Scientists / Publications

Publications

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DISPLAYING 3551 - 3600 OF 15390 RESULTS

Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Yong Ma; Josefa Dela Cruz-Chuh; S. Cyrus Khojasteh; Peter Dragovich; Thomas H. Pillow; Donglu Zhang
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CHAPTER 11: Duocarmycin-PBD Dimers as Antibody-Drug Conjugate (ADC) Payloads
RSC Drug Discovery Series, ISSN: 20413211 20413203
Thomas H. Pillow; Moana Tercel
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A potent and effective suicidal listeria vaccine platform
Infection and Immunity, ISSN: 10985522 00199567
William G. Hanson; Erin L. Benanti; Edward E. Lemmens; Weiqun Liu; Justin Skoble; Meredith L. Leong; Chris S. Rae; Marcella Fassò; Dirk Brockstedt; Chen Chen; Daniel A. Portnoy; Thomas W. Dubensky; Peter Lauer
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Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Advances in Therapy, ISSN: 18658652 0741238X
Marilyn K Glassberg; Steven D Nathan; Chin-Yu Lin; Elizabeth A. Morgenthien; John L. Stauffer; Willis Chou; Paul W. Noble
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Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
JCI insight, ISSN: 23793708
Denise P. Muñoz; Steven M. Yannone; Anneleen Daemen; Yu Sun; Funda Vakar-Lopez; Misako Kawahara; Adam M. Freund; Francis Rodier; Jennifer D. Wu; Pierre-Yves Desprez; David H. Raulet; Peter S. Nelson; Laura J. van't Veer; Judith Campisi; Jean-Philippe Coppé
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The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
Life Science Alliance, ISSN: 25751077
Mattias Rydenfelt; Matthew Wongchenko; Bertram Klinger; Yibing Yan; Nils Blüthgen
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GDC-0810 pharmacokinetics and transporter-mediated drug interaction evaluation with an endogenous biomarker in the first-in-human, dose escalation study
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Kit Wun Kathy Cheung; Yoshida; Sravanthi Cheeti; Buyun Chen; Roland Morley; Iris Chan; Srikumar Sahasranaman; Lichuan Liu
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Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer
Anti-Cancer Drugs, ISSN: 14735741 09594973
Yang Luo; Wei Li; Zefei Jiang; Qingyuan Zhang; Liwei Wang; Yixiang Mao; Vivianne C G Tjan-Heijnen; Seock-Ah Im; Robin McConnell; Sara Bejarano; Fumagalli; José Bines; Wang; Amit Garg; Whitney P. Kirschbrown; Binghe Xu
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Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress
eLife, ISSN: 2050084X
Anna Shemorry; Jonathan M. Harnoss; Ofer Guttman; Scot A. Marsters; László Kömüves; David Lawrence; Avi Ashkenazi
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Absence of pharmacokinetic interactions between the Bruton’s tyrosine kinase inhibitor fenebrutinib and methotrexate
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Nicholas Steven Jones; Helen Winter; Tamiko R. Katsumoto; Marilyn Florero; Elaine R. Murray; Helen Walker; Nand Singh; Leslie Chinn
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Exposure-efficacy analysis of antibody-drug conjugates delivering an excessive level of payload to tissues
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Donglu Zhang; Peter Dragovich; Shang-Fan Yu; Yong Ma; Thomas H. Pillow; Jack D. Sadowsky; Dian Su; Wei Wang; Andrew G. Polson; Cyrus Khojasteh; Cornelis E. Hop
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Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody-drug conjugates
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Donglu Zhang; Aimee Fourie-O'Donohue; Peter Dragovich; Thomas H. Pillow; Jack D. Sadowsky; Katherine R. Kozak; Robert T. Cass; Liling Liu; Yuzhong Deng; Yichin Liu; Cornelis E. Hop; Cyrus Khojasteh
