Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3701 - 3750 OF 15390 RESULTS

October 25, 2018

Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Marian C. Bryan; Naomi S. Rajapaksa

October 23, 2018

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde

October 19, 2018

Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable

Organic Process Research and Development, ISSN: 1520586X 10836160

Stefan G. Koenig; David Leahy; Andrew S. Wells

October 18, 2018

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

Nature, ISSN: 14764687 00280836

Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage

October 17, 2018

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Science Translational Medicine, ISSN: 19466242 19466234

Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila

October 15, 2018

Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water

Science of the Total Environment, ISSN: 18791026 00489697

Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota

October 15, 2018

Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses

Journal of Immunology, ISSN: 15506606 00221767

Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould

October 8, 2018

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

Cancer Cell, ISSN: 18783686 15356108

Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek

October 6, 2018

Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry

Clinical Proteomics, ISSN: 15590275 15426416

Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews

October 5, 2018

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin

Journal of Organic Chemistry, ISSN: 15206904 00223263

Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin

October 3, 2018

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Xenobiotica, ISSN: 13665928 00498254

Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang

October 3, 2018

Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US

Journal of Medical Economics, ISSN: 1941837X 13696998

Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra

October 3, 2018

Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry

mAbs, ISSN: 19420870 19420862

Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu

October 3, 2018

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

mAbs, ISSN: 19420870 19420862

Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng

October 3, 2018

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

mAbs, ISSN: 19420870 19420862

Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus

October 3, 2018

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

mAbs, ISSN: 19420870 19420862

Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel

October 2, 2018

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, ISSN: 22111247

Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman

October 1, 2018

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics

Seminars in Cancer Biology, ISSN: 10963650 1044579X

Priti Hegde; Jeffery J. Wallin; Christoph Mancao

October 1, 2018

Efficacy of Ranibizumab in Eyes with Diabetic Macular Edema and Macular Nonperfusion in RIDE and RISE

Ophthalmology, ISSN: 15494713 01616420

Rahul K. Reddy; Dante Joseph Pieramici; Shamika Gune; Avanti Ghanekar; Na Lu; Carlos Quezada-Ruiz; Caroline R. Baumal

October 1, 2018

High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells

Biotechnology Journal, ISSN: 18607314 18606768

Meg Tung; Danming Tang; Szu-Han Wang; Dejin Zhan; Karen Kiplinger; Shu Pan; Yifeng Jing; Amy Shen; Patrick Ahyow; Snedecor; Martin Gawlitzek; Shahram Misaghi

October 1, 2018

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Meredith Rocca; LaRonda L. Morford; Diann Blanset; Wendy Halpern; Joy A. Cavagnaro; Christopher J. Bowman

October 1, 2018

Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Mary E. Krause; Ajit S. Narang; Gregory Barker; Sibylle Herzer; Smeet Deshmukh; Wenkui Lan; Daniel Fichana; John M. Wasylyk; Bahar Demirdirek; Limin Zhang; John Fiske; Matthew McGann; Monica L. Adams; Rajesh B. Gandhi

October 1, 2018

Development and validation of a novel semi-homogenous clinical assay for quantitation of Ranibizumab in human serum

Journal of Immunological Methods, ISSN: 18727905 00221759

John Lowe; Eric Wakshull; Theresa Shek; Anan Chuntharapai; Rebecca Elliott; Jeriza Rusit; Mauricio Maia

October 1, 2018

Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yi Yang; Anna Mah; Inn H. Yuk; Parbir Grewal; Abigail F.J. Pynn; Will Cole; Di Gao; Fan Zhang; Jia Chen; Lynn Gennaro; Christian Schöneich

October 1, 2018

An automated mapping method for Nissl-stained mouse brain histologic sections

Journal of Neuroscience Methods, ISSN: 1872678X 01650270

Smadar Shiffman; Sayantani Basak; Cleopatra Kozlowski; Reina N. Fuji

October 1, 2018

Modeled Prognostic Subgroups for Survival and Treatment Outcomes in BRAF V600-Mutated Metastatic Melanoma: Pooled Analysis of 4 Randomized Clinical Trials

JAMA Oncology, ISSN: 23742445 23742437

Axel Hauschild; James Larkin; Antoni Ribas; Brigitte Dréno; Keith Flaherty; Paolo A. Ascierto; Karl Lewis; Edward McKenna; Qian Zhu; Yong Mun; McArthur

October 1, 2018

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process

Molecular Pharmaceutics, ISSN: 15438392 15438384

Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess

October 1, 2018

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Nature Cell Biology, ISSN: 14764679 14657392

Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen

October 1, 2018

Using pH Gradient Dissolution with In-Situ Flux Measurement to Evaluate Bioavailability and DDI for Formulated Poorly Soluble Drug Products

AAPS PharmSciTech, ISSN: 15309932

Jane Li; Konstantin Tsinman; Oksana Tsinman; Larry Wigman

October 1, 2018

Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli

Nature Immunology, ISSN: 15292916 15292908

Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne

October 1, 2018

Anatomy and physiology of the digestive tract of drosophila melanogaster

Genetics, ISSN: 19432631 00166731

Irene Miguel-Aliaga; Heinrich Jasper; Bruno Lemaitre

October 1, 2018

Serum periostin as a biomarker in eosinophilic granulomatosis with polyangiitis

PLoS ONE, ISSN: 19326203

Rennie L. Rhee; Cecile Holweg; Kit Wong; David Cuthbertson; Simon Carette; Nader A. Khalidi; Curry L. Koening; Langford; Carol A. McAlear; Paul A. Monach; Larry W. Moreland; Christian Pagnoux; Seo; Specks; Antoine G. Sreih; Steven R. Ytterberg; Peter A. Merkel

October 1, 2018

Pertuzumab plus trastuzumab and chemotherapy for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (JACOB): final analysis of a double-blind, randomised, placebo-controlled phase 3 study

The Lancet Oncology, ISSN: 14745488 14702045

Tabernero; Paulo M. Hoff; Lin Shen; Atsushi Ohtsu; Manish A. Shah; Karen Cheng; Chunyan Song; Haiyan Wu; Jennifer Eng-Wong; Katherine Kim; Yoon-Koo Kang

October 1, 2018

Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial

Annals of Neurology, ISSN: 15318249 03645134

Wolinsky; Montalban; Stephen L. Hauser; Giovannoni; Patrick Vermersch; Corrado Bernasconi; Gurpreet Deol-Bhullar; Hideki Garren; Peter Chin; Belachew; Ludwig Kappos

October 1, 2018

Humoral immunity goes hormonal: Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to eshcerichia coli

Nature Immunology, ISSN: 15292916 15292908

Joseph Chavarria-Smith; Wouter L. W. Hazenbos; Menno van Lookeren Campagne

October 1, 2018

Ranibizumab Induces Regression of Diabetic Retinopathy in Most Patients at High Risk of Progression to Proliferative Diabetic Retinopathy

Kidney International Reports, ISSN: 24686530

Charles C. Wykoff; David Eichenbaum; Daniel B. Roth; Lauren Hill; Anne E. Fung; Zdenka Haskova

October 1, 2018

Identification of biological axes associated with stage II/III CRC recurrence risk and outcome after adjuvant therapy revealed a T-effector-independent prognostic role for granzyme B

Annals of Oncology, ISSN: 15698041

Meghna Das Thakur; Akshata R. Udyavar; Thomas Sandmann; Li; Bosch; William E. O'Gorman; Li; Amelia Au-Yeung; Chikara Takahashi; Richard Bourgon; Daemen; Priti Hegde; Carlos Bais

October 1, 2018

Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)

Annals of Oncology, ISSN: 15698041

Brian I Rini; Mahrukh Huseni; Michael B. Atkins; David McDermott; Thomas Powles; Bernard Escudier; Romain Banchereau; L-F Liu; Ning Leng; Fan; Doss; Sam C. Nalle; Carroll; Li; Christina Schiff; Marjorie Green; Robert J. Motzer

October 1, 2018

Clinical and analytical validation of an FDA approved comprehensive genomic profiling (CGP) assay incorporating multiple companion diagnostics for targeted and immunotherapies

Annals of Oncology, ISSN: 15698041

Li; James X. Sun; Skoletsky; Milbury; Burns; W-K Yip; Dewal; He; Tuesdell; Peters; Erica Schleifman; Johannes Noé; Jenkins; Elvin; Geoff A. Otto; Doron Lipson; Jeffrey S. Ross; Vincent A. Miller; Doherty; Vietz

October 1, 2018

Dissecting gastric cancer biology and how and when to use immunotherapy

Annals of Oncology, ISSN: 15698041

Meghna Das Thakur; Kwame Okrah; David S. Shames; Priti Hegde; Carlos Bais

October 1, 2018

Safety and tolerability of atezolizumab (atezo) plus bevacizumab (bev) vs sunitinib (sun) in untreated metastatic renal cell carcinoma (mRCC): Pooled analysis of IMmotion150 and IMmotion151

