Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)

Tetrahedron Letters, ISSN: 18733581 00404039

Jared Moore; Kevin Lau; Xiaofeng Xu; Yamin Zhang; Jason D. Burch

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March 4, 2019

Strategies to optimize drug half-life in lead candidate identification

Expert Opinion on Drug Discovery, ISSN: 1746045X 17460441

Broccatelli; Cornelis E. Hop; Matthew Wright

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March 1, 2019

Adverse Events in Giant Cell Arteritis and Rheumatoid Arthritis Patient Populations: Analyses of Tocilizumab Clinical Trials and Claims Data

Rheumatology and Therapy, ISSN: 21986584 21986576

Sara Gale; Huong Trinh; Katie Tuckwell; Neil Collinson; John H. Stone; Khaled Sarsour; Jinglan Pei; Jennie Best; Christine Birchwood; Shalini V. Mohan

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March 1, 2019

Living with Geographic Atrophy: An Ethnographic Study

Ophthalmology and Therapy, ISSN: 21936528 21938245

Sobha Sivaprasad; Elizabeth Tschosik; Robyn H. Guymer; Audrey Kapre; Ivan J. Suñer; Antonia M. Joussen; Paolo Lanzetta; Daniela Ferrara

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March 1, 2019

The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion

eLife, ISSN: 2050084X

Gareth W. Fearnley; Katherine A. Young; James R. Edgar; Robin Antrobus; Iain M. Hay; Wei-Ching Liang; Nadia Martinez-Martin; Wei Yu Lin; Janet E. Deane; Hayley J. Sharpe

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March 1, 2019

Deep learning predicts OCT measures of diabetic macular thickening from color fundus photographs

Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404

Filippo Arcadu; Fethallah Benmansour; Andreas Maunz; John Michon; Zdenka Haskova; Mcclintock; Anthony P. Adamis; Jeffrey R. Willis; Marco Prunotto

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March 1, 2019

Potential delays in diagnosis of idiopathic pulmonary fibrosis in Medicare beneficiaries

Annals of the American Thoracic Society, ISSN: 23256621

Joshua J. Mooney; Eunice Chang; Deepa Lalla; Elya Papoyan; Karina Raimundo; Sheila R. Reddy; John L. Stauffer; Tingjian Yan; Michael S. Broder

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March 1, 2019

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

Nature Immunology, ISSN: 15292916 15292908

Clémence Hollande; Jeremy Boussier; James Ziai; Tamaki Nozawa; Vincent Bondet; Wilson Phung; Binfeng Lu; Darragh Duffy; Valerie Paradis; Vincent Mallet; Gérard Eberl; Wendy N. Sandoval; Jill Schartner; Stanislas Pol; Barreira da Silva; Matthew L. Albert

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March 1, 2019

Physiology of the neonatal gastrointestinal system relevant to the disposition of orally administered medications

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

April Neal-Kluever; Jeffrey Fisher; Lawrence Grylack; Satoko Kakiuchi-Kiyota; Wendy Halpern

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March 1, 2019

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain

Journal of Molecular Biology, ISSN: 10898638 00222836

Ultsch; Wei Li; Eigenbrot; Paola Di Lello; Michael T. Lipari; Gerhardy; Andrew P. AhYoung; John Quinn; Yvonne Franke; Yongmei Chen; Monica Kong-Beltran; Andrew S. Peterson; Daniel Kirchhofer

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March 1, 2019

Engineered sigma factors increase full-length antibody expression in Escherichia coli

Metabolic Engineering, ISSN: 10967184 10967176

Rebekah McKenna; T. Noelle Lombana; Masaki Yamada; Kiran Mukhyala; Karthik Veeravalli

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March 1, 2019

Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express

Biotechnology Progress, ISSN: 15206033 87567938

Tomofumi Tadauchi; Cynthia Lam; Laura Liu; Yizhou Zhou; Danming Tang; Salina Louie; Snedecor; Shahram Misaghi

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March 1, 2019

Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis

Journal of Proteome Research, ISSN: 15353907 15353893

Veronica G. Anania; Kebing Yu; Francesco Pingitore; Qingling Li; Christopher M. Rose; Peter S. Liu; Wendy N. Sandoval; Ann E. Herman; Jennie R. Lill; W Rodney Mathews

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March 1, 2019

Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies

Clinical and Translational Science, ISSN: 17528062 17528054

Douglas Leipold; Saileta Prabhu

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March 1, 2019

Pharmaceutical industry perspective on combination toxicity studies: Results from an intra-industry survey conducted by IQ DruSafe Leadership Group

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Joanne Birkebak; Lorrene A. Buckley; Donna M. Dambach; Eunice Musvasva; Karen Price; Sherry Ralston; Aida Sacaan