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Drug concentration asymmetry in tissues and plasma for small molecule-related therapeutic modalities
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Donglu Zhang; Cornelis E. Hop; Gabriela Patilea-Vrana; Gautham Gampa; Herana Kamal Seneviratne; Jashvant D. Unadkat; Jane R. Kenny; Karthik Nagapudi; Li Di; Lian Zhou; Mark Zak; Matthew Wright; Namandjé N. Bumpus; Richard Zang; Xingrong Liu; Yurong Lai; Cyrus Khojasteh
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Perspectives from the innovation and quality consortium induction working group on factors impacting clinical drug-drug interactions resulting from induction: Focus on cytochrome 3a substrates
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Diane Ramsden; Conrad Fung; Niresh Hariparsad; Jane R. Kenny; Michael A. Mohutsky; Neil Parrott; Sarah M. Robertson; Donald J. Tweedie
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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
PLoS Biology, ISSN: 15457885 15449173
Vande Walle; Irma B. Stowe; Pavel Šácha; Bettina L. Lee; Dieter Demon; Amelie Fossoul; Filip Van Hauwermeiren; Pedro H.V. Saavedra; Petr Šimon; Vladimír Šubrt; Libor Kostka; Craig E. Stivala; Victoria Pham; Steven T. Staben; Sayumi Yamazoe; Jan Konvalinka; Nobuhiko Kayagaki; Lamkanfi
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Physician characteristics associated with treatment initiation patterns in idiopathic pulmonary fibrosis
Chronic Respiratory Disease, ISSN: 14799731 14799723
Peter P. LaCamera; Susan L. Limb; Tmirah Haselkorn; Elizabeth A. Morgenthien; John L. Stauffer; Mark L. Wencel
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Investigating the impact of albumin on the liver uptake of pitavastatin and warfarin in nagase analbuminemic rats
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jae H. Chang; Yi-Chen Chen; Jonathan Cheong; Robert S. Jones; Jodie Pang
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Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia
Journal of Experimental Medicine, ISSN: 15409538 00221007
Quang T. Le; Jonathan J. Lyons; Andrea N. Naranjo; Ana Olivera; Lazarus; Dean D. Metcalfe; Joshua D. Milner; Lawrence B. Schwartz
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Discovery of two highly divergent negative-sense RNA viruses associated with the parasitic nematode, Capillaria hepatica, in wild Mus musculus from New York City
Journal of General Virology, ISSN: 14652099 00221317
Simon H. Williams; Xiaoyu Che; Alexandra Oleynik; Joel A. Garcia; Dorothy Muller; Tanja S. Zabka; Cadhla Firth; Robert M. Corrigan; Thomas Briese; Komal Jain; W. Ian Lipkin
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Discovery and Development of Non-Covalent, Reversible Bruton's Tyrosine Kinase Inhibitor Fenebrutinib (GDC-0853)
ACS Symposium Series, ISSN: 19475918 00976156
James J. Crawford; Haiming Zhang
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The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis
ACS Symposium Series, ISSN: 19475918 00976156
Andreas Stumpf; Daniel P. Sutherlin; Christoph Dehnhardt; Remy Angelaud
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Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug
ACS Symposium Series, ISSN: 19475918 00976156
Stefan G. Koenig; Thomas H. Pillow
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From Discovery to Market Readiness: The Research and Development of the β-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib
ACS Symposium Series, ISSN: 19475918 00976156
Remy Angelaud; Steven T. Staben; Timothy P. Heffron; Andreas M. Schuster; Frederic St-Jean
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Comparative effectiveness of first-line nab-paclitaxel versus paclitaxel monotherapy in triple-negative breast cancer
Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305
Patricia Luhn; Chui; Angela Hsieh; Jingbo Yi; Almut Mecke; Preeti S. Bajaj; Waseem Hasnain; Adeline Falgas; Thanh G.N. Ton; Allison W. Kurian
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A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Bushra Husain; Sree R. Ramani; Eugene Y. Chiang; Isabelle Lehoux; Sairupa Paduchuri; Tia A. Arena; Patel; Blair Wilson; Pamela Chan; Yvonne Franke; Athena W. Wong; Jennie R. Lill; Shannon J. Turley; Lino C. Gonzalez Jr.; Jane L. Grogan; Nadia Martinez-Martin
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Imaging patients with metastatic castration-resistant prostate cancer using 89Zr-DFO-MSTP2109A anti-STEAP1 antibody
Journal of Nuclear Medicine, ISSN: 2159662X 01615505
Jorge A. Carrasquillo; Bernard M. Fine; Neeta Pandit-Taskar; Steven M. Larson; Stephen E. Fleming; Josef J. Fox; Sarah M. Cheal; Joseph A. O’Donoghue; Shutian Ruan; Govind Ragupathi; Serge K. Lyashchenko; John L. Humm; Scher; Mithat Gonen; Simon P. Williams; Daniel C. Danila; Michael J. Morris
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Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals
Organic and Biomolecular Chemistry, ISSN: 14770520
Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Daniel F. Ortwine; Antonio G. DiPasquale; Jun Liang; Xiaojing Wang; Jason R. Zbieg; Jun Li
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Evaluation of in-study cut points to enable appropriate interpretation of clinical immunogenicity results
Bioanalysis, ISSN: 17576199 17576180
Jochen Brumm; Kun Peng
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Immunogenicity of antibody-drug conjugates: Observations across 8 molecules in 11 clinical trials
Bioanalysis, ISSN: 17576199 17576180
Montserrat Carrasco-Triguero; Randall Dere; Marija Milojic-Blair; Ola M. Saad; Denise Nazzal; Kyu Hong; Surinder Kaur
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Streamlined Characterization of an Antibody-Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Alexandre Goyon; Michael Kim; Lu Dai; Christopher Cornell; Fred Jacobson; Davy Guillarme; Cinzia Stella
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Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer
Oncotarget, ISSN: 19492553
C. Andrew Boswell; Daniela Bumbaca Yadav; Eduardo E. Mundo; Shang-Fan Yu; Jennifer A. Lacap; Aimee Fourie-O’Donohue; Katherine R. Kozak; Gregory Z. Ferl; Crystal Zhang; Jason Ho; Sheila Ulufatu; Leslie A. Khawli; Kedan Lin
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Microglia in Brain Development, Homeostasis, and Neurodegeneration
Annual Review of Genetics, ISSN: 15452948 00664197
Christopher J. Bohlen; Brad A. Friedman; Borislav Dejanovic; Morgan Sheng
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2019 white paper on recent issues in bioanalysis: Chromatographic assays (part 1 - Innovation in small molecules and oligonucleotides & mass spectrometric method development strategies for large molecule bioanalysis)
Bioanalysis, ISSN: 17576199 17576180
Christine Fandozzi; Christopher Evans; Amanda Wilson; Dian Su; Melanie Anderson; Valerie Clausen; Lieve Dillen; Fabio Garofolo; Chris Holliman; Elliott Nickbarg; Timothy Olah; Ragu Ramanathan; Hui Zhang; Surinder Kaur; Renuka Pillutla; Hongbin Yu; Kevin Bateman; Lorella Di Donato; Shawna Hengel; Wenying Jian; Barry Jones; John Kellie; Anita Lee; Joe Palandra; Natasha Savoie; Petia Shipkova; Susan Spitz; Matthew Szapacs; Jian Wang; Katherine Wright; Jianing Zeng
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2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)
Bioanalysis, ISSN: 17576199 17576180
