Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 3851 - 3900 OF 15477 RESULTS

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: Insights from the faSScinate clinical trial in systemic sclerosis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Christopher P. Denton; Voon H Ong; Shiwen Xu; Haiyin Chen-Harris; Zora Modrusan; Robert Lafyatis; Dinesh Khanna; Angelika Jahreis; Jeffrey N. Siegel; Thierry Sornasse
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Erratum to: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (Nature Chemical Biology, (2018), 14, 6, (582-590), 10.1038/s41589-018-0035-2)
Nature Chemical Biology, ISSN: 15524469 15524450
Aaron H Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Christopher M. Koth; Wayne J. Fairbrother; Weiru Wang; Frederic J. De Sauvage; Rami N. Hannoush
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Autophagy and lysosomal pathways in nervous system disorders
Molecular and Cellular Neuroscience, ISSN: 10959327 10447431
Baris Bingol
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The Near-Term Viability and Benefits of eLabels for Patients, Clinical Sites, and Sponsors
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Jodi Smith-Gick; Nicola Barnes; Rocco Barone; Jeff Bedford; Jason R. James; Stacy Frankovitz Reisner; Michael Stephenson
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Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: Analyses from the pan-European TOCERRA register collaboration
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Kim Lauper; Dan C. Nordström; Karel Pavelka; Maria Victoria Hernández; Tore K. Kvien; Eirik Klami Kristianslund; Maria Jose Santos; Žiga Rotar; Florenzo Iannone; Catalin Codreanu; Galina Lukina; Sara Gale; Khaled Sarsour; Yves Luder; Delphine Sophie Courvoisier; Cem Gabay
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U-BIOPRED: evaluation of the value of a public–private partnership to industry
Drug Discovery Today, ISSN: 18785832 13596446
John Riley; Veit J. Erpenbeck; Matthews; Cécile T.J. Holweg; Chris H. Compton; Wolfgang Seibold; Tim Higenbottam; Scott Wagers; Anthony Rowe; David Myles
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species
Analytical Biochemistry, ISSN: 10960309 00032697
Jing Wang; Ryan Takahashi; Kevin Dement; Amy Gustafson; Jane R. Kenny; Simon G. Wong; Zhengyin Yan
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Patient-Reported Outcomes in OAK: A Phase III Study of Atezolizumab Versus Docetaxel in Advanced Non–Small-cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Rodolfo Bordoni; Fortunato Ciardiello; Joachim Von Pawel; Diego L Cortinovis; Thomas Karagiannis; Ballinger; Alan Sandler; Wei Yu; Pei He; Christina Matheny; Federico Felizzi; Achim Rittmeyer
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Long-term survival follow-up of atezolizumab in combination with platinum-based doublet chemotherapy in patients with advanced non–small-cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Stephen V. Liu; D. Ross Camidge; Scott Gettinger; Giuseppe Giaccone; Rebecca S. Heist; F. Stephen Hodi; Neal E. Ready; Wei Zhang; Jeffery J. Wallin; Roel Funke; Waterkamp; Paul Foster; Koho Iizuka; John D. Powderly
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Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study
European Journal of Cancer, ISSN: 18790852 09598049
Leora Horn; Scott Gettinger; Michael S. Gordon; Roy S. Herbst; Leena Gandhi; Enriqueta Felip; Lecia V. Sequist; David Spigel; Scott J. Antonia; Ani Balmanoukian; Philippe A. Cassier; Bo Liu; Marcin Kowanetz; Carol E. O'Hear; Marcella Fassò; William Grossman; Alan Sandler; Jean-Charles Soria
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Considerations from the innovation and quality induction working group in response to drug-drug interaction guidances from regulatory agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevances
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jane R. Kenny; Diane Ramsden; David Buckley; Shannon Dallas; Conrad Fung; Michael A. Mohutsky; Heidi J. Einolf; Liangfu Chen; Joshua G. DeKeyser; Maria Fitzgerald; Theunis C Goosen; Amy Siu; Robert L. Walsky; George Zhang; Donald J. Tweedie; Niresh Hariparsad
