Genentech: Publications

February 1, 2019

Fixed duration of venetoclax-rituximab in relapsed/refractory chronic lymphocytic leukemia eradicates minimal residual disease and prolongs survival: Post-treatment follow-up of the Murano phase III study

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Kater; John F. Seymour; Hillmen; Barbara Eichhorst; Anton W. Langerak; Carolyn J. Owen; Maria Verdugo; Jenny Q. Wu; Elizabeth A. Punnoose; Yanwen Jiang; Jue Wang; Michelle Boyer; Kathryn Humphrey; Mehrdad Mobasher; Thomas J. Kipps

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February 1, 2019

TET2-dependent hydroxymethylome plasticity reduces melanoma initiation and progression

Cancer Research, ISSN: 15387445 00085472

Elise Bonvin; Enrico Radaelli; Martin Bizet; Flavie Luciani; Emilie Calonne; Pascale Putmans; David Nittner; Nitesh Kumar Singh; Sara F. Santagostino; Valerie Petit; Lionel Larue; Jean-Christophe Marine; François Fuks

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February 1, 2019

Randomized phase II study evaluating AKT blockade with ipatasertib, in combination with abiraterone, in patients with metastatic prostate cancer with and without PTEN loss

Clinical Cancer Research, ISSN: 15573265 10780432

De Bono; Ugo De Giorgi; Daniel Nava Rodrigues; Christophe Massard; Sergio Bracarda; Albert Font; Jose Angel Arranz Arija; Kent Shih; George Daniel Radavoi; Xu; Wai Y. Chan; Han Ma; Steven Gendreau; Ruth Riisnaes; Premal Patel; Daniel Maslyar; Viorel Jinga

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February 1, 2019

Real-world use of bevacizumab in metastatic colorectal, metastatic breast, advanced ovarian and cervical cancer:A systematic literature review

Future Oncology, ISSN: 17448301 14796694

Sherif Raouf; Gianfilippo Bertelli; Agnes Ograbek; Polly Field; Irwin Tran

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February 1, 2019

Second-line and subsequent therapy and outcomes for follicular lymphoma in the United States: data from the observational National LymphoCare Study

British Journal of Haematology, ISSN: 13652141 00071048

Brian K. Link; Bann-Mo Day; Zhou; Zelenetz; Keith Dawson; James R. Cerhan; Christopher R. Flowers; Jonathan W. Friedberg

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February 1, 2019

TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays

Journal of Proteome Research, ISSN: 15353907 15353893

Christopher M. Rose; Brian K. Erickson; Devin K. Schweppe; Rosa Viner; Jae Choi; John Rogers; Ryan Bomgarden; Steven P. Gygi; Donald S. Kirkpatrick

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February 1, 2019

Multiethnic genome-wide association study of diabetic retinopathy using liability threshold modeling of duration of diabetes and glycemic control

Diabetes, ISSN: 1939327X 00121797

Samuela Pollack; Robert P. Igo; Richard A. Jensen; Mark Christiansen; Xiaohui Li; Ching-Yu Cheng; Maggie C. Y. Ng; Albert V Smith; Elizabeth Rossin; Ayellet V. Segrè; Samaneh Davoudi; Gavin S. Tan; Yii-Der Ida Chen; Jane Z. Kuo; Latchezar M. Dimitrov; Lynn K. Stanwyck; Weihua Meng; S. Mohsen Hosseini; Minako Imamura; Darryl Nousome; Jihye Kim; Yang Hai; Yucheng Jia; Jeeyun Ahn; Aaron Leong; Kaanan Shah; Kyu Hyung Park; Xiuqing Guo; Eli Ipp; Kent D. Taylor; Sharon G. Adler; John R. Sedor; Barry I. Freedman; I-Te Lee; Wayne H.-H. Sheu; Michiaki Kubo; Atsushi Takahashi; Samy Hadjadj; Michel Marre; David-Alexandre Trégouët; Roberta Mckean-Cowdin; Rohit Varma; Mark I. McCarthy; Leif Groop; Emma Ahlqvist; Valeriya Lyssenko; Elisabet Agardh; Andrew Morris; Alex S F Doney; Helen M. Colhoun; Iiro Toppila; Niina Sandholm; Per-Henrik Groop; Shiro Maeda; Craig L. Hanis; Alan Penman; Ching J. Chen; Heather Hancock; Paul Mitchell; Jamie E. Craig; Emily Y. Chew; Andrew D. Paterson; Michael A. Grassi; Colin Palmer; Donald W. Bowden; Brian L. Yaspan; David Siscovick; Mary Frances Cotch; Jie Jin Wang; Kathryn P. Burdon; Andrew K. Wong; Barbara E.K. Klein; Ronald Klein; Jerome I. Rotter; Sudha K. Iyengar; Alkes L. Price; Lucia Sobrin

