Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4101 - 4150 OF 15390 RESULTS

January 1, 2018

Cardiovascular effects of renal distal tubule deletion of the fgf receptor 1 gene

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Xiaobin Han; Ross; Ganesh Kolumam; Min Pi; Junichiro Sonoda; Gwendalyn King; Darryl Quarles

January 1, 2018

Opposing roles of dendritic cell subsets in experimental GN

Journal of the American Society of Nephrology, ISSN: 15333450 10466673

Sebastian Brähler; Bernd H. Zinselmeyer; Saravanan Raju; Maximilian Nitschke; Hani Suleiman; Brian T. Saunders; Michael W. Johnson; Alexander M.C. Böhner; Susanne F. Viehmann; Derek J. Theisen; Nicole M. Kretzer; Carlos G. Briseño; Konstantin Zaitsev; Olga Ornatsky; Qing Chang; Javier A. Carrero; Jeffrey B. Kopp; Maxim N. Artyomov; Christian Kurts; Kenneth M. Murphy; Jeffrey H. Miner; Andrey S. Shaw

January 1, 2018

CD8+ T cell infiltration in breast and colon cancer: A histologic and statistical analysis

PLoS ONE, ISSN: 19326203

James Ziai; Houston N. Gilbert; Oded Foreman; Jeffrey Eastham-Anderson; Felix Chu; Mahrukh Huseni; Kim

January 1, 2018

A solid-phase approach for the synthesis of α-Aminoboronic acid peptides

RSC Advances, ISSN: 20462069

Blake E. Daniels; Craig E. Stivala

January 1, 2018

Detection of PD-L1 in circulating tumor cells and white blood cells from patients with advanced non-small-cell lung cancer

Annals of Oncology, ISSN: 15698041 09237534

Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Chamorey; Salomé Lalvée; Eric Selva; Leroy; Charles-Hugo Marquette; Marcin Kowanetz; Priti Hedge; Elizabeth A. Punnoose; Paul Hofman

January 1, 2018

Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: Results from the ETOP Lungscape Project

Annals of Oncology, ISSN: 15698041 09237534

Keith M. Kerr; Urania Dafni; Katja Schulze; Erik Thunnissen; Lukas Bubendorf; Hager; Stephen P. Finn; Biernat; Vliegen; Losa; Antonio Marchetti; Richard Cheney; Arne Warth; Ernst Jan M. Speel; Blackhall; Kim Monkhorst; Jantus Lewintre; Verena Tischler; Clark; Bertran-Alamillo; Meldgaard; Gately; Wrona; Vandenberghe; Enriqueta Felip; De Luca; Spasenija Savic; Muley; Smit; Anne-Marie C. Dingemans; Priest; Baas; Carlos Camps; Weder; Polydoropoulou; Thomas R. Geiger; Roswitha Kammler; Teiko Sumiyoshi; Molina; David S. Shames; Rolf A Stahel; Solange Peters; Boss

January 1, 2018

The Integumentary System

Fundamentals of Toxicologic Pathology: Third Edition,

Kelly L. Diegel; Dimitry Danilenko; Zbigniew W. Wojcinski

January 1, 2018

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

PLoS Pathogens, ISSN: 15537374 15537366

Nicole D. Marino; Michael W. Panas; Magdalena Franco; Terence C. Theisen; Adit Naor; Suchita Rastogi; Kerry R. Buchholz; Hernan A. Lorenzi; John C. Boothroyd

January 1, 2018

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

EMBO Reports, ISSN: 14693178 1469221X

Dan Du; Yoko Katsuno; Dominique Meyer; Erine H Budi; Si-Han Chen; Koeppen; Hongjun Wang; Rosemary J Akhurst; Rik Derynck

January 1, 2018

Nonclinical safety assessment of anti-factor d: Key strategies and challenges for the nonclinical development of intravitreal biologics

Journal of Ocular Pharmacology and Therapeutics, ISSN: 15577732 10807683

Vlad Bantseev; Rebecca Erickson; Douglas Leipold; Caroline Amaya; Paul Miller; Helen Booler; Evan A Thackaberry

January 1, 2018

First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL

Oncotarget, ISSN: 19492553

John C. Byrd; Stephen Smith; Nina D. Wagner-Johnston; Jeff P. Sharman; Chen; Ranjana H. Advani; Bradley Augustson; Paula Marlton; S. Renee Commerford; Kwame Okrah; Lichuan Liu; Elaine R. Murray; Elicia M. Penuel; Ashley F. Ward; Ian W. Flinn

January 1, 2018

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: Study protocol for a randomised trial