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March 1, 2019

Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Alexander Amberg; Roxanne Andaya; Lennart T. Anger; Chris Barber; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Zoryanna Cammerer; Kevin P. Cross; Laura Custer; Krista Dobo; Helga Gerets; Véronique Gervais; Susanne Glowienke; Stephen Gomez; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Candice Johnson; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; Russell Naven; John Nicolette; Alexis Parenty; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Jennifer C. Sasaki; Lidiya Stavitskaya; Andrew Teasdale; Alejandra Trejo-Martin; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; David Woolley; Glenn J. Myatt

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March 1, 2019

Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yi-Chen Chen; Jane R. Kenny; Matthew Wright; Cornelis E. Hop; Zhengyin Yan

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March 1, 2019

Atezolizumab Plus nab-Paclitaxel in the Treatment of Metastatic Triple-Negative Breast Cancer with 2-Year Survival Follow-up: A Phase 1b Clinical Trial

JAMA Oncology, ISSN: 23742445 23742437

Sylvia Adams; Jennifer R. Diamond; Hamilton; Paula R. Pohlmann; Tolaney; Ching-Wei Chang; Wei Zhang; Koho Iizuka; Paul Foster; Luciana L. Molinero; Roel Funke; John D. Powderly

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March 1, 2019

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma

Pigment Cell and Melanoma Research, ISSN: 1755148X 17551471

Webster; Trang Pham; Xiumin Wu; Nicolas W. Hughes; Zhongwu Li; Klara Totpal; Ho-June Lee; Philamer C. Calses; Mira S. Chaurushiya; Eric Stawiski; Zora Modrusan; Matthew T. Chang; Christopher Tran; Wyne P. Lee; Sreedevi Chalasani; Jeffrey Hung; Neeraj Sharma; Sara M. Chan; Kathy Hötzel; Eric Talevich; Alan Shain; Mengshu Xu; Jennie R. Lill; Vishva M. Dixit; Boris C. Bastian; Anwesha Dey

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March 1, 2019

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

Nature Immunology, ISSN: 15292916 15292908

Clémence Hollande; Jeremy Boussier; James Ziai; Tamaki Nozawa; Vincent Bondet; Wilson Phung; Binfeng Lu; Darragh Duffy; Valerie Paradis; Vincent Mallet; Gérard Eberl; Wendy N. Sandoval; Jill Schartner; Stanislas Pol; Rosa Barreira da Silva; Matthew L. Albert

View on Scopus

March 1, 2019

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain

Journal of Molecular Biology, ISSN: 10898638 00222836

Ultsch; Wei Li; Eigenbrot; Paola Di Lello; Michael T. Lipari; Gerhardy; Andrew P. AhYoung; John Quinn; Yvonne Franke; Chen; Monica Kong-Beltran; Andrew S. Peterson; Daniel Kirchhofer

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February 28, 2019

Integration of cell of origin into the clinical CNS International Prognostic Index improves CNS relapse prediction in DLBCL

Blood, ISSN: 15280020 00064971

Magdalena Klanova; Laurie H. Sehn; Isabelle Bence-Bruckler; Federica Cavallo; Jie Jin; Maurizio Martelli; Douglas A. Stewart; Umberto Vitolo; Francesco Zaja; Qingyuan Zhang; Federico Mattiello; Gila Sellam; Elizabeth A. Punnoose; Edith Szafer-Glusman; Christopher R. Bolen; Mikkel Z. Oestergaard; Guenter Fingerle-Rowson; Tina Nielsen; Marek Trneny

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February 26, 2019

PD-L1 and tumor-associated macrophages in de novo DLBCL

Blood advances, ISSN: 24739537 24739529

Mccord; Christopher R. Bolen; Koeppen; Edward E. Kadel III; Mikkel Z. Oestergaard; Tina Nielsen; Laurie H. Sehn; Jeffrey M. Venstrom

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February 21, 2019

From Discovery to Bedside: Targeting the Ubiquitin System

Cell Chemical Biology, ISSN: 24519448 24519456

Ingrid E. Wertz; Xiaojing Wang

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February 17, 2019

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

mAbs, ISSN: 19420870 19420862

Ayse Meric Ovacik; Ji Li; Marie Lemper; Dimitry Danilenko; Nicola J. Stagg; Mary Mathieu; Diego Ellerman; Vinita Gupta; Navdeep Kalia; Trung Nguy; Vicki Plaks; Clarissa David Johnson; Weiru Wang; Jochen Brumm; Bernard M. Fine; Teemu T. Junttila; Kedan Lin; Paul J. Carter; Saileta Prabhu; Christoph Spiess; Amrita Kamath