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February 1, 2019

A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer

European Journal of Cancer, ISSN: 18790852 09598049

Bang; Yoon-Koo Kang; Ng; Hyun Cheol Chung; Zev A. Wainberg; Steven Gendreau; Wai Y. Chan; Xu; Daniel Maslyar; Raymond D. Meng; Chau; Jaffer A. Ajani

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February 1, 2019

Atezolizumab in patients with advanced non-small cell lung cancer and history of asymptomatic, treated brain metastases: Exploratory analyses of the phase III OAK study

Lung Cancer, ISSN: 18728332 01695002

Shirish M. Gadgeel; Rimas V. Lukas; Jerome H Goldschmidt; Paul Conkling; Keunchil Park; Diego L Cortinovis; Filippo De Marinis; Achim Rittmeyer; Jyoti D. Patel; Joachim Von Pawel; Carol E. O'Hear; Catherine Lai; Hu; Ballinger; Alan Sandler; Mayank Gandhi; Louis Fehrenbacher

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February 1, 2019

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Heleen Scheerens; Ashley Smith; Olga Li; Lee Honigberg; Harris; Gabriële Holtappels; Claus Bachert

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February 1, 2019

Ribonucleoprotein Transfection for CRISPR/Cas9-Mediated Gene Knockout in Primary T Cells

Current Protocols in Immunology, ISSN: 1934368X 19343671

Soyoung A. Oh; Akiko Seki; Sascha Rutz

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February 1, 2019

Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Hao Helen Hou; Aniruddha Rajesh; Keyur Pandya; Joseph W. Lubach; Ariel Muliadi; Edward Yost; Wei Jia; Karthik Nagapudi

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February 1, 2019

A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Ida Netterberg; Chi-Chung Li; Luciana L. Molinero; Nageshwar Budha; Siddharth Sukumaran; Mark Stroh; E. Niclas Jonsson; Lena E. Friberg

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February 1, 2019

Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms

Genes and Immunity, ISSN: 14765470 14664879

Asher Haug-Baltzell; Tushar Bhangale; Diana Chang; Amy Dressen; Brian L. Yaspan; Ward Ortmann; Matthew J. Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Timothy W. Behrens; Robert R. Graham; Arthur Wuster

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February 1, 2019

Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab

Applied Immunohistochemistry and Molecular Morphology, ISSN: 15334058 15412016

Bharathi Vennapusa; Brian Baker; Marcin Kowanetz; Jennifer Boone; Ina Menzl; Jean-Marie Bruey; Gregg D. Fine; Sanjeev Mariathasan; Ian McCaffery; Mocci; Sandra Rost; Dustin Smith; Eslie Dennis; Szu-Yu Tang; Bita Damadzadeh; Espen Walker; Priti Hegde; Williams; Koeppen; Zachary Boyd

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February 1, 2019

Clinicopathologic Correlation of Aneurysmal Type 1 Neovascularization in Age-Related Macular Degeneration

Kidney International Reports, ISSN: 24686530

Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Kenneth R. Sloan; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund

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January 25, 2019

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

Genome Biology, ISSN: 1474760X 14747596

Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin

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January 24, 2019

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Benjamin D. Sellers; Antonio G. DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; Johnson; C. Lee Robinette; Charles J. Cohen; Brian S. Safina; Daniel P. Sutherlin; Daniel F. Ortwine; Christoph Dehnhardt

