Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3751 - 3800 OF 15477 RESULTS

Understanding Phase Behavior of Nearly Energetically Equivalent Polymorphs to Achieve Controlled Crystallization for a Nav1.7 Pain Inhibitor Compound
Molecular Pharmaceutics, ISSN: 15438392 15438384
Paroma Chakravarty; Antonio G. DiPasquale; Andreas Stumpf; Joseph W. Lubach; Karthik Nagapudi
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Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney i Cells in Permeability Screening and Efflux Substrate Determination
Molecular Pharmaceutics, ISSN: 15438392 15438384
Eugene C. Chen; Broccatelli; Emile G. Plise; Buyun Chen; Liling Liu; Jonathan Cheong; Shu Zhang; Jamie Jorski; Katherine Gaffney; Kayla K. Umemoto; Laurent Salphati
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Self-reported healthcare utilization by adults with diabetic retinopathy in the United States
Ophthalmic Epidemiology, ISSN: 17445086 09286586
Jeffrey R. Willis; Quan V. Doan; Michelle Gleeson; Zdenka Haskova; Pradeep Ramulu; Lawrence S. Morse; Ronald A. Cantrell
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Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Salman Siddiqui; Aarti Shikotra; Matthew Richardson; Emma Doran; David F. Choy; Alex Bell; Cary D. Austin; Jeffrey Eastham-Anderson; Beverley Hargadon; Joseph R. Arron; Andrew J. Wardlaw; Chris E. Brightling; Liam G. Heaney; Peter Bradding
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A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Sharmila Rajan; Junichiro Sonoda; Timothy Tully; Ambrose Jon Williams; Feng Yang; Frank D. Macchi; Terry Hudson; Mark Chen; Shannon Liu; Nicole R. Valle; Kyra J. Cowan; Thomas R. Gelzleichter
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Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Ruth Semprini; Mathew Williams; Alex Semprini; Alice McDouall; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite
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Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Lichuan Liu; Sravanthi Cheeti; Yoshida; Edna F. Choo; Eugene C. Chen; Buyun Chen; Mary Gates; Stina M. Singel; Roland Morley; Joseph A. Ware; Srikumar Sahasranaman
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Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Van Nguyen; Lynn Kamen; Kai Zheng; Bianca Vora; An Song
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Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
Clinical and Translational Science, ISSN: 17528062 17528054
Meric A. Ovacik; Kedan Lin
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Crystal anisotropy explains structure-mechanics impact on tableting performance of flufenamic acid polymorphs
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Abhay Jain; Harsh S. Shah; Paul R. Johnson; Ajit S. Narang; Ken R. Morris; Rahul V. Haware
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NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Nature Immunology, ISSN: 15292916 15292908
Zuliang Jie; Jin-Young Yang; Meidi Gu; Hui Wang; Xiaoping Xie; Yanchuan Li; Ting Liu; Lele Zhu; Jianhong Shi; Lingyun Zhang; Xiaofei Zhou; Donghyun Joo; Hans D. Brightbill; Yingzi Cong; Daniel Lin; Xuhong Cheng; Shao-Cong Sun
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Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
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Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas K. Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
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Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies
Biotechnology Progress, ISSN: 15206033 87567938
Mandy Yim; David Shaw
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Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus
Gut, ISSN: 14683288 00175749
Alba Llibre; Yusuke Shimakawa; Estelle Mottez; Shaun Ainsworth; Tan-Phuc Buivan; Rick Firth; Elliott Harrison; Arielle R Rosenberg; Jean-François Meritet; Arnaud Fontanet; Pablo Castan; Antonio Madejón; Mark Laverick; Allison Glass; Raquel Viana; Stanislas Pol; C Patrick McClure; William Lucien Irving; Gino Miele; Matthew L. Albert; Darragh Duffy
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Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle G. Schweiger; Jessica A. Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Gregory Z. Ferl; C. Andrew Boswell
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Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Elena Santagostino; Maggie Moore; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres
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FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1–Selected Patients With NSCLC
Journal of Thoracic Oncology, ISSN: 15561380 15560864
David Spigel; Jamie E. Chaft; Scott Gettinger; Bo H. Chao; Luc Dirix; Schmid; Laura Q.M. Chow; Rodney Hicks; Larry Leon; Jill Fredrickson; Marcin Kowanetz; Alan Sandler; Roel Funke; Naiyer A. Rizvi
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Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Mary Kate Alexander; Anh Miu; Angela Oh; Mike Reichelt; Hoangdung Ho; Cecile Chalouni; Sharada Labadie; Lan Wang; Jun Liang; Nicholas N. Nickerson; Huiyong Hu; Lan Yu; Miaofen Du; Donghong Yan; Summer Park; Janice Kim; Min Xu; Benjamin D. Sellers; Hans E. Purkey; Nicholas J. Skelton; Michael F. T. Koehler; Jian Payandeh; Vishal A. Verma; Yiming Xu; Christopher M. Koth; Mireille Nishiyama
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Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV
Birth Defects Research, ISSN: 24721727
Paula Katavolos; Prell; Doris Zane; Rong Deng; Wendy Halpern
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Draft genome sequence of an erwinia tracheiphila isolate from an infected muskmelon (Cucumis melo)