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Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Travis A. Clark; Jon H. Chung; Mark Kennedy; Jason D. Hughes; Niru Chennagiri; Daniel S. Lieber; Bernard Fendler; Lauren Young; Mandy Zhao; Michael Coyne; Virginia Breese; Geneva Young; Amy Donahue; Dean Pavlick; Alyssa Tsiros; Timothy Brennan; Shan Zhong; Tariq Mughal; Mark Bailey; Jie He; Steven Roels; Garrett M Frampton; Jill M. Spoerke; Steven Gendreau; Lackner; Erica Schleifman; Peters; Jeffrey S. Ross; Siraj M. Ali; Vincent A. Miller; Jeffrey P. Gregg; Phillip J. Stephens; Allison Welsh; Geoff A. Otto; Doron Lipson
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Zinc finger protein 521 regulates early hematopoiesis through cell-extrinsic mechanisms in the bone marrow microenvironment
Molecular and Cellular Biology, ISSN: 10985549 02707306
Courtney J. Fleenor; Tessa Arends; Hong Lei; Josefine Ahsberg; Kazuki Okuyama; Jacob Kuruvilla; Susana Cristobal; Jennifer L. Rabe; Ahwan Pandey; Thomas Danhorn; Desiree Straign; Joaquin M. Espinosa; Søren Warming; Eric Pietras; Mikael Sigvardsson; Hagman
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EGFL7 enhances surface expression of integrin α 5 β 1 to promote angiogenesis in malignant brain tumors
EMBO Molecular Medicine, ISSN: 17574684 17574676
Nevenka Dudvarski Stanković; Frank Bicker; Stefanie Keller; David T.W. Jones; Patrick N Harter; Arne Kienzle; Clarissa Gillmann; Philipp Arnold; Anna Golebiewska; Olivier Keunen; Alf Giese; von Deimling; Tobias Bäuerle; Simone P Niclou; Michel Mittelbronn; Weilan Ye; Stefan M. Pfister; Mirko HH Schmidt
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MicroRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD
European Respiratory Journal, ISSN: 13993003 09031936
Hataitip Tasena; Alen Faiz; Timens; Jacobien Noordhoek; Machteld N. Hylkema; Reinoud Gosens; Pieter S. Hiemstra; Avrum Spira; Dirkje S. Postma; Tew; Michele A. Grimbaldeston; van den Berge; Irene H. Heijink; Brandsma
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Effect of cell culture medium additives on color and acidic charge variants of a monoclonal antibody
Biotechnology Progress, ISSN: 15206033 87567938
Natarajan Vijayasankaran; Sharat Varma; Yi Yang; Steven Meier; Robert Kiss
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An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors
Cancer Discovery, ISSN: 21598290 21598274
Tao Wang; Rong Lu; Payal Kapur; Bijay S. Jaiswal; Raquibul Hannan; Ze Zhang; Ivan Pedrosa; Jason Luke; He Zhang; Leonard D. Goldstein; Qurratulain Yousuf; Yi-Feng Gu; Tiffani McKenzie; Allison Joyce; Min S. Kim; Xinlei Wang; Danni Luo; Oreoluwa Onabolu; Christina Stevens; Zhiqun Xie; Mingyi Chen; Alexander Filatenkov; Jose Torrealba; Xin Luo; Wenbin Guo; Jingxuan He; Eric Stawiski; Zora Modrusan; Durinck; Somasekar Seshagiri; James Brugarolas
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Progress in understanding slow inactivation speeds up
Journal of General Physiology, ISSN: 15407748 00221295
Jian Payandeh
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An introduced crop plant is driving diversification of the virulent bacterial pathogen Erwinia tracheiphila
mBio, ISSN: 21507511 21612129
Lori R. Shapiro; Joseph N. Paulson; Brian J. Arnold; Erin D. Scully; Olga Zhaxybayeva; Naomi E. Pierce; Jorge Rocha; Vanja Klepac-Ceraj; Kristina Holton; Roberto Kolter
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The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation
PLoS Biology, ISSN: 15457885 15449173
Konstantin Knoblich; Sara Cruz Migoni; Susan M. Siew; Elizabeth Jinks; Baksho Kaul; Hannah C. Jeffery; Alfie T. Baker; Muath Suliman; Katerina Vrzalikova; Hisham Mehenna; Paul G. Murray; Francesca Barone; Ye H. Oo; Philip N. Newsome; Gideon Hirschfield; Deirdre Kelly; Steven P. Lee; Biju Parekkadan; Shannon J. Turley; Anne L. Fletcher
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Placental and fetal effects of onartuzumab, a Met/HGF signaling antagonist, when administered to pregnant cynomolgus monkeys
Toxicological Sciences, ISSN: 10960929 10966080
Prell; Noel Dybdal; Akihiro Arima; Yutaka Chihaya; Ihsan Nijem; Wendy Halpern
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The Border of Macular Atrophy in Age-Related Macular Degeneration: A Clinicopathologic Correlation
American Journal of Ophthalmology, ISSN: 18791891 00029394