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January 21, 2019

CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer

BMC Cancer, ISSN: 14712407

Zi-Ming Zhao; Susan E. Yost; Katherine E. Hutchinson; Sierra Min Li; Yate-Ching Yuan; Javad Noorbakhsh; Zheng Liu; Charles Warden; Johnson; Xiwei Wu; Jeffrey H. Chuang; Yuan Yuan

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January 18, 2019

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 -sp 2 Suzuki Coupling of a Benzyl Carbonate

Organic Process Research and Development, ISSN: 1520586X 10836160

Lauren E. Sirois; Matthew M. Zhao; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu

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January 16, 2019

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies

Bioconjugate Chemistry, ISSN: 15204812 10431802

Nicholas Vance; Neelie Zacharias; Ultsch; Guangmin Li; Aimee Fourie; Peter S. Liu; Julien Lafrance-Vanasse; James A. Ernst; Wendy N. Sandoval; Katherine R. Kozak; Gail L. Phillips; Weiru Wang; Jack D. Sadowsky

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January 14, 2019

Study of a Competing Hydrodefluorination Reaction during the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde

Organometallics, ISSN: 15206041 02767333

Frederic St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Remy Angelaud; Francis Gosselin

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January 14, 2019

Directed Cp Rh III -Catalyzed Fluorosulfonylvinylation of Arenes

Organometallics, ISSN: 15206041 02767333

Gqwetha Ncube; Malcolm P. Huestis

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January 11, 2019

Fatty acid recognition in the Frizzled receptor family

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Aaron H Nile; Rami N. Hannoush

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January 9, 2019

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

Journal of the American Chemical Society, ISSN: 15205126 00027863

Seung Wook Kim; Leyah A. Schwartz; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

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January 8, 2019

Why Computed Protein Folding Landscapes Are Sensitive to the Water Model

Journal of Chemical Theory and Computation, ISSN: 15499626 15499618

Ramu Anandakrishnan; Saeed Izadi; Alexey V. Onufriev

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January 8, 2019

Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion

BMC Ophthalmology, ISSN: 14712415

W. Lloyd Clark; Mimi Liu; John Kitchens; Pin-Wen Wang; Zdenka Haskova

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January 7, 2019

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

BMC Pulmonary Medicine, ISSN: 14712466

Tracy Staton; Kun Peng; Ryan Owen; David F. Choy; Christopher R. Cabanski; Alice Fong; Flavia Brunstein; Kathila R. Alatsis; Hubert Chen

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January 7, 2019

In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability

Molecular Pharmaceutics, ISSN: 15438392 15438384

Stijn H.S. Koshari; Purnendu K. Nayak; Shalini Burra; Isidro E. Zarraga; Karthikan Rajagopal; Yun Liu; Norman J. Wagner; Abraham M. Lenhoff

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January 7, 2019

Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures

Molecular Pharmaceutics, ISSN: 15438392 15438384

Karthikan Rajagopal; Debby P. Chang; Purnendu K. Nayak; Saeed Izadi; Thomas W. Patapoff; Jennifer Zhang; Robert F. Kelley; Alavattam Sreedhara

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January 7, 2019

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches

Molecular Pharmaceutics, ISSN: 15438392 15438384

Kelly M. Loyet; Hass; Wendy N. Sandoval; Ashley Morando; Peter S. Liu; Whitney Shatz; Leslie Dickmann; Margaret Kenrick; Jeremy Good; Teresa Davancaze; Alyssa M. Morimoto; Robert F. Kelley; Justin M. Scheer

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January 5, 2019

Seeking universal detectors for analytical characterizations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Kelly Zhang; Kenji L. Kurita; Venkatramani; David J. Russell

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January 4, 2019

Macrolactamization Approaches to Arylomycin Antibiotics Core

Organic Letters, ISSN: 15237052 15237060

Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin

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January 4, 2019

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

Science, ISSN: 10959203 00368075

Oliver J. Harrison; Jonathan L. Linehan; Han-Yu Shih; Nicolas Bouladoux; Seong-Ji Han; Margery Smelkinson; Shurjo K. Sen; Allyson L. Byrd; Michel Enamorado; Chen Yao; Samira Tamoutounour; Francois Van Laethem; Charlotte Hurabielle; Nicholas Collins; Andrea Paun; Rosalba Salcedo; John J. O'Shea; Yasmine Belkaid

