Genentech: Publications

February 1, 2019

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

Nature Metabolism, ISSN: 25225812

Pedro Sousa-Victor; Joana Neves; Wendy Cedron-Craft; P. Britten Ventura; Chen-Yu Liao; Rebeccah Riley; Ilya Soifer; Nicholas Van Bruggen; Ganesh Kolumam; Saul A. Villeda; Deepak A. Lamba; Heinrich Jasper

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February 1, 2019

Clinicopathologic Correlation of Aneurysmal Type 1 Neovascularization in Age-Related Macular Degeneration

Kidney International Reports, ISSN: 24686530

Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Kenneth R. Sloan; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund

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January 25, 2019

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

Genome Biology, ISSN: 1474760X 14747596

Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin

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January 24, 2019

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Benjamin D. Sellers; Antonio G. DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; Johnson; C. Lee Robinette; Charles J. Cohen; Brian S. Safina; Daniel P. Sutherlin; Daniel F. Ortwine; Christoph Dehnhardt

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January 21, 2019

CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer

BMC Cancer, ISSN: 14712407

Zi-Ming Zhao; Susan E. Yost; Katherine E. Hutchinson; Sierra Min Li; Yate-Ching Yuan; Javad Noorbakhsh; Zheng Liu; Charles Warden; Johnson; Xiwei Wu; Jeffrey H. Chuang; Yuan Yuan

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January 18, 2019

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 -sp 2 Suzuki Coupling of a Benzyl Carbonate

Organic Process Research and Development, ISSN: 1520586X 10836160

Lauren E. Sirois; Matthew M. Zhao; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu

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January 16, 2019

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies

Bioconjugate Chemistry, ISSN: 15204812 10431802

Nicholas Vance; Neelie Zacharias; Ultsch; Guangmin Li; Aimee Fourie; Peter S. Liu; Julien Lafrance-Vanasse; James A. Ernst; Wendy N. Sandoval; Katherine R. Kozak; Gail L. Phillips; Weiru Wang; Jack D. Sadowsky

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January 14, 2019

Directed Cp Rh III -Catalyzed Fluorosulfonylvinylation of Arenes

Organometallics, ISSN: 15206041 02767333

Gqwetha Ncube; Malcolm P. Huestis

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January 14, 2019

Study of a Competing Hydrodefluorination Reaction during the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde

Organometallics, ISSN: 15206041 02767333

Frederic St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Remy Angelaud; Francis Gosselin

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January 11, 2019

Fatty acid recognition in the Frizzled receptor family

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Aaron H Nile; Rami N. Hannoush

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January 9, 2019

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

Journal of the American Chemical Society, ISSN: 15205126 00027863

Seung Wook Kim; Leyah A. Schwartz; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

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January 8, 2019

Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion

BMC Ophthalmology, ISSN: 14712415

W. Lloyd Clark; Mimi Liu; John Kitchens; Pin-Wen Wang; Zdenka Haskova

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January 8, 2019

Why Computed Protein Folding Landscapes Are Sensitive to the Water Model

Journal of Chemical Theory and Computation, ISSN: 15499626 15499618

Ramu Anandakrishnan; Saeed Izadi; Alexey V. Onufriev

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January 7, 2019

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches

Molecular Pharmaceutics, ISSN: 15438392 15438384

Kelly M. Loyet; Hass; Wendy N. Sandoval; Ashley Morando; Peter S. Liu; Whitney Shatz; Leslie Dickmann; Margaret Kenrick; Jeremy Good; Teresa Davancaze; Alyssa M. Morimoto; Robert F. Kelley; Justin M. Scheer

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January 7, 2019

Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures

Molecular Pharmaceutics, ISSN: 15438392 15438384

Karthikan Rajagopal; Debby P. Chang; Purnendu K. Nayak; Saeed Izadi; Thomas W. Patapoff; Jennifer Zhang; Robert F. Kelley; Alavattam Sreedhara

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January 7, 2019

In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability

Molecular Pharmaceutics, ISSN: 15438392 15438384

Stijn H.S. Koshari; Purnendu K. Nayak; Shalini Burra; Isidro E. Zarraga; Karthikan Rajagopal; Yun Liu; Norman J. Wagner; Abraham M. Lenhoff