Rosa Dolz-Marco; Chandrakumar Balaratnasingam; Jeffrey D. Messinger; Miaoling Li; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species
Analytical Biochemistry, ISSN: 10960309 00032697
Jing Wang; Ryan Takahashi; Kevin Dement; Amy Gustafson; Jane R. Kenny; Simon Wong; Zhengyin Yan
View on Scopus
Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Travis Clark; Jon H. Chung; Mark Kennedy; Jason D. Hughes; Niru Chennagiri; Daniel S. Lieber; Bernard Fendler; Lauren Young; Mandy Zhao; Michael Coyne; Virginia Breese; Geneva Young; Amy Donahue; Dean Pavlick; Alyssa Tsiros; Timothy Brennan; Shan Zhong; Tariq Mughal; Mark Bailey; Jie He; Steven Roels; Garrett M Frampton; Jill M. Spoerke; Steven Gendreau; Lackner; Erica Schleifman; Peters; Jeffrey S. Ross; Siraj M. Ali; Vincent A. Miller; Jeffrey P. Gregg; Phillip J. Stephens; Allison Welsh; Geoff A. Otto; Doron Lipson
View on Scopus
Emicizumab prophylaxis in patients who have hemophilia a without inhibitors
New England Journal of Medicine, ISSN: 15334406 00284793
Johnny N. Mahlangu; Johannes Oldenburg; Paz-Priel; Claude Negrier; Markus Niggli; Mancuso; Christophe Schmitt; Jiménez-Yuste; Kempton; Dhalluin; Michael U. Callaghan; Bujan; Midori Shima; Adamkewicz; Elina Asikanius; Gallia Levy; Kruse-Jarres
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An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Cell, ISSN: 10974172 00928674
Nadia Martinez-Martin; Jessica Marcandalli; Christine S. Huang; Christopher P. Arthur; Michela Perotti; Mathilde Foglierini; Hoangdung Ho; Annie M. Dosey; Stephanie K. Shriver; Jian Payandeh; Alexander Leitner; Antonio Lanzavecchia; Laurent Perez; Claudio Ciferri
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Gut-selective integrin-targeted therapies for inflammatory bowel disease
Journal of Crohn's and Colitis, ISSN: 18764479 18739946
Christopher A. Lamb; Sharon O'Byrne; Mary E. Keir; Eugene C. Butcher
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Kinase domain dimerization drives RIPK3-dependent necroptosis
Science Signaling, ISSN: 19379145 19450877
Saravanan Raju; Daniel M. Whalen; Meron Mengistu; Carter J. Swanson; John Quinn; Taylor; Webster; Kim Newton; Andrey S. Shaw
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Development of an Efficient Manufacturing Process for Reversible Bruton's Tyrosine Kinase Inhibitor GDC-0853
Organic Process Research and Development, ISSN: 1520586X 10836160
Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin
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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
Molecular Cell, ISSN: 10974164 10972765
Tsun-Kai Chang; David Lawrence; Min Lu; Jenille Tan; Jonathan M. Harnoss; Scot A. Marsters; Peter S. Liu; Wendy N. Sandoval; Scott E. Martin; Avi Ashkenazi
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Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations
Blood, ISSN: 15280020 00064971
Sarah C. Rutherford; Angela A. Fachel; Sheng Li; Seema Sawh; Ashlesha Muley; Jennifer Ishii; Ashish Saxena; Pilar M. Dominguez; Eloisi Caldas Lopes; Xabier Agirre; Nyasha Chambwe; Fabian Correa; Yanwen Jiang; Kristy L. Richards; Doron Betel; Rita Shaknovich
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Facile quantitation of free thiols in a recombinant monoclonal antibody by reversed-phase high performance liquid chromatography with hydrophobicity-tailored thiol derivatization
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Leslie Welch; Xiao Dong; Daniel Hewitt; Michelle Irwin; Luke McCarty; Christina Tsai; Tomasz K. Baginski
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ERK Mutations and amplification confer resistance to ERK-inhibitor therapy
Clinical Cancer Research, ISSN: 15573265 10780432
Bijay S. Jaiswal; Durinck; Eric Stawiski; Jianping Yin; Weiru Wang; Eva Lin; John Moffat; Scott E. Martin; Zora Modrusan; Somasekar Seshagiri
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Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K. Cheung; David Arnott; E. Megan Flynn; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
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Reply to J.J. Tao et al
Journal of Clinical Oncology, ISSN: 15277755 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
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Scaffold-Hopping Approach to Discover Potent, Selective, and Efficacious Inhibitors of NF-ΰB Inducing Kinase