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February 15, 2019

An anti–CLL-1 antibody–drug conjugate for the treatment of acute myeloid leukemia

Clinical Cancer Research, ISSN: 15573265 10780432

Bing Zheng; Shang-Fan Yu; Geoffrey del Rosario; Leong; Genee Y. Lee; Rajesh Vij; Cecilia Chiu; Wei-Ching Liang; Yan Wu; Cecile Chalouni; Jack D. Sadowsky; Vanessa Clark; Angela Hendricks; Kirsten Achilles Poon; Wayne Chu; Thomas H. Pillow; Melissa Schutten; Flygare; Andrew G. Polson

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February 15, 2019

Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma

Clinical Cancer Research, ISSN: 15573265 10780432

Inês Pires da Silva; Kevin Y.X. Wang; James S. Wilmott; Jeff Holst; Matteo S. Carlino; John J. Park; Camelia Quek; Matthew Wongchenko; Yibing Yan; Graham Mann; Douglas B. Johnson; Jennifer L. McQuade; Rajat R. Rai; Richard F. Kefford; Helen Rizos; Richard A. Scolyer; Yang; Georgina V. Long; Alexander M. Menzies

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February 15, 2019

The autoimmune susceptibility gene C5orf30 regulates macrophage-mediated resolution of inflammation

Journal of Immunology, ISSN: 15506606 00221767

Emma R. Dorris; Simon J. Tazzyman; John Moylett; Nandhini Ramamoorthi; Jason A. Hackney; Michael J. Townsend; Munitta Muthana; Myles J. Lewis; Costantino Pitzalis; Anthony G. Wilson

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February 15, 2019

Atoh1 + secretory progenitors possess renewal capacity independent of Lgr5 + cells during colonic regeneration

EMBO Journal, ISSN: 14602075 02614189

David Castillo-Azofeifa; Elena N Fazio; Roy Nattiv; Hayley J Good; Tomas Wald; Michael A Pest; Frederic J. De Sauvage; Ophir D Klein; Samuel Asfaha

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February 15, 2019

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Daniel G. Shore; Zachary K. Sweeney; Alan Beresford; Bryan K. Chan; Huifen Chen; Jason H. Drummond; Andrew Gill; Tracy L. Kleinheinz; Xingrong Liu; Andrew D. Medhurst; Edward G. McIver; John Moffat; Haitao Zhu; Anthony A. Estrada

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February 14, 2019

Trastuzumab emtansine for residual invasive HER2-positive breast cancer

New England Journal of Medicine, ISSN: 15334406 00284793

Gunter Von Minckwitz; Chiun-Sheng Huang; Max Mano; Sibylle Loibl; Eleftherios P. Mamounas; Untch; Norman Wolmark; Priya Rastogi; Andreas Schneeweiss; Andres Redondo; Hans H. Fischer; William Jacot; Alison K. Conlin; Claudia Arce-Salinas; Irene L. Wapnir; Christian Jackisch; Michael P. DiGiovanna; Peter A. Fasching; John Crown; Pia Wülfing; Zhimin Shao; Elena Rota Caremoli; Haiyan Wu; Lisa H. Lam; David Tesarowski; Melanie Smitt; Hannah Douthwaite; Stina M. Singel; Charles E. Geyer Jr.

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February 11, 2019

Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy

Cancer Cell, ISSN: 18783686 15356108

Tuba N. Gide; Camelia Quek; Alexander M. Menzies; Annie T. Tasker; Ping Shang; Jeff Holst; Jason Madore; Su Yin Lim; Rebecca Velickovic; Matthew Wongchenko; Yibing Yan; Serigne Lo; Matteo S. Carlino; Alexander Guminski; Robyn P.M. Saw; Angel Pang; Helen M. McGuire; Umaimainthan Palendira; John F. Thompson; Helen Rizos; Ines Pires da Silva; Marcel Batten; Richard A. Scolyer; Georgina V. Long; James S. Wilmott

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February 11, 2019

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Acta Neuropathologica, ISSN: 14320533 00016322

Claudia Cicognola; Gunnar Brinkmalm; Jessica Wahlgren; Erik Portelius; Johan Gobom; Nicholas C. Cullen; Oskar Hansson; Lucilla Parnetti; Radu Constantinescu; Kristin R. Wildsmith; Hsu-Hsin Chen; Thomas G. Beach; Tammaryn Lashley; Henrik Zetterberg; Kaj Blennow; Kina Höglund

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February 7, 2019

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Cell, ISSN: 10974172 00928674