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January 7, 2019

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

BMC Pulmonary Medicine, ISSN: 14712466

Tracy Staton; Kun Peng; Ryan Owen; David F. Choy; Christopher R. Cabanski; Alice Fong; Flavia Brunstein; Kathila R. Alatsis; Hubert Chen

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January 5, 2019

Seeking universal detectors for analytical characterizations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Kelly Zhang; Kenji L. Kurita; Venkatramani; David J. Russell

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January 4, 2019

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

Science, ISSN: 10959203 00368075

Oliver J. Harrison; Jonathan L. Linehan; Han-Yu Shih; Nicolas Bouladoux; Seong-Ji Han; Margery Smelkinson; Shurjo K. Sen; Allyson L. Byrd; Michel Enamorado; Chen Yao; Samira Tamoutounour; Francois Van Laethem; Charlotte Hurabielle; Nicholas Collins; Andrea Paun; Rosalba Salcedo; John J. O'Shea; Yasmine Belkaid

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January 4, 2019

Macrolactamization Approaches to Arylomycin Antibiotics Core

Organic Letters, ISSN: 15237052 15237060

Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin

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January 3, 2019

A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles

Tetrahedron Letters, ISSN: 18733581 00404039

Kyle Clagg; Sara Hold; Archana Kumar; Stefan G. Koenig; Remy Angelaud

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January 3, 2019

Cellular Plasticity in Intestinal Homeostasis and Disease

Cell Stem Cell, ISSN: 18759777 19345909

Felipe de Sousa e Melo; Frederic J. De Sauvage

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January 2, 2019

High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

mAbs, ISSN: 19420870 19420862

T. Noelle Lombana; Marissa L. Matsumoto; Amy M. Berkley; Evangeline Toy; Ryan Cook; Yutian Gan; Du; Paul D. Schnier; Wendy N. Sandoval; Zhengmao Ye; Jill Schartner; Kim; Christoph Spiess

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January 2, 2019

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases

Expert Opinion on Drug Delivery, ISSN: 17447593 17425247

Whitney Shatz; Jeffrey Aaronson; Stefan T. Yohe; Robert F. Kelley; Yogeshvar N. Kalia

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January 2, 2019

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Analytical Chemistry, ISSN: 15206882 00032700

Jordan Baker; Dana McDaniel; David Cain; Paula Lee Tao; Charlene Li; Yuting Huang; Hongbin Liu; Judith Zhu-Shimoni; Milady Ninonuevo

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January 2, 2019

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

mAbs, ISSN: 19420870 19420862

Robert G. Brinson; John P. Marino; Frank Delaglio; Luke W. Arbogast; Ryan M. Evans; Anthony Kearsley; Geneviève Gingras; Houman Ghasriani; Yves Aubin; Gregory K. Pierens; Xinying Jia; Mehdi Mobli; Hamish G. Grant; David W. Keizer; Kristian Schweimer; Jonas Ståhle; Göran Widmalm; Edward R. Zartler; Chad W. Lawrence; Patrick N. Reardon; John R. Cort; Ping Xu; Feng Ni; Saeko Yanaka; Koichi Kato; Stuart R. Parnham; Desiree Tsao; Andreas Blomgren; Torgny Rundlöf; Nils Trieloff; Peter Schmieder; Ross; Ken Skidmore; Kang Chen; David Keire; Darón I. Freedberg; Thea Suter-Stahel; Gerhard Wider; Gregor Ilc; Janez Plavec; Scott A. Bradley; Donna M. Baldisseri; Mauricio Luis Sforça; Ana Carolina de Mattos Zeri; Julie Yu Wei; Christina M. Szabo; Carlos A. Amezcua; John B. Jordan; Mats Wikström

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January 2, 2019

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Chengfeng Ren; Aaron O. Bailey; Erica Vanderporten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth F. Harris; Yichin Liu; Guanghui Han; Wendy N. Sandoval