Steven Piccoli; Devangi Mehta; Alessandra Vitaliti; John Allinson; Shashi Amur; Steven Eck; Cherie Green; Michael Hedrick; Shirley Hopper; Allena Ji; Alison Joyce; Virginia Litwin; Kevin Maher; Joel Mathews; Kun Peng; Afshin Safavi; Yow-Ming C. Wang; Yan Zhang; Lakshmi Amaravadi; Nisha Palackal; Sai Thankamony; Chris Beaver; Eris Bame; Thomas Emrich; Grimaldi; Jonathan Haulenbeek; Vellalore Kakkanaiah; David Lanham; Andrew Mayer; Paul C Trampont; Laurent Vermet; Naveen Dakappagari; Catherine Aversa Fleener; Fabio Garofolo; Cynthia Rogers; Shabnam Tangri; Yuanxin Xu; Meina Liang; Manoj Rajadhyaksha; Susan Richards; Becky Schweighardt; Shobha Purushothama; Daniel Baltrukonis; Jochen Brumm; Elana Cherry; Jason Delcarpini; Carol Gleason; Susan Kirshner; Robert J Kubiak; Luying Pan; Michael A. Partridge; Joao Pedras-Vasconcelos; Qiang Qu; Venke Skibeli; Therese Solstad Saunders; Roland F Staack; Kay Stubenrauch; Albert Torri; Verthelyi; Haoheng Yan; Boris Gorovits; Rachel Palmer; Milton; Brian Long; Bart Corsaro; Vahid Farrokhi; Michele Fiscella; Neil Henderson; Vibha Jawa; Jim McNally; Rocio Murphy; Hanspeter Waldner; Tong-Yuan Yang
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2019 White Paper on Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2-Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Brian Booth; Lauren Stevenson; Renuka Pillutla; Michael H. Buonarati; Chris Beaver; Daniela Fraier; Fabio Garofolo; Sam Haidar; Rafiqul Islam; Christopher James; John Kadavil; Olga Kavetska; Li; Christina Satterwhite; Natasha Savoie; Sriram Subramaniam; Nilufer Tampal; Theingi Thway; Eric Woolf; Olivier Le Blaye; Matthew Andisik; Chad Briscoe; Stephanie Cape; Arindam Dasgupta; Saloumeh Kadkhodayan Fischer; Roger Hayes; John Kamerud; Gustavo Mendes Lima Santos; Corey Nehls; Catherine Soo; Stephen Vinter; Emma Whale; Keyang Xu; Seongeun Julia Cho; Anna Edmison; Sean Kassim; Thais Correa Rocha; Jan Welink; Shashi Amur; Abbas Bandukwala; Elana Cherry; Shirley Hopper; Akiko Ishii-Watabe; Susan Kirshner; Kevin Maher; Joao Pedras-Vasconcelos; Yoshiro Saito; Therese Solstad Saunders; Venke Skibeli; Verthelyi; Yow-Ming C. Wang; Haoheng Yan
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Immunoaffinity LC-MS/MS to quantify a PEGylated anti-Factor D Fab biotherapeutic in cynomolgus monkey serum
Bioanalysis, ISSN: 17576199 17576180
Luna Liu; Yanqiu Liu; Lu Dai; Cinzia Stella; Morse Faria; Junlong Shao; Jamie L Hicks; Diego F. Cortes; William R. Mylott; Eric Wakshull; Surinder Kaur; Keyang Xu
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Phase i Study of DSTP3086S, an antibody-drug conjugate targeting six-transmembrane epithelial antigen of prostate 1, in metastatic castration-resistant prostate cancer
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Daniel C. Danila; Russell Z. Szmulewitz; Ulka Vaishampayan; Celestia S. Higano; Ari Baron; Houston N. Gilbert; Flavia Brunstein; Marija Milojic-Blair; Wang; Omar Kabbarah; Michael Mamounas; Bernard M. Fine; Daniel Maslyar; Alexander Ungewickell; Scher
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Healthcare costs of potential glucocorticoid-associated adverse events in patients with giant cell arteritis
ClinicoEconomics and Outcomes Research, ISSN: 11786981
Jennie Best; Amanda M. Kong; David Smith; Ibrahim Abbass; Margaret Michalska
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Cisplatin Ineligibility for Patients with Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives among US Oncologists
Bladder Cancer, ISSN: 23523735 23523727
Matthew D. Galsky; Esprit Ma; Bijal Shah-Manek; Rosalina Mills; Long Ha; Craig Krebsbach; Eric Blouin; Darren Tayama; Sarika Ogale
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Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study
Nature Methods, ISSN: 15491676 15491277