Microbiology Resource Announcements, ISSN: 2576098X
Lori R. Shapiro; Andres Andrade; Erin D. Scully; Jorge Rocha; Joseph N. Paulson; Roberto Kolter
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A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Sonia Ventura; Florencia Cano; Yashaswini Kannan; Felix Breyer; Michael J. Pattison; Mark S. Wilson; Steven C. Ley
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Targeting the MAPK Pathway in RAS Mutant Cancers
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Sarah G. Hymowitz; Shiva Malek
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
PLoS Genetics, ISSN: 15537404 15537390
Nisha Rathore; Sree R. Ramani; Homer Pantua; Jian Payandeh; Tushar Bhangale; Arthur Wuster; Manav Kapoor; Yonglian Sun; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Ali A. Zarrin; Alison M. Goate; David V. Hansen; Timothy W. Behrens; Robert R. Graham
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Assessment of OATP transporter-mediated drug–drug interaction using physiologically-based pharmacokinetic (PBPK) modeling – a case example
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Yuan Chen; Rui Zhu; Fang Ma; Jialin Mao; Eugene C. Chen; Edna F. Choo; Srikumar Sahasranaman; Lichuan Liu
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A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
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Multiproduct resin reuse for clinical and commercial manufacturing - Methodology and acceptance criteria
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Rizwan Sharnez; Steve Doares; Shane Manning; Krunal Mehta; Ekta Mahajan; Angela To; William Daniels; Judy Glynn; Sagar Dhamane; Xiaona Wen; Yunjuan Wang; Pankaj Gour; Constanze Guenther; Derek Foley; Ronan Hayes; Adam Mott; Sunil Prabhu; Dawn Tavalsky; Michael Hendershot; David Haas; Ashley Hesslein; Norbert Schuelke; Hendri Tjandra
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Safety and clinical activity of atezolizumab in head and neck cancer: Results from a phase I trial
Annals of Oncology, ISSN: 15698041 09237534
A. Dimitrios Colevas; Rastilav Bahleda; Fadi S. Braiteh; Ani Balmanoukian; Brana; Chau; Indrani Sarkar; Luciana L. Molinero; William Grossman; Fairooz F. Kabbinavar; Marcella Fassò; Carol O’Hear; John D. Powderly
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Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis
Kidney International Reports, ISSN: 24686530
Marco A. Zarbin; Steve Francom; Susanna M. Grzeschik; Lisa Tuomi; Zdenka Haskova; Wayne Macfadden; Philippe Margaron; Howard Snow; Alan Cruess; Giovanni Staurenghi; Cornelia Dunger-Baldauf
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A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara M. Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
View on Scopus
Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Rosa Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
View on Scopus
Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
View on Scopus
CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Alzheimer's and Dementia, ISSN: 15525279 15525260
Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw
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IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)
Annals of Oncology, ISSN: 15698041
Tony SK Mok; Martin Reck; Leora Horn; Lam; David S. Shames; Liu; Fairooz F. Kabbinavar; Lin; Alan Sandler; Stephen V. Liu
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Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit
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GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran
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Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Naomi S. Rajapaksa
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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde
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Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; David Leahy; Andrew S. Wells
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A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
Nature, ISSN: 14764687 00280836
Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage
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Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
Science Translational Medicine, ISSN: 19466242 19466234
Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila
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Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water
Science of the Total Environment, ISSN: 18791026 00489697
Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota
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Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses
Journal of Immunology, ISSN: 15506606 00221767
Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould
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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Cancer Cell, ISSN: 18783686 15356108
Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek
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Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry
Clinical Proteomics, ISSN: 15590275 15426416
Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews
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Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
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Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra
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Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
mAbs, ISSN: 19420870 19420862
Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu
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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
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