Annals of Oncology, ISSN: 15698041

Cristina Suárez; Toni K. Choueiri; David McDermott; Bernard Escudier; Michael B. Atkins; Thomas Powles; Brian I Rini; Robert J. Motzer; Sumanta Kumar Pal; Lawrence Fong; De Giorgi; Wang; Tarik Khaznadar; Di Nucci; Constanze Kaiser; Darren Tayama; Frede Donskov

October 1, 2018

IMpassion130: Results from a global, randomised, double-blind, phase III study of atezolizumab (atezo) + nab-paclitaxel (nab-P) vs placebo + nab-P in treatment-naive, locally advanced or metastatic triple-negative breast cancer (mTNBC)

Annals of Oncology, ISSN: 15698041

Schmid; Sylvia Adams; Hope S. Rugo; Andreas Schneeweiss; Carlos H. Barrios; Iwata; Diéras; Roberto Hegg; Seock-Ah Im; Wright; Henschel; Luciana L. Molinero; Chui; Roel Funke; Amreen Husain; Eric P. Winer; Loi; Leisha A. Emens

October 1, 2018

IMpower130: Progression-free survival (PFS) and safety analysis from a randomised phase III study of carboplatin + nab-paclitaxel (CnP) with or without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC

Annals of Oncology, ISSN: 15698041

Federico Cappuzzo; Michael McCleod; Maen Hussein; Alessandro Morabito; Achim Rittmeyer; Henry J Conter; Hans-Georg Kopp; Davey B Daniel; Steven McCune; Tarek Mekhail; Alona Zer; Niels Reinmuth; Ahad Sadiq; Venice Archer; Tania Ochi Lohmann; Lijia Wang; Marcin Kowanetz; Wei Lin; Alan Sandler; Howard West

October 1, 2018

MORPHEUS: A phase Ib/II umbrella study platform evaluating the safety and efficacy of multiple cancer immunotherapy (CIT)-based combinations in different tumour types

Annals of Oncology, ISSN: 15698041

Chau; Haag; Rahma; Teresa Macarulla; Steven McCune; Denise A. Yardley; Benjamin Solomon; Melissa L. Johnson; Vidal; Schmid; Guillem Argiles; Dimick; Sami Mahrus; Abdullah; He; Sayyed; Barak; Bleul; Edward Cha; Alexandra Drakaki

October 1, 2018

Biological features and clinical outcomes in atezolizumab (atezo)-treated patients (pts) with metastatic urothelial cancer (mUC) of the upper vs lower urinary tract (UTUC vs LTUC)

Annals of Oncology, ISSN: 15698041

Matthew D. Galsky; Romain Banchereau; Edward E. Kadel III; Teresa Ramirez-Montagut; Sanjeev Mariathasan; AnnChristine Thåström; Jonathan E. Rosenberg; Thomas Powles; Michiel S Van Der Heijden; Andrea Necchi

October 1, 2018

Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)

Annals of Oncology, ISSN: 15698041

Edward S. Kim; Velcheti; Tarek Mekhail; Leal; Dowell; Tsai; Dakhil; Stella; Shen; Hu; Sarah M. Paul; David S. Shames; Erica Schleifman; David Fabrizio; Yun; Phan; Mark A. Socinski

October 1, 2018

Long-term safety of pirfenidone: Results of the prospective, observational PASSPORT study

ERJ Open Research, ISSN: 23120541

Vincent Cottin; Dirk Koschel; Andreas Günther; Carlo Albera; Arata Azuma; C Magnus Sköld; Sara Tomassetti; Philip Hormel; John L. Stauffer; Indiana Strombom; Klaus-Uwe Kirchgaessler; Toby M. Maher

September 27, 2018

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Michael Siu; Arundhati Sengupta Ghosh; Joe Lewcock

September 24, 2018

A phase Ib study to assess the efficacy and safety of vismodegib in combination with ruxolitinib in patients with intermediate- or high-risk myelofibrosis 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Journal of Hematology and Oncology, ISSN: 17568722

Stephen Couban; Giulia Benevolo; William Donnellan; Jennifer Cultrera; Steffen Koschmieder; Srdan Verstovsek; Gregory Hooper; Christian Hertig; Tandon; Natalie Dimier; Vikram Malhi; Francesco Passamonti

September 19, 2018

Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)

Alzheimer's Research and Therapy, ISSN: 17589193

Stephen Salloway; Lee Honigberg; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; David Clayton; Deborah L. Mortensen; Tobias Bittner; Carole Ho; Christina Rabe; Stephen P. Schauer; Kristin R. Wildsmith; Reina N. Fuji; Shehnaaz Suliman; Eric M. Reiman; Kewei Chen; Robert Paul

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.