Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3501 - 3550 OF 15390 RESULTS

January 1, 2019

Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients with Metastatic Triple-Negative Breast Cancer: A Phase 1 Study

JAMA Oncology, ISSN: 23742445 23742437

Leisha A. Emens; Cristina Cruz; Joseph Paul Eder; Fadi S. Braiteh; Cathie Chung; Tolaney; Irene Kuter; Rita Nanda; Philippe A. Cassier; Delord; Michael S. Gordon; Ehab Elgabry; Ching-Wei Chang; Indrani Sarkar; William Grossman; Carol E. O'Hear; Marcella Fassò; Luciana L. Molinero; Schmid

January 1, 2019

A Patient-Reported Outcome Instrument to Assess Symptom Burden and Predict Survival in Patients with Advanced Cancer: Flipping the Paradigm to Improve Timing of Palliative and End-of-Life Discussions and Reduce Unwanted Health Care Costs

Oncologist, ISSN: 1549490X 10837159

Stuart L. Goldberg; Dhakshila Paramanathan; Raya Khoury; Sharmi Patel; Dayo Jagun; Srikesh Arunajadai; Victoria DeVincenzo; Ruth Pe Benito; Brooke Gruman; Sukhi Kaur; Scott Paddock; Andrew D. Norden; Eric V. Schultz; John Hervey; Terrill Jordan; Andre Goy; Andrew L. Pecora

January 1, 2019

A Proposed Complete Methodology to Predict Gravity Flow Obstruction of Pharmaceutical Powders in Drug Product Manufacturing

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Lap Yin Leung; Chen Mao; Sigrid Roza Pieters; Chia-Yi Yang

January 1, 2019

Association of Cancer Immunotherapy with Acute Macular Neuroretinopathy and Diffuse Retinal Venulitis

JAMA Ophthalmology, ISSN: 21686165

Leisha A. Emens; S. Lindsey Davis; Scott C. N. Oliver; Christopher H. Lieu; Ashvini Reddy; Sharon D. Solomon; Lingmin He; Roland Morley; Marcella Fassò; Andrea Pirzkall; Hina Patel; Carol E. O'Hear; Daniela Ferrara

January 1, 2019

Strategies for Pathway Analysis Using GWAS and WGS Data

Current Protocols in Human Genetics, ISSN: 19348258 19348266

Marquitta J White; Brian L. Yaspan; Olivia J. Veatch; Paǵe Goddard; Oona S. Risse-Adams; Maria G. Contreras

January 1, 2019

The effect of emicizumab prophylaxis on health-related outcomes in persons with haemophilia A with inhibitors: HAVEN 1 Study

Haemophilia, ISSN: 13652516 13518216

Johannes Oldenburg; Johnny N. Mahlangu; Bujan; Peter C. Trask; Michael U. Callaghan; Guy Young; Elina Asikanius; Flora Peyvandi; Elena Santagostino; Kruse-Jarres; Claude Negrier; Craig Kessler; Jin Xu; Jerzy Windyga; Midori Shima; Sylvia von Mackensen

January 1, 2019

Long-term survival in patients with advanced non–small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study

European Journal of Cancer, ISSN: 18790852 09598049

Joachim Von Pawel; Rodolfo Bordoni; Satouchi; Louis Fehrenbacher; Manuel Cobo; Ji-Youn Han; Toyoaki Hida; Moro-Sibilot; Paul Conkling; David R. Gandara; Achim Rittmeyer; Mayank Gandhi; Wei Yu; Christina Matheny; Hina Patel; Alan Sandler; Ballinger; Marcin Kowanetz; Keunchil Park

January 1, 2019

Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade

Cancer Letters, ISSN: 18727980 03043835

Jing Zheng; Yonggang Sha; Logan Roof; Oded Foreman; John Lazarchick; Jagadish Kummetha Venkta; Cleopatra Kozlowski; Cristina Gasparetto; Nelson J. Chao; Allen Ebens; Jianda Hu; Yubin Kang

January 1, 2019

LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation

Journal of Immunology, ISSN: 15506606 00221767

Cara Skon; Juan Zhang; Xiumin Wu; Meredith Sagolla; Naruhisa Ota; Arthur Wuster; Jennifer A. Tom; Emma Doran; Nandhini Ramamoorthi; Patrick Caplazi; John G. Monroe; Wyne P. Lee; Timothy W. Behrens

January 1, 2019

Controlled Ice Nucleation using ControLyo® pressurization-depressurization method

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Jacob Luoma; Graham Magill; Lokesh Kumar; Zakaria Yusoff

