Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4101 - 4150 OF 15477 RESULTS

Optimized RNP transfection for highly efficient CRI SPR/Cas9-mediated gene knockout in primary T cells
Journal of Experimental Medicine, ISSN: 15409538 00221007
Akiko Seki; Sascha Rutz
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Patient-centered assessment on disease burden, quality of life, and treatment satisfaction associated with acromegaly
Journal of Investigative Medicine, ISSN: 17088267 10815589
Shuqian Liu; Daphne T. Adelman; Yaping Xu; Jillone Sisco; Susan M. Begelman; Susan M. Webb; Xavier Badia; Tina K. Thethi; Vivian Fonseca; Lizheng Shi
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Intratumoral payload concentration correlates with the activity of antibody–drug conjugates
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Donglu Zhang; Shang-Fan Yu; S. Cyrus Khojasteh; Yong Ma; Thomas H. Pillow; Jack D. Sadowsky; Dian Su; Katherine R. Kozak; Keyang Xu; Andrew G. Polson; Peter Dragovich; Cornelis E. Hop
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An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Sunil Bhakta; Lisa Crocker; Chen; Meredith Hazen; Melissa Schutten; Dongwei Li; Coenraad Kuijl; Rachana Ohri; Fiona Zhong; Kirsten Achilles Poon; MaryAnn Go; Eric Cheng; Robert Piskol; Ron Firestein; Aimee Fourie-O'Donohue; Katherine R. Kozak; Helga Raab; Hongo; Deepak Sampath; Dennis; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula
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Quantitative intracerebral microdialysis studies to determine unbound extracellular fluid drug concentrations in discrete areas of the brain
Current Protocols in Pharmacology, ISSN: 19348290 19348282
Matthew Durk
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Pertuzumab, trastuzumab, and standard anthracycline- and taxane-based chemotherapy for the neoadjuvant treatment of patients with HER2-positive localized breast cancer (BERENICE): A phase II, open-label, multicenter, multinational cardiac safety study
Annals of Oncology, ISSN: 15698041 09237534
Sandra M. Swain; Michael S. Ewer; Giuseppe Viale; Delaloge; Jean-Marc Ferrero; Verrill; Ramon Colomer; Vieira; Werner; Hannah Douthwaite; Bradley; Waldron-Lynch; Astrid Kiermaier; Jennifer Eng-Wong; Chau T. Dang
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Mechanistic investigation on grinding-induced subvisible particle formation during mixing and filling of monoclonal antibody formulations
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Benson Gikanga; Ada Hui; Maa
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Homozygous ksr1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of ras-driven pancreatic cancer
PLoS ONE, ISSN: 19326203
Elizabeth A. Germino; Joseph P. Miller; Laurie Diehl; Carter J. Swanson; Durinck; Zora Modrusan; Jeffrey H. Miner; Andrey S. Shaw
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A risk index and data display for process performance in the pharmaceutical industry
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Bert Gunter; Daniel A. Coleman; Aaron Goerke; Theo Koulis; Jens Lamerz; Yiming Peng
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Vemurafenib for BRAF V600-mutant erdheim-chester disease and langerhans cell histiocytosis analysis of data from the histology-independent, phase 2, open-label VE-BASKET study
JAMA Oncology, ISSN: 23742445 23742437
Eli L. Diamond; Vivek Subbiah; Albert Craig Lockhart; Jean-Yves Blay; Igor Puzanov; Chau; Noopur S. Raje; Jurgen Wolf; Joseph P. Erinjeri; Jean Torrisi; Mario E. Lacouture; Elena Elez; Ferran Martínez-Valle; Benjamin Durham; Maria E. Arcila; Gary A. Ulaner; Omar Abdel-Wahab; Bethany Pitcher; Makrutzki; Todd Riehl; Baselga; David Hyman
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Maximum reading speed in patients with geographic atrophy secondary to age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Rohit Varma; Eric H. Souied; Adnan Tufail; Elizabeth Tschosik; Daniela Ferrara; Jiameng Zhang; David Silverman; Chantal M. Dolan; Neil M. Bressler
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Next generation antibody drugs: Pursuit of the 'high-hanging fruit'
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Paul J. Carter; Greg A. Lazar
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Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate
Chemistry - A European Journal, ISSN: 15213765 09476539
Xin Linghu; Nathaniel Segraves; Ifat Abramovich; Nicholas Wong; Barbara Müller; Nadja Neubauer; Serena M. Fantasia; Sebastian Rieth; Stephan Bachmann; Michael Jansen; C. Gregory Sowell; David Askin; Stefan G. Koenig; Francis Gosselin
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Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial
The Lancet, ISSN: 1474547X 01406736