Trials, ISSN: 17456215

Catherine E. Hanratty; Matthews; Joseph R. Arron; David F. Choy; Ian D. Pavord; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Ratko Djukanovic; Nicola Gallagher; Stephen J. Fowler; Tim Hardman; Timothy Harrison; Cécile T.J. Holweg; Peter Howarth; James Lordan; Adel Mansur; Andrew Menzies-Gow; Mosesova; Robert Niven; Douglas S. Robinson; Dominick E. Shaw; Samantha Walker; Ashley Woodcock; Liam G. Heaney; Ian Adcock; Boriello; Matthew Catley; Kian Fan Chung; Richard W. Costello; Sebastian Johnston; Frank Keane; Richard May; Lisa Pierre; Dirk Smith; Chris Stevenson; Val Hudson; David Supple; Gainsborough; Horn

January 1, 2018

Status and future of 3D cell culture in toxicity testing

Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153

Monicah A. Otieno; Jinping Gan; William R. Proctor

January 1, 2018

Immune-modified response evaluation criteria in solid tumors (imrecist): Refining guidelines to assess the clinical benefit of cancer immunotherapy

Journal of Clinical Oncology, ISSN: 15277755 0732183X

F. Stephen Hodi; Ballinger; Benjamin Lyons; Jean-Charles Soria; Mizuki Nishino; Tabernero; Thomas Powles; David Smith; Axel Hoos; Chris McKenna; Ulrich Beyer; Ina Rhee; Gregg D. Fine; Nathan Winslow; Daniel S. Chen; Jedd D Wolchok

January 1, 2018

Selective ligands and drug discovery targeting the voltage-gated sodium channel nav1.7

Handbook of Experimental Pharmacology, ISSN: 18650325 01712004

Jian Payandeh; David Hackos

January 1, 2018

The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort

Alzheimer's and Dementia: Translational Research and Clinical Interventions, ISSN: 23528737

Pierre N. Tariot; Francisco Lopera; Jessica B. Langbaum; Ronald G. Thomas; Suzanne Hendrix; Lon S. Schneider; Silvia Rios-Romenets; Margarita Giraldo; Natalia Acosta; Carlos Tobon; Claudia Ramos; Alejandro Espinosa; William Cho; Michael Ward; David Clayton; Michel Friesenhahn; Howard M. Mackey; Lee Honigberg; Sandra M. Sanabria-Bohorquez; Kewei Chen; Trisha Walsh; Carolyn Langlois; Eric M. Reiman

January 1, 2018

Applications of genetics, genomics and bioinformatics in drug discovery

Pacific Symposium on Biocomputing, 2018, ISSN: 23356936 23356928

Richard Bourgon; Frederick E. Dewey; Zhengyan Kan; Shuyu D. Li

January 1, 2018

Inspiring process innovation: Via an improved green manufacturing metric: IGAL

Green Chemistry, ISSN: 14639270 14639262

Frank Roschangar; Yanyan Zhou; David J. C. Constable; Juan Colberg; David P. Dickson; Peter Dunn; Martin D. Eastgate; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; David Leahy; Ingrid Mergelsberg; Ulrich Scholz; Austin G. Smith; Manuel Henry; Jason Mulder; Jörg Brandenburg; Juan R. Dehli; Daniel R. Fandrick; Keith R. Fandrick; Frieder Gnad-Badouin; Georg Zerban; Klaus Groll; Paul T. Anastas; Roger A. Sheldon; Chris H. Senanayake

January 1, 2018

Elastomer change out - Justification for minimizing the removal of elastomers to prevent cross-contamination in a multiproduct facility

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Michael Parks; Niamh O'Dwyer; Jeremy Bollinger; Alan Johnson; Brian Goss; Ned Wyman; Adeyma Arroyo; Joseph Wood; Derek Willison-Parry

January 1, 2018

Process Variability Source Analysis for a Multi-step Bio-process

Computer Aided Chemical Engineering, ISSN: 15707946

Yuan Jin; Joe Qin; Victor Saucedo; Zheng Li; Angela Meier; Siddhartha Kunda; Salim Charaniya

January 1, 2018

Real-World Effectiveness of Chemotherapy in Elderly Patients with Metastatic Bladder Cancer in the United States

Bladder Cancer, ISSN: 23523735 23523727

Matthew D. Galsky; Sumanta Kumar Pal; Shih Wen Lin; Sarika Ogale; Marko Zivkovic; Joe Simpson; Christina L. Derleth; Christina Schiff; Guru Sonpavde

January 1, 2018

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

Nature Medicine, ISSN: 1546170X 10788956

David R. Gandara; Sarah M. Paul; Marcin Kowanetz; Erica Schleifman; Wei Zou; Yan Li; Achim Rittmeyer; Louis Fehrenbacher; Geoff A. Otto; Christine Malboeuf; Daniel S. Lieber; Doron Lipson; Jacob Silterra; Lukas Amler; Todd Riehl; Cummings; Priti Hegde; Alan Sandler; Ballinger; David Fabrizio; Tony Mok; David S. Shames