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January 3, 2019

Cellular Plasticity in Intestinal Homeostasis and Disease

Cell Stem Cell, ISSN: 18759777 19345909

Felipe de Sousa e Melo; Frederic J. De Sauvage

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January 3, 2019

A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles

Tetrahedron Letters, ISSN: 18733581 00404039

Kyle Clagg; Sara Hold; Archana Kumar; Stefan G. Koenig; Remy Angelaud

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January 2, 2019

Borrowing From Historical Control Data in Cancer Drug Development: A Cautionary Tale and Practical Guidelines

Statistics in Biopharmaceutical Research, ISSN: 19466315

Connor Jo Lewis; Somnath Sarkar; Jiawen Zhu; Bradley P. Carlin

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January 2, 2019

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer

Structure, ISSN: 18784186 09692126

Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang

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January 2, 2019

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Chengfeng Ren; Aaron O. Bailey; Erica Vanderporten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth F. Harris; Yichin Liu; Guanghui Han; Wendy N. Sandoval

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January 2, 2019

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

mAbs, ISSN: 19420870 19420862

Robert G. Brinson; John P. Marino; Frank Delaglio; Luke W. Arbogast; Ryan M. Evans; Anthony Kearsley; Geneviève Gingras; Houman Ghasriani; Yves Aubin; Gregory K. Pierens; Xinying Jia; Mehdi Mobli; Hamish G. Grant; David W. Keizer; Kristian Schweimer; Jonas Ståhle; Göran Widmalm; Edward R. Zartler; Chad W. Lawrence; Patrick N. Reardon; John R. Cort; Ping Xu; Feng Ni; Saeko Yanaka; Koichi Kato; Stuart R. Parnham; Desiree Tsao; Andreas Blomgren; Torgny Rundlöf; Nils Trieloff; Peter Schmieder; Ross; Ken Skidmore; Kang Chen; David Keire; Darón I. Freedberg; Thea Suter-Stahel; Gerhard Wider; Gregor Ilc; Janez Plavec; Scott A. Bradley; Donna M. Baldisseri; Mauricio Luis Sforça; Ana Carolina de Mattos Zeri; Julie Yu Wei; Christina M. Szabo; Carlos A. Amezcua; John B. Jordan; Mats Wikström

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January 2, 2019

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Analytical Chemistry, ISSN: 15206882 00032700

Jordan Baker; Dana McDaniel; David Cain; Paula Lee Tao; Charlene Li; Yuting Huang; Hongbin Liu; Judith Zhu-Shimoni; Milady Ninonuevo

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January 2, 2019

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases

Expert Opinion on Drug Delivery, ISSN: 17447593 17425247

Whitney Shatz; Jeffrey Aaronson; Stefan T. Yohe; Robert F. Kelley; Yogeshvar N. Kalia

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January 2, 2019

High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

mAbs, ISSN: 19420870 19420862

T. Noelle Lombana; Marissa L. Matsumoto; Amy M. Berkley; Evangeline Toy; Ryan Cook; Yutian Gan; Du; Paul D. Schnier; Wendy N. Sandoval; Zhengmao Ye; Jill Schartner; Kim; Christoph Spiess

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January 1, 2019

Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

Multiple Sclerosis Journal - Experimental, Translational and Clinical,

Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers

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January 1, 2019

Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173

Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers

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January 1, 2019

Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a

Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173

Erin L MacMillan; Julia J Schubert; Irene Vavasour; Roger Tam; Alexander Rauscher; Carolyn Taylor; Rick White; Hideki Garren; David Clayton; Victoria Levesque; David K. B. Li; Shannon Kolind; Traboulsee

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January 1, 2019

HPLC and UHPLC for biopharmaceutical analysis

HPLC and UHPLC for Practicing Scientists,

Jennifer C. Rea; Taylor Zhang

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January 1, 2019

Process validation

Comprehensive Biotechnology,

David H. Reifsnyder; Nathan McKnight; Kelley

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January 1, 2019