Thomas Powles; Ignacio Durán; Michiel S Van Der Heijden; Yohann Loriot; Nicholas J. Vogelzang; Ugo De Giorgi; Stephane Oudard; Margitta M. Retz; Daniel Castellano; Aristotelis Bamias; Aude Fléchon; Gwenaëlle Gravis; Syed Hussain; Toshimi Takano; Ning Leng; Edward E. Kadel III; Romain Banchereau; Priti Hegde; Sanjeev Mariathasan; Na Cui; Xiaodong Shen; Christina L. Derleth; Marjorie Green; Alain Ravaud
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Cluster Size and Quinary Structure Determine the Rheological Effects of Antibody Self-Association at High Concentrations
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Wenhua Wang; Wayne G. Lilyestrom; Zhi Yu Hu; Thomas M. Scherer
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Nature, ISSN: 14764687 00280836
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E. Kadel III; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Romain Banchereau; Yagai Yang; Yinghui Guan; Cecile Chalouni; James Ziai; Yasin Senbabaoglu; Stephen Santoro; Daniel Sheinson; Jeffrey Hung; Jennifer M. Giltnane; Andrew A Pierce; Kathryn Mesh; Steve Lianoglou; Johannes Riegler; Richard A. D. Carano; Pontus Eriksson; Mattias Höglund; Loan Somarriba; Daniel L Halligan; Michiel S Van Der Heijden; Yohann Loriot; Jonathan E. Rosenberg; Lawrence Fong; Ira Mellman; Daniel S. Chen; Marjorie Green; Christina L. Derleth; Gregg D. Fine; Priti Hegde; Richard Bourgon; Thomas Powles
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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads
Bioconjugate Chemistry, ISSN: 15204812 10431802
Donglu Zhang; Hoa Le; Josefa Dela Cruz-Chuh; Sudheer Bobba; Jun Guo; Leanna Staben; Chenghong Zhang; Yong Ma; Katherine R. Kozak; Gail L. Phillips; Breanna S. Vollmar; Jack D. Sadowsky; Richard L. Vandlen; Binqing Wei; Dian Su; Peter W. Fan; Peter Dragovich; S. Cyrus Khojasteh; Cornelis E. Hop; Thomas H. Pillow
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High-Throughput Cysteine Scanning to Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Bioconjugate Chemistry, ISSN: 15204812 10431802
Rachana Ohri; Sunil Bhakta; Aimee Fourie-O'Donohue; Josefa Dela Cruz Chuh; Siao Ping Tsai; Ryan Cook; Binqing Wei; Carl Ng; Athena W. Wong; Aaron B. Bos; Farzam Farahi; Jiten Bhakta; Thomas H. Pillow; Helga Raab; Richard L. Vandlen; Paul G. Polakis; Yichin Liu; Hans Erickson; Jagath R. Junutula; Katherine R. Kozak
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Targeted therapy for advanced solid tumors on the basis of molecular profiles: Results from mypathway, an open-label, phase IIA multiple basket study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
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Challenges of developing small-molecule kinase inhibitors for brain tumors and the need for emphasis on free drug levels
Neuro-Oncology, ISSN: 15235866 15228517
Timothy P. Heffron
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Two-Step Synthesis of 3,4-Dihydropyrrolopyrazinones from Ketones and Piperazin-2-ones
Organic Letters, ISSN: 15237052 15237060
Cosme Sandoval; Ngiap-Kie Lim; Haiming Zhang
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Synthesis of a selective estrogen receptor degrader via a stereospecific elimination approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Andrew McClory; Chong Han; Haiming Zhang; Antonio G. DiPasquale; Francis Gosselin
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell, ISSN: 10974164 10972765
Tatiana Goncharov; Stefanie Hedayati; Melinda M. Mulvihill; Anita Izrael-Tomasevic; Zobel; Surinc Er Jeet; Anna V. Fedorova; Celine Eidenschenk; Jason Devoss; Kebing Yu; Andrey S. Shaw; Donald S. Kirkpatrick; Wayne J. Fairbrother; Deshayes; Domagoj Vucic
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How many human proteoforms are there?
Nature Chemical Biology, ISSN: 15524469 15524450
Ruedi Aebersold; Jeffrey N Agar; I Jonathan Amster; Mark S Baker; Carolyn Bertozzi; Emily S Boja; Catherine E Costello; Benjamin F Cravatt; Catherine Fenselau; Benjamin A. Garcia; Ying Ge; Jeremy Gunawardena; Ronald C Hendrickson; Paul J Hergenrother; Christian G Huber; Alexander R Ivanov; Ole N Jensen; Michael C Jewett; Neil L Kelleher; Laura Kiessling; Nevan J. Krogan; Martin R Larsen; Joseph A Loo; Rachel R Ogorzalek Loo; Emma Lundberg; Michael J Maccoss; Parag Mallick; Vamsi K Mootha; Milan Mrksich; Tom W Muir; Steven M Patrie; James J Pesavento; Sharon J Pitteri; Henry Rodriguez; Alan Saghatelian; Wendy N. Sandoval; Hartmut Schlüter; Salvatore Sechi; Sarah A Slavoff; Lloyd M Smith; Michael Snyder; Paul M Thomas; Mathias Uhlén; Jennifer E Van Eyk; Marc Vidal; David R Walt; Forest M. White; Evan R Williams; Therese Wohlschlager; Vicki H Wysocki; Nathan A Yates; Nicolas L Young; Bing Zhang
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How many human proteoforms are there?