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette M. Castanedo; Jason D. Burch; Leonid M. Berezhkovskiy; Hans D. Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter W. Fan; Jianwen A. Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah G. Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne P. Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent Mckenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren C. Wu; Yamin Zhang; Zoe Zhong; Steven T. Staben
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The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Mariya Pindrus; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Sanket Dahotre; Anthony Tomlinson; Baiwei Lin; Sandeep Yadav
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In vitro assessment of chemotherapy-induced neuronal toxicity
Toxicology in Vitro, ISSN: 18793177 08872333
Chelsea Snyder; Lanlan Yu; Tin Ngo; Daniel Sheinson; Yuda Zhu; Min Tseng; Misner; Karin Staflin
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, ISSN: 1573904X 07248741
Michael T. Jones; Hanns-Christian Mahler; Sandeep Yadav; Dilbir Bindra; Vincent Corvari; R. Matthew Fesinmeyer; Kapil Gupta; Alexander M. Harmon; Kenneth D. Hinds; Atanas Koulov; Wei Liu; Kevin Maloney; John Wang; Ping Y. Yeh; Satish K. Singh
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Adsorption of polysorbate 20 and proteins on hydrophobic polystyrene surfaces studied by neutron reflectometry
Colloids and Surfaces B: Biointerfaces, ISSN: 18734367 09277765
Zhenhuan Zhang; Sara Orski; Ann Marie Woys; Guangcui Yuan; Isidro E. Zarraga; Norman J. Wagner; Yun Liu
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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Navpreet Kaur; Ajit S. Narang; Arvind Kumar Bansal
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Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce Mccall; Jill Fredrickson; Eric Wakshull; Stephen M. Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review
Archives of Dermatological Research, ISSN: 1432069X 03403696
Vanessa W. Stevens; David D. Stenehjem; Olga V. Patterson; Kamauu; Yeun Mi Yim; Rob Morlock; Scott L. Duvall
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Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Amy Dressen; Abbas Alexander; Christopher R. Cabanski; Janina Reeder; Thirumalai R. Ramalingam; Margaret Neighbors; Tushar Bhangale; Matthew J. Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; William F. Forrest; Harold R. Collard; Paul J. Wolters; Jonathan A Kropski; Lisa H Lancaster; Timothy S. Blackwell; Joseph R. Arron; Brian L. Yaspan
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Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design
International Journal of Stroke, ISSN: 17474949 17474930
Sharon D. Yeatts; Joseph P. Broderick; Anjan Chatterjee; Edward C Jauch; Steven R. Levine; Jose G Romano; Jeffrey L. Saver; Achala Vagal; Barbara Purdon; Jenny Devenport; Pooja Khatri
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Corrigendum to ‘Effects of RG7652, a Monoclonal Antibody Against PCSK9, on Low-Density Lipoprotein Cholesterol (LDL-C), LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or with Established Coronary Heart Disease (From the Phase 2 EQUATOR Study)’ (The American Journal of Cardiology (2017) 119(10) (1576–1583), (S0002914917302060) (10.1016/j.amjcard.2017.02.020))
American Journal of Cardiology, ISSN: 18791913 00029149
Amos Baruch; Mosesova; John Davis; Nageshwar Budha; Alexandr Vilimovskij; Robert S. Kahn; Kun Peng; Kyra J. Cowan; Laura Pascasio Harris; Thomas R. Gelzleichter; Josh Lehrer; John C. Davis; Whittemore G. Tingley
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Digoxin in Patients With BRAFV600 Mutation–Positive Metastatic Malignancy
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Weijiang Zhang; Christine McIntyre; Melissa Kuhn; Harper Forbes; Kim; Jeeyun Lee; Lev Demidov; Dawn Colburn
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
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Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Margaret Neighbors; Christopher R. Cabanski; Thirumalai R. Ramalingam; X Rebecca Sheng; Tew; Chunyan Gu; Guiquan Jia; Kun Peng; Jill M. Ray; Brett Ley; Paul J. Wolters; Harold R. Collard; Joseph R. Arron
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