January 1, 2019

Trastuzumab emtansine (T-DM1) in patients with previously treated HER2-overexpressing metastatic non–small cell lung cancer: Efficacy, safety, and biomarkers

Clinical Cancer Research, ISSN: 15573265 10780432

Solange Peters; Rolf A Stahel; Lukas Bubendorf; Philip D. Bonomi; Augusto Villegas; Dariusz M Kowalski; Christina S. Baik; Dolores Isla; Javier De Castro Carpeno; Pilar Garrido; Achim Rittmeyer; Marcello Tiseo; Christoph Meyenberg; Sanne De Haas; Lisa H. Lam; Michael W. Lu; Thomas E. Stinchcombe

January 1, 2019

Characterization of Ring-Opening Reaction of Succinimide Linkers in ADCs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Kai Zheng; Yan Chen; John Wang; Laura Zheng; Matthew Hutchinson; Josefine Persson; Junyan A. Ji

January 1, 2019

Microinjection and oviduct transfer procedures for rat model generation with CRISPR-Cas9 technology

Methods in Molecular Biology, ISSN: 10643745

Tuija M. Alcantar; Xin Y. Rairdan

January 1, 2019

Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A

AAPS Journal, ISSN: 15507416

Kun Peng; Yehong Wang; Ketevan A. Siradze; Erickson; Saloumeh Kadkhodayan Fischer; Tracy Staton

January 1, 2019

Genomic alterations associated with recurrence and TNBC subtype in high-risk early breast cancers

Molecular Cancer Research, ISSN: 15573125 15417786

Wilson; Akshata R. Udyavar; Ching-Wei Chang; Jill M. Spoerke; Junko Aimi; Heidi Savage; Anneleen Daemen; O'Shaughnessy; Richard Bourgon; Lackner

January 1, 2019

Micro-CT imaging and structural analysis of glomeruli in a model of adriamycin-induced nephropathy

American Journal of Physiology - Renal Physiology, ISSN: 15221466 03636127

Luke Xie; Georgios Koukos; Kai H. Barck; Oded Foreman; Wyne P. Lee; Robert Brendza; Jeffrey Eastham-Anderson; Brent Mckenzie; Andrew S. Peterson; Richard A. D. Carano

January 1, 2019

Continued access to investigational medicinal products for clinical trial participants-An industry approach

Cambridge Quarterly of Healthcare Ethics, ISSN: 14692147 09631801

Ariella Kelman; Anna Kang; Brian Crawford

January 1, 2019

The Escherichia coli -barrel assembly machinery is sensitized to perturbations under high membrane fluidity

Journal of Bacteriology, ISSN: 10985530 00219193

Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter A. Smith; James T. Koerber; Steven T. Rutherford

January 1, 2019

Extracellular protein microarray technology for high throughput detection of low affinity receptor-ligand interactions

Journal of Visualized Experiments, ISSN: 1940087X

Bushra Husain; Sairupa Paduchuri; Sree R. Ramani; Nadia Martinez-Martin

January 1, 2019

Tumor-infiltrating lymphocytes in patients receiving trastuzumab/pertuzumab-based chemotherapy: A TRYPHAENA Substudy

Journal of the National Cancer Institute, ISSN: 14602105 00278874

Michail Ignatiadis; Gert G.G.M. Van Den Eynden; Salgado Roberto; Marco Fornili; Yacine Bareche; Christine Desmedt; Rothé; Maetens; David Venet; Esther Holgado; Virginia McNally; Astrid Kiermaier; Heidi Savage; Wilson; Javier Cortés; Andreas Schneeweiss; Karen Willard-Gallo; Elia Biganzoli; Christos Sotiriou

January 1, 2019

Investigating the Value of Urine Volume, Creatinine, and Cystatin C for Urinary Biomarkers Normalization for Drug Development Studies

International Journal of Toxicology, ISSN: 1092874X 10915818

Adedeji; Tony Pourmohamad; Yafei Chen; Jennifer Burkey; Catherine J. Betts; Susan J. Bickerton; Manisha Sonee; James E. McDuffie

January 1, 2019

Split-cakes, still delicious

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Philippe Lam; Thomas W. Patapoff

January 1, 2019

Quantifying the vial capping process: Residual seal force and container closure integrity

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Robert Ovadia; Alexander Streubel; Yenny Webb-Vargas; Lea Ulland; Joerg Luemkemann; Kamila Rauch; Juergen Eder; Philippe Lam; Vassia Tegoulia; Maa

January 1, 2019

Timely, consistent, transparent assessment of market access evidence: Implementing tools based on the HTA Core Model® in a pharmaceutical company