January 1, 2018

Detection of necroptosis by phospho-RIPK3 immunohistochemical labeling

Methods in Molecular Biology, ISSN: 10643745

Webster; Margaret Solon; Susan Haller; Kim Newton

January 1, 2018

A validated surrogate analyte LC-MS/MS assay for quantitation of endogenous kynurenine and tryptophan in human plasma

Bioanalysis, ISSN: 17576199 17576180

Dennis Miller; Lei Tan; Dorshorst; Kari M. Morrissey; Sami Mahrus; Dennis Milanowski; McKnight; Stephanie Cape; Brian J. Dean; Xiaorong Liang

January 1, 2018

Interpreting the language of polyubiquitin with linkage-specific antibodies and mass spectrometry

Methods in Molecular Biology, ISSN: 10643745

Marissa L. Matsumoto; Erick R. Castellanos; Yi Jimmy Zeng; Donald S. Kirkpatrick

January 1, 2018

Optimization and qualification of the single molecule array digital immunoassay for IL-12p70 in plasma of cancer patients

Bioanalysis, ISSN: 17576199 17576180

Vinita Gupta; Navdeep Kalia; Mahesh Yadav; Amy Noyes; Jeremy Good; Robert Hendricks; Wenfeng Xu

January 1, 2018

Disorders of the Spleen

Hematopathology: A Volume in the Series: Foundations in Diagnostic Pathology,

Robert S. Ohgami; James Ziai; Daniel A. Arber

January 1, 2018

Optimal management of pigment epithelial detachments in eyes with neovascular age-related macular degeneration

Retina, ISSN: 15392864 0275004X

Arshad M. Khanani; David Eichenbaum; Patricio G. Schlottmann; Lisa Tuomi; David Sarraf

January 1, 2018

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Journal of Experimental Medicine, ISSN: 15409538 00221007

Bettina L. Lee; Irma B. Stowe; Aaron Gupta; Opher S. Kornfeld; Merone Roose-Girma; Keith R. Anderson; Søren Warming; Juan Zhang; Wyne P. Lee; Nobuhiko Kayagaki

January 1, 2018

Combinations of bevacizumab with cancer immunotherapy

Cancer Journal (United States), ISSN: 1540336X 15289117

Daniel S. Chen; Herbert Hurwitz

January 1, 2018

Utility of pooled cryopreserved human enterocytes as an in vitro model for assessing intestinal clearance and drug-drug interactions

Drug Metabolism Letters, ISSN: 18723128

Susan C. Wong; Utkarsh Doshi; Peter Vuong; Ning Liu; Suzanne Tay; Hoa Le; Mika Kosaka; Jane R. Kenny; Albert P. Li; Zhengyin Yan

January 1, 2018

Key Green Chemistry research areas from a pharmaceutical manufacturers' perspective revisited

Green Chemistry, ISSN: 14639270 14639262

Marian C. Bryan; Peter Dunn; David Entwistle; Fabrice Gallou; Stefan G. Koenig; John Hayler; Matthew Hickey; Shaun Hughes; Michael E. Kopach; Gerard Moine; Paul Richardson; Frank Roschangar; Alan Steven; Franz J. Weiberth

January 1, 2018

Reproducibility of the Measurement of Bulk/Tapped Density of Pharmaceutical Powders Between Pharmaceutical Laboratories

Journal of Pharmaceutical Sciences, ISSN: 00223549

Ilgaz Akseli; Jon Hilden; Jeffrey M. Katz; Ron C. Kelly; Timothy T. Kramer; Chen Mao; Frederick Osei-Yeboah; John C. Strong

January 1, 2018

Optimizing hybrid LC-MS/MS binding conditions is critical: Impact of biotransformation on quantification of trastuzumab

Bioanalysis, ISSN: 17576199 17576180

Luna Liu; Keyang Xu; Jenny Li; Mauricio Maia; Mary Mathieu; Rebecca Elliott; Yang; Ihsan Nijem; Surinder Kaur

January 1, 2018

Discovery and Development of GDC-0994: A Selective and Efficacious Small Molecule Inhibitor of ERK1/2

ACS Symposium Series, ISSN: 19475918 00976156

Xin Linghu; Nicholas Wong; James F. Blake; John J. Gaudino; John Moffat

January 1, 2018

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes

Science immunology, ISSN: 24709468

Teresita L. Arenzana; Steve Lianoglou; Akiko Seki; Celine Eidenschenk; Tommy K. Cheung; Dhaya Seshasayee; Thijs Hagenbeek; Arivazhagan Sambandam; Rajkumar Noubade; Ivan Peng; Justin Lesch; Jason Devoss; Xiumin Wu; Wyne P. Lee; Patrick Caplazi; Webster; Jinfeng Liu; Victoria Pham; David Arnott; Jennie R. Lill; Zora Modrusan; Anwesha Dey; Sascha Rutz