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January 2, 2019

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer

Structure, ISSN: 18784186 09692126

Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang

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January 2, 2019

Borrowing From Historical Control Data in Cancer Drug Development: A Cautionary Tale and Practical Guidelines

Statistics in Biopharmaceutical Research, ISSN: 19466315

Connor Jo Lewis; Somnath Sarkar; Jiawen Zhu; Bradley P. Carlin

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January 1, 2019

Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Thomas B. Casale; Allan T. Luskin; William W. Busse; Robert S. Zeiger; Benjamin L. Trzaskoma; Ming Yang; Noelle M. Griffin; Bradley E. Chipps

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January 1, 2019

Consistently very poorly controlled asthma is associated with greater activity and school impairment in children with severe or difficult-to-treat asthma

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Leonard B. Bacharier; Ronina A. Covar; Tmirah Haselkorn; Ahmar Iqbal; Cynthia Alvarez; David R. Mink; Hubert Chen; Robert S. Zeiger

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January 1, 2019

Change in biomarkers of type-2 inflammation following severe exacerbations of asthma

Thorax, ISSN: 14683296 00406376

Ruth Semprini; Nick Shortt; Stefan Ebmeier; Alex Semprini; Rachel Varughese; Cécile T.J. Holweg; Matthews; James Fingleton; Mark Weatherall; Beasley; Irene Braithwaite

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January 1, 2019

Combined Assessment of Serum Periostin and YKL-40 May Identify Asthma-COPD Overlap

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Toshihiro Shirai; Keita Hirai; Yasuhiro Gon; Shuichiro Maruoka; Kenji Mizumura; Mari Hikichi; Cecile Holweg; Kunihiko Itoh; Hiromasa Inoue; Shu Hashimoto

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January 1, 2019

Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Karthik Nagapudi; Peter W. Fan; Jia Liu

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January 1, 2019

Quantification of Moisture-Induced Cohesion in Pharmaceutical Mixtures

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Raj Mukherjee; Koyel Sen; Lauren Fontana; Chen Mao; Bodhisattwa Chaudhuri

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January 1, 2019

Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury

Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236

Michael E. Rothenberg; Yehong Wang; Annemarie N. Lekkerkerker; Dimitry Danilenko; Romeo MacIuca; Erickson; Ann E. Herman; Stefanich; Timothy T. Lu

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January 1, 2019

Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients with Metastatic Triple-Negative Breast Cancer: A Phase 1 Study

JAMA Oncology, ISSN: 23742445 23742437

Leisha A. Emens; Cristina Cruz; Joseph Paul Eder; Fadi S. Braiteh; Cathie Chung; Tolaney; Irene Kuter; Rita Nanda; Philippe A. Cassier; Delord; Michael S. Gordon; Ehab Elgabry; Ching-Wei Chang; Indrani Sarkar; William Grossman; Carol E. O'Hear; Marcella Fassò; Luciana L. Molinero; Schmid

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January 1, 2019

A Patient-Reported Outcome Instrument to Assess Symptom Burden and Predict Survival in Patients with Advanced Cancer: Flipping the Paradigm to Improve Timing of Palliative and End-of-Life Discussions and Reduce Unwanted Health Care Costs

Oncologist, ISSN: 1549490X 10837159

Stuart L. Goldberg; Dhakshila Paramanathan; Raya Khoury; Sharmi Patel; Dayo Jagun; Srikesh Arunajadai; Victoria DeVincenzo; Ruth Pe Benito; Brooke Gruman; Sukhi Kaur; Scott Paddock; Andrew D. Norden; Eric V. Schultz; John Hervey; Terrill Jordan; Andre Goy; Andrew L. Pecora

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January 1, 2019

A Proposed Complete Methodology to Predict Gravity Flow Obstruction of Pharmaceutical Powders in Drug Product Manufacturing

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Lap Yin Leung; Chen Mao; Sigrid Roza Pieters; Chia-Yi Yang

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January 1, 2019

Association of Cancer Immunotherapy with Acute Macular Neuroretinopathy and Diffuse Retinal Venulitis