International Journal of Technology Assessment in Health Care, ISSN: 14716348 02664623

Pierre Ducournau; Cornelia Irl; Iain Tatt; Mary McCarvil; Marlene Gyldmark

January 1, 2019

Current trends in biotherapeutic higher order structure characterization by irreversible covalent footprinting mass spectrometry

Protein and Peptide Letters, ISSN: 18755305 09298665

Natalie K. Garcia; Galahad Deperalta; Aaron T. Wecksler

January 1, 2019

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Xiaojing Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae H. Chang; Po-Chang Chiang; Coura Diène; Jason H. Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoffrey Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dionysos S. Slaga; Minghua Sun; Vickie Tsui; Heidi J. A. Wallweber; Shang-Fan Yu; Allen Ebens

January 1, 2019

Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to induce type 2 inflammation from human lymphocytes

Journal of Immunology, ISSN: 15506606 00221767

Vladimir Ramirez-Carrozzi; Naruhisa Ota; Arivazhagan Sambandam; Kit Wong; Jason A. Hackney; Nadia Martinez-Martin; Wenjun Ouyang; Rajita Pappu

January 1, 2019

Making the move towards modernized greener separations: Introduction of the analytical method greenness score (AMGS) calculator

Green Chemistry, ISSN: 14639270 14639262

Michael B. Hicks; William P. Farrell; Christine Aurigemma; Laurent Lehmann; Lauren Weisel; Kelly Nadeau; Heewon Lee; Carol Moraff; Mengling Wong; Yun Huang; Paul Ferguson

January 1, 2019

Rheumatoid arthritis-interstitial lung disease in the United States: Prevalence, incidence, and healthcare costs and mortality

Journal of Rheumatology, ISSN: 14992752 0315162X

Karina Raimundo; Joshua J. Solomon; Amy L. Olson; Amanda M. Kong; Ashley L. Cole; Aryeh Fischer; Jeffrey J. Swigris

January 1, 2019

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1

Science, ISSN: 10959203 00368075

Meng He; Mira S. Chaurushiya; Webster; Sarah K. Kummerfeld; Rohit Reja; Subhra Chaudhuri; Ying-Jiun Chen; Zora Modrusan; Benjamin Haley; Dugger; Jeffrey Eastham-Anderson; Shari Lau; Anwesha Dey; Roger Caothien; Merone Roose-Girma; Kim Newton; Vishva M. Dixit

January 1, 2019

MAVERICC, a randomized, biomarker-stratified, phase II study of mFOLFOX6-Bevacizumab versus FOLFIRI-bevacizumab as first-line chemotherapy in metastatic colorectal cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Aparna R. Parikh; Fa-Chyi Lee; Linda Yau; Han Koh; James Knost; Edith Mitchell; Ivan Bosanac; Nicholas Choong; Frank A. Scappaticci; Christoph Mancao; Heinz-Josef Lenz

January 1, 2019

Exposure-effect relationships in established rat adjuvant-induced and collagen-induced arthritis: A translational pharmacokinetic-pharmacodynamic analysis

Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565

Harvey Wong; Lichuan Liu; Wenjun Ouyang; Yuzhong Deng; Matthew Wright; Cornelis E. Hop

January 1, 2019

Mutational analysis of patients with colorectal cancer in CALGB/SWOG 80405 identifies new roles of microsatellite instability and tumor mutational burden for patient outcome

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Federico Innocenti; Fang-Shu Ou; Xueping Qu; Tyler J. Zemla; Donna Niedzwiecki; Rachel Tam; Shilpi Mahajan; Richard M. Goldberg; Monica M. Bertagnolli; Charles D. Blanke; Hanna Sanoff; James Atkins; Blase Polite; Alan P. Venook; Heinz-Josef Lenz; Omar Kabbarah

January 1, 2019

Visualization of mass cytometry signal background to enable optimal core panel customization and signal threshold gating

Methods in Molecular Biology, ISSN: 10643745

Amelia Au-Yeung; Chikara Takahashi; W Rodney Mathews; William E. O'Gorman

January 1, 2019

Cellular mechanisms of etrolizumab treatment in inflammatory bowel disease

Frontiers in Pharmacology, ISSN: 16639812

Charlotte Lichnog; Sha Klabunde; Emily Becker; Franklin Fuh; Philipp Tripal; Raja Atreya; Entcho Klenske; Erickson; Chiu; Chae Reed; Shan Chung; Clemens Neufert; Imke Atreya; Jacqueline McBride; Markus F. Neurath; Sebastian Zundler