Hui Xu; Tianbo Li; Alexis Rohou; Christopher P. Arthur; Foteini Tzakoniati; Evera Wong; Alberto Estevez; Christine Kugel; Yvonne Franke; Jun Chen; Claudio Ciferri; David Hackos; Christopher M. Koth; Jian Payandeh

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February 5, 2019

Multi-arm PEG-maleimide conjugation intermediate characterization and hydrolysis study by a selective HPLC method

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Jennifer Wang; Samuel H. Yang; Kelly Zhang

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February 5, 2019

Enabling genome-wide association testing with multiple diseases and no healthy controls

Gene, ISSN: 18790038 03781119

Jennifer A. Tom; Diana Chang; Arthur Wuster; Kiran Mukhyala; Karen T. Cuenco; Amy Cowgill; Jan Vogel; Jens Reeder; Brian L. Yaspan; Julie Hunkapiller; Matthew J. Brauer; Timothy W. Behrens; William F. Forrest; Tushar Bhangale

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February 5, 2019

Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin ® ), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Angelica Quartino; Hanbin Li; Whitney P. Kirschbrown; Ranvir Mangat; D. Russell Wada; Amit Garg; Jin Y. Jin; Bert L. Lum

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February 5, 2019

Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Xiaolin Zhang; Xiao Ding; Jianshuang Wang; Brian J. Dean

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February 1, 2019

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

Nature Metabolism, ISSN: 25225812

Pedro Sousa-Victor; Joana Neves; Wendy Cedron-Craft; P. Britten Ventura; Chen-Yu Liao; Rebeccah Riley; Ilya Soifer; Nicholas Van Bruggen; Ganesh Kolumam; Saul A. Villeda; Deepak A. Lamba; Heinrich Jasper

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February 1, 2019

Correction: Rheumatoid arthritis-interstitial lung disease in the United States: Prevalence, incidence, and healthcare costs and mortality (Journal of Rheumatology (2018))

Journal of Rheumatology, ISSN: 14992752 0315162X

Karina Raimundo; Joshua J. Solomon; Amy L. Olson; Amanda M. Kong; Ashley L. Cole; Aryeh Fischer; Jeffrey J. Swigris

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February 1, 2019

Comparative Effectiveness of Non-cisplatin First-line Therapies for Metastatic Urothelial Carcinoma: Phase 2 IMvigor210 Study Versus US Patients Treated in the Veterans Health Administration

European Urology Oncology, ISSN: 25889311

Nancy Vander Velde; Annie Guérin; Raluca Ionescu-Ittu; Sherry Shi; Eric Q. Wu; Shih Wen Lin; Ling-I Hsu; Kai-Uwe Saum; Sabine de Ducla; Jingjing Wang; Shi Li; AnnChristine Thåström; Shuqian Liu; Lizheng Shi; John T. Leppert

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February 1, 2019

Correlation of cytomegalovirus (CMV) disease severity and mortality with CMV viral burden in CMV-seropositive donor and CMV-seronegative solid organ transplant recipients

Open Forum Infectious Diseases, ISSN: 23288957

Jacqueline McBride; Daniel Sheinson; Jenny Jiang; Nicholas Lewin-Koh; Barbara G. Werner; Jennifer K.L. Chow; Xiaoning Wu; Jorge A. Tavel; David R. Snydman

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February 1, 2019

Evaluation of polysaccharide-based chiral stationary phases in modern SFC-MS/MS for enantioselective bioanalysis

Bioanalysis, ISSN: 17576199 17576180

Liuxi Chen; Brian J. Dean; Xiaorong Liang

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February 1, 2019

MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

eLife, ISSN: 2050084X

Brian A. Hodge; Xiping Zhang; Miguel A. Gutierrez-Monreal; Yi Cao; David W. Hammers; Zizhen Yao; Christopher A. Wolff; Ping Du; Denise Kemler; Andrew R. Judge; Karyn A. Esser

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February 1, 2019

Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma

Blood Cancer Journal, ISSN: 20445385

A. Keith Stewart; Amrita Y. Krishnan; Seema Singhal; Ralph V. Boccia; Manish R. Patel; Ruben Niesvizky; Chanan-Khan; Sikander Ailawadhi; Jochen Brumm; Kirsten E. Mundt; Kyu Hong; Jacqueline McBride; Quyen Shon-Nguyen; Yuanyuan Xiao; Vanitha Ramakrishnan; Andrew G. Polson; Divya Samineni; Douglas Leipold; Eric W. Humke; James Scott McClellan; Jesus G. Berdeja

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February 1, 2019

Targeting IL-10 family cytokines for the treatment of human diseases

Cold Spring Harbor Perspectives in Biology, ISSN: 19430264

Xiaoting Wang; Kit Wong; Wenjun Ouyang; Sascha Rutz

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