January 1, 2018

A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease

Neurology, ISSN: 1526632X 00283878

Jeffrey L. Cummings; Sharon Cohen; Christopher H. Van Dyck; Mark Brody; Craig Curtis; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; Lee Honigberg; Reina N. Fuji; David Clayton; Deborah L. Mortensen; Carole Ho; Robert Paul; Christina Rabe

January 1, 2018

A different perspective: How much innovation is really needed for monoclonal antibody production using mammalian cell technology?

Advances in Biochemical Engineering/Biotechnology, ISSN: 07246145

Kelley; Robert Kiss; Mike Laird

January 1, 2018

Risk mitigation in preventing adventitious agent contamination of mammalian cell cultures

Advances in Biochemical Engineering/Biotechnology, ISSN: 07246145

Masaru Shiratori; Robert Kiss

January 1, 2018

Fully disposable manufacturing concepts for clinical and commercial manufacturing and ballroom concepts

Advances in Biochemical Engineering/Biotechnology, ISSN: 07246145

Berthold Boedeker; Adam Goldstein; Ekta Mahajan

January 1, 2018

Survey of Customers Requesting Medical Information: Preferences and Information Needs of Patients and Health Care Professionals to Support Treatment Decisions

Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790

Stacey M. Fung; Cheryl Sud; Matt Suchodolski

January 1, 2018

Isoform selective PI3K inhibitors for treating cancer

Topics in Medicinal Chemistry, ISSN: 1862247X 18622461

Steven T. Staben

January 1, 2018

Surface dynamics of micronized active particles

Particle Technology Forum 2018 - Core Programming Area at the 2018 AIChE Annual Meeting,

Vibha Puri; Jagdeep Shur; Robert Price; Ajit S. Narang

January 1, 2018

Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity

Science immunology, ISSN: 24709468

Christian Perez-Shibayama; Cristina Gil-Cruz; Hung-Wei Cheng; Lucas Onder; Andrea Printz; Urs Mörbe; Mario Novkovic; Conglei Li; Constantino Lopez-Macias; Matthew B. Buechler; Shannon J. Turley; Matthias Mack; Charlotte Soneson; Mark D. Robinson; Elke Scandella; Jennifer L. Gommerman; Burkhard Ludewig

January 1, 2018

Stimulus-response mechanisms: An overview

Development of Antibody-Based Therapeutics: Translational Considerations and Challenges,

Mohammad A. Tabrizi; Shraddha Sadekar; Isabel Figueroa; Ayse Meric Ovacik

January 1, 2018

Elevated levels of BRAFV600 mutant circulating tumor DNA and circulating hepatocyte growth factor are associated with poor prognosis in patients with metastatic melanoma

JCO Precision Oncology, ISSN: 24734284

William Lu; Luciana Burton; James Larkin; Paul B. Chapman; Paolo A. Ascierto; Antoni Ribas; Caroline Robert; Jeffrey A. Sosman; McArthur; Ilsung Chang; Ivor Caro; Elicia M. Penuel; Yibing Yan; Matthew Wongchenko

January 1, 2018

Effects of molecular heterogeneity on survival of patients with BRAFV600-mutated melanoma treated with vemurafenib with or without cobimetinib in the coBRIM study

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Antoni Ribas; Paolo A. Ascierto; Brigitte Dréno; Anna Maria Di Giacomo; Claus Garbe; Ilsung Chang; Jessie Hsu; Isabelle Rooney; William Lu; Koeppen; James Larkin; Yibing Yan; McArthur

January 1, 2018

ALK testing trends and patterns among community practices in the United States

JCO Precision Oncology, ISSN: 24734284

Peter B. Illei; Wong; Ning Wu; Laura Chu; Ravindra Gupta; Katja Schulze; Gubens

January 1, 2018

Intracellular regulation of TNF activity in health and disease

Cytokine, ISSN: 10960023 10434666

Eugene Varfolomeev; Domagoj Vucic

January 1, 2018

Mechanistic overview of immune checkpoints to support the rational design of their combinations in cancer immunotherapy

Annals of Oncology, ISSN: 15698041 09237534

Rotte; Jin Y. Jin; Vincent Lemaire

Join Our Team

The little things we do every day add up to big breakthroughs. Making a difference in the lives of millions starts when you make a change in yours.

Two Scientists Walk Into a Bar

Two Scientists Walk Into a Bar

Listen to our podcast, where researchers talk about their work answering the toughest questions in human biology.