January 1, 2019

Probing interaction of lipid-modified wnt protein and its receptors by ELISA

Methods in Molecular Biology, ISSN: 19406029 10643745

Aaron H Nile; Rami N. Hannoush

January 1, 2019

Unequal absorption of radiolabeled and nonradiolabeled drug from the oral dose leads to incorrect estimates of drug absorption and circulating metabolites in a mass balance study

Drug Metabolism Letters, ISSN: 18723128

Ryan Takahashi; Jae H. Chang; Jodie Pang; Xiaorong Liang; Shuguang Ma

January 1, 2019

Correction: First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL (Oncotarget(2018) 9 (13023 -13035) DOI: 10.18632/oncotarget.24310)

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

January 1, 2019

Durable remissions with obinutuzumab-based chemoimmunotherapy: Long-term follow-up of the phase 1b GALTON trial in CLL

Blood, ISSN: 15280020 00064971

Jennifer R. Brown; Susan O'Brien; C. Daniel Kingsley; Herbert Eradat; John M. Pagel; Jamie Hirata; Tammy McIver; Rodica Morariu-Zamfir; Thomas J. Kipps

January 1, 2019

Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substituted: N -acyl indole-derived enol carbonates

Chemical Science, ISSN: 20416539 20416520

Eric J. Alexy; Tyler J. Fulton; Haiming Zhang; Brian M. Stoltz

January 1, 2019

Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli

Journal of Bacteriology, ISSN: 10985530 00219193

Caitlin Sande; Catrien Bouwman; Elisabeth Kell; Nicholas N. Nickerson; Sharookh B. Kapadia; Chris Whitfield

January 1, 2019

Bioanalytical challenges in development of ultrasensitive Home Brew assays: A case study using IL-13

Bioanalysis, ISSN: 17576199 17576180

Gizette Sperinde; Martha Hokom; Kun Peng; Saloumeh Kadkhodayan Fischer

January 1, 2019

Effects of PI3K inhibition on afucosylated antibody-driven FcgRIIIa events and phospho-S6 activity in NK cells

Journal of Immunology, ISSN: 15506606 00221767

Valentina Romeo; Sarah Gierke; Kyle A. Edgar; Scot D. Liu

January 1, 2019

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, ISSN: 16643224

Shadi Toghi Eshghi; Amelia Au-Yeung; Chikara Takahashi; Christopher R. Bolen; Maclean N. Nyachienga; Sean P. Lear; Cherie Green; William Mathews; William E. O'Gorman

January 1, 2019

Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard M. Fine; Sandhya Girish; Chunze Li; Jin Y. Jin

January 1, 2019

High-throughput protein analysis using negative stain electron microscopy and 2D classification

Methods in Molecular Biology, ISSN: 19406029 10643745

Christopher P. Arthur; Claudio Ciferri

January 1, 2019

A flexible and scalable high-throughput platform for recombinant membrane protein production

Methods in Molecular Biology, ISSN: 19406029 10643745

Hui Xu; Thomas Clairfeuille; Christine C. Jao; Hoangdung Ho; Zachary K. Sweeney; Jian Payandeh; Christopher M. Koth

January 1, 2019

Semiautomated small-scale purification method for high-throughput expression analysis of recombinant proteins

Methods in Molecular Biology, ISSN: 19406029 10643745

Edward Kraft; Yvonne Franke; Katharine Heeringa; Stephanie K. Shriver; Inna Zilberleyb; Christine Kugel; Trisha Dela Vega; Athena W. Wong; Bobby Brillantes; Claudio Ciferri; George Dutina; Grace Lee; Isabelle Lehoux; Zhong Rong Li; Lee Lior-Hoffmann; Jiyoung Hwang; Chris Lonergan; Lynn Martin; Kyle Mortara; Lananh Nguyen; Jian Payandeh; Andrew Perez; Jun Sampang; Lovejit Singh; Kurt A. Schroeder; Christine Tam; Shu Ti; Ye Naing Win; Krista K. Bowman

January 1, 2019

A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Robert Piskol; Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Rachel Tam; Rajesh Patel; Jeremy B. Burton; Elicia M. Penuel; Xueping Qu; Koeppen; Teiko Sumiyoshi; Frederic J. De Sauvage; Lackner; Felipe de Sousa e Melo; Omar Kabbarah

January 1, 2019

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Journal of Immunology, ISSN: 15506606 00221767

Jooho Chung; Vedran Radojcic; Eric Perkey; Timothy J. Parnell; Yashar Niknafs; Xi Jin; Ann Friedman; Nathalie Labrecque; Bruce R. Blazar; Todd V. Brennan; Christian W. Siebel; Ivan Maillard

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.