Nature Chemical Biology, ISSN: 15524469 15524450
Ruedi Aebersold; Jeffrey N Agar; I Jonathan Amster; Mark S Baker; Carolyn Bertozzi; Emily S Boja; Catherine E Costello; Benjamin F Cravatt; Catherine Fenselau; Benjamin A. Garcia; Ying Ge; Jeremy Gunawardena; Ronald C Hendrickson; Paul J Hergenrother; Christian G Huber; Alexander R Ivanov; Ole N Jensen; Michael C Jewett; Neil L Kelleher; Laura Kiessling; Nevan J. Krogan; Martin R Larsen; Joseph A Loo; Rachel R Ogorzalek Loo; Emma Lundberg; Michael J Maccoss; Parag Mallick; Vamsi K Mootha; Milan Mrksich; Tom W Muir; Steven M Patrie; James J Pesavento; Sharon J Pitteri; Henry Rodriguez; Alan Saghatelian; Wendy N. Sandoval; Hartmut Schlüter; Salvatore Sechi; Sarah A Slavoff; Lloyd M Smith; Michael Snyder; Paul M Thomas; Mathias Uhlén; Jennifer E Van Eyk; Marc Vidal; David R Walt; Forest M White; Evan R Williams; Therese Wohlschlager; Vicki H Wysocki; Nathan A Yates; Nicolas L Young; Bing Zhang
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Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India
BMC Medical Genetics, ISSN: 14712350
Viswanathan Mohan; Venkatesan Radha; Thong T Nguyen; Eric Stawiski; Kanika Bajaj Pahuja; Leonard D. Goldstein; Jennifer A. Tom; Ranjit Mohan Anjana; Monica Kong-Beltran; Tushar Bhangale; Suresh Jahnavi; Radhakrishnan Chandni; Vijay Gayathri; Paul George; Na Zhang; Sakthivel Murugan; Sameer Phalke; Subhra Chaudhuri; Ravi Gupta; Jingli A. Zhang; Sam Santhosh; Stinson; Zora Modrusan; Vedam Laxmi Ramprasad; Somasekar Seshagiri; Andrew S. Peterson
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Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Binqing Wei; Janet Gunzner; Hui Yao; Tao Wang; Jing Wang; Zijin Xu; Jinhua Chen; John Wai; Jim Nonomiya; Siao Ping Tsai; Josefa Chuh; Katherine R. Kozak; Yichin Liu; Shang-Fan Yu; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Douglas Leipold; Amrita Kamath; Dian Su; Keyang Xu; Eigenbrot; Stefan Steinbacher; Rachana Ohri; Helga Raab; Leanna Staben; Guiling Zhao; Flygare; Thomas H. Pillow; Vishal A. Verma; Luke Masterson; Philip W. Howard; Brian S. Safina
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Grking the smoothened signal
Science Signaling, ISSN: 19379145 19450877
Hayley J. Sharpe; Frederic J. De Sauvage
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Ocrelizumab: A New Therapeutic Paradigm for Multiple Sclerosis
Biochemistry, ISSN: 15204995 00062960
Peter Chin; Andrew A. Chan
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Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
eLife, ISSN: 2050084X
Daniel J. Fazakerley; Rima Chaudhuri; Pengyi Yang; Ghassan J. Maghzal; Kristen C. Thomas; James R. Krycer; Sean J. Humphrey; Benjamin L. Parker; Kelsey H. Fisher-Wellman; Christopher C. Meoli; Nolan J. Hoffman; Ciana Diskin; James G. Burchfield; Mark J. Cowley; Warren Kaplan; Zora Modrusan; Ganesh Kolumam; Yang; Daniel L. Chen; Samocha-Bonet; Greenfield; Kyle L. Hoehn; Roland Stocker; David E. James
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Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Sanjoy Ketan Paul; Olga Montvida; Jennie Best; Sara Gale; Attila Pethoe-Schramm; Khaled Sarsour
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Curvature of designed armadillo repeat proteins allows modular peptide binding
Journal of Structural Biology, ISSN: 10958657 10478477
Simon Hansen; Patrick Ernst; Sebastian L.B. König; Christian Reichen; Christina Ewald; Daniel Nettels; Peer R. E. Mittl; Benjamin Schuler; Pluckthun
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Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma
Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538
Thomas B. Casale; Bradley E. Chipps; Karin Rosén; Benjamin L. Trzaskoma; Tmirah Haselkorn; Theodore A. Omachi; Greenberg; Nicola A. Hanania
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Does site-of-care for oncology infusion therapy influence treatment patterns, cost, and quality in the United States?