Michael Wainberg; Anubha Mahajan; Anshul Kundaje; Mark I. McCarthy; Erik Ingelsson; Nasa Sinnott-Armstrong; Manuel Rivas
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Disposable bioreactors
Comprehensive Biotechnology,
Oosterhuis; Terry Hudson; Alberto D’Avino; Zijlstra; Ashraf Amanullah
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Process validation
Comprehensive Biotechnology,
David H. Reifsnyder; Nathan McKnight; Kelley
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HPLC and UHPLC for biopharmaceutical analysis
HPLC and UHPLC for Practicing Scientists,
Jennifer C. Rea; Taylor Zhang
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Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Erin L MacMillan; Julia J Schubert; Irene Vavasour; Roger Tam; Alexander Rauscher; Carolyn Taylor; Rick White; Hideki Garren; David Clayton; Victoria Levesque; David K. B. Li; Shannon Kolind; Traboulsee
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Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers
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Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Multiple Sclerosis Journal - Experimental, Translational and Clinical,
Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers
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2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)
Bioanalysis, ISSN: 17576199 17576180
Steven Piccoli; Devangi Mehta; Alessandra Vitaliti; John Allinson; Shashi Amur; Steven Eck; Cherie Green; Michael Hedrick; Shirley Hopper; Allena Ji; Alison Joyce; Virginia Litwin; Kevin Maher; Joel Mathews; Kun Peng; Afshin Safavi; Yow-Ming C. Wang; Yan Zhang; Lakshmi Amaravadi; Nisha Palackal; Sai Thankamony; Chris Beaver; Eris Bame; Thomas Emrich; Grimaldi; Jonathan Haulenbeek; Vellalore Kakkanaiah; David Lanham; Andrew Mayer; Paul C Trampont; Laurent Vermet; Naveen Dakappagari; Catherine Aversa Fleener; Fabio Garofolo; Cynthia Rogers; Shabnam Tangri; Yuanxin Xu; Meina Liang; Manoj Rajadhyaksha; Richards; Becky Schweighardt; Shobha Purushothama; Daniel Baltrukonis; Jochen Brumm; Elana Cherry; Jason Delcarpini; Carol Gleason; Susan Kirshner; Robert J Kubiak; Luying Pan; Michael A. Partridge; Joao Pedras-Vasconcelos; Qiang Qu; Venke Skibeli; Therese Solstad Saunders; Roland F Staack; Kay Stubenrauch; Albert Torri; Verthelyi; Haoheng Yan; Boris Gorovits; Rachel Palmer; Milton; Brian Long; Bart Corsaro; Vahid Farrokhi; Michele Fiscella; Neil Henderson; Vibha Jawa; Jim McNally; Rocio Murphy; Hanspeter Waldner; Tong-Yuan Yang
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A Patient-Reported Outcome Instrument to Assess Symptom Burden and Predict Survival in Patients with Advanced Cancer: Flipping the Paradigm to Improve Timing of Palliative and End-of-Life Discussions and Reduce Unwanted Health Care Costs
Oncologist, ISSN: 1549490X 10837159
Stuart L. Goldberg; Dhakshila Paramanathan; Raya Khoury; Shilpen Patel; Dayo Jagun; Srikesh Arunajadai; Victoria DeVincenzo; Ruth Pe Benito; Brooke Gruman; Sukhi Kaur; Scott Paddock; Andrew D. Norden; Eric V. Schultz; John Hervey; Terrill Jordan; Andre Goy; Andrew L. Pecora
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Micro-CT imaging and structural analysis of glomeruli in a model of adriamycin-induced nephropathy
American Journal of Physiology - Renal Physiology, ISSN: 15221466 1931857X
Luke Xie; Georgios Koukos; Kai H. Barck; Oded Foreman; Wyne P. Lee; Robert Brendza; Jeffrey Eastham-Anderson; Brent Mckenzie; Andrew S. Peterson; Richard A. D. Carano
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Marie-Gabrielle Braun; Alba Díaz-Rodríguez; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Shaun Hughes; Mark McLaws; Paul Richardson; Markus Schober; Austin G. Smith; Alan Steven; Jack A. Terrett; Timothy White; Jingjun Yin
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