JAMA Ophthalmology, ISSN: 21686165

Leisha A. Emens; S. Lindsey Davis; Scott C. N. Oliver; Christopher H. Lieu; Ashvini Reddy; Sharon D. Solomon; Lingmin He; Roland Morley; Marcella Fassò; Andrea Pirzkall; Hina Patel; Carol E. O'Hear; Daniela Ferrara

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January 1, 2019

Strategies for Pathway Analysis Using GWAS and WGS Data

Current Protocols in Human Genetics, ISSN: 19348258 19348266

Marquitta J White; Brian L. Yaspan; Olivia J. Veatch; Paǵe Goddard; Oona S. Risse-Adams; Maria G. Contreras

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January 1, 2019

The effect of emicizumab prophylaxis on health-related outcomes in persons with haemophilia A with inhibitors: HAVEN 1 Study

Haemophilia, ISSN: 13652516 13518216

Johannes Oldenburg; Johnny N. Mahlangu; Bujan; Peter C. Trask; Michael U. Callaghan; Guy Young; Elina Asikanius; Flora Peyvandi; Elena Santagostino; Kruse-Jarres; Claude Negrier; Craig Kessler; Jin Xu; Jerzy Windyga; Midori Shima; Sylvia von Mackensen

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January 1, 2019

Long-term survival in patients with advanced non–small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study

European Journal of Cancer, ISSN: 18790852 09598049

Joachim Von Pawel; Rodolfo Bordoni; Satouchi; Louis Fehrenbacher; Manuel Cobo; Ji-Youn Han; Toyoaki Hida; Moro-Sibilot; Paul Conkling; David R. Gandara; Achim Rittmeyer; Mayank Gandhi; Wei Yu; Christina Matheny; Hina Patel; Alan Sandler; Ballinger; Marcin Kowanetz; Keunchil Park

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January 1, 2019

Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade

Cancer Letters, ISSN: 18727980 03043835

Jing Zheng; Yonggang Sha; Logan Roof; Oded Foreman; John Lazarchick; Jagadish Kummetha Venkta; Cleopatra Kozlowski; Cristina Gasparetto; Nelson J. Chao; Allen Ebens; Jianda Hu; Yubin Kang

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January 1, 2019

LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation

Journal of Immunology, ISSN: 15506606 00221767

Cara Skon; Juan Zhang; Xiumin Wu; Meredith Sagolla; Naruhisa Ota; Arthur Wuster; Jennifer A. Tom; Emma Doran; Nandhini Ramamoorthi; Patrick Caplazi; John G. Monroe; Wyne P. Lee; Timothy W. Behrens

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January 1, 2019

Controlled Ice Nucleation using ControLyo® pressurization-depressurization method

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Jacob Luoma; Graham Magill; Lokesh Kumar; Zakaria Yusoff

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January 1, 2019

Trastuzumab emtansine (T-DM1) in patients with previously treated HER2-overexpressing metastatic non–small cell lung cancer: Efficacy, safety, and biomarkers

Clinical Cancer Research, ISSN: 15573265 10780432

Solange Peters; Rolf A Stahel; Lukas Bubendorf; Philip D. Bonomi; Augusto Villegas; Dariusz M Kowalski; Christina S. Baik; Dolores Isla; Javier De Castro Carpeno; Pilar Garrido; Achim Rittmeyer; Marcello Tiseo; Christoph Meyenberg; Sanne De Haas; Lisa H. Lam; Michael W. Lu; Thomas E. Stinchcombe

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January 1, 2019

Characterization of Ring-Opening Reaction of Succinimide Linkers in ADCs

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Kai Zheng; Yan Chen; John Wang; Laura Zheng; Matthew Hutchinson; Josefine Persson; Junyan A. Ji

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January 1, 2019

Microinjection and oviduct transfer procedures for rat model generation with CRISPR-Cas9 technology

Methods in Molecular Biology, ISSN: 10643745

Tuija M. Alcantar; Xin Y. Rairdan

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January 1, 2019

Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A

AAPS Journal, ISSN: 15507416

Kun Peng; Yehong Wang; Ketevan A. Siradze; Erickson; Saloumeh Kadkhodayan Fischer; Tracy Staton

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