Journal of Medical Economics, ISSN: 1941837X 13696998
Sari Hopson; Adrianne Casebeer; Stephen Stemkowski; Dana Drzayich Antol; Zhuliang Tao; Andrew Howe; Jeffrey Patton; Art Small; Anthony Masaquel
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Comparison of platform host cell protein ELISA to process-specific host cell protein ELISA
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Feny Gunawan; Julie C. Nishihara; Peter S. Liu; Wendy N. Sandoval; Vanderlaan; Heidi Zhang; Denise C. Krawitz
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The Use of a 2,2'-Azobis (2-Amidinopropane) Dihydrochloride Stress Model as an Indicator of Oxidation Susceptibility for Monoclonal Antibodies
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Michelle Z. Dion; Y. John Wang; Daniel Bregante; Wayman Chan; Nisana Andersen; Amy Hilderbrand; Danielle L. Leiske; Cleo M. Salisbury
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Correction to: Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC) (Cancer Chemotherapy and Pharmacology, (2017), 80, 6, (1147-1159), 10.1007/s00280-017-3443-1)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li
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A short field guide to fibroblast function in immunity
Seminars in Immunology, ISSN: 10963618 10445323
Matthew B. Buechler; Shannon J. Turley
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Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Jinze Li; Eric Morinello; Thomas Larsen; Denzil Frost; Ivor Caro; Stephen Gould; Lisa Wong; Angela Hendricks; Noel Dybdal; Donna M. Dambach; Melissa Schutten
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Leveraging Humanized Animal Models to Understand Human Drug Disposition: Opportunities, Challenges, and Future Directions
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Edna F. Choo; Laurent Salphati
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Pharmacokinetics and exposure-response analysis of RG7667, a combination of two anticytomegalovirus monoclonal antibodies, in a phase 2a randomized trial to prevent cytomegalovirus infection in high-risk kidney transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Rong Deng; Yehong Wang; Mauricio Maia; Tracy Burgess; Jacqueline McBride; X. Charlene Liao; Jorge A. Tavel; William D. Hanley
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Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies
Pharmaceutical Research, ISSN: 1573904X 07248741
Lin Zhang; Sandeep Yadav; John Wang; Olivier Mozziconacci; Christian Schöneich
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Transporter expression in noncancerous and cancerous liver tissue from donors with hepatocellular carcinoma and chronic hepatitis C infection quantified by LC-MS/MS proteomics
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Sarah Billington; Adrian S. Ray; Laurent Salphati; Guangqing Xiao; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Caroline A. Lee; Anita Mathias; Cornelis E. Hop; Christopher Rowbottom; Raymond Evers; Yurong Lai; Edward J. Kelly; Bhagwat Prasad; Jashvant D. Unadkat
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Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid – Case Study of GDC-0810
Pharmaceutical Research, ISSN: 1573904X 07248741
Hao Helen Hou; Wei Jia; Lichuan Liu; Sravanthi Cheeti; Jane Li; Ewa Nauka; Karthik Nagapudi
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SUV420H2 is an epigenetic regulator of epithelial/ mesenchymal states in pancreatic cancer
Journal of Cell Biology, ISSN: 15408140 00219525
Manuel Viotti; Catherine Wilson; Mark L. McCleland; Koeppen; Benjamin Haley; Suchit Jhunjhunwala; Christiaan N. Klijn; Zora Modrusan; David Arnott; Marie Classon; Jean-Philippe Stephan; Ira Mellman
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Microglia in Alzheimer's disease
Journal of Cell Biology, ISSN: 15408140 00219525
David V. Hansen; Jesse E. Hanson; Morgan Sheng
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Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: Results from the open-label period of a phase II randomised controlled trial (faSScinate)
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Dinesh Khanna; Christopher P. Denton; Celia J.F. Lin; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Janet E. Pope; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Helen Spotswood; Laura Burke; Jeffrey N. Siegel; Angelika Jahreis; Daniel E. Furst
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Racial and Ethnic Composition of Cancer Clinical Drug Trials: How Diverse Are We?
Oncologist, ISSN: 1549490X 10837159
Leslie Dickmann; Jennifer L. Schutzman
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Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Elena Tortosa; Casper C Hoogenraad
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Engineered cysteine antibodies: An improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability
Protein Engineering, Design and Selection, ISSN: 17410134 17410126
Sussman; Westendorf; Meyer; Leiske; Anderson; Okeley; Stephen C. Alley; Lyon; Sanderson; Paul J. Carter; Benjamin
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